Best 365 By Whole Foods Market Vitamin B Supplements in 2026

A comprehensive b vitamins and trimethylglycine supplement designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range.*

Features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; betaine anhydrous trimethylglycine; and B6, B2, and B12 vitamins.*

The b complex nutrients in this formula are provided in activated forms (methylated B12, methylated folate, pyridoxal 5 phosphate, riboflavin 5 phosphate) to support enhanced methylation and overall cardiovascular health.*

This vitamin b complex contains the entire b vitamin spectrum to support healthy mood, cardiovascular health, and features premium nutrients often included in adrenal support supplements.*

Top tier, activated forms of vitamins B2, B12 as methylcobalamin, and a B6 Vitamin as P-5-P. Thiamine benfotiamine is a fat soluble, more physiologically active form of thiamin. Includes both niacin and niacinamide supplement forms.*

Methyl folate elevates this b vitamin complex with Quatrefolic, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF. This form of folate can act as a methylation and mood support supplement.*

A comprehensive b vitamins and trimethylglycine supplement designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range.*

Features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; betaine anhydrous trimethylglycine; and B6, B2, and B12 vitamins.*

The b complex nutrients in this formula are provided in activated forms (methylated B12, methylated folate, pyridoxal 5 phosphate, riboflavin 5 phosphate) to support enhanced methylation and overall cardiovascular health.*

Premium multi mineral / multivitamin without iron featuring high-quality vitamin and mineral forms selected for optimum utilization.*

May be suitable as both a men and womens multivitamin and mineral supplement. Includes with chelated minerals including magnesium malate and zinc selenium glycinate forms, and bioactive B vitamins like methyl folate, B12 as methylcobalamin and B6 as P5P.*

Promotes foundational wellness and supports health in those with poor nutrient intake. Provides antioxidant activity with a vitamin c complex, vitamin e, and antioxidant supplement beta-carotene from vitamin A.

Supports calmness and relaxation*

Combines key B vitamins, including 5-MTHF as Quatrefolic and Albion di-magnesium malate, with critical amino acids to support overall central nervous system health.*

The key difference between original Mood Food and Mood Food ES is that ES contains addition of Suntheanine, vitamin C, and selenium further enhance synthesis of chemical messengers that support calmness and a healthy nervous system.*

Features a comprehensive blend of nutrients and botanical extracts targeted (sometimes referred to as adaptogens) to supporting the body’s adaptogenic response to promote adrenal health.* Supports energy and stamina.*

Designed to promote the body's normal process of natural energy production, adrenal support, stamina, and the management of everyday stressors.*

Features rhodiola rosea extract, glycyrrhiza glabra, Vit C, schisandra extract, pantothenic acid, and eleuthero root.

High potency folate, provided as Quatrefolic l-methylfolate (as 5 methyltetrahydrofolate), is the most biologically active form of the water-soluble B vitamin, folic acid.

Data indicates that supplementing with the L Methyl Folate form increases plasma folate more effectively than folic acid, which may make this product an ideal choice over a standard folic acid supplement.*

The preferred methyl vitamin b form of folate supplementation due to an array of conditions that can limit conversion or absorption of folic acid. Provided here with 17,000 mcg DFE l-methyl-folate per 2-capsule serving (one capsule is 8,500 or 5 MTHF 5mg).