Best Softgel Enzyme Supplements in 2026

Prebiotic Probiotic Combo : Our Pre-Pro is designed to support digestive health & gut health. A great choice for those looking to support a diverse healthy microbiome - contains 250mg of Prebiotic Chicory Root Inulin.

Prebiotic Focused: Our Prebiotic-Probiotic is crafted to create a synergistic combo that helps support your gut health. Contains 10B CFU of 3 diverse Lactobacillus probiotic strains.Expertly crafted to support occasional constipation, diarrhea, gas & bloating!

Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 10 Billion Colony forming units (CFU) to achieve this!

Digestive Enzymes with Prebiotics & Probiotics: One before a meal to find relief from occasional bloating, gas, and discomfort from food and alcohol.

Advanced Enzymes Blend: Replenishes digestive enzymes that may decline with age to help break down alcohol, meat, dairy, fried foods, and raw vegetables.

Clinically Proven DE111 Probiotic: Guaranteed to arrive alive and work within hours in small intestine where 90% of nutrient absorption occurs + 70% of immune system resides.

Promote Muscle Growth: CLA supplements may support metabolic activity and lean muscle gain.* CLA may encourage the body’s production of energy for sustained physical activity.*

Encourage Exercise Benefits: Conjugated Linoleic Acid, or CLA, may encourage greater benefits from exercise by influencing the activity of certain enzymes that play a role in the metabolism of fatty acids.* CLA may also contribute to the production of energy for stamina and endurance.*

Premium Quality: NatureWise CLA comes from pure, premium-quality, non-GMO safflower oil obtained from certified sources and standardized to a high potency of 80%. Each 1250 mg softgel contains 1000 mg of CLA.

Daily dose of vitamin d3 - We recommend that adults get between 125 mcg and 200 mcg of vitamin D3 every day. That makes a vitamin D3 supplement like this one the perfect complement to your multivitamin. Support bone, brain and immune health with just one softgel a day.

Bone & brain health - Vitamin D helps get calcium into your bone matrix—the lattice-like structure that gives your bones their strength and rigidity. Vitamin D is good for your brain, too: healthy levels of vitamin D3 have been shown to correspond to better cognitive health scores as you age!

Immune health & supporting already-healthy blood pressure – Vitamin D3 plays a critical role in immune function. It also promotes endothelial health and can help maintain already-healthy blood pressure…which makes getting enough daily vitamin D3 a really, really good idea!

240 Capsules of Vitamin B12 In Each Bottle

2,000mcg of Vitamin B12 (Methylcobalamin) in each (Vegetarian) Capsule

High Quality B12, Vegetarian Friendly, Non-GMO, Gluten Free

DOCTOR FORMULATED PROBIOTICS FOR DAILY DIGESTIVE AND IMMUNE SUPPORT: Once Daily Prenatal Probiotic provides 20 Billion CFU and 16 Probiotic Strains plus Prebiotic Fiber, for probiotic and prebiotic support during pregnancy and lactation

PRENATAL PROBIOTICS BY GARDEN OF LIFE: This probiotic supplement includes Lacto and Bifido strains, including B. longum and infantis, L. acidophilus and L. rhamnosus HN001—which has been clinically shown to support the immune systems of mom and baby

PROBIOTICS AND PREBIOTICS FOR WOMEN: Once Daily Prenatal is a hypoallergenic probiotic supplement and a prebiotic supplement, with 115mg Organic Potato and Organic Acacia prebiotic fiber to help feed good bacteria in the gut—in just 1 capsule a day

Compare active ingredients to Caltrate 600

Support for bone health

High in calcium

60 BILLION CFUs - This probiotic supplement features 10 unique strains of probiotics and contains a proprietary blend of 4 incredible prebiotics you won't find anywhere else. Each capsule features a delayed-release. Recommended usage is only 1 capsule per day. Includes a 30 day supply.

𝗨𝗦𝗔 𝗚𝗠𝗣 𝗖𝗘𝗥𝗧𝗜𝗙𝗜𝗘𝗗 𝗠𝗔𝗡𝗨𝗙𝗔𝗖𝗧𝗨𝗥𝗜𝗡𝗚 - Our state-of-the-art manufacturing facilities are located in the US and are staffed with highly trained individuals who formulate superior products. Being certified under US laws and regulations (GMP Certified), these facilities are uncompromising when it comes to cleanliness and quality control.

𝗜𝗡𝗖𝗥𝗘𝗗𝗜𝗕𝗟𝗘 𝗜𝗡𝗚𝗥𝗘𝗗𝗜𝗘𝗡𝗧𝗦 - We're sorry to say it, but if you’re looking for cheap, you’re in the wrong place. We search far and wide, domestic and international, to provide high-quality ingredients for which your body will thank you. Unfortunately, getting the best ingredients from domestic and international farms can come at a higher-than-normal cost. If quality, satisfaction, and results are essential to you, you’re in the right place!

MAXIMUM STRENGTH UBIQUINOL CoQ10 1000MG – CoQ10 levels in the heart and body may begin to naturally decline after age 40, while statin drugs for cholesterol may deplete the body’s CoQ10 levels. Mecinalis CoQ10 Ubiquinol supplement features double potency co q10. Liposomal CoQ10 1000mg supplement provides 1000mg per soft gel for a 60-day supply, beneficial to get your natural CoQ10 levels and heart and cardiovascular system.

SUPERIOR FORM OF UBIQUINOL COQ10 – UBIQUINOL OR UBIQUINONE? Ubiquinol CoQ10 is the active antioxidant form of Coenzyme Q10 (Co-Q10), which is the most utilized by your cells whereas regular CoQ10 (ubiquinone) has to be converted by your body into ubiquinol. Our Liposomal CoQ10 Ubiquinol is 3X times more bioavailable than regular CoQ10 ubiquinone.

5X BETTER ABSORPTION WITH LIPOSOMAL – The Liposomal delivery system encapsulates Q10 in molecular structures which are then enveloped into liposomes, which allows it to bypass your stomach, driving higher bioavailability and absorption. The enhanced liposomal ubiquinol helps to absorb the Co-Q10 supplements better than the regular Ubiquinol CoQ10 supplements. Easy-to-Swallow Liposomal soft gel achieves maximum bioavailability of ubiquinol.

Calcium magnesium supplement – formulated to support bone health

Supports calcium utilization - uses a calcium to phosphorus and calcium to magnesium ratio of 2:1 to support calcium utilization and the body’s availability of calcium. This healthful blend of calcium and magnesium contains 1000mg calcium, 500mg magnesium and 500mg phosphorus per serving

1000mg calcium - To support healthy bones - adequate calcium throughout life, as part of a well-balanced diet

EXTRA STRENGTH MAGNESIUM CITRATE & OXIDE SUPPLEMENT: Each capsule of our magnesium citrate supplement contains a 500mg blend of magnesium citrate and oxide. Our high quality Magnesium Capsules are convenient, tasteless and easy to swallow. Magnesium is an important mineral for your health!

HELPS SUPPORT BONES, CARDIOVASCULAR HEALTH & ENERGY PRODUCTION: Magnesium is critical for healthy enzyme function and helps support energy production and healthy muscles. Whether you are magnesium deficient or looking to improve your health with our Magnesium Complex, our magnesium citrate and oxide 500mg blend is a powerful dose of two forms magnesium.

500MG OF MAGNESIUM PER CAPSULE: Unlike some other magnesium oxide capsules, magnesium glycinate, magnesium malate, magnesium powder, magnesium liquid, magnesium chelate or magnesium tablets, our magnesium formula includes both magnesium citrate and magnesium oxide, which provides you with two different forms of Magnesium in one capsule!

Highest Quality vitamins and supplements since 1973

For immune system health

Involved in healthy vision and smell

GNC Probiotic Complex Daily Need: Supplies 1 Billion CFUs 8 unique strains, including clinically studied probiotics

May provide digestive & immune support*

No artificial flavors, no wheat, no soy

Urinary Function: Saw palmetto has been utilized for decades to support urinary function.*

Saw Palmetto Plus with Nettle Root Extract helps maintain proper testosterone metabolism for optimal urinary health.*

Hormone Metabolism: Nettle root, also known as stinging nettles, has indicated the ability to support healthy enzyme activity and maintain healthy hormone metabolism.*

Spark your energy: Jump-start your body’s ability to produce energy with support from Coenzyme Q10, an all-natural antioxidant and catalyst for ATP production

For your heart: Helps maintain heart and cardiovascular health; Aids cognitive health; Blended with rice bran oil for improved absorption

Cellular power: CoQ10 works within the mitochondria to convert food into the energy that fuels cells throughout the body, in particular the heart and brain

PREBIOTICS AND PROBIOTICS SUPPLEMENT: Formulated with a prebiotic and 7 live probiotic strains, this supplement can help to replenish the natural balance of gut flora within the digestive system and help support immune system balance.

ACID- & BILE-RESISTANT PROBIOTIC CAPSULES: Our durable probiotic supplement contains 7 different probiotic strains of human origin, so it's easier to adapt to the human body. This men’s and women’s probiotic is also resistant to stomach acid and bile.

MADE WITH CARE: These capsules are mindfully sourced and contain the following natural probiotic strains: L. acidophilusL. casei (10%); L. plantarum (10%); L. rhamnosus (10%); B. lactis (10%); B. longum (5%); and S. thermophilus (5%).

Advanced 2-in-1 digestive support: Combines Digest Gold with 1.5 billion active probiotic cultures to help relieve occasional bloating, gas, and irregularity, while supporting a healthy microbiome

Speeds up digestion: When you feel bloated and heavy (no matter what you eat), this enzyme blend helps break down food more quickly while promoting a healthy microflora so digestion works smoothly

Most advanced support: One capsule with every meal provides powerful enzymes to digest proteins, carbohydrates, dairy, fats, and fibers – even for your largest meals

GASTROINTESTINAL SUPPORT/HELPS DIGEST GLUTEN AND CEREAL GRAINS: Take 1 capsule at the beginning of any meal that may contain gluten.

SPECIALLY FORMULATED INGREDIENT: NOW Gluten Digest, with BioCore DPP IV, is a comprehensive enzyme blend formulated to promote the complete digestion of cereal grains.

CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Kosher, Soy Free, Vegan/Vegetarian, Keto Friendly, Made without Gluten

True TG Form - Unlike many omega 3 fish oils, our TruTG Fish Oils are in the Triglyceride form (TG), the same form found in fish. TruTG may support superior bioavailability than the standard EE form.*

1200 Mg Omega 3 Fatty Acids - 600mg EPA. 400mg DHA. Magnesium may support healthy joints, immunity, healthy skin & hair, and cardiovascular health.*

Improved Digestibility & No Fishy Aftertaste - The enzyme Lipase helps ensure optimal digestion and prevent any fishy aftertaste.*

DigestZen TerraZyme Digestive Enzyme Complex is a blend of whole-food enzymes and supporting cofactors that help strengthen the body's production of enzymes which is important in the process of healthy digestion of food nutrients and cellular metabolism of nutrients to energy

Supports healthy digestion and metabolism of enzyme-deficient, processed foods

Supports conversion of food nutrients to cellular energy

✔️【Long-Lasting Antioxidant Formula, 450mg Per Softgel】Our sulforaphane supplement contains 150mg sulforaphane + 300mg glucoraphanin from Broccoli Seed Extract. Sulforaphane in cruciferous vegetables occurs in a stored, inactive form as glucoraphanin. Glucoraphanin (Precursor of Sulforaphane) is converted to sulforaphane's active form by the enzyme myrosinase. The powerful combination dramatically enhances the potency and makes a long-lasting effect.

✔️【Advanced Liposomal Delivery for Maximum Absorption】Unlike regular sulforaphane supplements, Osasuna liposomal sulforaphane offers Maximum Absorbability. Liposomal encapsulation forms a protective shield around sulforaphane that does not come into contact with the stomach acid to achieve the Highest Bioavailability.

✔️【Optimized With Proprietary Sulforaphan Boost Blend】Your body can’t make sulforaphane in the gut without the myrosinase enzyme. Each serving contains 250MG of Organic Mustard Seed, Myrosinase Enzyme, etc. The Myrosinase and Mustard Seed aid in activating the bioavailability of Sulforaphane.

ALL NATURAL INFLAMMATORY RESPONSE - A blend of herbs, vitamins and minerals are included in this formula to protect tissues and provide necessary botanical extracts, proteolytic enzymes, and targeted nutrients combined to create a powerful 3-pronged formula that supports the body’s natural inflammatory response.

AYURVEDIC APPROACH - Traditional Indian Ayurvedic herbs promote a healthy tissue response to physical stress and may positively influence feelings of discomfort due to strenuous physical activity.

PHYSICAL RECOVERY - Proteolytic enzymes are protein-digesting enzymes. When taken with meals, these enzymes can help to breakdown food nutrients but when taken in between meals, these enzymes may have beneficial effects on tissue response to stress, overexertion, strenuous physical activity and exercise.

Systemic enzyme for optimum circulatory health.*

Clears fibrins and toxins from the blood for smooth blood flow.*

Based on natto, a Japanese soy food.

Bloated Belly Relief - Flatter Me is a blend of full-spectrum enzymes for digestion and bloating relief for women.*

What's Inside - Flatter Me's unique no bloat formula contains 18 full-spectrum digestive enzymes plus ginger, peppermint leaf, and fennel seed, avoiding the need for individual products like peppermint capsules for bloating and more.*

Digestion Support - This anti bloat formula includes ginger and peppermint leaf to support digestive health. Fennel seed helps soothe digestion and support nutrient absorption. A potent digestive enzyme blend helps break down food for gas and bloating relief.*

For a Perfectly Balanced Gut: Boost energy and digestive function with our probiotic and prebiotic for women and men. This digestion aid assists metabolism and keeps a happy gut flora with 750 Million CFU, vegan superfoods, and fiber.

Organic Blend with No Added Crap: Our probiotics and prebiotic powder features 3 premium plant-based strains — bifidobacterium longum, lactobacillus gasseri, and bifidobacterium bifidum, and natural fruits to make you feel better every day.

Bursting with Flavor: This anti-bloating powder serves as an immune system booster with tasty vitamins and antioxidant-rich ingredients such as Organic Tapioca, Apple, Raspberry, and Stevia that add sweetness minus the carbs and calories for optimal weight management.

Proudly Made in the USA: Terranics CoQ10 is made in the USA in a state-of-the-art, GMP-Certified facility under the highest possible standards. Every CoQ10 Softgel is third-party tested for purity, quality, and potency.

Pure Formula and Top Grade Ingredients: Our CoQ10 are made with USP Verified, naturally fermented Non-GMO ingredients. Dairy & Gluten Free. Verified 100% free of sugar, artificial colors, or flavors.

Clinically Proven for Heart Health and Energy Production*: Our Coenzyme Q10 has been medically proven to support heart health, improve blood pressure, enhance overall cardiovascular health, and support healthy aging.* It also has been shown to help preserve normal cholesterol and blood sugar levels, and boost antioxidant activity.*

THE PERFECT NIGHT TIME SUPPLEMENT: No sleeping pills needed. This ingenious combination of probiotics, digestive enzymes, Melatonin and Chamomile aids gut relief and helps support a peaceful rest. Super smart probiotic supplements for men and women.

FEEL REFRESHED: Groundbreaking probiotic supplement and digestive enzymes support healthy digestion and promote relaxation and sleep. Melatonin assists with getting a good nights sleep. Best natural sleep aids for adults. Wake up feeling great!

NATURAL BOTANICAL BLEND: Non habit forming Melatonin promotes restful sleep and Chamomile has nervine qualities, which can help the body cope with tension. Powerful dual action botanicals provide sleep aid naturally.

COMPLETE SUPPORT. Complete Digestion is a comprehensive formula that contains gentle digestive enzyme blends to calm digestive complaints like occasional gas, bloating, and indigestion while also working to provide you with the nutrition and fuel you need to be at your best.*

HEALTHY DIGESTION SUPPORT. Complete Digestion is the ideal digestive enzyme supplement for those with mild to moderate discomfort or for those who want general digestive support.*

3 BENEFITS IN 1. This digestion supplement provides 3-in-1 support with a classic strength digestive enzyme blend, a hardy probiotic blend at 125 million CFU per capsule, and ATPro for energy promotion.*

VIABILITY : We use only those probiotic strains that have survived the intense fermentation process needed to make Kimchi - and by extension, the harshest conditions of the gastrointestinal tract. In fact, 90% of these probiotics reach the intestine in a living state - compared to only 20-30% of animal lactic acid bacteria found in other probiotic foods.

PATENTED STRAIN : Lactobacillus Sakei proBio65 is patented* and clinically shown to "Reduce atopic dermatitis(eczema) and allergy-related disorders" by improving immune function. *US 8,034,606 B2 (Patent No.)

DAILY DIGESTIVE & IMMUNE SUPPORT: Lactobacillus Brevis proBio-96 and Weissella Koreensis proBio-97 replenish friendly bacteria to restore gut health to its optimal state. Enjoy improved digestive and immune function, and find relief from uncomfortable bloating, gas, and constipation.

【OPTIMAL DIGESTIVE PERFORMANCE】- Unleash the power of super digestive enzymes with our unique blend, supporting your digestive health and support: experience papain lactase pills and the vitality of systemic enzymes.

【HEALTHY DIGESTION MADE SIMPLE】: Dive into the world of optimal gut health with these digestive support enzymes, featuring the power of bromelain supplement, lactase and papaya nzymes for digestion. Specifically crafted for gastrointestinal wellness, these capsules are the beacon for men and women seeking the zenith in digestive health.

【DAILY HERBAL FOOD DIGESTIVE ENZYMES】: As time passes, our bodies often struggle to break down proteins and other essential nutrients. Enter our proteolytic digestive enzyme supplements, enriched with bromelain supplement, lactase and papaya enzymes for digestion.