Best Organic Enzyme Nutritional Supplements in 2026

Daisy
Last Updated: Jul 19, 2026

At a Glance: Our Top Picks for Organic Enzyme Nutritional Supplements

Designs for Health Nattokinase with Serrapeptidase - Natto-Serrazime + Proteolytic Enzymes - Designed to Support a Healthy Circulatory System + Immune Health - Non-GMO Supplement (120 Capsules)
#TOP1
Designs For Health Nattokinase With Serrapeptidase - Natto-Serrazime
9.6
PM SCORE
Designs for Health Digestzymes - Digestive Enzymes with Ox Bile & Betaine Hydrochloride (HCl with Pepsin) Digestion Supplement to Support Optimal Breakdown of Proteins, Fats + Carbohydrates (180 Caps)
#TOP2
Designs For Health Digestzymes - Digestive Enzymes With
9.6
PM SCORE
Designs for Health Plant Enzyme Digestive Formula - Vegetarian Digestive Enzymes Supplement - Gut Support with Hemicellulase, Protease + More - May Support Occasional Gas + Bloating (90 Capsules)
#TOP3
Designs For Health Plant Enzyme Digestive Formula -
9.5
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Organic Enzyme Nutritional Supplements of 2026

Designs For Health Nattokinase With Serrapeptidase - Natto-Serrazime + Proteolytic Enzymes - Designed To Support A Healthy Circulatory System + Immune Health - Non-Gmo Supplement (120 Capsules)

DESIGNS FOR HEALTH
NTS120
1.75 X 1.33 X 3.00 Inches
0.16 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

This formula is designed to support the body’s ability to breakdown and remove damaged cellular debris, tissue, and specific protein structures that are produced during the natural inflammatory process in response to trauma or injury.*

These proteolytic enzymes may help maintain healthy joints, support healthy circulatory, respiratory, and immune function, and promote a normal inflammatory response.*

Natto-Serrazime is a blend of two health-promoting proteolytic enzymes, Nattozimes and Serrazimes, derived from the fungi Aspergillus oryzae and Aspergillus melleus.

Vegetarian & Non-GMO - This product is Vegetarian-Friendly. Made without GMOs or Dairy. Tinted glass bottles offer a barrier against moisture and oxygen, which helps protect nutrient viability.*

Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

#TOP2

Designs For Health Digestzymes - Digestive Enzymes With Ox Bile & Betaine Hydrochloride (Hcl With Pepsin) Digestion Supplement To Support Optimal Breakdown Of Proteins, Fats + Carbohydrates (180 Caps)

DESIGNS FOR HEALTH
DIG180
16.00 X 16.00 X 9.00 Inches
0.33 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

Support Food Breakdown + Nutrient Absorption - This digestive enzyme supplement is a multi enzyme blend of a proprietary blend of digestive enzymes alongside betaine HCl with pepsin to support optimal digestion of proteins, fats, and carbohydrates.*

Occasional Gas or Bloating After Meals? The use of Digestzyme before meals may offer occasional bloating relief. Enzymes may be helpful for those experiencing occasional gas after eating, constipation, or a feeling of fullness after eating only a small quantity of food.* Take one digestion supplement capsule before meals for digestive support.*

Synergistic Enzyme Blend - Contains protease DPP IV (dipeptidyl peptidase IV), which aids in the breakdown of casomorphin (from casein protein) and gluteomorphin (from gluten). Lactase enzyme helps break down the dairy sugar lactose. Also includes a blend of lipase amylase bromelain enzymes.

Why Add Bile Salts to Your Digestive Aid? Ox bile extract provides bile acids, which are key to the digestion of fat and fat-soluble vitamins. Digestive enzyme supplements can offer support for malabsorption and maldigestion, including fats.*

Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength digestive health supplements since 1989. Our "Science First" philosophy ensures our enzymes for digestive health are based on the most recent research and use the highest quality raw ingredients.

Designs For Health Plant Enzyme Digestive Formula - Vegetarian Digestive Enzymes Supplement - Gut Support With Hemicellulase, Protease + More - May Support Occasional Gas + Bloating (90 Capsules)

DESIGNS FOR HEALTH
PEF090
2.25 X 3.00 X 4.00 Inches
0.09 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

You Are What You Absorb - A proper diet is the foundation for good health and maintaining an appropriate body. However, the well-known phrase "you are what you eat" is only part of the equation. We are not just what we eat; we are also what we digest, absorb, and assimilate. If your digestive function is compromised, we cannot fully benefit from the nutrients in our diet, no matter how high the quality of our foods.*

No Animal Byproducts - Plant Enzyme Digestive Formula contains no animal products. It is presented in a vegetable capsule and is suitable for vegetarians. It may be particularly useful for the improved digestion of plant foods like grains and beans, as well as dairy products, which commonly induce digestive upset. Strengthened digestion means we will harness more of the essential, life-building nutrients in the quality foods we choose.*

Comprehensive Formula - Plant Enzyme Digestive Formula includes support for digesting all three macronutrients, carbohydrates, proteins, and fats. It includes the carbohydrate-digesting enzymes - amylase, glucoamylase, cellulase, hemicellulase, diastase, beta-glucanase, and invertase. This product also contains lactase, for the digestion of lactose - the 'milk sugar' along with the protein-digesting enzymes - protease, acid protease, alpha-galactosidase, and protease SP.*

Always Pure & Effective Products - This product is Non-GMO, Vegetarian-friendly, and contains No Gluten.*

Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

#TOP4

Designs For Health Betaine Hcl With Pepsin - 750Mg Betaine Hydrochloride + Protein Digestive Enzyme - Non-Gmo Supplement To Support Digestive Function (120 Capsules)

DESIGNS FOR HEALTH
BHC120
0.38 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

REQUIRED FOR THE PROPER ABSORPTION OF NUTRIENTS - Betaine HCl is an excellent source of hydrochloric acid, which is produced by the parietal cells of the stomach. Hydrochloric acid is required for the proper absorption of nutrients, including vitamin B12 and minerals such as calcium, magnesium, zinc, iron, and selenium. *

SUPPORT DIGESTIVE FUNCTION - Betaine HCl provides 750 mg betaine hydrochloride along with pepsin, a key protein digestive enzyme produced in the stomach. This product is ideal for those who are looking to support their stomachs digestive function. Taking one capsule before a meal aids digestion, especially the digestion of protein-containing foods, and supports the assimilation of nutrients. *

UPGRADED DELIVERY - This product was previously in a tablet form. However, we have upgraded to a capsule. This change ensures delivery of betaine HCl and pepsin to the stomach where they are needed to initiate digestion. *

ALWAYS PURE & EFFECTIVE PRODUCTS - This product is Non-GMO and contains No Gluten, Dairy or Soy. DFH is transitioning to tinted glass bottles. In addition to being more eco-conscious, tinted glass offers a greater moisture barrier against moisture and oxygen, which helps protect nutrient viability.*

OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

Designs For Health Allergzyme Digestive Enzymes Supplement - Supports Digestion Of Gluten, Dairy + Problematic Proteins With Protease + Bromelain - Non-Gmo + Dairy Free (60 Capsules)

DESIGNS FOR HEALTH
AGZ090
9.00 X 7.00 X 4.00 Inches
0.14 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

SUPPORT FOR THE MODERN DIET - Over the years, high protein/low carbohydrate diets have become very popular. These types of diets are fast becoming lifestyle changes for many people. *

ASSISTS WITH THE DIGESTION OF PROTEIN - AllerGzyme is a full spectrum proteolytic enzyme complex that assists with the digestion of difficult-to-break-down proteins such as gluten, gliadin, and casein from whey and dairy, as well as many other protein sources in the diet, including soy and rice. *

POWERFUL KEY INGREDIENTS - Featuring Glutalytic endo & exo-peptidase complexes as well as bromelain, which expands the proteolytic effectiveness of these enzymes and contributes in supporting the digestive system.*

HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly.

#1 IN CONSUMER SATISFACTION - Designs for Health was voted #1 in Consumer Satisfaction in 2016 and 2017 in a Consumer Labs survey of Healthcare Practitioner Brands.

Designs For Health Paleozyme - Paleo-Friendly Digestive Enzymes + Bromelain Supplement - Support Digestion + Gut Health - Delayed Release Capsule With Pancreatic Enzyme, Ox Bile (90 Capsules)

DESIGNS FOR HEALTH
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

PANCREATIC ENZYMES & OX BILE - These pancreatic enzymes are nearly bioidentical to human enzymes and support protein, carbohydrate, and fat digestion. PaleoZyme also includes bromelain to promote protein digestion and ox bile to aid the emulsification of fats.*

ALLERGEN-FREE & PALEO COMPLIANT - Free of grain, legume, and dairy-sourced ingredients, making it ideal for those with sensitivities to these common foods/food groups and those who prefer to maintain a strict Paleo diet.*

DELAYED RELEASE - Enteric coating protects the enzymes from stomach acid. This helps preserve their activity for the first section of small intestine, where pancreatic enzymes are intended to function.*

HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Gluten-Free Non-GMO.

OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

Designs For Health Carminagest - Herbal Digestive Bitters Supplement To Support Healthy Digestion, Target Gas & Bloating With Gentian Root, Dandelion Root Extract - Tincture Alternative (120 Capsules)

DESIGNS FOR HEALTH
MADFS-005
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Designs for Health 9.95

Features

HERBAL DIGESTIVE BITTERS - Powerful blend of herbal bitters to support healthy digestion.* Combines ginger, fennel, dandelion, gentian, and lemon balm.

TARGET GAS & BLOATING - Designed to optimize healthy digestion and help reduce occasional gastrointestinal discomfort after meals, such as gas, bloating, and excessive fullness.*

ALTERNATIVE TO ALCOHOL-BASED LIQUIDS - Capsule form offers powerful digestive support without needing an alcohol-based delivery method.*

NON-GMO + VEGAN - Suitable for vegetarians and vegans who may benefit from digestive support but who prefer to avoid animal-sourced digestive enzymes. Formulated with no gluten, soy or dairy. Packaged in premium tinted glass.

OVER 50,000 PRACTITIONERS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

Top 10 enzyme nutritional supplements Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Designs For Health 7

Top 10 enzyme nutritional supplements Brands Pie Chart


We've carried out a comprehensive analysis of 1,279 reviews on enzyme nutritional supplements, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select enzyme nutritional supplements priced around $50.56, with top brands including enzymedica, ancient nutrition, smarternutrition, global healing center, enzyme science, now, bioptimizers, wonderland herbs and naturelo and microbiome labs

Our team of expert editors reviewed these high-quality items and handpicked the top 7 enzyme nutritional supplements for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include netrush, ancient nutrition, smarter nutrition, global healing usa, enzyme science ™, amazon.com, bioptimizers, akersunder and naturelo and fortressbrand .

We are dedicated to assisting our users in finding the right supplements Products based on their needs, saving them considerable time when choosing which enzyme nutritional supplements to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.