Best Midol Acetaminophen in 2026

Daisy
Last Updated: Jul 17, 2026

At a Glance: Our Top Picks for Midol Acetaminophen

Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg, Pain Reliever and Fever Reducer, 50 Pouches of 2 Caplets Each, Total 100
#TOP1
Amazon Basic Care Extra Strength Acetaminophen Caplets 500
10.0
PM SCORE
Tylenol 8 Hour Muscle Aches & Pain Acetaminophen Tablets for Muscle & Back Pain, 100 Count
#TOP2
Tylenol 8 Hour Muscle Aches & Pain Acetaminophen
10.0
PM SCORE
Tylenol, Extra Strength Caplets with 500 mg Acetaminophen Pain Reliever Fever Reducer ct, Multicolor, 10 Count
#TOP3
Tylenol, Extra Strength Caplets With 500 Mg Acetaminophen
10.0
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Midol Acetaminophen of 2026

Market Overview
Midol Acetaminophen Reviewed
  • Reviews Analyzed: 214199 Items
  • PM Avg. Rating: 7.9 / 10
38 Products Evaluated
  • Highest Price: $32.60
  • Lowest Price: $1.49
  • Avg. Price: $13.85

Amazon Basic Care Extra Strength Acetaminophen Caplets 500 Mg, Pain Reliever And Fever Reducer, 50 Pouches Of 2 Caplets Each, Total 100

AMAZON BASIC CARE
3.25 X 4.25 X 4.75 Inches
0.19 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg's active ingredient is acetaminophen 500 mg. Compare to the active ingredient of Extra Strength Tylenol Caplets.

PAIN RELIEVER AND FEVER REDUCER: Temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps Also temporarily reduces fever

EASY TO SWALLOW: Count on these easy-to-swallow caplets for fast-acting headache and fever relief. Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg may be used as a pain reliever and fever reducer for adults and children 12 years and over.

EXTRA STRENGTH PAIN RELIEF: When pain has you in its grips, even small tasks can be tough Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg provides strong, fast pain relief in convenient travel size packs for when you're on the go

ASPIRIN AND CAFFEINE FREE Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg provides the pain relief and fever reduction you need and is safe when taken as directed This product is gluten free

Tylenol 8 Hour Muscle Aches & Pain Acetaminophen Tablets For Muscle & Back Pain, 100 Count

TYLENOL
493961
2.38 X 2.38 X 4.00 Inches
42.00 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

100 Count bottle of Tylenol 8 Hour Muscle Aches & Pains Acetaminophen Tablets to provide temporary relief of minor aches and pains such as muscle aches, joint pain, back pain, headache, toothache, the common cold, and menstrual cramps

Each extended-release tablet contains 650 mg of acetaminophen and features two unique layers - the first is fast-acting and the second is long-lasting - for effective minor joint, minor arthritis and muscle pain that works as hard as you do

This oral pain reliever medicine reduces fever and helps alleviate minor aches and pains, so you can take control of your joint and muscle pain and take back your day with pain relief that works as hard as you do

These pain relief tablets can be used by adults and children who are 12 years and older to relieve minor muscle aches and pain for up to 8 hours. When used as directed, these pain relief tablets have an excellent safety profile

Experience fast-acting, effective relief and alleviate muscle, joint, knee and arthritis aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction

Tylenol, Extra Strength Caplets With 500 Mg Acetaminophen Pain Reliever Fever Reducer Ct, Multicolor, 10 Count

TYLENOL
472598
0.80 X 3.40 X 3.80 Inches
7.00 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

10-count of Tylenol Extra Strength Caplets with acetaminophen to provide temporary relief of minor aches and pains and help reduce fever

Each extra strength caplet contains 500 mg of acetaminophen for effective, lasting pain relief, and has an excellent safety profile when used as directed

Use as a fever reducer and to help alleviate common pain symptoms including headache, backache, toothache, menstrual cramps and pain caused by the common cold

This oral pain reliever can be used by adults and children who are 12 years and older

From the #1 doctor-recommended brand of pain relievers, experience relief from minor aches and pains with Tylenol.

Midol Complete, Menstrual Period Symptoms Relief Including Premenstrual Cramps, Pain, Headache, And Bloating, Caplets, 40 Count, Packaging May Vary

MIDOL
B001G7QVDG
3.25 X 1.60 X 2.25 Inches
0.11 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

1 box of 40 count Midol Complete Menstrual Pain Relief Caplets with Acetaminophen, Caffeine and Pyrilamine Maleate for Menstrual Symptom Relief

Contains acetaminophen for effective period pain relief while also providing backache, muscle ache and headache relief

Includes caffeine and pyrilamine maleate to relieve fatigue, bloating and water weight gain

Available in easy to take caplet form for effective period pain and PMS relief you can take with you everywhere you go

Take 2 caplets with water and repeat every six hours as needed, but don't take more than 6 caplets a day

Tylenol Extra Strength Caplets With 500 Mg Acetaminophen, Pain Reliever & Fever Reducer, Acetaminophen For Minor Arthritis Pain, Headache, Backache & Menstrual Pain Relief, 100 Ct

TYLENOL
340200
3.80 X 2.00 X 2.00 Inches
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

100-count of Tylenol Extra Strength Caplets with 500 mg of acetaminophen to provide temporary relief of minor aches and pains and help reduce fever

Each extra strength caplet contains 500 mg of acetaminophen for effective pain relief, and has an excellent safety profile when used as directed

Use 500 mg acetaminophen caplets as a fever reducer and to help provide relief of common pain symptoms including headache, backache, toothache, menstrual cramps and pain caused by the common cold

This extra strength acetaminophen pain reliever can be used by adults and children who are 12 years and older. To use, take two caplets every six hours while symptoms last and do not take more than six caplets in 24 hours

From the #1 doctor recommended brand for pain relief and fever reduction, experience relief from minor aches and pains with Tylenol

Rite Aid Extra Strength Acetaminophen, 500Mg - 500 Caplets | Pain Reliever & Fever Reducer | Migraine Relief Products | Joint & Muscle Pain Relief Pills | Menstrual Pain Relief | Back Pain Relief

RITE AID
011822300230
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Rite Aid, Inc. 9.98

Features

PAIN RELIEVER & FEVER REDUCER: Rite Aid Extra Strength Acetaminophen caplets reduce fevers temporarily while offering minor headache or migraine relief, relief from muscular and body aches, and pains often associated with arthritis and/or joint pain.

EXTRA STRENGTH: Compare Rite Aid’s Extra Strength Acetaminophen 500mg caplets to the active ingredient in Extra Strength Tylenol. Get all the benefits of an effective pain reliever with Rite Aid Acetaminophen— designed for effective pain relief.

EASY TO SWALLOW CAPLETS: Acetaminophen caplets’ shape make them easier to swallow. Rite Aid Acetaminophen’s easy-to-swallow caplet makes these menstrual pain relief, joint/muscle pain relief, and migraine relief pills ideal for use at home or on-the-go.

ASPIRIN FREE: These pain relief pills contain 500 mg of pain relieving, fever reducing acetaminophen without any aspirin. This aspirin-free muscle, joint, or back pain relief medicine is formulated for those with aspirin allergies or sensitivities.

TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.

Percogesic Original Strength, Acetaminophen And Diphenhydramine, 90 Tablets, Pack Of 2

PERCOGESIC
AXPB33191(2)_USF-CA
6.00 X 4.00 X 4.00 Inches
0.50 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Vitabox 9.88

Features

Percogesic Fast Acting Original Strength provides, prescription-free, pharmacist recommended relief for common aches and pain from headaches, arthritis, menstrual cramps and more

Pharmacist recommended ingredients, Acetaminophen and Diphenhydramine HCl, provide aspirin-free relief that you can trust without worrying about a prescription

Effective analgesic with enhanced pain relief

Easy-to-swallow coated tablets

Pharmacist recommended

Excedrin Tension Headache Relief Caplets Without Aspirin For Head, Neck And Shoulder Pain Relief - 100 Count

EXCEDRIN
204591
6.00 X 5.00 X 4.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief

Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress

Delivers muscle ache, shoulder and neck pain relief

Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches

Contains a trusted formula that combines a pain reliever and an amplifier

Effectively relieves tension-type headaches in convenient caplet form

Advil Dual Action With Acetaminophen + Ibuprofen Pain Reliever 72 Caplets

ADVIL
PF014772
2.00 X 4.00 X 3.50 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One box of 72 Advil Dual Action Coated Caplets with Acetaminophen, 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief

Advil Dual Action coated tablets relieve pain with ibuprofen to target pain at the source and acetaminophen to block pain signals, and new packaging will feature 20% less plastic to keep nearly 500,000 pounds of plastic out of landfills

Multi symptom pain medication that provides headache, toothache, menstrual cramp, muscle pain and lower back pain relief while also relieving minor aches and pains associated with arthritis

Easy to swallow pain medicine that provides longer lasting relief than Tylenol Extra Strength and targets pain at the sight of inflammation

The first and only FDA approved pain relief medication with a combination of acetaminophen and ibuprofen

Pain pills that relieve pain in two ways, providing powerful relief with a lower maximum daily dose of each medication

Advil is a top selling OTC pain reliever, providing safe and effective pain relief when used as directed for more than 35 years

Excedrin Pm Sleep Aid With Headache Relief Caplets For Nighttime Headaches And Sleeplessness - 100 Count

EXCEDRIN
NOV05691
4.25 X 2.00 X 2.00 Inches
0.25 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One bottle of 100 Excedrin PM Pain Reliever, Headache Relief and Nighttime Sleep-Aid Caplets

Pain reliever and nighttime sleeping aid that provides temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness

Caffeine-free diphenhydramine, aspirin and acetaminophen caplets are ideal for nighttime headache sufferers

Nighttime Excedrin caplets that relieve headaches fast to help you get to sleep

Triple action formula combines two effective pain relievers with a nighttime sleep-aid

Pain reliever available in convenient caplet form

Effective headache and muscle pain relief

Valumeds Pm Pain Reliever And Nighttime Sleep Aid (375-Caplets) Acetaminophen 500Mg | Fast-Acting Relief For Headaches, Minor Aches | Non-Habit Forming

VALUMEDS
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ValuMeds 9.90

Features

Relieve Pain Fast – Formulated with 500mg of Acetaminophen, our PM pain reliever can help relieve muscle, joint, headache, and arthritis pain quickly.

Deep, Restful Sleep – Also a nighttime sleep aid, each serving contains 25mg of Diphenhydramine HCl to help your mind and your body safely relax and unwind.

Extra Strength Support – ValuMeds pain reliever and sleep aid contains maximum strength ingredients to give you faster, more reliable results to help relieve pain fast.

Easy-to-Swallow Caplets – A small, smooth shape makes it easier for men and women to swallow our PM pain reliever with water right before bedtime.

Non-Habit Forming – This sleep-aid for adults is gentle on your stomach and is non-addictive to ensure it’s completely safe for regular use. Consult a doctor for details.

Valumeds Extra Strength Headache Relief Caplets (300-Count) | Nonsteroidal Anti-Inflammatory Pain Reliever | Migraine Relief, Arthritis, Muscles, Joints

VALUMEDS
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ValuMeds 9.90

Features

Powerful Migraine Relief: Valumeds Extra Strength Headache Relief offers fast and effective pain relief, providing potent relief from migraines and headaches. With each count, you'll have a reliable solution to combat the pain and discomfort that often accompanies these conditions.

Trusted Brand Quality: Comparable to Tylenol and Excedrin, our Acetaminophen formula delivers effective relief. Trust in the quality and reliability of our trusted brand, backed by years of experience in providing pain relief medicine to millions of satisfied customers.

Versatile Pain Management: Our medication isn't limited to migraines alone; it also effectively addresses other types of pain. From arthritis pain to muscle tension, our extended-release formula ensures long-lasting relief throughout the day.

Travel Size Packaging: Each bottle contains 300 caplets easy and on-the-go use. Whether you're at home, work, or traveling, you'll have immediate access to pain relief whenever you need it.

Suitable for Adults: Valumeds Extra Strength Headache Relief is designed for adults seeking fast and effective pain relief. With our Acetaminophen pills, you can bid farewell to headaches, migraines, and various other types of pain, allowing you to get back to your daily activities with ease.

Healtha2Z Extra Strength Pain Relief, 500 Caplets, Acetaminophen 500Mg

HEALTHA2Z
2.75 X 2.75 X 5.50 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
HealthA2Z 9.95

Features

Use as a fever reducer and to help relieve minor aches and pains including headache, backache, toothache, cramps and pain.

Aspirin can irritate the stomach and does little to reduce fevers. Using acetaminophen, can relieve your pain without irritating your stomach and fevers commonly associated with the cold or flu.

HealhA2Z Extra Strength Pain Relief is suitable for adults

Take 2 caplets every 6 hours while symptoms last. Do not take more than 8 caplets in 24 hours. Do not take for more than 10 days unless directed by a doctor.

No gluten added product

Unisom Pm Pain Nighttime Sleep-Aid + Pain Reliever, Acetaminophen & Diphenhydramine Hci, 30 Caplets, 50Mg

UNISOM
B003CYLE7Y
3.25 X 1.69 X 3.00 Inches
0.11 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Alef Beis 9.95

Features

INCLUDES: One (1) 30-count bottle of Unisom PM Pain Nighttime Sleep-aid + Pain Reliever; one caplet per dose

MAKE THE NIGHT RESTFUL, NOT PAINFUL: Unisom PM Pain is one caplet with two solutions: nighttime sleep-aid combined with a leading pain reliever* *acetaminophen

NON-HABIT FORMING: Dual-action sleep-aid is safe if used as directed, non-habit forming and helps you sleep soundly

TRUST UNISOM, THE SLEEP EXPERT: The #1 Pharmacist Recommended OTC Sleep-Aid Brand* *Data represents brand/product selections from the 2019 Pharmacy Times Survey of Pharmacists' OTC Recommendations

FIND A NIGHTTIME SLEEP SOLUTION THAT'S RIGHT FOR YOU: Millions of people turn to Unisom for a restful night's sleep; Unisom SleepGels, SleepTabs, SleepMinis, SleepMelts or PM Pain can help you take on your day

Safrel - Tension Headache Relief Pain Reliever With Acetaminophen 500 Mg And Caffeine 65 Mg (200 Caplets) Value Pack | Extra Strength For Head And Body Aches | Generic Excedrin Tension Headache

SAFREL
105-02
2.00 X 2.00 X 4.50 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Safrel 9.89

Features

✅ ACTIVE INGREDIENT: The active ingredient in this product is Acetaminophen and Caffeine, it provides headache and pain relief. Compare Safrel All Day Allergy Relief to the active ingredient of Excedrin Extra Strength Headache Relief.

✅ COMPLETE AND FAST PAIN RELIEF – This extra-strength headache medicine also helps relieve other aches and pains, such as arthritis, muscles aches, toothaches, and menstrual cramps. Caffeine provides you energy and restore mental focus to keep you active during the day.

✅ HELPS WITH HEADACHE & OTHER ACHES/PAIN: Provides relief from Headaches, Toothaches, menstrual cramps, arthritis, joint pain and more in one easy to swallow caplet. Adults and children 12 years and older : take 2 caplets every 6 hours.

✅ VALUE PACK SAVINGS: Each bottle of our pain relief medicine contains 200 total caplets to help you and your entire family find long-lasting relief you can count on.

✅ 100% SATISFACTION GUARANTEE: Click Buy Now and get this Extra Strength Headache Relief formula to enjoy your day free from headache and other minor aches/pain.

16 Oz Bottle Acetaminophen Cherry Flavored Liquid

GERICARE
57896018016
1.00 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Premium Supplies Limited 9.94

Features

McKesson Brand *GeriCare Liquid Pain Relief (Acetaminophen)

Mfr# 57896018016

160 mg per 5 mL dose, 16 oz Bottle, Cherry Flavor, Pain Reliever/Fever Reducer.

Not made with natural rubber latex.

Item is sold by 1/Each (1/Bottle)

Drkids Children's Pain And Fever Acetaminophen, Pre-Measured Single-Use Vials, Free From, Travel Compliant, 3.4 Fl Oz, 20 Count (Pack Of 2)

DR. KIDS
000270-2
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Children’s Over-the-Counter Pain Reliever and Fever Reducer. Relieves minor aches and pains due to: common cold, headache, sore throat, and toothache.

Safe & Convenient - Child-proof packaging to prevent accidental overdose.

Single-Use Vials - Dr. Kids single-use vials are individually filled to eliminate the risk of recontamination due to dosing cups or syringes.

Always the Right Dose - Stop guessing the right dosage for your child and avoid measuring errors that could lead to unnecessary emergency room visits.

Travel Friendly - Dr. Kids single-use vials can be conveniently taken everywhere you go and even TSA compliant.

#TOP18

Quality Choice Menstrual Pain Relief, Maximum Strength, Multi-Symptom Relief Caplet, 20Ct

QUALITY CHOICE
QC99445
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
PLQC 9.85

Features

Compare to the Active Ingredients in Maximum Strength Pamprin Multi-Symptom

Relieves: Cramps, Irritability, Headache, Bloating & Backach

20 Caplets

#TOP19

Midol Max Caplets Size 16S Midol Meximum Strength Multi-Symptom Menstrual Relief

MIDOL
4150
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING

Features

#TOP20

Midol Caplets Menstr Max/Str 16 By Midol

MIDOL
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
SaleEase 5.46

Features

womens-health-medications

Midol Long Lasting Relief, Menstrual Pain Reliever & Fever Reducer, Caplets With Acetaminophen For Menstrual Symptom Relief - 20 Count (Packaging May Vary)

MIDOL
15859
6.00 X 4.00 X 4.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One box of 20 count Midol Long Lasting Relief Menstrual Pain Relief Caplets with Acetaminophen

Effective up to 8 hour pain relief of pain due to premenstrual and menstrual symptoms

With extended-release acetaminophen for back pain, muscle pain, headache relief and period pain relief

Relieves premenstrual and menstrual symptoms such as pain from period cramps

Available in portable and easy-to-take caplet form for menstrual pain relief

Top 10 acetaminophen midol Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Midol 16
Tylenol 5
Advil 2
Dr. Kids 2
Excedrin 2
Rite Aid 2
Valumeds 2
Amazon Basic Care 1
Gericare 1
Healtha2Z 1

Top 10 acetaminophen midol Brands Pie Chart


We've carried out a comprehensive analysis of 214,199 reviews on acetaminophen midol, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select acetaminophen midol priced around $13.85, with top brands including midol, tylenol, motrin, dr. kids, excedrin, healtha2z, gericare, advil and a+health and safrel

Our team of expert editors reviewed these high-quality items and handpicked the top 21 acetaminophen midol for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, healtha2z, pharmapacks_, premium supplies limited, pcp ny, royal meds, mymedexpress, grm lc and safrel and lovinio .

We are dedicated to assisting our users in finding the right acetaminophen Products based on their needs, saving them considerable time when choosing which acetaminophen midol to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.