Best Liquid Cold Flu Medicine in 2026

Nose spray

Unblocks your nose fast

Lasts up to 10 hours

20-count of Sudafed PE Non-Drowsy Head Congestion + Pain Relief Caplets for effective nasal congestion relief and nasal swelling relief, now coupled with the powerful pain relief of ibuprofen

From the #1 pharmacist recommended brand among oral OTC decongestants, it provides non-drowsy relief from head congestion and pain symptoms caused by head colds

Each coated caplet contains 200 milligrams of ibuprofen, the #1 doctor-recommended pain reliever, to help reduce fever while also helping to alleviate headache and minor body aches and pains

ACTIVE INGREDIENT: The active ingredient in Amazon Basic Care Nasal Decongestant PE is Phenylephrine HCl 10 mg, a nasal decongestant, which compares to the active ingredient in Sudafed PE Congestion

NASAL DECONGESTANT: This product provides maximum strength, non-drowsy relief for nasal and sinus congestion, and sinus pressure due to the common cold, hay fever or other upper respiratory allergies

MAXIMUM STRENGTH: This nasal decongestant provides powerful relief for sinus pressure, nasal and sinus congestion

24-count box of Sudafed PE Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus

Sinus relief medicine contains 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction. Also has 200 mg of guaifenesin, an expectorant, for mucus reduction

Head congestion tablets temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold

ACTIVE INGREDIENT: The active ingredient in GoodSense Maximum Strength Nasal Decongestant PE is phenylephrine HCl 10 mg, a nasal decongestant, which compares to the active ingredient in Sudafed PE Congestion

NASAL DECONGESTANT: This product provides maximum strength, non-drowsy relief for nasal and sinus congestion, and sinus pressure due to the common cold, hay fever or other upper respiratory allergies

MAXIMUM STRENGTH: GoodSense Maximum Strength Nasal Decongestant PE provides maximum strength relief for sinus pressure, nasal and sinus congestion

A non-drowsy formula that quickly clears sinus pressure and nasal congestion

Each tablet contains: Phenylephrine HCl 10mg

Compare active ingredient to Sudafed PE

4-fluid ounces of Children's Sudafed PE Cold + Cough cold medicine for kids temporarily relieves various symptoms due to common cold, hay fever, and other upper respiratory allergies

Contains a cough suppressant, dextromethorphan HBr, and a nasal decongestant, phenylephrine HCl for multi symptom cold and cough relief for your children aged 4 and up

Non-drowsy, multi-symptom cold medicine for kids with a kid-friendly grape flavor