Best Powder Prebiotic Supplements in 2026

Daisy
Last Updated: Feb 9, 2026

At a Glance: Our Top Picks for Powder Prebiotic Supplements

Pendulum Akkermansia Light - The ONLY Brand with Akkermansia | A Live Probiotic Supplement for Women and Men - Supports GLP-1, Improves Digestive Health, Includes Fiber
#TOP1
Pendulum Akkermansia Light - The Only Brand With
9.2
PM SCORE
Pendulum Akkermansia for Gut Health | The ONLY Brand with Live Akkermansia Muciniphila | A Probiotic Supplement for Women and Men | Supports GLP-1, Improves Digestive Health, with Prebiotic Fiber
#TOP2
Pendulum Akkermansia For Gut Health | The Only
9.2
PM SCORE
Pendulum Akkermansia & Polyphenol Booster Bundle - Live Probiotic Supplement for Improving Digestive & Cardio Health
#TOP3
Pendulum Akkermansia & Polyphenol Booster Bundle - Live
5.1
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Powder Prebiotic Supplements of 2026

Pendulum Akkermansia Light - The Only Brand With Akkermansia | A Live Probiotic Supplement For Women And Men - Supports Glp-1, Improves Digestive Health, Includes Fiber

PENDULUM
PAL-30B
0.09 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pendulum Therapeutics, Inc. 9.86

Features

✔ NEW LIGHT FORMULA - Akkermansia Light delivers the same powerful benefits as Akkermansia, but in a lighter introductory formulation that lets you ease into seeing how this keystone strain for gut health works for you. With 20 million AFUs per capsule, Akkermansia Light offers a gentle yet effective way to strengthen your gut lining and improve digestive health, perfect for those who are new to probiotics or may have sensitive GI systems.

✔ HEALTHY GUT - Akkermansia is a novel probiotic strain that naturally occurs in the large intestines and works by protecting and enhancing the gut lining. This unique strain is called a keystone strain for gut health as it restores, protects, and strengthens the digestive lining, as well as supports GLP-1 production and helps support a healthy weight. Take 1 capsule daily to unlock the power of your gut microbiome.

✔ IMPROVES OVERALL HEALTH - A well-balanced gut microbiome helps with overall health. Higher amounts of Akkermansia muciniphila mean your gut is healthier. Akkermansia is an anaerobic strain, meaning it needs to be grown in an oxygen-free environment (like your gut). Pendulum built the first and only oxygen-free manufacturing facility that enables commercial-scale production of Akkermansia and other next generation anaerobic strains.

✔ SAFE & EFFECTIVE - Akkermansia Light effectively increases the level of Akkermansia muciniphila in your gut without any harmful chemicals or drugs in its formulation. It is non-GMO and is designated as GRAS (Generally Recognized As Safe). Each capsule is encased in a plant-based, acid-resistant, delayed release capsule, so that the strain gets through the stomach acid and to the gut microbiome where it can do its job.

✔ POTENT INGREDIENTS - Aside from the proprietary Akkermansia muciniphila strain, Akkermansia Light also contains chicory inulin, a prebiotic fiber that passes through the lower gut and stimulates the growth of good bacteria. It acts as food for the Akkermansia probiotic. The combination of these ingredients helps create a diverse and healthy gut microbial ecosystem.

Pendulum Akkermansia For Gut Health | The Only Brand With Live Akkermansia Muciniphila | A Probiotic Supplement For Women And Men | Supports Glp-1, Improves Digestive Health, With Prebiotic Fiber

PENDULUM
P-AKK
0.21 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pendulum Therapeutics, Inc. 9.86

Features

✔ POWERFUL PROBIOTIC - Akkermansia contains 100 million AFU of a patented strain of Akkermansia muciniphila. It is a novel probiotic strain that naturally occurs in the layer of the large intestines and works by protecting and enhancing the gut lining. Studies show that the Akkermansia strain makes up approximately 4% of the intestinal bacteria in healthy people, making it essential for a healthy gut microbiome. Akkermansia increases the levels of these good bacteria in your gut.

✔ HEALTHY GUT - An increased level of the Akkermansia muciniphila strain in the gut results in a stronger intestinal wall, which is important for keeping your digestive system in good shape. This unique strain is called a keystone strain for gut health as it restores, protects, and strengthens the digestive lining. Take 1 capsule daily to help fuel and boost your gut microbiome and eliminate digestive problems.

✔ IMPROVES OVERALL HEALTH - A well-balanced gut microbiome helps with overall health. Higher amounts of Akkermansia muciniphila mean your gut is healthier, so take a probiotic that contains this beneficial bacteria. Pendulum is the only brand on the market with Akkermansia.

✔ SAFE & EFFECTIVE - Akkermansia effectively increases the level of Akkermansia muciniphila in your gut without any harmful chemicals or drugs in its formulation. It is non-GMO and is designated as GRAS (Generally Recognized As Safe). Each capsule is encased in a plant-based, acid-resistant, delayed release capsule, so that the strain gets through the stomach acid and to the gut microbiome where it can do its job.

✔ POTENT INGREDIENTS - Aside from the proprietary Akkermansia muciniphila strain, Akkermansia also contains chicory inulin, a prebiotic fiber that passes through the lower gut and stimulates the growth of good bacteria. It acts as food for the Akkermansia probiotic. The combination of these ingredients helps create a diverse and healthy gut microbial ecosystem.

Pendulum Akkermansia & Polyphenol Booster Bundle - Live Probiotic Supplement For Improving Digestive & Cardio Health

PENDULUM
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pendulum Therapeutics, Inc. 9.88

Features

✔ POWERFUL PROBIOTIC — Akkermansia contains 100 million AFU of a patented strain of Akkermansia muciniphila. It is a novel probiotic strain that’s naturally found in the intestines and works by protecting and enhancing the gut lining. Studies show that Akkermansia muciniphila makes up approximately 4% of the intestinal bacteria in healthy people, making it essential for a healthy gut microbiome. Pendulum Akkermansia increases the levels of these good bacteria in your gut.

✔ HEALTHY GUT — An increased level of the Akkermansia muciniphila strain in the gut results in a stronger intestinal wall. This unique strain is called a keystone strain for gut health as it restores, protects, and strengthens the digestive lining. Take 1 capsule of Akkermansia daily to help fuel and boost your gut microbiome, and help eliminate digestive problems.

✔ POWERFUL POLYPHENOLS — Polyphenol Booster contains a unique blend of antioxidants and polyphenols. Through in vitro testing, polyphenols were shown to increase the levels of Akkermansia muciniphila, an essential bacterial strain found in high volumes in healthy people. For best results, pair with Akkermansia.

✔ IMPROVED HEALTH — A boost in prebiotic micronutrients like polyphenols and antioxidants has been shown to improve cardio health, support healthy aging, and increase the antioxidants and polyphenols in your system.

✔ SAFE & EFFECTIVE — Non-GMO, gluten-free, vegan, and additive-free, this supplement is encased in a plant-based, acid-resistant, delayed release capsule so that the strain gets through the stomach acid and to the gut microbiome where it can do its job. Manufactured in the USA.

Pendulum Polyphenol Booster, Antioxidant From Superfoods, Beneficial Plant Compounds For Good Health, Boosts & Targets Akkermansia And Supports Cardio Health

PENDULUM
P-PPB
0.13 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pendulum Therapeutics, Inc. 9.86

Features

✔ POWERFUL POLYPHENOLS — Polyphenol Booster contains a unique blend of antioxidants and polyphenols. Through in vitro testing, polyphenols were shown to increase the levels of Akkermansia muciniphila, an essential bacterial strain found in high volumes in healthy people. For best results, pair with Pendulum Akkermansia.

✔ HEALTHY GUT — Microbiome diversity is an excellent indicator of gut health. By supporting the proliferation of probiotic strains like Akkermansia muciniphila, an increase in polyphenols can result in stronger intestinal walls, eased digestion, and greater overall gut health. Take 2 capsules a day to maximize the effectiveness of Pendulum Akkermansia and boost your digestive health.

✔ IMPROVED HEALTH — A boost in prebiotic micronutrients like polyphenols and antioxidants has been shown to improve cardio health, support healthy aging, and increase the antioxidants and polyphenols in your system.

✔ POTENT BLEND — Polyphenol Booster is derived from natural, plant-based ingredients: pomegranate (90% ellagic acid), grape seed (95% ellagic acid, catechin), and green tea (95% proanthocyanidins). The combination of these ingredients effectively supports the proliferation of beneficial microbiota in your gut microbiome.

Pendulum Akkermansia For Gut Health | The Only Brand With Live Akkermansia Muciniphila | A Probiotic Supplement For Women And Men | Supports Glp-1, Improves Digestive Health, With Prebiotic Fiber

PENDULUM
P-AKK
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pendulum Therapeutics, Inc. 9.86

Features

✔ POWERFUL PROBIOTIC - Akkermansia contains 100 million AFU of a patented strain of Akkermansia muciniphila. It is a novel probiotic strain that naturally occurs in the layer of the large intestines and works by protecting and enhancing the gut lining. Studies show that the Akkermansia strain makes up approximately 4% of the intestinal bacteria in healthy people, making it essential for a healthy gut microbiome. Akkermansia increases the levels of these good bacteria in your gut.

✔ HEALTHY GUT - An increased level of the Akkermansia muciniphila strain in the gut results in a stronger intestinal wall, which is important for keeping your digestive system in good shape. This unique strain is called a keystone strain for gut health as it restores, protects, and strengthens the digestive lining. Take 1 capsule daily to help fuel and boost your gut microbiome and eliminate digestive problems.

✔ IMPROVES OVERALL HEALTH - A well-balanced gut microbiome helps with overall health. Higher amounts of Akkermansia muciniphila mean your gut is healthier, so take a probiotic that contains this beneficial bacteria. Pendulum is the only brand on the market with Akkermansia.

✔ SAFE & EFFECTIVE - Akkermansia effectively increases the level of Akkermansia muciniphila in your gut without any harmful chemicals or drugs in its formulation. It is non-GMO and is designated as GRAS (Generally Recognized As Safe). Each capsule is encased in a plant-based, acid-resistant, delayed release capsule, so that the strain gets through the stomach acid and to the gut microbiome where it can do its job.

✔ POTENT INGREDIENTS - Aside from the proprietary Akkermansia muciniphila strain, Akkermansia also contains chicory inulin, a prebiotic fiber that passes through the lower gut and stimulates the growth of good bacteria. It acts as food for the Akkermansia probiotic. The combination of these ingredients helps create a diverse and healthy gut microbial ecosystem.

Pendulum Metabolic Daily & Polyphenol Booster Bundle - Proprietary Akkermansia Probiotic Supplement Blend For Improving Metabolism & Cardio Health

PENDULUM
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pendulum Therapeutics, Inc. 9.86

Features

✔ UNIQUE BLEND OF HEALTHY PROBIOTICS — Metabolic Daily contains a mix of health boosting live probiotics, some of which are exclusively sold by Pendulum, including: Akkermansia muciniphila, Anaerobutyricum hallii, Clostridium beijerinckii, Clostridium butyricum, Bifidobacterium infantis.

✔ REDUCE SUGAR CRAVINGS — Targeted formula improves fiber break down which supports beneficial postbiotics and hormones, like butyrate and GLP-1, resulting in less sugar cravings and sustained energy throughout the day.

✔ POWERFUL POLYPHENOLS — Polyphenol Booster contains a unique blend of antioxidants and polyphenols. Through in vitro testing, polyphenols were shown to increase the levels of Akkermansia muciniphila, an essential bacterial strain found in high volumes in healthy people.

✔ IMPROVED HEALTH — A boost in prebiotic micronutrients like polyphenols and antioxidants has been shown to improve cardio health, support healthy aging, and increase the antioxidants and polyphenols in your system.

✔ SAFE & EFFECTIVE — Non-GMO, gluten-free, vegan, and additive-free, this supplement is encased in a plant-based, acid-resistant, delayed release capsule, so that the strain gets through the stomach acid and to the gut microbiome where it can do its job. Manufactured in the USA.

Top 10 prebiotic supplements Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Pendulum 6

Top 10 prebiotic supplements Brands Pie Chart


We've carried out a comprehensive analysis of 733 reviews on prebiotic supplements, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select prebiotic supplements priced around $66.66, with top brands including garden of life, microbiome labs, gobiotix, prescribed for life, biohm, primal harvest, teraganix, earth's pearl and essential stacks and viome

Our team of expert editors reviewed these high-quality items and handpicked the top 6 prebiotic supplements for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, fortressbrand, gobiotix, prescribed for life, biohm, primal harvest, teraganix, inc., luv ur gut and essential stacks and viome .

We are dedicated to assisting our users in finding the right supplements Products based on their needs, saving them considerable time when choosing which prebiotic supplements to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.