Best 365 By Whole Foods Market Vitamin B Supplements in 2026

HEALTHY ENERGY LEVELS: Active B12 with L-5-MTHF by Seeking Health provides 1,360 mcg DFE (800 mcg) of pure non-racemic L-methylfolate in an easy-to-take lozenge, along with two active “coenzyme” forms of vitamin B12 to give you the energy you need.*

HEALTHY MOOD AND FOCUS: Experience a supported healthy mood, focus, energy, and clarity. Note: This is a situational supplement; only take it when you feel that you need it. Other than those times, don’t take it, or as directed by your healthcare professional.*

IDEAL FOR MTHFR GENE MUTATION: By taking this combination of methylated nutrients—methylfolate and methylcobalamin—in Active Vitamin B12 with L-5-MTHF, your methylation pathway is supported and your MTHFR gene mutation symptoms are supported.*

Comprehensive formula: Folate (L-methylfolate or 5-MTHF), R-5-P (riboflavin 5’-phosphate), Vitamin B12 (methylcobalamin & adenosylcobalamin), and P-5-P (pyridoxal 5’-phosphate) work together to support your homocysteine pathway

Ideal for MTHFR gene mutation: By taking additional Betaine (TMG), you support methylation not only via MTHFR, but also via the BHMT gene, and all other homocysteine genes are supported because of the targeted active ingredients in HomocysteX Plus

Multiple health benefits: The vitamin B complex helps balance homocysteine levels, which in turn may contribute to better nitric oxide levels and supports healthy blood pressure. The addition of adenosylcobalamin supports nerve health

EACH VEGAN LOZENGE provides 1000 mcg of B12 as hydroxocobalamin and 800 mcg DFE of folate as folinic acid.

MAY HELP SUPPORT support cellular and cognitive health*

NON-METHYLATED forms of important B vitamins in a naturally flavored lozenge format.

EACH 5 MG (5,000 mcg) lozenge contains two active coenzyme forms of vitamin B12.

THE ACTIVE B12 lozenges dissolve in the mouth within a few minutes. They can also be chewed if you desire.

VITAMIN B12 SUPPORTS red blood cell formation, methylation reactions, brain and nervous system function, energy metabolism and immune system regulation.*

Targeted support: Provides 25 mg of active vitamin B6, an important coenzyme that supports healthy protein metabolism, brain function and cognitive development, homocysteine metabolism support, and immune system function

Vegan and vegetarian dietary support: Seeking Health P-5-P capsules are suitable for vegetarians and vegans who may not receive adequate B6 levels without animal food sources

Easily Absorbed: Easy-to-swallow pyridoxal-5-phosphate capsules offer a bioavailable, convenient way to supplement a healthy diet with B6 vitamins, and may support healthy kidney function, mood, and overall energy

Potent vitamin B complex: Provides bioactive B complex, including vitamin B1 (thiamin), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B6 (P-5-P), pantothenic acid, and biotin. It’s free of B12 and folate and is a great biotin supplement for women

Multiple health benefits: B Minus contains a comprehensive blend of 6 essential B vitamins to support a healthy metabolism, energy production, hormone balance, detoxification, immune system function, positive mood, and cognitive function. The addition of biotin also supports healthy skin, hair, and nail growth

Methylation support: Contains high-quality B complex vitamins, without vitamin B12 or folate; an especially great option for those sensitive to methylated nutrients

Targeted support: B Complex MF by Seeking Health is formulated with folinic acid, riboflavin, vitamin b6, biotin, vitamin B12, niacin, thiamin, and pantothenic acid to support healthy energy production, a healthy immune system, balanced mood, MTHFR support, and balanced homocysteine levels

Non-methylated forms of B12 and folate: Formulated with folinic acid, adenosylcobalamin, and hydroxocobalamin to provide support for those sensitive to methylated nutrients. If you experience nervousness, headaches, or rapid heartbeat with your supplements, we recommend B Complex MF

Contains niacin: When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin