Best Bottle Probiotic Supplements in 2026

100% Spore-Based Probiotics for Digestive Health - This unique all spore probiotic formula offers enhanced gut support by effectively reconditioning the gut (unlike many gut health probiotics that 'reseed' with strains that cannot survive digestion). It promotes microbial diversity and the maintenance of key health-promoting, commensal gut flora.

DNA-Verified Bacillus Strains - Includes bacillus subtilis, bacillus indicus, bacillus subtilis, bacillus licheniformis, bacillus clausii and a bacillus coagulans probiotic. As a daily probiotic, start with 1/2 spore based probiotic capsule or 1 full capsule with food and slowly increase to 2 capsules per day or as directed by your healthcare practitioner.

Stomach Survivor - The bi-phasic life cycle of the Bacillus spore probiotic allows them to remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing to support a healthy gut.*

Delicious Spore-Based Probiotic for Kids - Tasty, easy-to-digest, chewable probiotic gummies contain four strains of the health-supportive, spore-forming Bacillus probiotics for digestive health found in Microbiome Labs' flagship spore-based probiotic supplement.*

Gut Health & Immune Support Gummies - Each probiotic gummy contains a 100% spore-based kids probiotics blend designed to support gut microbial diversity, healthy gut barrier and offer immune support.*

Research-Backed Strains, No Refrigeration Required - Probiotics backed by multiple research studies and extensive clinical validation. A bacillus spore probiotic can survive digestion because of its bi-phasic life cycle. Unlike many probiotics for kids, dormant Bacillus bacteria spore forms encapsulate in an endospore, a tough, natural outer shell that protects them from light, heat, acid, and other environmental factors.*

100% Spore-Based Probiotics for Digestive Health - This unique all spore probiotic formula offers enhanced gut support by effectively reconditioning the gut (unlike many gut health probiotics that 'reseed' with strains that cannot survive digestion). It promotes microbial diversity and the maintenance of key health-promoting, commensal gut flora.

DNA-Verified Bacillus Strains - Includes bacillus subtilis, bacillus indicus, bacillus subtilis, bacillus licheniformis, bacillus clausii and a bacillus coagulans probiotic. As a daily probiotic, start with 1/2 spore based probiotic capsule or 1 full capsule with food and slowly increase to 2 capsules per day or as directed by your healthcare practitioner.

Stomach Survivor - The bi-phasic life cycle of the Bacillus spore probiotic allows them to remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing to support a healthy gut.*

Advanced Dual-Action Probiotic Supplement - Combines well-studied probiotic strains Saccharomyces boulardii, Bacillus subtilis HU58, and Bacillus clausii SC109. This combination of pro biotic yeast and spore based strains offers comprehensive digestive flora support with an advanced approach to maintain a healthy intestinal environment.*

Immune & Digestive Support - Designed to support gut health, digestive health, and the body's detoxification process. Helps maintain regularity, healthy bowel movements and may act as an immune support supplement.*

S boulardii Probiotic Upgrade - Saccharomyces boulardii probiotics are well-studied for their ability to offer digestion and immune support. However, a product containing only S. boulardii has limitations with regards to other probiotic functions. RestorFlora represents an advancement that overcomes these limitations with the addition of Bacillus subtilis HU58 and Bacillus clausii SC109.

2 Product bundle with MegaSporeBiotic (60 Capsules) Probiotic and MegaPre prebiotic (120 Capsules).

MegaSporeBiotic is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function.

This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut flora. MegaSporeBiotic boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.*

2 Product gut and immune support bundle with MegaSporeBiotic (60 Capsules) and MegaIgG2000 (120 Capsules).

MegaSporeBiotic is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function.

This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut flora. MegaSporeBiotic boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.*

2 Product bundle with MegaSporeBiotic (60 Capsules) Probiotic and MegaMucosa (5.5oz Powder) gut mucosa support.*

MegaSporeBiotic is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function.

This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut flora. MegaSporeBiotic boasts a 2-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.*

2 Product bundle with MegaSporeBiotic (60 Capsules) Probiotic and MegaPre prebiotic powder.

MegaSporeBiotic is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function.

This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut flora. MegaSporeBiotic boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.*

Two Products Featuring trail-blazing psychobiotic 1714, a unique strain of Bifidobacterium longum that can help support the management of occasional stress and its biochemical expression within the human body.*

ZenBiome Cope is designed to help clients better handle life’s occasional stressors. Pairs the well-researched psychobiotic 1714 with other vital nutrients like B vitamins and herbal extracts to provide targeted support for coping with day-to-day, periodic stressors and mood changes.*

ZenBiome Cope is designed to help clients better handle life’s occasional stressors. Pairs the well-researched psychobiotic 1714 with other vital nutrients like B vitamins and herbal extracts to provide targeted support for coping with day-to-day, periodic stressors and mood changes.*

2 Product Probiotic + Gut Specific Fish Oil Bundle - Spore & yeast probiotic + full-spectrum fish oil scientifically formulated to support a healthy gut microbiome.*

Gut-Specific Fish Oil is a comprehensive fish oil scientifically formulated to support a healthy gut microbiome with a superior ratio of EPA, DHA, and the 'forgotten' DPA to support healthy immune and gut barrier function.

DPA, also known as the 'forgotten fatty acid', is receiving more attention in the omega-3 family due to its unique ability to support EPA and DHA tissue status, but it also supports a healthy gut.*

2 Product Probiotic + Digestive Enzymes Bundle - Spore & yeast probiotic + enzymes to help break down potentially troublesome FODMAP foods.

RestorFlora - Three well-studied and widely used probiotic strains - Saccharomyces boulardii, Bacillus subtilis HU58, and Bacillus clausii SC109. Supports a balanced intestinal flora, immune function, intestinal health, and healthy bowel movement.*

Advanced, dual-action approach to maintain a healthy intestinal environment.*

This 3-product bundle creates the perfect environment for your body’s daily activities to occur, which is the 'Digest and Rest' mode that we all require on a regular basis. This bundle offers your gut the ultimate digestive and rest aid.*

FODMATE is an innovative enzyme formula designed for short-term use that can help support digestive health, including relief from occasional cramping, bloating, gas, and abdominal pain that may result from the consumption of high FODMAP foods.

Adding FODMATE digestive enzyme formula to an elimination diet, such as low FODMAP, may make the diet more manageable. FODMATE can be used in conjunction with a low-FODMAP diet or to support the digestion of high FODMAP foods.*

2 Product MegaSporeBiotic + Gut Specific Fish Oil Bundle - All-spore antioxidant producing probiotic supplement + full-spectrum fish oil scientifically formulated to support a healthy gut microbiome.*

MegaSporeBiotic - Broad-acting probiotic blend of 5 Bacillus spores that have been shown to help maintain healthy gut barrier and immune function.* No refrigeration required.

99.99% survivability through the digestive tract. The Bacillus spore life cycle allows them to remain dormant in harsh environments. Once inside the large intestine, dormant spores can change into their active forms and begin colonizing in the gut.*

Researchers coined the term 'gut-skin axis' to describe the communication pathway between the gut and skin. A healthy gut microbiome is often mirrored as healthy, vibrant skin.*

SereneSkin is a probiotic-powered skincare supplement that supports a radiant, youthful complexion as well as supporting total body health.*

Probiotics help support digestive balances, working to maintain skin moisture retention and texture.*