Best Kirkland Signature Allergy Medicine in 2026

Daisy
Last Updated: Jul 19, 2026

At a Glance: Our Top Picks for Kirkland Signature Allergy Medicine

Benadryl Allergy Ultra TAB 100
#TOP1
Benadryl Allergy Ultra Tab 100
10.0
PM SCORE
ValuMeds Allergy Medicine (600 Tablets) Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing
#TOP2
Valumeds Allergy Medicine (600 Tablets) Antihistamine, Diphenhydramine Hcl
10.0
PM SCORE
ValuMeds 24-Hour Allergy Medicine (300-Count Cetirizine HCl) Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets
#TOP3
Valumeds 24-Hour Allergy Medicine (300-Count Cetirizine Hcl) Antihistamine
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Kirkland Signature Allergy Medicine of 2026

Market Overview
Kirkland Signature Allergy Medicine Reviewed
  • Reviews Analyzed: 195624 Items
  • PM Avg. Rating: 8.2 / 10
53 Products Evaluated
  • Highest Price: $146.70
  • Lowest Price: $8.58
  • Avg. Price: $30.51

Benadryl Allergy Ultra Tab 100

BENADRYL
JJ-2306
1.69 X 3.31 X 1.75 Inches
0.10 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

100-count bottle of Benadryl Ultratabs Antihistamine Allergy Relief Tablets with 25 mg diphenhydramine HCl for powerful allergy & cold relief in 1 pill* *temporarily relieves runny nose & sneezing due to upper respiratory allergies or the common cold

The small, oval shaped coated tablets with the antihistamine diphenhydramine HCl provides relief for hay fever or other upper respiratory allergy symptoms & cold symptoms like sneezing & runny nose

Effective & powerful multi-symptom allergy relief for unexpected allergies from an allergist recommended brand. Works when you need it most.

A trusted allergy brand, Benadryl Ultratabs provide powerful relief for unexpected allergies & relieves symptoms like sneezing, runny nose & itchy, watery eyes & cold symptoms like sneezing & runny nose

Allergy medicine from a doctor recommended brand for safe & effective*** allergy relief in a small, easy-to-swallow tablet form to be used by adults & children ages six & up for relief of both indoor & outdoor allergies ***when used as directed

Effective Allergy Relief When You Need It!

Sneezing

Running Nose

Itchy Throat

Watery Eyes

Valumeds Allergy Medicine (600 Tablets) Antihistamine, Diphenhydramine Hcl 25 Mg | Children And Adults | Relieve Itchy Eyes, Runny Nose, Sneezing

VALUMEDS
60535-2
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ValuMeds 9.90

Features

Breathe a Little Easier – A powerful antihistamine, our formula helps control coughs and runny noses for clearer, healthier breathing.

Clear, Healthy Eyes – Reduce the dry, itchy eyes and redness caused by pollen, dander, and seasonal allergies for true clarity.

Relieve Common Cold Symptoms – This anti-allergy medicine for kids and adults also helps reduce sneezing and itchy noses and throats.

Rest Better – Diphenhydramine HCl can cause drowsiness which can help your body relax for a better night’s rest. Avoid driving after use.

Use as Directed – These HCl antihistamine tablets should always be used as directed. Please read package for more details on proper use and dosage.

Valumeds 24-Hour Allergy Medicine (300-Count Cetirizine Hcl) Antihistamine For Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine Hcl 10Mg Caplets

VALUMEDS
SHOEPADS6
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ValuMeds 9.90

Features

Relieve Allergy Symptoms – This non-drowsy allergy medicine can help relieve dry, itchy, watery eyes, a scratchy nose and throat, sneezing, and other allergy symptoms.

Provides 24 Hour Relief – Just a single dose of our Cetirizine HCl 10mg tablets can help relieve allergy symptoms for a full day, making it easier to get through the day.

Safe, Non-Drowsy Formula – Similar to active ingredients in Zyrtec, ValuMeds allergy medicine for kids and adults won’t cause drowsiness.

Fast, Reliable Support – This 24-hour allergy relief medicine starts working within one hour of ingestion and keep providing support around the clock for trusted relief.

Indoor and Outdoor Protection – ValuMeds allergy medicine can help relieve symptoms around the clock to give you clarity no matter where your travels take you.

#TOP4

Kirkland Signature Funlbh Aller-Tec Cetirizine Hcl 10 Mg Antihistamine Tablets, 365 Tablets (2 Pack)

KIRKLAND SIGNATURE
096619311675-2-A2
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ecompare 9.50

Features

24 Hour Relief of Sneezing, Runny Nose, Itchy, Watery Eyes, Itchy Throat or Nose

Helps with indoor and outdoor allergies

Non-Drowsy

Cetirizine HCL/Antihistamine 10 mg

Kirkland Signature Kirkland Aller-Flo Fluticasone Propionate (Glucorticoid), 0.54 Fl Oz (Pack Of 5)

KIRKLAND SIGNATURE
1028472
10.25 X 1.50 X 7.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Queens Express 9.93

Features

Compare to Flonase Allergy Relief Active Ingredient

Fluticasone Propionate(Glucocorticoid) 50 mcg.

Indoor/Outdoor Allergy Relief

Non-Drowsy

5 Bottles, 120 Sprays Each

Diphenhydramine Hci 25 Mg - Kirkland Brand - Allergy Medicine And Antihistaminecompare To Active Ingredient Of Benadryl® Allergy Generic - 600 Count Personal Healthcare / Health Care

KIRKLAND SIGNATURE
BERGW-1066
2.25 X 2.25 X 4.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
iToon 9.84

Features

Diphenhydramine HCI 25 Mg - Kirkland Brand - Allergy Medicine and AntihistamineCompare to Active Ingredient of Benadryl Allergy Generic - 600 Count Personal Healthcare / Health Care

Diphenhydramine HCI 25 Mg - Kirkland Brand - Allergy Medicine and AntihistamineCompare to Active Ingredient of Benadryl Allergy Generic - 600 Count

Claritin 24 Hour Allergy Medicine, Non-Drowsy Prescription Strength Allergy Relief, Loratadine Antihistamine Tablets, 100 Count

CLARITIN
B078BBYNLC
3.76 X 1.55 X 3.08 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Powerful, 24 hour, non drowsy indoor and outdoor allergy relief

#1 doctor recommended non-drowsy oral allergy brand. *

No prescription needed: Find relief of symptoms triggered by over 200 different allergens from pets, pollen, dust and mold.

Relief of your worst allergy symptoms including sneezing, runny nose, itchy/watery eyes and itchy throat/nose

Claritin contains 10 milligrams of loratadine per tablet, that blocks the effects of histamines in the body.

Flonase Sensimist Allergy Relief Nasal Spray Non-Drowsy Allergy Medicine For Kids And Allergy Medicine For Adults, Gentle Mist Multipack - 120 Sprays Total (2 Bottles Of 60 Sprays)

FLONASE
HL6-K856
6.13 X 10.00 X 4.00 Inches
0.62 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One 60-spray bottle each of Flonase Sensimist Allergy Relief Nasal Spray Non-Drowsy Allergy Medicine for Kids and Allergy Medicine for Adults, with a gentle mist kids or adults will barely feel

Unlike most allergy pills, Flonase Sensimist is a multi-symptom 24 hour allergy medicine providing powerful nasal congestion, sneezing, itchy nose, itchy eyes, watery eyes and runny nose relief

Allergy nasal spray delivered as a fine, gentle mist with no aftertaste, no odor and virtually no dripping

Each product has an ergonomically designed bottle to fit the noses of kids or adults, with a mini nozzle that delivers an ultra-fine lightweight mist you'll barely feel

Non drowsy allergy relief formula gives kids or adults more complete relief against all their allergy symptoms to keep them energized and focused throughout the day

Nasal decongestant allergy medication for indoor, outdoor, year round and seasonal allergy relief

Flonase Children's Sensimist is formulated and safe for children 2 to 11 years old. Adult Flonase Sensimist is formulated for adults and children 12 years of age and older.

Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray - 144 Sprays

FLONASE
1
1.88 X 5.55 X 4.97 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Better Price For You LLC 9.83

Features

One 144-spray bottle of Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray, stops your body from overreacting to allergens

Containing the most prescribed allergy medication(2), Flonase relieves runny nose, sneezing, itchy nose and watery, itchy eyes, while also providing nasal congestion relief

Allergy nasal spray that provides 24 hour all-in-one relief for even your worst seasonal, year-round, indoor and outdoor allergy symptoms

24 hour allergy medicine that delivers prescription-strength non-drowsy relief all day and night

Easy to use allergy relief nasal spray formulated for adults and children 12 years of age and older

Spray this allergy spray only one to two times daily in each nostril for powerful, non-drowsy all-day relief that lasts

Use up to two sprays in each nostril daily

Healtha2Z Fluticasone Propionate Nasal Sprays, 2 Pack * 120 Sprays, 24 Hour Allergy Relief

HEALTHA2Z
FPA025
2.85 X 1.75 X 4.90 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Life Direct 9.95

Features

HealthA2Z Fluticasone Propionate Nasal Spray contains a powerful antihistamine in the fight against allergy symptoms

24-HOUR ALLERGY RELIEF: HealthA2Z Fluticasone Propionate Nasal Spray temporarily relieves symptoms of hay fever or other upper respiratory allergies: Itchy, Watery Eyes, Nasal Congestion, Runny Nose, Itchy Nose, Sneezing.

NON-DROWSY: A non-drowsy nasal spray that allows you to go about your day with all day relief from common allergy symptoms.

WARNINGS: only for use in the nose. Do not spray into your eyes or mouth.

DIRECTIONS: Week 1: use 2 sprays in each nostril daily/Week 2 through 6 months: use 1 or 2 sprays in each nostril once daily, as needed to treat symptoms/After 6 months of daily use: ask a doctor if you can keep using.

Zyrtec 24 Hour Allergy Relief Tablets, Bundle With 1 X 30Ct And 3 X 1Ct Travel Packs

ZYRTEC
PVFH8F
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Bundle pack containing one 30-count bottle and three 1-count travel packs of Zyrtec 24 Hour Allergy Tablets for powerful relief of your worst indoor & outdoor allergy symptoms, including runny nose, sneezing, itchy, watery eyes, & itchy nose & throat

These prescription-strength cetirizine allergy pills work fast and stay strong by providing all-day allergy relief that starts working hard at hour one and works twice as hard when taken again the next day

Each powerful antihistamine tablet contains 10 mg of cetirizine hydrochloride and effectively treats indoor allergies caused by dust, mold, and pet dander, as well as outdoor seasonal allergies caused by tree pollen, weeds, and grasses

Get effective allergy relief from symptoms caused by hay fever & other upper respiratory allergies from Zyrtec, the #1 allergist-recommended brand among over the counter oral antihistamines

Suitable for those 6 years of age and older, this allergy relief medication provides powerful, effective relief from allergy symptoms for a full 24 hours in just a single dose

Flonase Children's Allergy Relief Nasal Spray, Non Drowsy Allergy Medicine - 72 Sprays

FLONASE
1.88 X 5.53 X 4.97 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Cool & Cheap 9.85

Features

One 72-spray bottle of Flonase Children's Allergy Relief Nasal Spray, relieves kids' worst allergy symptoms in an easy to use bottle

Children's Flonase contains the number 1 pediatrician prescribed allergy medicine (based on the cumulative IMS prescription data 2009-April 2016)

Unlike most allergy medicines, Children's Flonase nasal spray relieves runny nose, sneezing, itchy nose, itchy eyes, watery eyes and nasal congestion (vs. single-ingredient antihistamines which do not contain a nasal decongestant)(1)

Children's allergy medicine with a non drowsy formula that gives kids relief against all their nasal allergy symptoms to keep them energized and focused throughout the day

Just one dose per day provides 24 hours of prescription strength, non drowsy allergy medicine for indoor and outdoor, year-round and seasonal allergy relief

Healthcareaisle Allergy Relief - Fexofenadine Hydrochloride Tablets Usp, 180 Mg – 180 Tablets – Allergy Medication, Non-Drowsy 24-Hour Allergy Relief

HEALTHCAREAISLE
2.75 X 2.75 X 4.75 Inches
0.49 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Fexofenadine is a non-drowsy allergy medicine that provides effective relief from indoor and outdoor allergies

Our Fexofenadine Hydrochloride is an antihistamine that temporarily relieves allergy symptoms due to hay fever or other upper respiratory allergies such as runny nose; itchy, watery eyes; sneezing; and itching of the nose or throat

Comparable to the national brand: Has the same active ingredient as Allegra Allergy 24 Hour Tablets

Fexofenadine tablets provide 24 hours of allergy relief

Take one 180 mg tablet with water once a day; do not take more than 1 tablet in 24 hours; see package label for warnings, directions and other important information; use only as directed

Hyland's 4 Kids Stuffy Nose & Sinus Cold And Allergy Medicine For Children Ages 2+ Headache Relief And Nasal Decongestant, 50 Tablets

HYLAND'S
1.38 X 2.75 X 4.00 Inches
0.05 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Temporarily relieves symptoms of stuffy nose and sinus in children including: nasal congestion, sinus pressure, and headache

Hyland's 4 Kids medicines are made with natural active ingredients, and created especially for kids ages 2 to 12

Free of diphenhydramine, antihistamines, ibuprofen, acetaminophen and steroids

SAFE AND GENTLE: Hyland's formulas are made with natural active ingredients and have no known drug interactions

KEEPING FAMILIES HEALTHY: Hyland’s Naturals is a leading consumer health brand with more than a century of history making high quality products to help people live healthier and happier lives

#TOP15

Kirkland Allergy Medicine, Diphenhydramine Hci 25 Milligram 600 Tablets (Pack Of 3)

KIRKLAND SIGNATURE
536099
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
HealthandOutdoors 9.63

Features

Relief from sneezing and running nose.

Reduces and relieves itching, watery eyes, hay fever symptoms.

Reduces and relieves itching of nose or throat.

#TOP16

Kirkland Brand, Diphenhydramine Hci 25 Mg, (1,800 Count)-Allergy Medicine And Antihistaminecompare To Active Ingredient Of Benadryl Allergy Generic

KIRKLAND SIGNATURE
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
whizzotech 9.86

Features

Relief from sneezing and running nose

Itching, Watery Eyes,Hay Fever symptoms

Itching of Nose or throat.

Forces Of Nature - Natural Organic Allergy Maximum Strength Medicine (10Ml) Non Drowsy, Non Addictive, Non Gmo -Fight Indoor, Outdoor Allergies, Sneezing, Runny Nose, Itchy Eyes, Throat And Nose

FORCES OF NATURE
830743013018
1.13 X 2.50 X 4.38 Inches
0.08 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Forces of Nature USA 9.59

Features

CONTAINS 1 - 10ML (.34oz). Up to 40 sublingual doses for long lasting allergy relief.

EFFECTIVE & SAFE RELIEF from allergy symptoms such as stuffy, runny nose, nasal congestion, sneezing, postnasal drip, sinus pain itchy nose and throat, cough, watery, itchy, red eyes and fatigue.

NATURAL, NON-DROWSY, NON-HABIT FORMING, long lasting, effective natural antihistamine for allergies. Treats seasonal allergy symptoms caused by hay fever, upper respiratory allergies, pollen, trees, grasses, ragweed and animal dander.

FREE OF HARMFUL CHEMICALS our products are 100% natural, plant based, USDA Certified Organic, FDA Registered, Non-GMO Project Verified, Leaping Bunny Certified (cruelty free), vegan friendly, non-toxic, no side effects, no artificial fragrances or colors.

COMPARE TO OTHER ALLERGY RELIEF brands like GoodSense, Flonase, Allegra, Xyzal, FlutiCare, Benadryl, Claritin, Basic Care, Zyrtec, Kirkland Signature, Alavert, Basic Care, Hylands, Boiron, GoodSense,Genexa, WishGarden

Top 10 allergy medicine kirkland signature Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Kirkland Signature 37
Flonase 3
Healtha2Z 3
Idea Shop Usa 2
Valumeds 2
Benadryl 1
Claritin 1
Forces Of Nature 1
Healthcareaisle 1
Hyland's 1

Top 10 allergy medicine kirkland signature Brands Pie Chart


We've carried out a comprehensive analysis of 195,624 reviews on allergy medicine kirkland signature, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select allergy medicine kirkland signature priced around $30.51, with top brands including zyrtec, benadryl, visine, idea shop usa, valumeds, claritin, hyland's, kirkland signature and healtha2z and healthcareaisle

Our team of expert editors reviewed these high-quality items and handpicked the top 17 allergy medicine kirkland signature for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, idea shop usa, valumeds, itoon, hollywood traders, first choice online, the chosen shop, jft-online and speedy ships and avanvitca .

We are dedicated to assisting our users in finding the right medicine Products based on their needs, saving them considerable time when choosing which allergy medicine kirkland signature to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.