Best 365 By Whole Foods Market Vitamin B Supplements in 2026

TWO B VITAMINS IN ONE CAPSULE: Instead of the cheaper forms, these B vitamins are the active forms of methyl folate (as 5-MTHF) and vitamin B 12 (as methylcobalamin). Good for those with the MTHFR gene. 5-MTHF is the only form of folate used directly by the body. It’s up to 7 times more bioavailable than standard folic acid.

FOLATE BENEFITS: Helps promote healthy DNA function, maintains already normal homocysteine levels, promotes healthy skin, a healthy digestive tract, and even a healthy immune response. Also known as B-9.

A LITTLE EXTRA VITAMIN B-12: Methylated Vitamin B 12 supports brain health by helping to maintain healthy homocysteine levels. When combined with folate, B12 helps w/ red blood cell production, too. Made w/ methylcobalamin, the bioactive form of vitamin B12.

MANY PEOPLE NEED A B6 SUPPLEMENT - Your body doesn’t produce vitamin B6, so you have to get it from foods like eggs, brewer’s yeast, carrots, chicken, fish, brown rice, whole grains and cabbage. If you don’t eat enough of these foods, you should choose a high-quality supplement—because B6 is really, really good for you.

CARDIOVASCULAR HEALTH – There’s an amino acid called homocysteine that’s a well-known marker for both heart and brain health. Maintaining homocysteine levels already within normal range is good for your cardiovascular system and your circulatory health. Vitamin B6 helps maintain already-healthy homocysteine levels...which keeps your blood flowing freely!

IMMUNE HEALTH, MOOD & MORE – Vitamin B6 helps encourage a healthy immune response, so you’re ready for what the world throws at you. And because your body uses vitamin B6 to make the neurotransmitter serotonin, this essential vitamin helps support a better mood. And because of its aforementioned effect on homocysteine, vitamin B6 promotes brain health, too.

BIOLOGICALLY ACTIVE FOLIC ACID — Our Optimized Folate formula promotes both cardiovascular and cognitive health with 1700 mcg of folate in the form of 5-MTHF (L-Methylfolate), the metabolically active form of folic acid.

WHY FOLATE? – Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with heart and brain health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.

HEART & BRAIN-FRIENDLY NUTRIENT – Because folate helps inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular biomarker. Since healthy homocysteine levels have been associated with cognitive health, getting enough folate is especially crucial for individuals who want to maintain brain health.

POWERFUL “B” COMBINATION – We’ve combined the active forms of folate (as 5-MTHF) and vitamin B12 (as methylcobalamin). Together, these nutrients (both members of the vitamin Bfamily) promote heart, brain and digestive health. 5-MTHF is the only form of folate used directly by the body, and it’s up to seven times more bioavailable than folic acid.

WHAT DOES FOLATE DO? – Folate is a form of vitamin B. It is found in abundance in leafy greens vegetables. Folate helps promote healthy DNA function, maintains already normal homocysteine levels, supports heart health, promotes healthy skin, a healthy digestive tract, and even a healthy immune response.

A LITTLE EXTRA VITAMIN B12 – Vitamin B12 supports brain and heart health by helping to maintain healthy homocysteine levels. And when combined with folate, B12 helps with red blood cell production, too. We use methylcobalamin, the bioactive form of this vitamin.

BE ALL YOU CAN “B”– Energize your body and keep your mind sharp with our BioActive Complete B-Complex. It features a nourishing combination of the full spectrum of vitamin B benefits in a highly absorbable formula, providing the biologically active forms of the Bs you need to thrive.

ARE YOU GETTING ENOUGH VITAMIN B? – There are more forms of it than you may think, and each plays a different role in your body. So, it’s important to get a wide spectrum of the vitamin B family, every day. BioActive Complete B-Complex is made with the biologically active forms of each nutrient, optimizing absorption, and giving your body what it needs to keep you healthy.

WHY DO I NEED ALL THESE Bs? – B-vitamins help release energy from the foods you eat, such as carbohydrates, fat and protein. Vitamin B coenzymes are also crucial to how your body generates cellular energy fuel. BioActive Complete B-Complex provides all the daily vitamin B benefits your body needs. It’s the perfect complement to any well-rounded nutritional regimen.

BONE BUILDING VITAMINS - Vitamin D is essential for absorbing calcium from the digestive tract into the blood stream. And vitamin K2 helps maintain bone density by promoting calcium transport from the bloodstream into the bone. Both of these nutrients are essential for helping maintain strong, healthy bones and teeth.

BONE-HEALTHY MINERALS - Magnesium, zinc and other bone-healthy minerals are needed to maintain strong bones. Bone Restore with Vitamin K2 contains 300 mg of magnesium from magnesium oxide.

BORON FOR BONES - Boron is a trace mineral with beneficial effects for bone and joint strength. This formula contains patented Fruitex B OsteoBoron, made from a calcium/carbohydrate/boron complex similar to what’s found in fruits and vegetables.

NEW SIZE: 180 Vegetarian Capsules of 250mg Life Extension Benfotiamine with Thiamine

SUPERIOR FORMULATION: Contains two forms of B vitamins for better results

FAT & WATER SOLUBLE: Contains 250mg of Benfotiamine which is fat-soluble and 10mg Thiamine which is water-soluble

BRAIN HEALTH - Methylcobalamin is a form of vitamin B12 that is active in the central nervous system and supports cognitive function. Getting enough of this essential nutrient isn’t always easy—especially as you get older. We’ve created convenient B12 lozenges that can be chewed or dissolved in your mouth.

HEART AND NERVE HEALTH – Like other vitamins in the B family, methylcobalamin helps maintain already-healthy homocysteine levels. Homocysteine is a byproduct of metabolism, and maintaining healthy levels is key to both heart and nerve health.

RED BLOOD CELL HEALTH – Methylcobalamin is essential to the growth and replication of our cells—especially red blood cells, the ones that carry oxygen from our lungs to the rest of our bodies. On their way back, red blood cells take carbon dioxide to the lungs to be exhaled.

TWO B12s FOR YOUR BRAIN – Chances are you’ve heard of vitamin B12. You may even have heard that its good for your brain. But there are certain kinds of B12—called “active forms” because your body can make use of them right away—that are better for your brain than others. This formula has two of these B12 forms: adenosylcobalamin and methylcobalamin.

Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery

HELPS PROTECT BRAIN CELLS – Methylcobalamin is perhaps the most famous neurologically active form of B12. It’s essential for the healthy growth and replication of brain cells. This form of B12 also helps maintain already-healthy homocysteine levels...a key to healthy brain function.

BEAUTIFYING B7 – If you’re trying to maintain healthy, youthful hair, skin and nails there’s no better vitamin B than biotin, sometimes referred to as vitamin B7. This is because biotin is necessary for production of keratin.

ABUNDANT ENERGY LEVELS – Because it’s a B vitamin, biotin offers so much more than a pretty face. It’s also a chemical co-factor, which means it helps enzymes in your body do important work like creating cellular energy, breaking down amino acids and even supporting already-healthy blood sugar.

GOOD GENES – There is growing evidence that biotin may help you unlock the healthy inner you; biotin plays an important role in healthy gene expression. If you think your diet doesn’t have enough biotin, this supplement is a good place to start.

MAINTAIN ALREADY-HEALTHY LEVELS OF HOMOCYSTEINE - Homocysteine is a natural compound produced by your cells. But over time, it can begin to build up in the bloodstream, affecting cardiovascular health, cognitive function and more. Contains a selection of B vitamins specially formulated to help your body maintain already-healthy levels of homocysteine and to support heart and brain health

Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery

A WIDE-SPECTRUM OF HEART AND BRAIN SUPPORT - A B vitamin supplement specially formulated for your heart and brain. It helps your body maintain heart-healthy levels of homocysteine already within normal range. Homocysteine is a natural compound produced by your cells. But as we age, homocysteine can begin to build up in the bloodstream, affecting cardiovascular health, cognitive function and more

BRAIN HEALTH - Methylcobalamin is a form of vitamin B12 that is active in the central nervous system. We’ve created convenient B12 lozenges that can be chewed or dissolved in your mouth because getting enough of this essential nutrient isn’t always easy—especially as you get older.

HEART AND NERVE HEALTH – Like other vitamins in the B family, methylcobalamin helps maintain already-healthy homocysteine levels. Homocysteine is a byproduct of metabolism. Inhibiting excess homocysteine levels is a key indicator of both cardiovascular and nerve health.

RED BLOOD CELLS – Methylcobalamin is essential to the growth and replication of our cells—especially red blood cells, the ones that carry oxygen from our lungs to the rest of our bodies. On their way back, red blood cells take carbon dioxide to the lungs to be exhaled.

✅ NEW VALUE SIZE of LifeExtension P5P 100mg - 90 Count

✅ MORE POWERFUL: P-5-P is the metabolically active form of vitamin B-6

✅ 100 ENZYMATIC REACTIONS rely on vitamin B 6

HEART & BRAIN HEALTH SUPPORT IN ONE - Maintaining already-normal homocysteine levels is associated with both cardiovascular and cognitive health. Folate, a type of vitamin B, helps maintain already-healthy homocysteine levels. However, not everyone can efficiently convert folate into an active form so the body can use it. Our formula is designed to deliver an ultra-bioavailable form of folate called folic acid (5-MTHF).

FOLATE VS. FOLIC ACID - Folic acid is a common B-vitamin supplement. After you ingest it, your body is supposed to convert folic acid into 5MTHF (5-methyltetrahydrofolate). But research shows that many people lack sufficient activity of the enzyme that’s necessary to do this. That’s why our folate formula delivers 8500 mcg DFE of 5-MTHF, saving your body the trouble.

SUPPORT ALREADY-HEALTHY HOMOCYSTEINE LEVELS - Folate helps maintain healthy homocysteine levels already within the normal range. By helping to inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular health biomarker, especially over time. In some studies, 5-MTHF has been shown to be more bioavailable than folic acid.

METABOLICALLY ACTIVE B6 - Vitamin B6 plays an important role in many of your body’s essential processes. Pyridoxal 5’-phosphate is the metabolically active form of vitamin B6.

GLYCATION AND AGEs (AND AGING) – “Glycation” is when blood sugar reacts with proteins and lipids in your body to create advanced glycation end products, or AGEs. Your body can’t use AGEs for anything, so they simply accumulate...and contribute to the physiological effects of aging. Vitamin B6 helps inhibit glycation reactions—which helps keep you young on the inside.

BRAIN, KIDNEY & EYE HEALTH – Turns out, inhibiting glycation has nearly system-wide benefits. Doing so supports eye, heart and brain health. It also helps encourage healthy kidney function, and can even help your body mount a more effective and healthy immune response.

BE VITAMIN B-5 ALIVE — Pantothenic acid, or vitamin B-5, is not nearly as famous as its cousins vitamin B3 niacin or B12 methylcobalamin. But B5 is vitally important in its own right. This member of the vitamin B family is essential to several aspects of healthy metabolism—mainly the healthy metabolism of lipids, amino acids and glucose...as well as supporting cellular energy production.

BUILDS COENZYME A – You’re probably wondering how B5 helps with so many different things. The answer is that your body uses pantothenic acid to build a compound called coenzyme A. This coenzyme is super important: along with its value for metabolic health, coenzyme A facilitates hemoglobin, neurotransmitter, hormone, protein and lipid synthesis.

EASY ON YOUR STOMACH – Some pantothenic acid supplements can be hard on the stomach. That’s why we’ve combined our pantothenic acid formula with calcium. This makes it easier on your stomach, and it also makes it more shelf-stable.

GET THE ZZZs YOU NEED - A powerful antioxidant, melatonin is well-known for its sleep-friendly properties. And this sleep superstar is just one ingredient in our formula. We also added high-quality vitamins and minerals such as B-vitamins, and mood supporting inositol and magnesium, calcium, chromium and free-radical quenching vitamin C - together, these nutrients promote healthy, restful sleep.

MORE THAN JUST SLEEP SUPPORT - Put occasional sleeplessness to bed and provide your body with the additional health benefits that come from getting regular, quality sleep. The essential vitamins and minerals in our formula supports a healthy immune response, healthy mood and cognitive performance. Quiet Sleep Melatonin also helps inhibit oxidative stress caused by free radicals.

IMMEDIATE RELEASE FORMULA - Our immediate-release formula helps usher in those dreams more quickly, promoting healthy sleep/wake patterns and encouraging healthy sleep quality. For your convenience, simply take one easy-to-swallow capsule at least 30 minutes before your bedtime and snuggle tight.

ANTIOXIDANT SUPPORT – Alpha lipoic acid helps you fight back against free radicals. It encourages antioxidant production and has been shown to boost glutathione levels — an essential antioxidant your body makes.

HEALTHY CELLS, HEALTHY YOU – According to studies, alpha lipoic acid has been shown to promote markers of cellular health and support endothelial cells, the delicate cells that line the inside of your blood vessels. It’s also been shown to support the body’s ability to process already-healthy blood sugar and insulin, supporting nerve health.

BIOTIN FOR EXTRA BENEFITS – We added biotin, a water-soluble B-vitamin that complements lipoic acid’s role in supporting cellular metabolic health, energy production and healthy gene expression.

YOUTHFUL MEMORY & COGNITION AT ANY AGE - Maintaining optimal brain health is key to promoting cognitive performance, especially as we age. Studies show that the combination of alpha-glyceryl phosphorylcholine, phosphatidylserine and wildcrafted whole blueberry fruit extract lays the groundwork for promoting healthy brain cells and overall cognitive function

Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery

THREE BRAIN-HEALTHY NUTRIENTS IN ONE - Our formula features three nutrients that are essential to supporting optimal cognitive performance. These three nutrients in our brain health supplement provide targeted nutrition to help support healthy brain structure and encourage healthy communication between neurons, essential for a sharp mind and healthy memory, concentration and attention

YOUTHFUL DOPAMINE LEVELS – Dopamine is the“feel good” neurotransmitter. But did you know it’s also essential for cognitive function? We’ve combined two nutrients—phellodendron bark extract and a special form of vitamin B12—to help maintain normal dopamine levels.

STAY SHARP & FOCUSED – If you want your mind in tip-top shape, you’ve got to take care of oxidative stress. Vitamin B12 can help...but you’ll need a form that can cross the blood-brain barrier, like adenosylcobalamin B12. Another plus: adenosylcobalaminpositively modulates the activity of LRRK2, an enzyme that regulates dopamine levels.

PROMOTES COGNITIVE HEALTH – Phellodendron amurenseis commonly known as theamur cork tree. Its bark has many health benefits—including ones that help protect your mind. Specifically, amur cork extract inhibits MAO-B, an enzyme that contributes to age-related declines in dopamine levels.

RECLAIM YOUTHFUL ENERGY LEVELS : If you feel like your energy levels aren’t what they used to be, you’re probably not imagining it. General fatigue is a common complaint of women going through perimenopause—and it’s not the only one. Our Youthful Woman 40+ with B-Complex is designed to help you stay youthful and vibrant during this inevitable life transition.

EIGHT B VITAMINS TO SUPPORT HEALTHY ENERGY LEVELS : We’ve combined eight active B vitamins to help energize your body, support overall health and promote a healthy response to stress.

PLUS SIBERIAN RHUBARB EXTRACT : We also added a Siberian rhubarb extract to help relieve discomforts like the occasional hot flash and promote vaginal comfort.

WOMENS MULTI-VITAMIN - An ideal multivitamin for women, Country Life Core Daily-1 for Women delivers daily nutritional support. It features a blend of B vitamins to support energy metabolism. Saw Palmetto, Pygeum, Lycopene and Pumpkin Seed promote prostate health. Probiotics and enzymes help maintain healthy digestion.

ONE EASY-TO-SWALLOW TABLET DAILY - With just one easy to swallow tablet, you get more than just a simple multivitamin. Core Daily-1 Multivitamins contain Probiotics, Whole Foods, Aloe, B Vitamins, enzymes and more. Instead of 6 different pill bottles and boxes, it’s just one comprehensive tablet to help you with versatile, across the board nutritional support.

CONTAINS ABSOLUTELY NO: Wheat - Preservatives - Artificial Colors - Artificial Flavors - Artificial Sweeteners - Magnesium Stearate