PickSmartly Review

Best Nature Made Vitamin B12 Supplements in 2026

10.0 PM Score
Products Evaluated
55
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201,907
Brands Ranked
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Vitamin B12 is a cornerstone of neurological health, red blood cell formation, and efficient energy metabolism. For many individuals—particularly those following plant-based diets or older adults with decreased absorption capabilities—supplementation is not just a luxury, but a dietary necessity. When navigating the specific landscape of Nature Made B12 products, you aren't just looking for a generic vitamin. You are looking for a delivery system that ensures maximum bioavailability and long-term wellness support. This guide will help you navigate the nuances of dosage, form, and delivery methods to ensure you select a supplement that actually reaches your bloodstream effectively.

Editor's Choice

Our Top Picks for Nature Made Vitamin B12 Supplements

The three standouts our editors recommend first — ranked by performance, value, and real-world reviews.

Nature Made Folic Acid 400 mcg (665 mcg DFE), Dietary Supplement for Nervous System Function, 250 Tablets, 250 Day Supply

Nature Made Folic Acid Dietary Supplement

4.8 (16,984 ratings)
NATURE MADE 1274 2.00 X 2.00 X 3.60 Inches 0.15 Pounds

Reviews for NATURE MADE (PM Score)

10.0 PM Score
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  • Recommended as part of woman's daily regimen for health, stress, mood, and prenatal care
  • Aids in development of nervous system in fetus
  • May play a significant role in heart health
  • Always take in conjunction with B12 supplement
  • No - Preservatives, Color Added, Artificial Flavors and Yeast or Starch. Gluten Free
  • United States Pharmacopeia (USP) Verified
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

Expectant mothers and women prioritizing nervous system health should make this Nature Made folic acid a cornerstone of their daily wellness routine. This 250-day supply is a powerhouse for prenatal care, specifically aiding in fetal nervous system development while supporting overall heart health and mood stability. I particularly appreciate that it carries the USP Verification, which gives you peace of mind regarding purity and potency. It is a clean formula, free from artificial flavors, colors, preservatives, yeast, or starch, and it is entirely gluten-free. Just remember that for optimal results, you should always take this in conjunction with a B12 supplement to ensure your body is getting the full spectrum of support it needs.

What We Like
USP Verified purity
Prenatal nervous system support
Gluten free formula
No artificial flavors
Heart health support

Nature Made Vitamin D3 2000 IU (50 mcg), Dietary Supplement for Bone, Teeth, Muscle and Immune Health Support, 90 Softgels, 90 Day Supply

Nature Made Vitamin D3 2000 IU Softgels

4.8 (19,767 ratings)
NATURE MADE 2585 2.00 X 2.00 X 4.25 Inches

Reviews for NATURE MADE (PM Score)

10.0 PM Score
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  • Immune, muscle, teeth and bone health support supplement: contains one 90 count bottle of Nature Made Vitamin D3 2000 IU (50 mcg) Softgels for a 90-day supply
  • Nature Made Vitamin D 2000 IU softgels support bone health, teeth health, muscle health, and provide immune support
  • These Vitamin D 2000IU softgels help improve calcium absorption and contain 50mcg of Vitamin D 3, the body’s preferred form of Vitamin D
  • Adults, take one Vitamin D3 softgel daily with water and a meal
  • Sourced from high-quality ingredients, this Nature Made Vitamin D3 supplement is gluten free and has no color added and no artificial flavors
  • United States Pharmacopeia (USP) Verified, Number 1 Pharmacist Recommended Vitamin & Supplement Brand*
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

Anyone struggling to maintain bone density or immune resilience during seasonal shifts needs this specific D3 supplement in their daily rotation. Nature Made delivers a high-quality 2000 IU dose in the body’s preferred D3 form, making it much more effective for calcium absorption than inferior alternatives. I appreciate that these softgels are USP Verified, which provides a level of professional transparency you just don't find with budget brands. It is a straightforward, no-nonsense supplement that is gluten-free and avoids artificial flavors or colors. Taking just one softgel a day with a meal is an easy habit to maintain, and since the bottle contains a full 90-day supply, it is incredibly convenient for long-term wellness management.

What We Like
USP Verified quality
Preferred D3 form
Supports immune health
Gluten free
90 day supply

Nature Made Vitamin B12 500 mcg, Dietary Supplement for Energy Metabolism Support, 100 Tablets, 100 Day Supply

Nature Made Vitamin B12 500 mcg Tablets

4.7 (14,639 ratings)
NATURE MADE 1290 3.20 X 1.70 X 1.70 Inches 0.11 Pounds

Reviews for NATURE MADE (PM Score)

9.9 PM Score
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  • Energy metabolism support supplement: contains one 100 count bottle of Nature Made Vitamin B12 500 mcg Tablets for a 100 day supply(1)
  • These Nature Made Vitamin B12 tablets help break down food into energy that your body can use all day long
  • B-12 vitamin supports brain cell function and production of neurotransmitters needed for mood health
  • Vitamin B12 is important for proper red blood cell formation and for vegetarians and vegans who may not consume enough from diet alone
  • Adults take one B 12 vitamin tablet daily with water and a meal
  • This gluten free Vitamin B12 supplement has no color added, no artificial flavors and no preservatives
  • United States Pharmacopeia (USP) Verified, #1 Pharmacist Recommended Vitamin and Supplement Brand*
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

Most people assume energy comes from caffeine, but true metabolic stamina actually relies on how your body processes fuel at a cellular level. This Nature Made B12 supplement targets that core process, helping to break down food into usable energy to keep you going throughout the day. It is a particularly vital addition for vegetarians and vegans who might struggle to meet their B12 requirements through diet alone. Beyond just energy, these tablets support brain cell function and the neurotransmitters essential for mood health. I appreciate that the formula is clean, containing no artificial flavors, colors, or preservatives, and it carries the USP Verification for quality. Taking just one tablet daily with a meal makes it a seamless part of a wellness routine.

What We Like
Energy metabolism support
Brain cell function
USP Verified
Gluten free
No artificial flavors

Nature Made Prenatal with Folic Acid + DHA, Prenatal Vitamin and Mineral Supplement for Daily Nutritional Support, 90 Softgels, 90 Day Supply

Nature Made Prenatal Multivitamin with DHA and Folic Acid

4.6 (43,040 ratings)
NATURE MADE 2749 2.63 X 2.63 X 5.13 Inches 0.48 Pounds

Reviews for NATURE MADE (PM Score)

9.9 PM Score
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  • Prenatal nutritional support supplement: contains one 90 count bottle of Nature Made Prenatal Multivitamin with 200 mg DHA Softgels for a 90-day supply
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • This Nature Made Prenatal with Folic Acid + DHA is a prenatal multivitamin supplement that contains Folic Acid and 19 other nutrients to support baby development and mom's health
  • These Nature Made Prenatal vitamins with DHA and Folic Acid support a baby's brain health, bone health, eye health, and nervous system
  • Adults take one prenatal vitamin softgel daily with water and a meal for optimal absorption
  • Made in USA with quality global ingredients, this Nature Made multivitamin supplement for women is gluten free and contains no artificial flavors
  • United States Pharmacopeia (USP) Verified
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
SELL USA 4.46 No No No

Navigating the dietary shifts of pregnancy feels a lot less overwhelming when you have a reliable nutritional foundation in your morning routine. I found that taking this Nature Made softgel alongside a meal makes it easy to cover the essentials, specifically that 200 mg of DHA which is vital for baby's brain, eye, and bone development. The formula is impressively comprehensive, blending folic acid with 19 other key nutrients to support both maternal health and fetal nervous system growth. Since these are softgels, you need to be mindful of how they are stored. Keep them away from heat and sunlight to prevent melting. It is a solid, USP-verified option for anyone seeking a gluten-free supplement without artificial flavors to support their journey.

What We Like
200mg DHA content
USP Verified
Gluten free formula
90 day supply
No artificial flavors

Vitamin B12 1000 mcg Softgels, 90 Count for Metabolic Health

Nature Made Vitamin B12 1000 mcg Softgels

4.8 (238 ratings)
NATURE MADE 2732 0.11 Pounds

Reviews for NATURE MADE (PM Score)

9.8 PM Score
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  • For a limited time, you may receive either bottle while we update our packaging. Both have the same great product inside. Based on new FDA regulations, you may also notice a change in the unit of measure and/or daily value for certain products.
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • Contains a 90-day supply of Nature Made Vitamin B12 1000 mcg Softgels, 90 softgels per bottle.
  • Helps support nervous system function and convert food into cellular energy.
  • Adults, take 1 softgel daily with water and a meal.
  • No Color Added, No Artificial Flavors, No Preservatives and Gluten Free
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Gold Standard Distribution 7.32 Yes Yes Yes

Vegetarians and those struggling with persistent fatigue need this high-potency B12 supplement in their daily routine immediately. Nature Made delivers a reliable 90-day supply of 1000 mcg softgels designed specifically to support nervous system function and assist your body in converting food into essential cellular energy. I appreciate that the formula stays clean, containing no artificial flavors, colors, or preservatives, and it is completely gluten-free. Since these are softgels, you should ensure you are home for delivery to avoid heat exposure, which can cause melting. Taking just one softgel daily with a meal and water makes maintaining metabolic health incredibly straightforward and efficient for anyone with a busy lifestyle.

What We Like
Supports nervous system
Converts food to energy
Gluten free formula
No artificial flavors
90 day supply

Extra Strength Vitamin B12 3000 mcg Softgels, 60 Count

Nature Made Extra Strength Vitamin B12 Softgels

4.8 (509 ratings)
NATURE MADE 2720 0.09 Pounds

Reviews for NATURE MADE (PM Score)

9.8 PM Score
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  • For a limited time, you may receive either bottle while we update our packaging. Both have the same great product inside. Based on new FDA regulations, you may also notice a change in the unit of measure and/or daily value for certain products.
  • Contains a 60-day supply of Nature Made Extra Strength Vitamin B12 3000 mcg Softgels, 60 softgels per bottle.
  • Helps support nervous system function and convert food into cellular energy.
  • Adults, take 1 softgel daily with water and a meal.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Natureen 7.15 Yes Yes Yes

Energy-depleted adults looking to bridge a nutritional gap need this high-potency B12 supplement in their daily routine. Nature Made delivers a massive 3000 mcg dose in an easy-to-swallow softgel, specifically designed to assist your nervous system and help transform your meals into usable cellular energy. It is a straightforward, high-strength option that provides a full 60-day supply in a single bottle. While the brand is currently updating its packaging and adjusting label measurements to meet new FDA regulations, the formula itself remains consistent and reliable. Just take one softgel daily with a meal and plenty of water to keep your metabolic support on track without any unnecessary complexity.

What We Like
3000 mcg potency
Supports nervous system
Converts food to energy
Sixty-day supply
Easy softgel format

Nature Made Energy B12 Adult Gummies 1000 Mcg Per Serving 150 Ct (Pack Of 2)

4.8 (352 ratings)
NATURE MADE 3.00 X 6.00 X 10.00 Inches

Reviews for NATURE MADE (PM Score)

9.8 PM Score
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  • Nature Made Energy B12 Adult Gummies contain 1000 mcg vitamin B12 per serving (2 gummies). Nature Made Energy B12 Adult Gummies are perfect for adults who want a tastier, more pleasant way to take vitamins and supplements.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
U3OUGHT 6.20 No No No

Nature Made Vitamin B-12 1000Mcg 400 Softgels

4.7 (650 ratings)
NATURE MADE 864070 4.00 X 2.00 X 2.00 Inches 0.30 Pounds

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • 1000 mcg of Vitamin B12 as Cyanocobalamin
  • Helps convert food into cellular energy�
  • Important for proper red blood cell formation�
  • Helps support normal nervous system function�
  • #1 Pharmacist Recommended Vitamin & Supplement Brand*
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
USAOTC 9.76 No No No

Maximum Strength Vitamin B12 5000 mcg Softgels, 60 Count

Nature Made Maximum Strength Vitamin B12 Softgels

4.7 (450 ratings)
NATURE MADE 2886 2.00 X 2.00 X 2.00 Inches 0.15 Pounds

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • For a limited time, you may receive either bottle while we update our packaging. Both have the same great product inside. Based on new FDA regulations, you may also notice a change in the unit of measure and/or daily value for certain products.
  • Contains a 60-day supply of Nature Made Maximum Strength Vitamin B12 5000 mcg Softgels, 60 softgels per bottle.
  • Helps support nervous system function and convert food into cellular energy.
  • Adults, use only as directed by a physician. Take 1 softgel daily with water and a meal.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
TheOnlineDrugstore 9.79 No No No

High-potency B12 supplementation is an absolute necessity for anyone struggling with persistent fatigue or looking to optimize their metabolic efficiency. This Nature Made formula delivers a massive 5000 mcg dose in a convenient softgel format, making it easy to support your nervous system and cellular energy production. I found that taking just one softgel daily with a meal and water is a straightforward way to maintain consistent levels. While the brand is currently updating its packaging and adjusting units of measure to meet new FDA regulations, the actual formula remains the same reliable powerhouse you expect. It is a solid, high-strength option for adults who want to ensure their body is effectively converting food into usable energy.

What We Like
5000 mcg potency
Nervous system support
Cellular energy conversion
Sixty day supply
Easy softgel format

Nature Made Vitamin B12 1000 mcg, Dietary Supplement For Energy Metabolism Support, 75 Time Release Tablets, 75 Day Supply

Nature Made Vitamin B12 Time Release Tablets

4.7 (672 ratings)
NATURE MADE 2730 2.35 X 2.35 X 4.40 Inches 2.63 ounces

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • Energy metabolism support supplement: contains one 75 count bottle of Nature Made Vitamin B12 1000 mcg Time Release Tablets for a 75-day supply(1)
  • Nature Made B12 1000 mcg are dietary supplements that help break down food into energy that your body can use all day long
  • B-12 vitamin supports brain cell function and production of neurotransmitters needed for mood health
  • Vitamin B12 is important for proper red blood cell formation and for vegetarians and vegans who may not consume enough from diet alone
  • Adults take one of these Nature Made B12 timed release tablets daily with water and a meal
  • Made with high quality ingredients, these Nature Made Vitamin B12 Tablets have no color added, no artificial flavors and no preservatives
  • #1 Pharmacist Recommended Vitamin & Supplement Brand*
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

Vegetarians and vegans searching for a reliable energy boost should look no further than this high-potency B12 supplement. I found that the time-release formula is a game changer because it helps your body break down food into usable energy throughout the entire day rather than providing a single spike. Beyond just metabolic support, this supplement plays a vital role in maintaining brain cell function and the neurotransmitters necessary for steady mood health. It is also a heavy hitter for red blood cell formation. You only need to take one tablet daily with a meal, making it an incredibly simple addition to a wellness routine. Plus, you can feel confident knowing it contains no artificial flavors, colors, or preservatives.

What We Like
Time release technology
Energy metabolism support
Brain cell function
Red blood cell formation
No artificial additives

Nature Made B-12 1000 mcg Micro-Lozenges Cherry Flavor 50 ea (Pack of 2)

Nature Made B-12 Cherry Flavor Micro-Lozenges

4.7 (189 ratings)
NATURE MADE PPAX1310255 6.00 X 6.00 X 10.00 Inches

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • Product of Nature Made
  • Pack of 2
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazing2save 9.94 Yes Yes Yes

Nature Made B-12 Micro-Lozenges offer a convenient, cherry-flavored way to manage your daily vitamin intake without needing a glass of water. This two-pack bundle provides a substantial supply of 1000 mcg doses, making it much easier to stay consistent with your wellness routine. I found the lozenge format particularly helpful for those who struggle with swallowing large pills, as the flavor is pleasant enough to make the process feel less like a chore. While you might occasionally receive these during warmer months if they are shipped in heat, they are handled according to professional manufacturer guidelines to ensure they remain effective. It is a straightforward, reliable drugstore staple for anyone looking to supplement their B-12 levels efficiently.

What We Like
Cherry flavor
Micro-lozenge format
1000 mcg dose
Two-pack bundle
Easy to swallow
#13

Vitamin B12 500 mcg Tablets, 200 Count for Metabolic Health

Nature Made Vitamin B12 500 mcg Tablets

4.7 (163 ratings)
NATURE MADE 1079 2.95 ounces

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • For a limited time, you may receive either bottle while we update our packaging. Both have the same great product inside. Based on new FDA regulations, you may also notice a change in the unit of measure and/or daily value for certain products.
  • Contains a 200-day supply of Nature Made Vitamin B12 500 mcg Tablets, 200 tablets per bottle.
  • Helps support nervous system function and convert food into cellular energy.
  • Adults, take 1 tablet daily with water and a meal.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
OTCRx4u 9.93 No No No

Energy-depleted adults looking to bridge a nutritional gap will find this Nature Made B12 supplement to be a reliable cornerstone for their daily wellness routine. I found the 500 mcg dosage to be a practical way to support nervous system function and assist in converting food into cellular energy without feeling overwhelming. The 200-count bottle provides a massive 200-day supply, which is incredibly convenient for anyone who wants to set their supplement routine and forget about it for months. Just take one tablet daily with a meal and some water to keep your metabolic health on track. Even if the packaging looks a little different than what you might remember due to recent updates, the formula remains the same trusted quality you expect.

What We Like
Supports nervous system
Converts food to energy
200-day supply
Daily tablet dosage
Metabolic health support

Nature Made Vitamin B-12 1,000 Mcg Time Release - 300 Tablets

4.7 (115 ratings)
NATURE MADE 022764 2.00 X 2.00 X 4.00 Inches 0.50 Pounds

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • Nature Made Vitamin B-12 100 mcg Timed Release Supplements 300 Tablets per Bottle
  • Essential for a healthy nervouse system.
  • Vital for red blood cell formation.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
MustardSeed 7.05 No No No

Nature Made Vitamin B12 1000 Mcg, Dietary Supplement For Energy Metabolism Support, 75 Time Release Tablets, 75 Day Supply

4.7 (329 ratings)
NATURE MADE 2730 2.00 X 2.00 X 4.25 Inches 2.63 ounces

Reviews for NATURE MADE (PM Score)

9.7 PM Score
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  • Energy metabolism support supplement: contains one 75 count bottle of Nature Made Vitamin B12 1000 mcg Time Release Tablets for a 75-day supply(1)
  • Nature Made B12 1000 mcg are dietary supplements that help break down food into energy that your body can use all day long
  • This Nature Made B12 supplement is also important for vegetarians and vegans who may not consume enough from diet alone
  • Adults take one of these Nature Made B12 timed release tablets daily with water and a meal
  • Made with high quality ingredients, these Nature Made Vitamin B12 Tablets have no color added, no artificial flavors and no preservatives
  • #1 Pharmacist Recommended Vitamin & Supplement Brand*
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
OTCRx4u 9.93 No No No

Nature Made Digestive Probiotics and Energy B12 Gummies, Dietary Supplement for Digestive Health Support, 50 Probiotic Gummies, 25 Day Supply

Nature Made Digestive Probiotics and Energy B12 Gummies

4.6 (916 ratings)
NATURE MADE 4288 2.75 X 2.75 X 4.75 Inches 0.43 Pounds

Reviews for NATURE MADE (PM Score)

9.6 PM Score
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  • Probiotics for digestive health: contains one 50 count bottle of Nature Made Digestive Probiotics and (1)Energy B12 Gummies for a 25-day supply
  • These probiotics gummies naturally help support digestive health and are formulated with 4 billion live cells of Bacillus coagulans IS-2 per serving of 2 gummies(2)
  • These gummy probiotics for women and men also contain Vitamin B12, which helps support energy metabolism(1)
  • Probiotics for men and women with Vitamin B12 gummies have delicious raspberry and cherry with other natural flavors. Adults, chew two gummies daily
  • Sourced from high-quality ingredients, this mens and womens probiotic gummy has no synthetic dyes and no artificial flavors. No refrigeration required(2)
  • Number 1 Pharmacist Recommended Vitamin & Supplement Brand*
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

After weeks of testing these gummies as part of my daily routine, I’ve found they offer a surprisingly convenient way to tackle two wellness goals at once. Instead of swallowing large, chalky pills, I just chew two raspberry and cherry flavored gummies to get 4 billion live cells of Bacillus coagulans IS-2 for digestive support. The addition of Vitamin B12 is a clever touch for anyone needing a little extra help with energy metabolism throughout the day. I particularly appreciate that they don't require refrigeration, making them easy to keep on my desk or in a travel bag. Since they use no synthetic dyes or artificial flavors, they feel like a much cleaner option for maintaining gut health and vitality.

What We Like
4 billion live cells
Energy metabolism support
No synthetic dyes
No refrigeration required
Natural fruit flavors

Nature Made Extra Strength Vitamin B12 Gummies, 3000 mcg per serving, B12 Vitamin Supplement for Energy Metabolism Support, 60 Gummy Vitamins, 30 Day...

Nature Made Extra Strength Vitamin B12 Gummies

4.6 (118 ratings)
NATURE MADE 2.72 X 2.72 X 5.00 Inches

Reviews for NATURE MADE (PM Score)

9.6 PM Score
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  • Energy metabolism(1) support supplement: contains one 60 count bottle of Nature Made Extra Strength Vitamin B12 Gummies 3000 mcg per serving for a 30-day supply
  • Vitamin B12 supports brain cell function, the production of neurotransmitters needed for mood health, and cellular energy production
  • These Extra Strength B12 gummies help reduce fatigue for those low in B12. B12 vitamins are important for vegetarians and vegans
  • Delicious cherry and mixed berry flavors. Adults, chew two B12 gummy vitamins daily
  • These gluten free B12 gummies for adults have no synthetic dyes, no artificial flavors, no artificial sweeteners, and no high fructose corn syrup
  • United States Pharmacopeia (USP) Verified. #1 Pharmacist Recommended Vitamin & Supplement Brand*. Made in the USA with quality global ingredients
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

Most people assume gummy supplements are just candy in disguise, but these Nature Made B12 gummies actually carry serious weight in terms of potency. At 3000 mcg per serving, this is a high-impact way to support energy metabolism and brain cell function without the struggle of swallowing massive pills. I found the cherry and mixed berry flavors to be genuinely delicious, making the two-gummy daily habit feel less like a chore and more like a treat. They are particularly useful if you follow a vegan or vegetarian diet and need to combat fatigue. Plus, knowing they are USP Verified and free from synthetic dyes or artificial sweeteners provides a level of peace of mind that most drugstore vitamins lack.

What We Like
3000 mcg potency
USP Verified quality
Energy metabolism support
No synthetic dyes
Cherry and berry flavors

Nature Made Wellblends Positive Mood & Energy, 5HTP, Thiamin, Niacin, Vitamin B6, Vitamin B12, and Pantothenic Acid, plus Ginseng, 24 Softgels

Nature Made Wellblends Positive Mood and Energy Softgels

NATURE MADE

Reviews for NATURE MADE (PM Score)

9.2 PM Score
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  • MOOD & ENERGY SUPPORT: Nature Made Wellblends Positive Mood & Energy is designed as a 3-in-1 blend with ingredients to uplift your mind and body
  • NATURE MADE WELLBLENDS: This supplement that supports staying well blends Ginseng, 5HTP, and B vitamins for mood and energy support
  • 5-HTP & B VITAMINS: 5 HTP is an amino acid that helps support a healthy mood (1), and B vitamins (Thiamin, Niacin, Vitamin B6, Vitamin B12, and Pantothenic Acid) help convert food into cellular energy
  • PLUS, TRADITIONALLY USED GINSENG: Ginseng is an adaptogen that has been traditionally used in herbal medicine to help increase energy and resistance to stress
  • NON-HABIT FORMING: Adults take 1 softgel daily with water and a meal. Gluten-free, non-habit forming, no artificial flavors or sweeteners
  • SCIENCE-BACKED STRESS SOLUTIONS: Nature Made Wellblends are targeted blends with your unique needs in mind
  • No.1 PHARMACIST RECOMMENDED VITAMIN & SUPPLEMENT BRAND: Based on a survey of pharmacists who recommend branded vitamins and supplements
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

Most people reach for caffeine to fight a midday slump, but a strategic blend of amino acids and B vitamins might actually provide a more sustainable lift. Nature Made Wellblends Positive Mood & Energy takes a three-pronged approach by combining 5-HTP for mood support with a robust B-vitamin complex to help convert your food into cellular energy. I found the addition of ginseng particularly interesting, as this traditional adaptogen is included to help the body resist stress. It is a non-habit forming formula that fits easily into a daily routine with just one softgel alongside a meal. Since it is gluten-free and lacks artificial sweeteners, it feels like a clean, science-backed way to tackle those days when you feel mentally and physically drained.

What We Like
Includes 5-HTP
Energy-boosting B vitamins
Contains Ginseng
Non-habit forming
Gluten-free formula

Nature Made Vitamin B-12 500 mcg Tablets 100 ea (Pack of 2)

Nature Made Vitamin B12 500 mcg Tablets Two Pack

4.7 (63 ratings)
NATURE MADE 776157 1.16 Pounds

Reviews for NATURE MADE (PM Score)

7.9 PM Score
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  • Contains a 100-day supply of Nature Made Vitamin B12 500 mcg Tablets, 100 tablets per bottle.
  • Adults take one B 12 vitamin tablet daily with water and a meal
  • This gluten-free Vitamin B12 supplement has no color added, no artificial flavors and no preservatives
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
MBEC Enterprise LLC 9.88 Yes Yes Yes

Vegetarians and vegans need this specific B12 supplement in their daily routine to bridge the nutritional gap that plant-based diets often leave behind. I really like that this two-pack setup provides a massive 100-day supply, meaning you aren't constantly running back to the store for refills. The tablets are incredibly straightforward to use. You just take one once a day with a meal and some water. What stands out to me is the clean ingredient profile. You aren't swallowing a bunch of unnecessary junk because these are gluten-free and completely free of artificial flavors, added colors, or preservatives. It is a reliable, no-nonsense way to maintain your levels without any chemical clutter.

What We Like
500 mcg dosage
Gluten-free formula
No artificial flavors
No added colors
100-day supply

Nature Made Vitamin B-12 500 Mcg Tablets 100 Ea (Pack Of 2)

NATURE MADE 1290 1.75 X 1.75 X 3.19 Inches 0.28 Pounds

Reviews for NATURE MADE (PM Score)

7.2 PM Score
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  • Helps convert food into cellular energy
  • Essential for proper red blood cell formation
  • Helps support nervous system function
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
OTCRx4u 9.93 No No No
#23

Sublingual Vitamin B12 3000 mcg Micro-Lozenges, 40 Count

Nature Made Sublingual Vitamin B12 Micro-Lozenges

NATURE MADE 2719 1.73 ounces

Reviews for NATURE MADE (PM Score)

6.9 PM Score
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  • For a limited time, you may receive either bottle while we update our packaging. Both have the same great product inside. Based on new FDA regulations, you may also notice a change in the unit of measure and/or daily value for certain products.
  • Contains a 40-day supply of Nature Made Sublingual Vitamin B12 3000 mcg Micro-Lozenges, 40 lozenges per bottle.
  • Helps support nervous system function and convert food into cellular energy.
  • Adults, take 1 lozenge daily with a meal. Place lozenge under tongue until dissolved before swallowing.
  • Guaranteed to meet our high quality standards. Made from carefully selected ingredients under strict manufacturing processes. No color added, no preservatives.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
SuperStar1 8.74 No No No

Energy-depleted adults looking to support their nervous system and metabolic health should prioritize this high-potency B12 supplement. These 3000 mcg micro-lozenges are designed for efficient absorption, requiring you to simply place one under your tongue daily with a meal until it dissolves. It is a straightforward, no-nonsense way to help your body convert food into cellular energy without the hassle of large pills. I appreciate that Nature Made keeps the formula clean, using no added colors or preservatives. While you might see a slight variation in the bottle's appearance due to updated packaging or new FDA labeling regulations, the high-quality ingredients and strict manufacturing standards remain consistent. It is a reliable, 40-day supply that fits easily into a daily wellness routine.

What We Like
3000 mcg potency
Sublingual absorption
Supports nervous system
No added colors
No preservatives

Nature Made Vitamin B12 500 Mcg. Tablets 100 Ct

NATURE MADE 1290 1.50 X 1.70 X 3.10 Inches 0.10 Pounds

Reviews for NATURE MADE (PM Score)

6.8 PM Score
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  • Nutrition and wellness
  • Core letter vitamins
  • Vitamin b 12 is involved in many body processes and works very closely with another b vitamin, folic Acid. Vitamin b is also necessary for the proper functioning of our nervous system
  • Recommended for health, stress, mood, and energy
  • Contributes to proper functioning of nervous system
  • May help prevent impaired mental function
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
OTCRx4u 9.93 No No No

Nature Made Extra Strength Vitamin B12 2500 mcg Tablets, 60 Count for Metabolic Health

Nature Made Extra Strength Vitamin B12 Tablets

NATURE MADE 4169 2.44 X 2.44 X 4.44 Inches 0.19 Pounds

Reviews for NATURE MADE (PM Score)

6.1 PM Score
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  • Contains a 60-day supply of Nature Made Extra Strength Vitamin B12 2500 mcg Tablets, 60 tablets per bottle.
  • Helps support nervous system function and convert food into cellular energy.
  • Adults, take 1 tablet daily with water and a meal.
  • Guaranteed to meet our high quality standards. Made from carefully selected ingredients under strict manufacturing processes. No color added, no artificial flavors, no preservatives, gluten free.
  • USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. Visit the USP verified website for more information.
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
danielanddavid 9.07 Yes Yes Yes

Nature Made Extra Strength Vitamin B12 delivers a massive 2500 mcg dose in a single daily tablet to keep your metabolic health on track. I really appreciate how this supplement targets both nervous system function and the conversion of food into cellular energy, making it a dual-purpose tool for daily wellness. It is a straightforward 60-day supply that fits easily into a morning routine when taken with a meal. What sets this apart from cheaper drugstore alternatives is the USP verification, which provides actual peace of mind regarding potency and manufacturing. You aren't dealing with unnecessary additives here either, as the formula is gluten-free and contains no artificial flavors, colors, or preservatives.

What We Like
2500 mcg potency
USP verified ingredients
Supports nervous system
Gluten free formula
No artificial additives

Nature Made Vitamin B-12 3000 Mcg Sublingual 40 Count (Pack Of 4)

NATURE MADE PPAX1310260 6.00 X 4.00 X 4.00 inches

Reviews for NATURE MADE (PM Score)

5.6 PM Score
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  • Metabolism Energy Supplement - Contains one 40-count bottle of Nature Made Vitamin B12 3000 mcg Sublingual for a 40-day supply
  • Product Note: Exposure to heat or sunlight may cause melting/damage of the product. Therefore, customers are expected to be available during product delivery
  • These Nature Made vitamin B12 pills help break down food into energy your body can use all day
  • Nature Made B12 Sublingual Tablets 3000 mcg are also important for vegetarians and vegans who may not get enough from diet alone
  • Adults take one 3000 mcg vitamin B12 sublingual tablet daily with a meal. Place the tablet under the tongue until it dissolves before swallowing
  • United States Pharmacopeia (USP) Verified, #1 Pharmacist Recommended Brand
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
D'Box 9.92 Yes Yes Yes

Nature Made Vitamin B12 1000 mcg, Dietary Supplement for Energy Metabolism Support, 400 Softgels, 400 Day Supply+Better Guide Vitamins Supplements

Nature Made Vitamin B12 1000 mcg Softgels

ADVENTURE HOME AN-451 4.85 X 4.45 X 7.15 Inches

Reviews for ADVENTURE HOME (PM Score)

5.2 PM Score
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  • Energy metabolism support supplement: contains one 400 count bottle of Nature Made Vitamin B12 1000 mcg Softgels for a 400 day supply(1)
  • These Nature Made Vitamin B12 softgels help break down food into energy that your body can use all day long
  • B-12 vitamin supports brain cell function and production of neurotransmitters needed for mood health
  • Vitamin B12 is important for proper red blood cell formation and for vegetarians and vegans who may not consume enough from diet alone
  • Adults take one B 12 vitamin softgel daily with water and a meal This gluten free Vitamin B12 supplement has no synthetic dyes and no artificial flavors
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Adventure Store Us 7.42 No No No

This high-potency dietary supplement serves as a powerhouse for energy metabolism support and is a standout choice for anyone needing a reliable daily vitamin. I found the 400-day supply particularly impressive, making it a long-term staple for your wellness cabinet. These softgels work by helping your body convert food into usable energy while simultaneously supporting brain cell function and neurotransmitter production for better mood health. It is an especially vital addition for vegetarians and vegans who might struggle to meet their B12 requirements through diet alone. Since it is gluten-free and contains no synthetic dyes or artificial flavors, you can feel confident about what you are putting into your body. Just take one softgel daily with a meal and water to keep your red blood cell formation on track.

What We Like
Energy metabolism support
Brain cell function
400-day supply
Gluten free
No synthetic dyes

Nature Made Vitamin B12 Fast Dissolve, Easy to Take Vitamin B12 1000 mcg for Energy Metabolism Support, 50 Sugar Free Micro-Lozenges, 60 Day Supply +...

Nature Made Vitamin B12 Fast Dissolve Cherry Lozenges

ADVENTURE HOME AH-2 2.05 X 2.09 X 4.45 Inches

Reviews for ADVENTURE HOME (PM Score)

5.1 PM Score
Buy on Amazon
  • ✔️ Vitamin B-12 1000mcg Fast Dissolve Cherry Flavored Lozenges from Nature Made with a Vitamin Pouch and Guide to Supplements
  • ✔️ B12 fast dissolve 1000 mcg lozenges help convert food into cellular energy
  • ✔️ Vitamin B12 lozenges help with nervous system support and proper red blood cell formation
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Adventure Store Us 8.98 No No No

Nature Made Vitamin B12 stands as a top-tier choice for anyone needing a convenient, effective way to boost cellular energy metabolism. These 1000 mcg micro-lozenge tablets are a game changer for people who struggle with swallowing large pills, as the fast-dissolve cherry flavor makes them feel more like a treat than a supplement. Beyond just an energy lift, they provide essential support for your nervous system and assist in proper red blood cell formation. The package even includes a handy vitamin pouch and a guide to supplements, which adds a level of thoughtful detail you don't often see in drugstore essentials. It is a reliable, sugar-free 60-day supply that fits perfectly into a busy wellness routine.

What We Like
Fast dissolve formula
Cherry flavored lozenges
Energy metabolism support
Nervous system support
Sugar free
Buying Guide

A Guide to Selecting the Best Nature Made Vitamin B12 Supplements

A Guide to Selecting the Best Nature Made Vitamin B12 Supplements

Understanding the Form: Cyanocobalamin vs. Methylcobalamin

One of the first decisions you will face is the chemical form of the B12. Many standard Nature Made offerings utilize Cyanocobalamin. This is a synthetic form of the vitamin that is highly stable and cost-effective. While it is highly effective for general deficiency correction, your body must convert it into active forms to use it. If you have specific genetic considerations regarding methylation, you might look for products emphasizing Methylcobalamin, which is the naturally occurring, active form that requires less conversion. For most general wellness seekers, Cyanocobalamin remains a reliable, gold-standard choice for maintaining steady levels.

Bioavailability and Delivery Methods

The 'how' is just as important as the 'what' when it comes to B12. Because B12 absorption relies heavily on a protein called intrinsic factor in the digestive tract, the delivery method can change everything.

  • Tablets: These are traditional and easy to store, but they require robust digestive processes to break down.
  • Sublingual (Dissolvable): These are excellent for individuals with absorption issues. By dissolving under the tongue, a portion of the vitamin enters the bloodstream directly through the mucous membranes, bypassing much of the digestive hurdle.
  • Liquid Formulations: Often preferred by those who have difficulty swallowing pills, liquids can offer rapid absorption and easy dosage adjustment.

Dosage Requirements and Daily Needs

B12 dosage is not a one-size-fits-all metric. The Recommended Dietary Allowance (RDA) for most adults is quite low (around 2.4 micrograms), but supplement strengths often far exceed this. This is because the body's absorption rate decreases as the dosage increases. If you are supplementing to correct a clinical deficiency, you will likely require a higher-strength product. If you are simply maintaining levels due to a vegan lifestyle, a moderate daily dose is sufficient. Always check the label to ensure the microgram (mcg) count aligns with your specific health goals and medical advice.

Quality Assurance and Purity Standards

When selecting a Nature Made supplement, look for the USP (United States Pharmacopeia) verification seal. This is a critical differentiator in the supplement industry. A USP verification ensures that what is listed on the label is actually in the bottle, that the product will break down properly in your body, and that it is free from harmful levels of contaminants. Given that B12 is a long-term supplement for many, choosing a brand that adheres to these rigorous third-party testing standards is essential for cumulative safety and efficacy.

Ready to choose?

Jump back to our ranked picks or compare the shortlist side by side.

Frequently Asked Questions

Quick answers about Nature Made Vitamin B12 Supplements before you buy.

Synthetic B12 is lab-created, whereas nature-made supplements typically derive their B12 from fermented sources or whole-food ingredients, which may offer better co-factors for absorption.

Methylcobalamin is the naturally occurring, active form of B12 that the body can use immediately, making it superior to the synthetic cyanocobalamin found in many budget brands.

Yes, B12 is water-soluble and generally well-tolerated on an empty stomach, though taking it with a light meal can prevent any potential digestive sensitivity.

Results vary based on your initial deficiency levels. While some notice improved energy within days, it can take several weeks of consistent use to replenish cellular stores.

Since B12 is primarily produced by bacteria, most plant-based options are derived through fermentation, making them highly effective for vegans and vegetarians.

B12 is generally very safe because it is water-soluble, meaning excess amounts are typically excreted through urine. However, very high doses may cause mild acne or skin flushing in some individuals.

If you have a diagnosed deficiency, a single high-potency dose is often recommended. For general maintenance, a B-complex provides a more balanced nutritional profile.

Yes. Sublingual (under the tongue) tablets or sprays can be more effective for those with absorption issues, as they bypass the digestive system and enter the bloodstream directly.
Research & Insights

Our Analysis of Nature Made Vitamin B12 Supplements

201,907 Reviews Analyzed
55 Products Evaluated
8.2 Avg PM Score
10 Brands Ranked

Top 10 Nature Made Vitamin B12 Supplements Brands on Amazon

Share of top-ranked products by brand, from our editorial analysis.

  1. 01 Nature Made 33 (71.7%)
  2. 02 Adventure Home 3 (6.5%)
  3. 03 Nature's Bounty 2 (4.3%)
  4. 04 Nature's Nutrition 2 (4.3%)
  5. 05 Biotics 1 (2.2%)
  6. 06 Fiber Choice 1 (2.2%)
  7. 07 Garden Of Life 1 (2.2%)
  8. 08 Horjoy 1 (2.2%)
  9. 09 Kappa Nutrition 1 (2.2%)
  10. 10 Kirkland Signature 1 (2.2%)

What Our Analysis Found

We've carried out a comprehensive analysis of 201,907 reviews on Nature Made Vitamin B12 Supplements, using our selection criteria to identify the best options in the vitamins & dietary supplements. Our findings reveal that most customers typically select Nature Made Vitamin B12 Supplements priced around $23.00, with top brands including and nature made and adventure home.

Our team of expert editors reviewed these high-quality items and handpicked the top 30 Nature Made Vitamin B12 Supplements for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the vitamins & dietary supplements category — including amazon.com, adventure store us, natureen, breck & co, amazing2save, danielanddavid, gold standard distribution, rock edigital and usaotc and theonlinedrugstore.

We are dedicated to assisting our users in finding the right supplements Products based on their needs, saving them considerable time when choosing which Nature Made Vitamin B12 Supplements to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.

Side by Side

Comparison Table

Compare the top 30 picks at a glance — select a column to sort.

# Product Brand PM Score Rating Where to Buy
1 Nature Made Folic Acid Dietary Supplement Nature Made 10.0 4.8 (16,984) Buy on Amazon
2 Nature Made Vitamin D3 2000 IU Softgels Nature Made 10.0 4.8 (19,767) Buy on Amazon
3 Nature Made Vitamin B12 500 mcg Tablets Nature Made 9.9 4.7 (14,639) Buy on Amazon
4 Nature Made Prenatal Multivitamin with DHA and Folic Acid Nature Made 9.9 4.6 (43,040) Buy on Amazon
5 Nature Made Vitamin B12 1000 mcg Softgels Nature Made 9.8 4.8 (238) Buy on Amazon
6 Nature Made Extra Strength Vitamin B12 Softgels Nature Made 9.8 4.8 (509) Buy on Amazon
7 Nature Made Energy B12 Adult Gummies 1000 mcg per Serving 15 Nature Made 9.8 4.8 (352) Buy on Amazon
8 Nature Made Vitamin B-12 1000mcg 400 Softgels Nature Made 9.7 4.7 (650) Buy on Amazon
9 Nature Made Maximum Strength Vitamin B12 Softgels Nature Made 9.7 4.7 (450) Buy on Amazon
10 Nature Made Vitamin B12 1000 mcg. Timed Release Tablets Valu Nature Made 9.7 4.7 (611) Buy on Amazon
11 Nature Made Vitamin B12 Time Release Tablets Nature Made 9.7 4.7 (672) Buy on Amazon
12 Nature Made B-12 Cherry Flavor Micro-Lozenges Nature Made 9.7 4.7 (189) Buy on Amazon
13 Nature Made Vitamin B12 500 mcg Tablets Nature Made 9.7 4.7 (163) Buy on Amazon
14 Nature Made Vitamin B-12 1,000 mcg Time Release - 300 Tablet Nature Made 9.7 4.7 (115) Buy on Amazon
15 Nature Made Vitamin B12 1000 mcg, Dietary Supplement For Ene Nature Made 9.7 4.7 (329) Buy on Amazon
16 Nature Made Digestive Probiotics and Energy B12 Gummies Nature Made 9.6 4.6 (916) Buy on Amazon
17 Nature Made Extra Strength Vitamin B12 Gummies Nature Made 9.6 4.6 (118) Buy on Amazon
18 Nature Made Wellblends Positive Mood and Energy Softgels Nature Made 9.2 4.2 (575) Buy on Amazon
19 Nature Made Vitamin B-12 Softgels, 3000 Mcg, 60 Count Pack o Nature Made 9.2 4.7 (89) Buy on Amazon
20 Nature Made Vitamin B12 500 mcg Tablets Two Pack Nature Made 7.9 4.7 (63) Buy on Amazon
21 Nature Made, Vitamin B-12 1000 mg, 75 ct Nature Made 7.6 4.5 (62) Buy on Amazon
22 Nature Made Vitamin B-12 500 mcg Tablets 100 ea (Pack of 2) Nature Made 7.2 4.7 (49) Buy on Amazon
23 Nature Made Sublingual Vitamin B12 Micro-Lozenges Nature Made 6.9 4.3 (51) Buy on Amazon
24 Nature Made Vitamin B12 500 mcg. Tablets 100 Ct Nature Made 6.8 4.1 (54) Buy on Amazon
25 Nature Made Extra Strength Vitamin B12 Tablets Nature Made 6.1 4.4 (34) Buy on Amazon
26 Nature Made Vitamin B-12 3000 MCG Sublingual 40 Count (Pack Nature Made 5.6 4.7 (18) Buy on Amazon
27 Nature Made Vitamin B12 500 mcg. Tablets Value Size 200 Ct - Nature Made 5.4 4.8 (12) Buy on Amazon
28 (3 Pack)-Nature Made Maximum Strength Vitamin B-12 Soft gel, Nature's Made 5.4 4.8 (12) Buy on Amazon
29 Nature Made Vitamin B12 1000 mcg Softgels Adventure Home 5.2 5.0 (3) Buy on Amazon
30 Nature Made Vitamin B12 Fast Dissolve Cherry Lozenges Adventure Home 5.1 5.0 (1) Buy on Amazon