Best Cardiovascular Health Enzyme Supplements in 2025

Bioactive B Vitamins - Methyl B-12 & Methyl Folate provides methylcobalamin (methyl B-12) & methyl folate, which are the biologically active forms of vitamin B12 and B9, plus pyridoxal-5-phosphate (P5P), the coenzyme form of vitamin B6.

Energy Support Benefits - This Jarrow Formulas supplement helps to support cellular energy metabolism production, brain function, DNA & neurotransmitter synthesis, and amino acid metabolism.

Homocysteine Metabolism - The unique combination of these B vitamins support the recycling of homocysteine to methionine to support cardiovascular health.

HIGHLY ABSORBED MAGNESIUM CHLORIDE - ReMag Liquid Magnesium Solution is made through a proprietary 18 point process which turns magnesium chloride into a 60,000ppm concentration of stabilized picometer ions of magnesium. Designed to optimize absorption and bypass gastric upset. 99.99% pure.

Magnesium is an essential cofactor required by 300 enzyme systems that promote thousands of biochemical reactors in the body. Magnesium supports 80% of known metabolic functions, facilitates the structural integrity of protein, stabilizes and protects DNA and RNA, transmits nerve signals, relaxes muscles, and creates Mg-ATP energy packets.

Magnesium also supports healthy bones by regulating calcium absorption and metabolizing the active form of Vitamin D from its storage form.

EXTRA STRENGTH MAGNESIUM CITRATE & OXIDE SUPPLEMENT: Each capsule of our magnesium citrate supplement contains a 500mg blend of magnesium citrate and oxide. Our high quality Magnesium Capsules are convenient, tasteless and easy to swallow. Magnesium is an important mineral for your health!

HELPS SUPPORT BONES, CARDIOVASCULAR HEALTH & ENERGY PRODUCTION: Magnesium is critical for healthy enzyme function and helps support energy production and healthy muscles. Whether you are magnesium deficient or looking to improve your health with our Magnesium Complex, our magnesium citrate and oxide 500mg blend is a powerful dose of two forms magnesium.

500MG OF MAGNESIUM PER CAPSULE: Unlike some other magnesium oxide capsules, magnesium glycinate, magnesium malate, magnesium powder, magnesium liquid, magnesium chelate or magnesium tablets, our magnesium formula includes both magnesium citrate and magnesium oxide, which provides you with two different forms of Magnesium in one capsule!

DOCTOR’S BEST STABILIZED R-LIPOIC ACID CONTAINS BIOENHANCED NA-RALA - the sodium salt of R-Lipoic acid (RLA). BioEnhanced Na-RALA is in its natural and stabilized form of RLA that won’t degrade at high temperatures, and is more bioavailable and biologically active. Lipoic acid (LA) plays an important role in glucose metabolism and energy production. LA is both fat and water soluble. D-Biotin is an integral part of enzyme activity necessary for the breakdown and conversion of fatty acids and carbohydrates into energy.

POWERFUL ANTIOXIDANT – Lipoic acid is a potent antioxidant that supports mitochondrial function, helps protect against oxidative stress and maintains cellular energy. Supports nerve health, glucose metabolism and cardiovascular health.

CELLULAR ENERGY - R-lipoic acid is made by the body in our mitochondria, the cells that provide energy. Protecting mitochondria from free radicals, R-Lipoic Acid supports energy at the cellular level.

Boost your recovery the natural way; Enzymedica’s SerraGold promotes healthy immune and cardiovascular system function so you can physically recover from injury or exercise

SerraGold also supports mobility, helps relieve joint and muscle discomfort and helps break down excess mucus, optimizing your body’s natural recovery processes

Take 1 capsule daily on an empty stomach, 1 hour before or 2 hours after a meal; Each capsule delivers a high potency of serrapeptase and is gentle on the stomach

True TG Form - Unlike many omega 3 fish oils, our TruTG Fish Oils are in the Triglyceride form (TG), the same form found in fish. TruTG may support superior bioavailability than the standard EE form.*

1200 Mg Omega 3 Fatty Acids - 600mg EPA. 400mg DHA. Magnesium may support healthy joints, immunity, healthy skin & hair, and cardiovascular health.*

Improved Digestibility & No Fishy Aftertaste - The enzyme Lipase helps ensure optimal digestion and prevent any fishy aftertaste.*

Spark your energy: Jump-start your body’s ability to produce energy with support from Coenzyme Q10, an all-natural antioxidant and catalyst for ATP production

For your heart: Helps maintain heart and cardiovascular health; Aids cognitive health; Blended with rice bran oil for improved absorption

Cellular power: CoQ10 works within the mitochondria to convert food into the energy that fuels cells throughout the body, in particular the heart and brain

SUPPORTS CARDIOVASCULAR HEALTH. Research suggests that healthy homecysteine levels play a role in cardiovascular health. Enzymes support healthy homocysteine levels in the blood and many are dependent on vitamin B-6.

ULTRA-MAG BENEFITS. Ultra-Mag uses a complex blend of highly bioactive forms of magnesium—citrate, taurinate, malate, glycinate and succinate— to provide all of the benefits that magnesium offers. In addition to supplying 100 percent of the body’s daily magnesium needs, our formula includes vitamin B-6 to further support cardiovascular health.

ABOUT SOURCE NATURALS ULTRA MAG. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, preservatives, or artificial color, flavor or fragrance.

PURE, FRESH & SUSTAINABLY SOURCED – Not all fish oils are created equal. Our Mega EPA/DHA formulais made with a wild fish oil concentrate derived from South Pacific Ocean anchovy. It's caught and processed within hours of harvest in a marine mammal-friendly fishery in Chile.

GOOD FOR HEART & MIND – Fish oil supports cardiovascular health, but that’s not all: omega-3s from fish oil have also been shown to promote healthy cognitive function, encourage healthy blood flow in the brain and even help maintain your mood. Something else to feel good about!

PROMOTES JOINT HEALTH – Here’s another great reason to take a potent fish oil supplement like Mega EPA/DHA: fish oil helps inhibit inflammatory factors to support joint health. With heart, brain and joint health benefits like these, don’t go another day with Mega EPA/DHA!

Compare to the Active ingredients in Mag-Ox 400 (483mg of elemental Magnesium as Magnesium Oxide)

Can help support the body with constipation, magnesium oxide also is known for how it Helps transport calcium and potassium ions through cell membranes.

Promotes Bone Mineralization and Cardiovascular Health*

iSerra 250,000 SPU is up to 6 times more potent than other Serrapeptase brand. iSerra is rated at 250,000 SPU per capsule ( maximum potency), compare to other Serrapeptase that requires two or more capsules to deliver 250.000 SPU. See below to understand the Science behind the Superiority

Utilizes Delayed Release Technology to protect the enzymes from stomach acid with out the use of chemicals and plastics commonly found in traditional enteric coatings. See below to understand the Science behind the Superiority.

Serrapeptase is one of the world's finest enzymes that supports normal mucus levels? iSerra 250,000 SPU is an excellent choice for Anti-Inflammation and Toxin Removal, Normal Blood Clotting, Normal Scar Tissue, Healthy Cardiovascular Health, Promote healthy sinus activity Potent fibrinolytic activity.

Mason Natural Vitamin B12 tablets contain 50 mcg of B12 that may help support the normal function of the cardiovascular, pulmonary, and central nervous systems.

These 50 mcg B12 tablets are guaranteed to have no added sugar or starch. They are wheat free, corn free, dairy free, and yeast free. Our vitamin B12 also contains no soy, egg, artificial colors, flavors or preservatives. Sodium free.

Our Vitamin B12 tablets may also help support the body’s energy production by aiding the metabolism of carbohydrates, fats and proteins. Vitamin B12 also helps many enzymes to perform essential chemical reactions, such as those that support the function of neurotransmitters, hormones, digestive enzymes, and many more.

ALL NATURAL – DOCTOR FORMULATED – MAX STRENGTH – Our product delivers 1000mg pure Berberine HCl per daily intake. Berberine has a rich and complex history in herbal medicine, and can support cardiovascular health and overall wellness. Vegan & Vegetarian friendly. *

BEST VALUE ON AMAZON – 180 CAPSULES – 3 MONTH SUPPLY – You receive 180 capsules for a FULL 90 day supply (others offer half for a more expensive price). Our max strength Berberine formula is 1000mg per serving (2 capsules), 500mg per capsule. If you are dissatisfied with our formula you have 30 days to return it for a full refund. *

NATURAL FORMULATION: No unnecessary fillers, binders, or potentially harmful preservatives or GMOs means no unwanted side effects for you! We go the extra mile to ensure our supplements have passed extensive quality control testing before being bottled and sold. We use only GMP compliant manufacturing facilities in the USA. *

Support Heart Health: MagMD Plus provides cardiovascular support, promoting coordination of heart activity and aiding enzyme activity that supports heart function.*

The Power of Three: Proper dosages of three essential nutrients, magnesium, vitamin D3, and zinc work together for beneficial absorption and whole-body benefits.*

Bone and Muscle Strength: Magnesium helps your body use and absorb calcium, promoting the body’s ability to maintain bone and muscle strength.*

Serra-125Kis up to 6 times more potent than other Serrapeptase brand. iSerra is rated at 125,000 SPU per capsule (maximum potency), compare to other Serrapeptase that requires multiple capsules to deliver125,000 SPU.

Utilizes Delayed Release Technology to protect the enzymes from stomach acid and gastric juices without the use of chemicals and plastics commonly found in traditional enteric coatings.

Serrapeptase is one of the world's finest enzymes that supports normal mucus levels. Serra-125K is an excellent choice for Anti-Inflammation and Toxin Removal, Normal Blood Clotting, Normal Scar Tissue, Healthy Cardiovascular Health, Promote healthy sinus activity Potent fibrinolytic activity.

GREENS ANTIOXIDANT SUPPLEMENT: Orange OxiMega Green is a true sports greens product. This blend is high in natural antioxidants for enhanced performance support. With added enzymes and probiotics for maximum absorption, you can establish a strong foundation for maximum gains in the gym and in life with Orange OxiMega Greens.

ATHLETE APPROVED: Orange Oximega Greens was designed and formulated for athletes who intentionally subject their bodies to incredible amounts of stress with training and cardio. This is no ordinary greens product; it has additional complexes geared towards real athletes. The “Cardi Oxidant Blend” is full of fruits & vegetables that are known to enhance the cardiovascular system and prolong fatigue in exercising humans.

OUR GUARANTEE: Our goal is to bring you a greens formula that works to support your overall health so you can continue to increase your results. If Orange Oximega Greens Spearmint isn’t the most effective supplement you’ve ever taken, we’ll give you your money back - guaranteed!

Proudly Made in the USA: Terranics CoQ10 is made in the USA in a state-of-the-art, GMP-Certified facility under the highest possible standards. Every CoQ10 Softgel is third-party tested for purity, quality, and potency.

Pure Formula and Top Grade Ingredients: Our CoQ10 are made with USP Verified, naturally fermented Non-GMO ingredients. Dairy & Gluten Free. Verified 100% free of sugar, artificial colors, or flavors.

Clinically Proven for Heart Health and Energy Production*: Our Coenzyme Q10 has been medically proven to support heart health, improve blood pressure, enhance overall cardiovascular health, and support healthy aging.* It also has been shown to help preserve normal cholesterol and blood sugar levels, and boost antioxidant activity.*

ADVANCED DIGESTIVE ENZYME FORMULA: A premium blend of high concentration lipase that supports fat digestion. Lipase HP is expertly designed to maximize the benefits of food we eat on a daily basis.*

RANGE OF USE: Supports healthy cholesterol levels and cardiovascular health. Promotes gallbladder function and nutrient absorption. It includes essential enzymes that promote absorption of omega-3 and fish oil supplements.*

ACHIEVE OPTIMUM DIGESTION OF FATS: Lipase HP Plus assists in the body’s natural process of fat digestion and absorption, ensuring you receive maximum benefits from the foods you consume.*

Nattokinase Organic: Natokinase is a powerful enzyme extracted from traditional Japanese Natto - soybeans that have been fermented with Bacillus Natto Bacterium. Nattokinase breaks down the clotting agent fibrin and may help lowering high blood pressure.

Cardiovascular Health: Used as a blood thinner in holistic medicine for centuries, natto kinase may improve circulation and decrease the chance of getting a blood clot in the legs during long plane flights.

Viatmin K & Sugar - Free: Unlike other blood circulation supplements, Yuve Nattokinase does not include K group vitamins that activate blood coagulation and has the opposite effect of nattokinase on the body.

✅ SUPPORTS ENERGY PRODUCTION: Magnesium is a mineral that is critical for energy production and metabolism of carbohydrates, amino acids and fats*.

✅ CRITICAL FOR ENZYME FUNCTION: It is a required cofactor for an estimated 300 enzymes.

✅ CARDIOVASCULAR HEALTH: Supports healthy heart rhythm and blood pressure by relaxing the smooth muscles within blood vessels*.

Supports the liver, good digestion, healthy heart, and normal blood sugar

Promotes normal bile flow during digestion

Maintains normal blood pressure, good circulation, and provides electrolyte balance

Black Seed Oil Ingredient

Ultra High Purity 99% Resveratrol ：Trans-Resveratrol 1100mg and Black Pepper Extract 50mg, in one serving size. Sourced from Polygonum cuspidatum root extract, active trans-resveratrol rich in with a purity of more than 99%. Adopt the Enzyme Directed Evolution technology extract the most authentic & stabilized Trans-Resveratrol. Supports potent anti-aging and boosts overall immunity while keeping your skin healthy for a radiant glow every day.

Synergistic Effect: Research has shown that resveratrol critical for activating sirtuin genes，The cellular repair function of Sirtuins plays a key role in helping us to extend our lifespan. Black Pepper extract can greatly increase bioavailability and absorption rate to improve overall health.

Herodianow resveratrol Provides powerful antioxidant support；Supports cellular and tissue health as well as Heart Healthy & Cardiovascular healthy by promoting circulation; And immune function support!

Boost Cardiovascular Health: 8 IN 1 Red Yeast Rice complex 8220mg* per serving can maximize your potential. Each bottle contains 90 capsules of 8 Organic Red Yeast Rice Coenzyme Q-10 supporting your brain health, and increasing focus and memory. 2 capsules of Ultra Herbs of Red Yeast Rice per day can help boost your efficiency.

Promote Healthy Cholesterol: Unique Red Yeast Rice formula can boost your heart health and overall wellness. The 8-IN-1 Red Yeast Rice combination can promote healthy cholesterol, circulation, and strength. 90 capsules per bottle can supply you 45-day of active, energetic life.

Efficient Formula: 1 capsule contains 8 powerful ingredients including Red Yeast Rice, enzyme CoQ10, Niacin, Beet Root, L-Arginine, Alpha Lipoic Acid, L-Citrulline, and Black Pepper. These ingredients are highly potent extracts that are different from other ingredients on the market.

BioEmblem Triple Magnesium Complex | 300mg of Magnesium Glycinate, Malate, & Citrate for Muscle Relaxation, Sleep, Heart, & Energy | High Absorption | Vegan, Non-GMO | 90 Capsules

BioEmblem Antarctic Krill Oil Supplement | 1000mg | Omega-3 Oil with High Levels of EPA + DHA, Astaxanthin, and Phospholipids | No Fishy Aftertaste | 60-Count Non-GMO Softgels

SUPPORTS RELAXATION, CALMNESS & SLEEP: Magnesium, especially in mag glycinate form, is an essential nutrient that supports healthy muscle and nerve function. This can help with muscle cramps and support a greater sense of relaxation, calm, and restful sleep.*

Cellular Energy: coenzyme Q10 is an important rate-limiting cofactor in the mitochondrial electron transport chain, the biochemical pathway in cellular respiration from which adenosine triphosphate, the form of energy used by the body, is derived.

Vitamin E Source: coenzyme Q10 Softgels contain pure coenzyme Q10 (ubiquinone). coenzyme Q10 is solubilized in a base of rice bran oil and vitamin E to enhance absorption of coenzyme Q10.

Heart & Metabolic: Our heart & metabolic formulas are developed to play an intimate role in supporting optimal cardiovascular health.*

Premium Ancestral Gum Supplement: Based on the wisdom of our ancestors, our liver, bone marrow, cartilage, thymus, vitamin D3, and magnesium supplement is rich in nutrients specific to the gum and supports gum health, gum resilience, strong gums, immune health, and overall vitality. Gum Restore targets the root cause of gum disease by bringing back essential animal-based nutrients. It's our way of restoring what has been removed from our diet for naturally robust gums and mouths.

Freeze-Dried to protect Heat-Sensitive Nutrients: Our desiccated supplement offers highly bioavailable nutrients. Liver is rich in Vitamin A, B12, CoQ10, Choline, Folate, Hyaluronic Acid, Heme Iron, Copper & Zinc. Bone Marrow is rich in Calcium, Phosphorus, Collagen, Stem Cells, Growth Factors, and Fat-soluble Activators. Cartilage is rich in Glucosamine and Chondroitin. Thymus contains Unique Peptides to regulate, strengthen, and support immune health and balance the inflammatory response.

Whole Food Nutrition Source: Our supplement offers nourishment that only whole foods (and whole food supplements) can provide to support the high nutrient demands of healthy gums. By adding Vitamin D3 for dental health, immune control, bone growth, and cardiovascular health, along with Magnesium, essential for numerous bodily functions and critical for gum and tooth development, our product ensures your body can effectively fight inflammation, support enzyme activities, and support immunity.

Boost the immune system – Zesty Paws Aller-Immune Bites are grain free soft chews that support immune, histamine, and digestive health for dogs with skin, seasonal, and environmental allergy issues.

Enhanced with Epicor – At 80 mg per chew, Epicor contains vitamins, protein, fiber, and antioxidants that are clinically proven to support the body's natural immune defenses to keep your dog healthy.

8-in-1 Formula - Zesty Paws Multifunctional Bites are functional supplement chews with premium ingredients and multivitamins that support physical performance, antioxidants, hip & joint, heart, immune, skin, liver, & gut health for dogs of all ages, breeds, and sizes.

Ultra Strength & Superior Absorption: Elixeed vegetarian formula provides 50 mg of elemental zinc that can rapidly bring your zinc levels up to optimal condition and assist in vital bodily functions in one per day capsule.* Our formula specifically uses zinc gluconate and zinc picolinate that has been fully chelated for superior absorption & bioavailability without GI distress.*

Immune & Energy Booster*: Zinc activates antioxidant properties to improve the growth & development of immune cells.* Elixeed high-potency zinc helps keep your immune system functioning at peak performance by speeding up immune recovery & supercharging immune resilience.* It also exerts enzyme activity and promotes metabolism for the increase in alertness & energy levels.*

Skin & Eye Health Enhancer*: Our zinc gluconate & picolinate acts as a co-factor of collagen synthesis to help fortify skin elasticity & boost skin regeneration.* It also supports eye health by reducing oxidative stress while counteracting the effects of aging on eyesight for the maintenance of visual clarity.*

5 In 1 High Potency Formula*: There are various types of magnesium and each type provides unique health benefits like muscle & bone strength, brain & heart health, and energy metabolism.* Formulated with five forms of magnesium (magnesium glycinate, citrate, malate, taurate, and oxide), Whollium Magnesium Complex provides a broader range of benefits with optimal bioavailability.* Each serving supplies 300 mg of elemental magnesium to support healthy magnesium levels.*

Muscle & Bone Health Support | Energy Booster*: Magnesium has been clinically proven to help regulate vitamin D, calcium, and zinc to support muscle contraction, improve your muscle function, and protect against occasional muscle discomforts as well as maintain bone density and strength.* As an essential cofactor in hundreds of enzyme reactions, magnesium also boosts the metabolism of nutrients for energy production and utilization.*

Nerve & Heart Health*: This product is clinically shown to improve your holistic health, achieving mind-body wellness.* We include high-quality forms of magnesium to help boost learning, memory, concentration, and other cognitive functions.* Sufficient magnesium intake also helps maintain normal blood pressure and regulate heartbeat rhythms to support overall cardiovascular health.*