Best Kirkland Signature Antacids in 2026

Daisy
Last Updated: Jul 19, 2026

At a Glance: Our Top Picks for Kirkland Signature Antacids

Kirkland Signature Omeprazole Delayed Release, Acid Reducer Tablets 20 mg, 42 Count
#TOP1
Kirkland Signature Omeprazole Delayed Release, Acid Reducer Tablets
9.9
PM SCORE
Kirkland Signature Kirkland Lansoprazole Delayed-Release Total 42 Capsules, Blue,14 Count (Pack of 3)
#TOP2
Kirkland Signature Kirkland Lansoprazole Delayed-Release Total 42 Capsules,
9.8
PM SCORE
Kirkland Signature Acid Controller 20mg, 250 Count Tablets
#TOP3
Kirkland Signature Acid Controller 20Mg, 250 Count Tablets
9.8
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Kirkland Signature Antacids of 2026

Market Overview
Kirkland Signature Antacids Reviewed
  • Reviews Analyzed: 13978 Items
  • PM Avg. Rating: 7.6 / 10
19 Products Evaluated
  • Highest Price: $52.48
  • Lowest Price: $14.99
  • Avg. Price: $22.01
#TOP1

Kirkland Signature Omeprazole Delayed Release, Acid Reducer Tablets 20 Mg, 42 Count

KIRKLAND SIGNATURE
1978
12.00 X 8.00 X 1.50 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Deal&Discount 9.69

Features

Treats frequent heartburn (occurs 2 or more days a week)

Not intended fro immediate relief of heartburn; this drug may take up to 1 to 4 days for full effect

Take every day for 14 days for full effect of treatment

You may repeat (if needed) a 14-day course every 4 months, Do not take for more than 14 days or more often than every 4 months unless directed by a doctor

#TOP2

Kirkland Signature Kirkland Lansoprazole Delayed-Release Total 42 Capsules, Blue,14 Count (Pack Of 3)

KIRKLAND SIGNATURE
805287-CA
6.50 X 5.50 X 8.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
WSAIMA LLC 9.41

Features

Three 14-day courses of treatment

Clinically proven to treat frequent heartburn

Compare to active ingredient in Prevacid 24 HR Capsules

Item Package Dimension: 2.54cm L x 17.78cm W x 25.4cm H

#TOP3

Kirkland Signature Acid Controller 20Mg, 250 Count Tablets

KIRKLAND SIGNATURE
1086592
8.00 X 6.00 X 1.00 Inches
0.20 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ShippedFast 9.98

Features

The active ingredient in Kirkland Signature Acid Controller Maximum Strength is Tablets, 20 mg, an H2 Blocker. These partially block production of acid in the stomach cells by inhibiting histamine, a substance that stimulates the secretion of stomach acid

Over-the-counter and prescription H2 blockers relieve heartburn associated with acid indigestion and sour stomach and prevent meal-induced heartburn.

USP 20 mg - Acid Reducer, Compare to Maximum Strength Pepcid

Prevents and Relieves Heartburn and Indigestion

Two Bottles, 125 Tablets Each.

#TOP4

Kirkland Signature Acid Controller (250 Tablets)

KIRKLAND SIGNATURE
916218
1.97 X 1.97 X 3.15 Inches
0.20 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Beauty and Me 9.78

Features

The active ingredient in Kirkland Signature Acid Controller Maximum Strength is Tablets, 20 mg, an H2 Blocker. These partially block production of acid in the stomach cells by inhibiting histamine, a substance that stimulates the secretion of stomach acid

Over-the-counter and prescription H2 blockers relieve heartburn associated with acid indigestion and sour stomach and prevent meal-induced heartburn.

USP 20 mg - Acid Reducer, Compare to Maximum Strength Pepcid

Prevents and Relieves Heartburn and Indigestion

Two Bottles, 125 Tablets Each.

Kirkland Signature Chewable Ultra Strength Antacid / Calcium Supplement 1000Mg 265 Count (Pack Of 2)

KIRKLAND SIGNATURE
096619879021
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
P0ssum 7.48

Features

Chewable

Rich in calcium

Relief of acid indigestion & heartburn

Assorted berry flavors

265 tablets x 2

#TOP6

Kirkland Lansoprazole 3 Pack Delayed-Release Total 84 Capsules

KIRKLAND SIGNATURE
805287
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Deals Palace LLC 9.64

Features

TWO PACK - Each Pack with Three 14-day courses of treatment.

Clinically proven to treat frequent heartburn.

Compare to active ingredient in Prevacid 24 HR Capsules.

Kirkland Signature Magnesium Acid Reducer (Compare To Nexium) 24 Hour Delayed-Release Capsules 20Mg, 42 Count

RAPHARY
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Premium Convenience 9.93

Features

Compare to Nexium 24HR Active Ingredient

Delayed Release Capsules

Three 14-day Courses of Treatment

Esomeprazole Magnesium Delayed Release Capsules 20 mg is a Proton Pump Inhibitor (PPI). PPIs deactivate the pumps in the stomach lining from producing acid, significantly inhibiting acid production (and its overproduction) at the source. PPIs are available over-the-counter or as a prescription to treat ulcers, gastroesophageal reflux disease (GERD) and erosive esophagitis.

#TOP8

Kirkland Signature Esomeprazole Magnesium Acid Reducer 42 Capsules 20Mg Delayed Release

KIRKLAND SIGNATURE
17V0675A
2.56 X 2.17 X 3.15 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
K&J'S MAX 9.49

Features

24 hour frequent heartburn protection in an easy-to-swallow tablet

Stay heartburn free All day and all night with just one pill a day

Gluten Free

Three 14 day course bottles

#TOP9

Kirkland Signature Acid Controller, 20 Mg Famotidine Tablet, 170 Tablets

KIRKLAND SIGNATURE
KKPPOA1465
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Directwaysavings 9.89

Features

170 Tablets of famotidine 20 mg

Prevents heartburn associated with acid indigestion and sour stomach brought on by eating & drinking

#TOP10

Kirkland Signature Maximum Strength Acid Controller, Famotidine Tablets Usp, 20 Mg, 85-Count (Pack Of 2)

KIRKLAND SIGNATURE
295735
3.00 X 2.50 X 4.50 Inches
0.17 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Beauty and Me 9.78

Features

Relieves heartburn

Prevents heartburn

170 tablets

#TOP11

Kirkland Signature Lansoprazole 3 Pack

KIRKLAND SIGNATURE
805287
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Hightide Family Retailers 9.77

Features

USP 15mg Acid Reduce

42 Delayed-Release Capsules

14 capsules per bottle

Active Ingredient (in each capsule) - Purpose.

Treats frequent heartburn (occurs 2 or more days a week)

#TOP12

Kirkland Signature Lansoprazole 42 Capsules

KIRKLAND SIGNATURE
805287
8.00 X 6.00 X 1.00 Inches
0.17 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Deal&Discount 9.69

Features

Compare to Active Ingredient in Prevacid 24 HR Capsules

Three 14-day Courses of Treatment

#TOP13

Ks Lansoprazole 15Mg Capsule 3X14 Count

KIRKLAND SIGNATURE
805287
8.00 X 6.00 X 1.00 Inches
0.24 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Deal&Discount 9.69

Features

Compare to Active Ingredient in Prevacid 24 HR Capsules

Three 14-day Courses of Treatment

#TOP14

Kirkland Signature Omeprazole 20 Mg, 42 Ct Bundle With Exclusive "Say "No" To Indigestion And Heartburn" - Better Idea Guide (2 Items)

IDEA SHOP USA
CTC-11D99C-KIRKLANDOME20MG-42CT-1P
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
IDEA SHOP USA 9.75

Features

Omeprazole 20 mg

Treats Frequent Heartburn Occurring 2 or More Days Per Week

Three 14-day Courses of Treatment

Inhibits Acid Production at the Source

Delayed-Release Tablets

#TOP15

Ks Fast Acting Lactase Caplets 180 Count

KIRKLAND SIGNATURE
561532
3.00 X 3.00 X 7.00 Inches
0.40 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
VitaCrush 9.81

Features

Natural Dairy Digestive Supplement

Helps Prevent Symptoms of Gas, Bloating and Diarrhea

#TOP16

Kirkland Signature Lansoprazole 15 Mg Delayed Release Capsule, 14 Capsule Bottles, 3 Ct Tej

KIRKLAND SIGNATURE
805287
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Cheapees 9.82

Features

Compare to Active Ingredient in Prevacid 24 HR Capsules

Three 14-day Courses of Treatment

#TOP17

Compare To Prevacid 24 Hr Active Ingredient - Kirkland Signature Lansoprazole 3 Pack

KIRKLAND SIGNATURE
805287
0.24 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Cheapees 9.82

Features

Compare to Active Ingredient in Prevacid 24 HR Capsules

Three 14-day Courses of Treatment

#TOP18

Kirkland Signature Acid Controller 20 Mg, 125 Ct Bundle With Exclusive "Say No To Indigestion And Heartburn" - Better Idea Guide (2 Items)

IDEA SHOP USA
CTC-11D79C-KACIDC20MG125CT-1P
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
IDEA SHOP USA 9.75

Features

The active ingredient in Kirkland Signature Acid Controller Maximum Strength is Tablets, 20 mg, an H2 Blocker.

Prevents and Relieves Heartburn and Indigestion

Item Elegível FSA

#TOP19

Kirkland Signature Non Drowsy Allerclear Loratadine Tablets, Antihistamine, 10Mg, All New Mega Pack 1095-(10Mg Tablets)

KIRKLAND SIGNATURE
529688
1.50 X 1.50 X 2.50 Inches
0.15 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Exquisite Buys 9.67

Features

AllerClear temporarily relieves symptoms due to hay fever or other upper respiratory allergies

This provides 24 hour indoor and outdoor allergies relief of sneezing, runny nose, itchy, watery eyes, and itchy throat or nose

The Loratadine tablets, 10mg formula is the original prescription strength

Do not take more than 1 tablet in 24 hours

The general directions are for adults and children 6 years and over

Top 10 antacids kirkland signature Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Kirkland Signature 16
Idea Shop Usa 2
Raphary 1

Top 10 antacids kirkland signature Brands Pie Chart


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