Best Vegetarian Enzyme Supplements in 2026

Daisy
Last Updated: Jul 18, 2026

At a Glance: Our Top Picks for Vegetarian Enzyme Supplements

Integrative Therapeutics Similase GFCF - Digestive Enzyme Supplement for Support Against Occasional Gas and Bloating* - Supports Gluten and Casein Digestion* - Dairy Free - 120 Vegan Capsules
#TOP1
Integrative Therapeutics Similase Gfcf - Digestive Enzyme Supplement
9.7
PM SCORE
Integrative Therapeutics Lipase Concentrate-HP - Enzyme Supplement for Men and Women That Aids in The Digestion of Fats* - Keto and Paleo Friendly* - 90 Vegan Capsules
#TOP2
Integrative Therapeutics Lipase Concentrate-Hp - Enzyme Supplement For
9.6
PM SCORE
Integrative Therapeutics Riboflavin - Cellular Energy and Red Blood Cell Production Support* - Vitamin B2 Supplement - High Potency - 30 400 mg Tablets
#TOP3
Integrative Therapeutics Riboflavin - Cellular Energy And Red
9.6
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Vegetarian Enzyme Supplements of 2026

Integrative Therapeutics Similase Gfcf - Digestive Enzyme Supplement For Support Against Occasional Gas And Bloating* - Supports Gluten And Casein Digestion* - Dairy Free - 120 Vegan Capsules

INTEGRATIVE THERAPEUTICS
73952
2.43 X 2.43 X 4.26 Inches
0.20 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Contains enzymes to support comprehensive digestion*

Provides dipeptidyl peptidase IV (DPP IV) activity for the digestion of proline-containing dipeptides from gluten and casein*

Helps relieve occasional indigestion, gas and bloating*

Dairy free. No artificial colors, flavors, or preservatives

Integrative Therapeutics Lipase Concentrate-Hp - Enzyme Supplement For Men And Women That Aids In The Digestion Of Fats* - Keto And Paleo Friendly* - 90 Vegan Capsules

INTEGRATIVE THERAPEUTICS
116004
1.81 X 1.81 X 3.28 Inches
0.05 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Lipase Concentrate-HP supports the digestion of fats*

Lipase Concentrate-HP is pH-stable and active in both acid and alkaline conditions

This lipase enzyme supplement supports the digestion of fats in gastrointestinal pH conditions*

This lipase enzyme supplement is vegan

Integrative Therapeutics Riboflavin - Cellular Energy And Red Blood Cell Production Support* - Vitamin B2 Supplement - High Potency - 30 400 Mg Tablets

INTEGRATIVE THERAPEUTICS
76843
2.02 X 2.02 X 4.02 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Riboflavin is important for red blood cell production and helps the body release energy*

Riboflavin (vitamin B2) is the central component in 2 cofactors: FMN and FAD

Riboflavin is required for other enzyme reactions, including the activation of other vitamins

These 400 mg Riboflavin tablets are gluten free and vegan

Integrative Therapeutics Similase Sensitive Stomach - Digestive Enzymes With Soothing Herbs* - Dietary Supplement With Marshmallow, Slippery Elm & Licorice Root - Dairy Free - 180 Vegetable Capsules

INTEGRATIVE THERAPEUTICS
136007
2.88 X 2.88 X 5.13 Inches
0.35 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Combines Microbial Enzymes with the demulcent herbs marshmallow and slippery elm to provide gentle support for the GI tract*

Gamma-oryzanol and licorice root complement the demulcent herbs*

Provides gentle support for GI tract*

Dairy free, vegan; no salt or artificial colors or flavors

Integrative Therapeutics Similase - Physician Developed Digestive Enzymes - Supplement For Women And Men - Dairy Free - Vegan - 180 Capsules

INTEGRATIVE THERAPEUTICS
74230
2.43 X 2.43 X 4.26 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Similase is a comprehensive, proprietary blend of digestive enzymes to support digestion of all food types*

Similase provides comprehensive support for digestion and assimilation of nutrients from the diet*

A proprietary microbial enzyme blend active across a broad pH range in the gastrointestinal tract, providing support of carbohydrate, protein, fat and fiber digestion*

Dairy free and vegan; contains no artificial colors, flavors or preservatives

#TOP6

Integrative Therapeutics Similase - Physician Developed Digestive Enzymes - Supplement For Women And Men - Dairy Free - Vegan - 90 Capsules

INTEGRATIVE THERAPEUTICS
74239
2.22 X 2.22 X 3.95 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.99

Features

Similase is a comprehensive, proprietary blend of digestive enzymes to support digestion of all food types*

Similase provides comprehensive support for digestion and assimilation of nutrients from the diet*

A proprietary microbial enzyme blend active across a broad pH range in the gastrointestinal tract, providing support of carbohydrate, protein, fat and fiber digestion*

Dairy free and vegan; contains no artificial colors, flavors or preservatives

#TOP7

Integrative Therapeutics Similase Sensitive Stomach - Digestive Enzymes With Soothing Herbs* - With Marshmallow, Slippery Elm, & Licorice Root - Gluten & Dairy Free - 90 Vegetable Capsules

INTEGRATIVE THERAPEUTICS
136006
2.43 X 2.43 X 4.26 Inches
0.20 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Combines Microbial Enzymes with the demulcent herbs marshmallow and slippery elm to provide gentle support for the GI tract*

Gamma-oryzanol and licorice root complement the demulcent herbs*

Provides gentle support for GI tract*

Gluten free, dairy free, vegan; no sugar, salt, artificial colors or flavors

#TOP8

Integrative Therapeutics Similase Bv - Physician Developed Digestive Enzymes For Digestion Of Beans And Vegetables* - Includes Alpha-Galactosidase - Dairy Free - 180 Vegetable Capsules

INTEGRATIVE THERAPEUTICS
106002
2.88 X 2.88 X 5.13 Inches
0.30 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.98

Features

Similase BV is a comprehensive Microbial Enzyme supplement that aids in the digestion of all food groups*

Provides additional enzyme activity for the digestion of beans, legumes and cruciferous vegetables (e.g. broccoli, cabbage, and Brussels sprout) that produce gas in sensitive individuals*

Similase BV features alpha-galactosidase to support the breakdown of difficult-to-digest sugars and oligosaccharides in offending foods*

Dairy free; contains no salt or artificial colors or flavors

Top 10 enzyme supplements Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Integrative Therapeutics 8

Top 10 enzyme supplements Brands Pie Chart


We've carried out a comprehensive analysis of 3,611 reviews on enzyme supplements, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select enzyme supplements priced around $35.47, with top brands including biomedic labs rx, nature's choice supplements, bulksupplements.com, enzyme science, home brew ohio, bluebonnet, now, wonderland herbs and garden of life and doctor's best

Our team of expert editors reviewed these high-quality items and handpicked the top 8 enzyme supplements for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include biomedic labs rx, nature's choice supplements!, bulksupplements, enzyme science ™, bluebonnet nutrition, nature and herbs, akersunder, amazon.com and holistic 4 all and lovewellness .

We are dedicated to assisting our users in finding the right supplements Products based on their needs, saving them considerable time when choosing which enzyme supplements to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.