Best Paleo Digestive Supplements in 2026

High Strength & Hypoallergenic - Premium support blend of 12 safe, complementary and well-studied species to support optimal gut flora, immune & GI health. Hypoallergenic 25 billion CFU in a base of chicory-derived prebiotic inulin.*

Probiotic Survival Without Extra Additives - Ther-Biotic does not need additive-packed spheres or tablets to promote probiotic survival. Advanced InTactic technology helps live probiotics reach the small intestine and colon. Each bottle is formulated with sufficient overages, handled with care, and tested for potency that delivers on its promise.*

Protection From Stomach Acid - On exposure to stomach acid, an InTactic 'shield' forms a gel-like matrix surrounding the probiotics, protecting them from damage. On passage into the duodenum, InTactic is designed to break down and release live microorganisms for optimal efficacy.*

25 billion CFU probiotic blend of 7 Lactobacillus and 5 Bifidobacterium supplied in a base of purified plant cellulose.

Specifically formulated without inulin or other fermentable carbohydrates, making it suitable for carbohydrate-sensitive individuals.*

Supports gastrointestinal and immune health*

A powerful yeast probiotic supplied in a based of plant cellulose.

American Type Culture Collection (ATCC) certified and freeze-dried to maintain maximum strength and viability.*

This hardy species is acid-resistant and temperature tolerant.

Broad-acting, 10-species probiotic formula offers comprehensive benefits for the healthy function of the entire gastrointestinal tract.*

The Lactobacillus species normally predominate in the small intestine while the Bifidobacterium species are important for the colon.*

This maintenance-dose vegetarian capsule supplies 5 billion CFU in a base of chicory-derived inulin.

MULTI ENZYME CHEWABLE - Many enzyme supplements offer limited enzymes such as protease, amylase, and lipase, but lack more specific enzymes needed for optimal digestion. Vital-Zymes is a multi-enzyme complex designed to address a full range of foods found in a typical meal.*

LIVE WITHOUT DIGESTIVE REGRET - Supplies serratia peptidase, DPP-IV activity, disaccharidases and more for a full complement of enzymes that lend maximum support for breaking down foods including proteins, fats, carbs, casein, lactose, gluten, sugars, and fibers. These enzymes are designed to support intestinal function, which may be related to bloating, fullness, or discomfort associated with occasional gas.*

FOR KIDS & ADULTS - A delicious choice for children or adults who have difficulty swallowing pills or may prefer a chewable tablet. Naturally cherry flavored and sweetened with xylitol.

A powerful yeast probiotic supplied in a base of cellulose.

American Type Culture Collection (ATCC) certified and freeze-dried to maintain maximum strength and viability.*

This hardy species is acid-resistant and temperature tolerant.

A broad-spectrum digestive enzyme formulation to provide maintenance-level support of digestive and intestinal health.*

Blend of 13 microbial and plant enzymes that can assist breakdown of proteins, fats, complex carbohydrates, sugars, and fibers.*

Includes a protease / peptidase complex with DPP-IV activity, bromelain, lactase, lipase, and more. Supplied in vegetarian capsules.

Not intended for long-term daily use. As part of a comprehensive program, InterFase Plus is intended for use under the direction of an appropriately trained healthcare professional.

A highly specialized enzyme formula with EDTA that supports normal gastrointestinal function and flora.*

Includes polysaccharide-specific enzymes, a protein and peptide-specific protease/peptidase complex, lysozyme (from egg white), enteric-coated Serratia peptidase, and EDTA (as disodium EDTA).

Powerful 20 Enzyme Blend - Many enzyme supplements offer limited enzymes such as protease, amylase, and lipase, but lack more specific enzymes needed for optimal digestion. This multi-enzyme, high-strength complex is designed to address a full range of foods found in a typical meal.*

Live Without Digestive Regret - Supplies serratia peptidase, DPP-IV activity, disaccharidases and more for a full complement of enzymes that lend maximum support for breaking down foods including proteins, fats, carbs, casein, lactose, gluten, sugars, and fibers. These enzymes are designed to support intestinal function, which may be related to bloating, fullness, or discomfort associated with occasional gas.*

Sensitivities In Mind - Sensitive to certain enzymes? This unique formula avoids fruit enzymes, porcine and other animal-derived enzymes. It also avoids excessive amounts of proteases that may irritate GI tissues. Free of the following common allergens: milk/casein, fish, shellfish, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.

Lactobacillus rhamnosus, 20 billion CFUs per capsule in an inulin base.*

L. rhamnosus has been recognized for robust L(+) lactic acid production and immune support.*

Proprietary InTactic technology helps ensure maximum delivery of live probiotics throughout the intestinal tract.*

25 billion CFU blend featuring 5 probiotic species to support GI colonization.*

Includes Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium bifidum, Streptococcus thermophilus, and Lactobacillus bulgaricus.

These transient and colonizing species have high tolerance to stomach acid and bile, which is important for maintaining viability in the intestinal environment.*

A highly specialized enzyme formula that supports normal gastrointestinal function and microbiota.*

Includes polysaccharide-specific enzymes, a protein- and peptide-specific protease/peptidase complex, lysozyme (from egg white), and enteric-coated Serratia peptidase.

As part of a comprehensive program, Interfase is intended for use under the direction of an appropriately trained healthcare professional.

50 billion CFU probiotic blend to support the body's natural detoxification process.*

Free of D(-)-lactic acid-producing species.

Proprietary InTactic technology helps ensure maximum delivery of live probiotics throughout the intestinal tract.*

Unique proteolytic enzyme & bioflavonoid formula designed to support the body's immune response.*

Quercetin is a potent bioflavonoid that protects cells and tissues against free radicals.*

Bromelain, papain, and pancreatin provide a mixture of protein-specific and other enzymes that help ensure proper breakdown of protein molecules that may otherwise cause occasional irritation.*

100 billion CFUs of freeze-dried probiotic cultures per capsule, provided in a base of purified plant cellulose.

Three Bifidobacterium and three Lactobacillus species for gastrointestinal support.*

Proprietary InTactic® technology helps ensure maximum delivery of live probiotics throughout the intestinal tract.*

Vegetarian enzymes with high DPP-IV activity.

Specifically formulated to assist in breaking down a broad range of plant and animal proteins, including casein (milk and dairy products), gluten (wheat, rye, oats, barley, and other grains), and soy proteins.*

The enzymes in this formulation are pH-stable, demonstrating activity over a wide range of pH conditions (pH of 2 to 12).

ProThera and Klaire Labs have unified under the Klaire Labs logo. This unification will be reflected in new packaging and a continuing commitment to the founding Klaire Labs principles of purity, potency, and performance.

Supports fibrinolytic activity.*

Produced from fermentation of non-GMO soybean isolates by Bacillus subtilis natto. Free of vitamin K.

Proteolytic vegetarian enzymes offer broad systemic support.*

This hypoallergenic product features highly purified, stable Serratia peptidase cultured from a bacterial source. Bromelain (from pineapple) papain (from papaya), and Catalase (bacterial source) help broaden proteolytic actions.*

Enteric coating protects enzyme activity against degradation by stomach acid.

SDC™ compliant formula featuring Lactobacillus acidophilus in a base of purified plant cellulose.*

This hardy species is provided in a potency of 3 billion CFUs per capsule.

L. acidophilus can aid digestion and absorption of nutrients, help stabilize bowel function, and produce lactase enzyme.*

SDC™ compliant formula featuring Lactobacillus acidophilus in a base of purified plant cellulose.*

This hardy species is provided in a potency of 3 billion CFUs per capsule.

L. acidophilus can aid digestion and absorption of nutrients, help stabilize bowel function, and produce lactase enzyme.*

A novel blend of 4 probiotic species documented to support the normal gastrointestinal microbiota.*

10 billion CFU supplied in a base of chicory-derived inulin.

A carefully researched blend of the non- pathogenic yeast Saccharomyces boulardii with Lactobacillus rhamnosus, Bifidobacterium bifidum, and Bifidobacterium breve.*

Supplies a blend of enzymes normally found in the small intestinal brush border that are critical for the final steps of carbohydrate and protein digestion.*

Disaccharide enzymes (lactase, maltase, and sucrase) are supplied together with glucoamylase to assist optimal cleaving of sugars and carbohydrates.*

Active enzyme blend of peptidase and protease with dipeptidyl peptidase IV (DPP-IV) activity. Peptidase and protease enzymes help break down plant and animal proteins, including casein (milk/dairy products), gluten (wheat, rye, oats, barley, and other grains), and soy.*

Powerful USP porcine pancreatic enzymes.*

Composed of amylase, lipase, and protease. Formulated to release the enzyme contents quickly upon reaching the small intestine to avoid destruction of enzymes by stomach acid.

Provides reliable and consistent enzyme activity specific for fat, protein, and carbohydrate (starch).*

Two product digestion support bundle. Ther-biotic Synbiotic is a probiotic Made for Sensitive Stomachs - Powerful probiotic supplement specifically designed for those with restricted diets, sensitive stomachs and food sensitivities.*

Clinically Proven Probiotics + a Low-FODMAP Prebiotic - Includes seven to support healthy digestion, GI comfort, and immune function.* Combined with a prebiotic to offer more profound effects on the microbiome than probiotics alone.*

Shelf Stable 50 Billion CFU. Delayed-release capsule technology delivers live probiotics where they’re needed most, while patented packaging protects probiotics at room temperature through expiry date. No refrigeration needed.

Pure, single ingredient Saccharomyces boulardii powder.

With a dual scoop for measuring accuracy, this clean-label formulation is particularly effective and uniquely convenient for use in high-potency titration protocols.

Supplies 9 billion CFU per small scoop & 45 billion CFU per large scoop.

Two products to support digestion and GI health.

Interfase Plus is a highly specialized enzyme formula that supports normal gastrointestinal function and flora.*

Not intended for long-term daily use. As part of a comprehensive program, InterFase Plus is intended for use under the direction of an appropriately trained healthcare professional.

High Strength & Hypoallergenic - Premium support blend of 12 safe, complementary and well-studied species to support optimal gut flora, immune & GI health. Hypoallergenic 25 billion CFU in a base of chicory-derived prebiotic inulin.*

Probiotic Survival Without Extra Additives - Ther-Biotic does not need additive-packed spheres or tablets to promote probiotic survival. Advanced InTactic technology helps live probiotics reach the small intestine and colon. Each bottle is formulated with sufficient overages, handled with care, and tested for potency that delivers on its promise.*

Protection From Stomach Acid - On exposure to stomach acid, an InTactic 'shield' forms a gel-like matrix surrounding the probiotics, protecting them from damage. On passage into the duodenum, InTactic is designed to break down and release live microorganisms for optimal efficacy.*