Best Probiotic Enzyme Supplements in 2026

Certified USDA Organic, Non-GMO Project Verified, Gluten Free, Dairy Free, Soy Free, Vegetarian

Immune System & Digestive Support

Vitamin C from Organic Amla (30mg), Vitamin D (400 IU) and prebiotic fiber all help maintain a healthy immune system.No Refrigeration Required

Made for Healthy Digestion & Gut Immune Function: Formulated with 4.4 billion CFU spore-forming probiotics with built-in prebiotics, this dietary supplement helps support digestion, gut health and gut immune function*

Designed for Easy Digestion & Absorption: Contains an active blend of probiotics, including DE111, a clinically tested spore-forming strain that withstands stomach acid and is released in the intestine for better absorption.

Advanced, Dual Benefit Formula: Built-in PreforPro Prebiotics boost the effectiveness of probiotics, even in small doses. Together prebiotics and probiotics support the normal proliferation of beneficial gut flora and help to ease the digestive process.

Prebiotic Probiotic Combo : Our Pre-Pro is designed to support digestive health & gut health. A great choice for those looking to support a diverse healthy microbiome - contains 250mg of Prebiotic Chicory Root Inulin.

Prebiotic Focused: Our Prebiotic-Probiotic is crafted to create a synergistic combo that helps support your gut health. Contains 10B CFU of 3 diverse Lactobacillus probiotic strains.Expertly crafted to support occasional constipation, diarrhea, gas & bloating!

Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 10 Billion Colony forming units (CFU) to achieve this!

Digestive Enzymes with Prebiotics & Probiotics: One before a meal to find relief from occasional bloating, gas, and discomfort from food and alcohol.

Advanced Enzymes Blend: Replenishes digestive enzymes that may decline with age to help break down alcohol, meat, dairy, fried foods, and raw vegetables.

Clinically Proven DE111 Probiotic: Guaranteed to arrive alive and work within hours in small intestine where 90% of nutrient absorption occurs + 70% of immune system resides.

Bioactive B Vitamins - Methyl B-12 & Methyl Folate provides methylcobalamin (methyl B-12) & methyl folate, which are the biologically active forms of vitamin B12 and B9, plus pyridoxal-5-phosphate (P5P), the coenzyme form of vitamin B6.

Energy Support Benefits - This Jarrow Formulas supplement helps to support cellular energy metabolism production, brain function, DNA & neurotransmitter synthesis, and amino acid metabolism.

Homocysteine Metabolism - The unique combination of these B vitamins support the recycling of homocysteine to methionine to support cardiovascular health.

HEALTHY INTESTINAL FLORA*/PROMOTES POSITIVE PROBIOTIC BALANCE*: Lactobacillus acidophilus, one of the most prominent types of resident bacteria in the intestinal tract, has been used as a probiotic for decades.* Take 1 NOW Acidophilus Two Billion capsule 1 to 4 times daily between meals or on an empty stomach. Keep refrigerated to maintain potency.

STRAIN VERIFIED: Probiotic Strain Verified products are NOW probiotic products in which the probiotic strains have been analyzed and their identity verified using the cutting-edge RiboPrinter microbial characterization system. The Probiotic Strain Verified seal is your assurance that the bacterial strains in these NOW probiotic products have been verified using the latest analytical methods.

CLASSIFICATIONS/CERTIFICATIONS: Non-GMO, Strain Verified, Soy Free, Vegan/Vegetarian, Nut Free, Gluten Free, Corn Free, Dairy Free, Egg Free, Keto Friendly

Cultivate digestive balance: Maintain healthy bacteria and support a healthy microbiome with help from our scientifically formulated probiotic and enzyme blend.

Cleanse your digestive system: Special enzymes help gently clear away unwanted bacteria and support normal yeast levels without the discomfort of "die-off"

Restore balance: Cultivate a healthy digestive system full of immune-boosting microflora with the combined support of nourishing prebiotics and pH resistant probiotics (13.6 billion CFU)

60 BILLION CFUs - This probiotic supplement features 10 unique strains of probiotics and contains a proprietary blend of 4 incredible prebiotics you won't find anywhere else. Each capsule features a delayed-release. Recommended usage is only 1 capsule per day. Includes a 30 day supply.

𝗨𝗦𝗔 𝗚𝗠𝗣 𝗖𝗘𝗥𝗧𝗜𝗙𝗜𝗘𝗗 𝗠𝗔𝗡𝗨𝗙𝗔𝗖𝗧𝗨𝗥𝗜𝗡𝗚 - Our state-of-the-art manufacturing facilities are located in the US and are staffed with highly trained individuals who formulate superior products. Being certified under US laws and regulations (GMP Certified), these facilities are uncompromising when it comes to cleanliness and quality control.

𝗜𝗡𝗖𝗥𝗘𝗗𝗜𝗕𝗟𝗘 𝗜𝗡𝗚𝗥𝗘𝗗𝗜𝗘𝗡𝗧𝗦 - We're sorry to say it, but if you’re looking for cheap, you’re in the wrong place. We search far and wide, domestic and international, to provide high-quality ingredients for which your body will thank you. Unfortunately, getting the best ingredients from domestic and international farms can come at a higher-than-normal cost. If quality, satisfaction, and results are essential to you, you’re in the right place!

EVERYTHING YOU NEED TO OPTIMIZE YOUR GUT HEALTH in one simple packet, including digestive enzymes, prebiotics, probiotics, and betaine HCl. Total Gut Health protects against all your digestion woes, including bloating, gas, indigestion, irritable bowel syndrome, leaky gut, and constipation. Simply take before your next meal and enjoy all the comforts of optimized digestion. Slip a packet in your pocket if you’re eating out or traveling.

BREAK DOWN FOOD & ABSORB NUTRIENTS. The total gut pack is designed to support the GI system with all the tools necessary to enhance nutrient absorption and support the cultivation of a healthy microbiome. New research is shedding light on the connection between the gut biome and optimal brain and immune function, suggesting that healthy digestion actually improves focus, mental clarity, and mood.

5 STRAINS OF PROBIOTICS selected for both their acid resistant qualities and positive effect on the gut. While yogurt, kombucha, and even kimchi are beneficial, they're limited to only 1 - 2 probiotic strains and offer fewer colony forming units. TGH fills this gap and even includes prebiotics to fuel the probiotic colonies, allowing good bacteria to thrive where the body needs it the most. Also includes probiotic yeast Saccharomyces Boulardii (SB), which supports healthy gut flora.

High Strength & Hypoallergenic - Premium support blend of 12 safe, complementary and well-studied species to support optimal gut flora, immune & GI health. Hypoallergenic 25 billion CFU in a base of chicory-derived prebiotic inulin.*

Probiotic Survival Without Extra Additives - Ther-Biotic does not need additive-packed spheres or tablets to promote probiotic survival. Advanced InTactic technology helps live probiotics reach the small intestine and colon. Each bottle is formulated with sufficient overages, handled with care, and tested for potency that delivers on its promise.*

Protection From Stomach Acid - On exposure to stomach acid, an InTactic 'shield' forms a gel-like matrix surrounding the probiotics, protecting them from damage. On passage into the duodenum, InTactic is designed to break down and release live microorganisms for optimal efficacy.*

120 Billion CFUS & 30 Strains Per Capsule: Vitalitown Women’s Probiotics contains 120 billion CFUs and 30 proven strains, providing the highest number of CFUs and the most researched probiotics strains. The formula is specially designed for women's specific health needs with unsurpassed quality & value. All Vitalitown products are 100% vegan and contain no GMOs, gluten, dairy, soy, eggs, fish, shellfish, tree nuts, or peanuts.

Pro + Pre + Digestive Enzymes + Organic Cranberry: Our Once Daily Probiotics for Women is enhanced with organic cranberry extract and natural plant-based digestive enzymes as well as water-soluble prebiotics fiber to help support the gut, immune and vaginal health.* All the ingredients work synergistically to maximize their strength and maintain natural gastrointestinal & urinary tract balance.*

Take Care of Women’s Health*: Cranberry is considered to be a superfood due to its high nutrient and antioxidant content. Organic cranberry extract is added in this formula with powerful antioxidants to help protect your body from free radicals.* It helps support immune health and urinary tract detox and protection without the sugar and calories.*

Contains the enzyme Lactase which aids in the digestion of lactose for lactose intolerance individuals

Promotes long term digestive and immune health with continued use

Helps lessen minor abdominal discomfort, bloating and may help relieve occasional diarrhea

DOG PROBIOTIC HEALTH SUPPLEMENTS: Feel good about feeding your dog or cat these pet health supplements that feature a blend of enzymes, prebiotics and vet strength PB6 probiotics designed for sensitive stomachs, pet diet changes and digestive issues.

CAT, DOG DIGESTIVE SUPPORT: This premium pet health supplement fuels your dog or cat with probiotics and prebiotics to help with changes in diet, consistent stool quality and stomach and intestinal balance. Each powder probiotic and cat prebiotic supplement features flavoring that tastes great.

IDEAL PET SUPPLEMENT FOR CAT DIGESTIVE PROBLEMS: It’s natural for animals to feel stress when boarding or during grooming. This stress can impact and cause digestive problems in dogs and cats. This dog supplement and cat supplement helps to counteract the stress and work to restore gastrointestinal health for dogs and cats.

Proprietary blend of the most beneficial known strain of Lactobacillus Acidophilus.

Acidophilus Probiotic Blend contains over 1 billion viable cells at the time of manufacture.

Designed to aid in the maintenance of probiotic activity in the intestine.

GNC Probiotic Complex Daily Need: Supplies 1 Billion CFUs 8 unique strains, including clinically studied probiotics

May provide digestive & immune support*

No artificial flavors, no wheat, no soy

PLANT ENZYMES PLUS PROBIOTICS assist in digestion and absorption of nutrients to maintain your pet’s good health.

BREAKS down fats, carbohydrates, cellulose, and protein.

OPTIMIZES food values. REDUCES flatulence. BOOSTS vitality. SUPPORTS immune system.

Each easy to swallow capsule contains 10 Billion CFU's of Bacillus Coagulans. The usage of specific probiotics after weight loss surgery may help reduce gastrointestinal issues (bloating, gas, and bowel irregularities), increase the absorption of vitamin B12, Increase metabolic balance to promote further weight loss after bariatric surgery, and enhance immune response.

Bariatric Fusion Probiotics contain Bacillus Coagulans, which has been shown specifically target the intestinal tract. Probiotic benefits may be effective to help create a microevironment inside your digestive system that encourages nutritional absorption and increase energy levels. s a probiotic strain resistant to heat and gastric acid. It may improve the immune system and treat diarrhea and constipation. Bacillus Coagulans forms reproductive structures called spores.

Very easy on your stomach and easy to digest. No GI side effects! May promote a healthy intestinal environment, improves energy levels and immunity!

⚕️PROPRIETARY COMBINATION OF STRAINS – This probiotic supplement contains 50 Billion CFU making it a highly potent health supplement. Additionally, our CONSTIPATION RELIEF probiotics are formulated with a unique proprietary blend of enzymes and other natural ingredients that aid in digestion while promoting your overall health and well-being.

💚DIGESTIVE ENZYME PROPERTIES – The blend of digestive enzymes in our ultimate flora probiotic helps your body properly digest food. Our vegan probiotics formula contains Milk Thistle and extract from the roots of Dandelion, Ginger, & Turmeric which have been shown to reduce inflammation in the body.

🌿 ESSENTIAL FOR GUT HEALTH – Taking our probiotics for women and men can restore the beneficial bacteria in your gut and work as a detox cleanse for your gut. This is necessary for improving the health of your liver, kidneys, and other organs. The prebiotics and probiotics replenish your intestinal ecology and can improve digestive health.

PROBIOTIC SUPPLEMENT: GI Natural's clinically designed formulation contains a unique blend of prebiotics, probiotics, enzymes, and supportive nutrients for a healthy gastrointestinal mucosal tract.

BEYOND DIGESTIVE AID: Our formula strengthens the GI tract’s vital mucosal lining. It may counter occasional heartburn, reflux, gas, bloating, diarrhea, and other digestive discomforts.

PURITY: GI Natural is hypoallergenic, gluten-free, vegetarian, and free from artificial colors and preservatives - helping to unlock the energy and health-boosting nutrition of foods.

GET 15 TIMES MORE SURVIVABILITY THAN WITH VEGGIE CAPSULES. With a patented delivery method, the probiotic organisms in this formula are released over an 8-10 hour period so they bypass your stomach acids and reach deep into your intestinal tract alive (where they are needed most) so you can experience the benefits that probiotics have to offer.

STAY WELL. 80% of your immune system is in your gut. PRO-15 digestive enzyme supplements help to replenish beneficial bacteria to support digestive and immune health. Life should be easy.

SUPPORT YOUR WEIGHT MANAGEMENT EFFORTS. Did you know that scientists can predict body weight more effectively from a person’s bacterial makeup (90 percent accuracy) than from their genes (58 percent accuracy)? It’s true. Studies suggest that gut flora may play a role in both metabolism and weight management.

Highest Potency for Women: Surebounty’s 1 veggie capsule comes in 4 powerful ingredients - 120 billion probiotics, raw prebiotics, natural enzymes, and organic cranberry extract - all specially designed to tailor to women’s specific needs and offer the HIGHEST POTENCY available in the market to supercharge women’s health.* Take ONE capsule daily, Feel Relieved, Cleansed, Lifted & Strengthened with Surebounty 4-IN-1 Feminine Probiotic.

From Gut + Vagina to Immunity*: Women are much more prone to disruptions, which can easily destroy good probiotics in our body & weaken our immune system, thus making us vulnerable to nasty invaders. This 4-in-1 blend is specially researched to replenish beneficial cultures, restore flora balance, reduce bloating, and strengthen immune function to keep feminine health in top shape.*

Premium For All: At Surebounty, we are committed to delivering BOUNTY of NUTRIENTS - vitamins, minerals, proteins... - with BEST VALUE at science-tested OPTIMAL DOSAGE. Every batch goes through intensive researches, strict manufacturing practices in a GMP facility in New York, and rigorous tests on ingredient potency, contaminants & heavy metal contents before they’re qualified for the market. You can always be sure of Surebounty. Trusted Quality, Highest Potency & Great Value.

Patented Strain to Alleviate Occasional Gas & Bloating.

Contains a special 3 ingredient Enzyme blend.

20 billion active probiotic cultures per serving guaranteed at time of manufacture. [storage, expiration and at time of manufacture statements to be confirmed with Quality]

3-IN-1 FORMULA: With a guaranteed 65 billion CFUs per capsule (that’s a lot of good bacteria), and enhanced with Cranberry fruit and 60mg of fiber inulin, this once daily delayed-release probiotic in a veggie capsule provides valuable gut and digestive tract support*

ENHANCED FORMULA: Our proprietary formula combines 16 strains of Lacto and Bifidobacteria shelf-stable probiotics, bringing you digestive enzyme and fatty acid production support, longer*

LONGER SHELF LIFE: Unlike other probiotics, our probiotic blend is guaranteed fresh through the expiration date, meaning you can reap the benefits of 65 billion CFUs for gut health and support

Probiotics for Women & Men: Our 100 Billion CFU probiotics contains 35 Strains probiotics, 5 Prebiotics, 7 Digestive Enzymes and Citrus Bioflavonoids, two capsules for daily life. This probiotic is selected for adults men and women, the most abundant strains and the most beneficial probiotic supplements to support your gut health. Our probiotics contains Lactobacillus acidophilus, paracasei, brevis, and bulgaricus as well as Bifidobacterium, lactis and longum to support your digestive health

Probiotics, Prebiotics & Digestive Enzymes: In order to maximize the utility of our probiotics for digestive health, we added a variety of supplements - 35 strains probiotics, organic fiber mixture prebiotics, digestive enzymes and Citrus flavonoids, help to rebuild the intestinal and bacteria environment. Our probiotic is beneficial to relieve* gas, bloating, constipation and help to support intestinal and immune system

Probiotics for Overall Health: We've added citrus flavanones into our probiotics which are natural extracts that are good for your overall health. They can help your body to fight cell-damaging free radicals, and immune support & respiratory support, also it is benefical for your daily life metabolism and improve your overall health. It is RAW, No GMOs, Gluten, Sugar, Soy, Yeast, Egg, Wheat, Corn, Peanuts, Fish, Shellfish, Dolomol, Artificial Ingredients, Fillers, Binders, or Preservatives

PREBIOTICS AND PROBIOTICS SUPPLEMENT: Formulated with a prebiotic and 7 live probiotic strains, this supplement can help to replenish the natural balance of gut flora within the digestive system and help support immune system balance.

ACID- & BILE-RESISTANT PROBIOTIC CAPSULES: Our durable probiotic supplement contains 7 different probiotic strains of human origin, so it's easier to adapt to the human body. This men’s and women’s probiotic is also resistant to stomach acid and bile.

MADE WITH CARE: These capsules are mindfully sourced and contain the following natural probiotic strains: L. acidophilusL. casei (10%); L. plantarum (10%); L. rhamnosus (10%); B. lactis (10%); B. longum (5%); and S. thermophilus (5%).

GUT AND DIGESTIVE HEALTH: Our propriety fiber blend feeds and promotes growth of good bacteria for sustained, natural support and protection through stomach acid environment

TESTED: 15+ billion CFUs and 15 clinically tested, documented probiotic strains with proven results in the small and large intestine to help with function in the digestive, metabolic, and immune system

DELIVERY: Patented, foil-sealed packaging protects culture viability through range of temperatures, ensuring they are live and active when consumed for enhanced absorption

Yeast Overgrowth Control: Yeast is a naturally occurring component that is virtually everywhere in our body; Imbalances in the body can cause yeast to overgrow, causing everything from vaginal yeast infections to brain fog, flatulence and constipation; Candex helps your body keep balanced yeast levels, bringing it down to manageable levels

100% Natural, Non-GMO Enzymes: Candex provides five potent enzymes that support a gentle yet potent cleanse to encourage superb gut balance, not only helping control your levels of yeast overgrowth but also promoting the overall health of your digestive system

Eat What You Like: The enzymes in Candex support a healthy microbiome without requiring major dietary changes; Candex should be taken on an empty stomach between meals for the best results

PREMIUM INGREDIENTS MADE IN USA – NWC Naturals products are made in the USA in a GMP Certified Factory. Under strict quality and safety standards, our products are formulated just for pets with human quality ingredients. All the probiotics used are approved by AFFCO as being safe for dogs, cats, and horses. Our wonderful Total-Biotics powder contains 14 of the most researched productive live and stabilized probiotics available.

SAFE FOR PETS OF ALL AGES: Start giving Total-Biotics when your pets are young, it will give them the vital support they need to grow and develop to their optimum level of health. No matter the breed or age, using Total-Biotics daily helps support regularity, good digestion, a strong immune system, and a healthy digestive tract. A healthy pet is a happy pet.

EXCLUSIVE DELIVERY OF NUTRIENTS: Total-Biotics by NWC Naturals is the only probiotic formula that uses the only patented stabilized glutamine in the world, MGG Chelate. With the Live Enzyme Activated Delivery System (L.E.A.D.S.), we ensure the best delivery and colonization of these probiotics. The L.E.A.D.S. system works to deliver the probiotics and activate the prebiotics to deliver the nutrients in this form.

Advanced 2-in-1 digestive support: Combines Digest Gold with 1.5 billion active probiotic cultures to help relieve occasional bloating, gas, and irregularity, while supporting a healthy microbiome

Speeds up digestion: When you feel bloated and heavy (no matter what you eat), this enzyme blend helps break down food more quickly while promoting a healthy microflora so digestion works smoothly

Most advanced support: One capsule with every meal provides powerful enzymes to digest proteins, carbohydrates, dairy, fats, and fibers – even for your largest meals

PROBIOTIC MULTI-ENZYME COMPLEX: Formulated with crucial probiotic strains and multiple food enzymes, MAV Nutrition’s Digestive Enzymes complex is designed to support digestion, ease gas and bloating, and increase nutrient absorption.*

BLOATING & GAS RELIEF: Beat the bloat! This powerful blend of essential enzymes like Lactase, Bromelain, Papain, Protease, and more provides digestive support and relief for gas and bloat after eating.

WITH 3 STRAINS OF LACTOBACILLUS: Our Digestive Enzymes are formulated with 3 potent strains of Lactobacillus probiotics to support optimal digestion and a healthy gut biome.*