Best Caplet Acetaminophen in 2026

100-count bottle of Tylenol PM Extra Strength Caplets Nighttime Pain Reliever & NonHabit Forming Sleep Aid to provide minor pain relief and help you fall asleep fast

Relieve nighttime pain and get the sleep you need with 25 mg diphenhydramine HCl and 500 mg acetaminophen per caplet. This nighttime sleep aid and pain relief medicine is non-habit forming when used as directed

Fall asleep fast and stay asleep and relieve minor pain with this nighttime sleep aid and pain relief medicine from the #1 doctor-recommended brand for pain relief and fever reduction

100-count (50-packets, 2 caplets each) of Tylenol Extra Strength Pain Relief Medicine Caplets with 500 mg of acetaminophen per caplet to provide temporary relief of minor aches and pains and reduce fever

Each extra strength caplet contains 500 mg of acetaminophen for effective, lasting pain relief, and has an excellent safety profile when used as directed. Tylenol won't raise blood pressure the way that Advil, Aleve or Motrin sometimes can*

Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual cramps and pain caused by the common cold

One bottle of 100 Excedrin PM Pain Reliever, Headache Relief and Nighttime Sleep-Aid Caplets

Pain reliever and nighttime sleeping aid that provides temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness

Caffeine-free diphenhydramine, aspirin and acetaminophen caplets are ideal for nighttime headache sufferers

For temporary relief of arthritis pain

8 hours patented time-release

One 250-count bottle of extra strength 650 mg arthritis pain caplets

✅ EXTRA STRENGTH RELIEF - Reach for GenCare extra strength Tension Headache Relief when suffering from mild to severe headaches, tension pain and muscle aches. Adults and children 12 and older take 2 caplets every 6 hours as needed with water.

✅ FULL BODY PAIN REMEDY - The potent combination of Acetaminophen (500mg) and Caffeine (65mg) isn't just for mild to severe headaches. It provides fast and effective relief for sore muscles, tooth aches, arthritis and joint pain.

✅ MENTAL FOCUS - Caffeine can help quickly restore energy levels and focus so you can get over the pain and back to being productive and at your best. This product contains as much caffeine as a cup of coffee so avoid taking this before bed or at night.

One bottle of 24 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms

Migraine medicine that delivers effective migraine headache pain relief

Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea

PAIN RELIEVER + NIGHTTIME SLEEP AID: Each Rite Aid caplet contains acetaminophen extra strength 500mg to relieve your pain quickly and effectively, plus it contains diphenhydramine HCI 25mg, a nighttime sleep aid for adults, so you can sleep at night.

NON-HABIT FORMING: Rite Aid PM pain reliever plus sleep aid is non-habit forming, so you can relieve pain, get the sleep you need, and wake up feeling refreshed. Compare Rite Aid Acetaminophen PM to the active ingredients in the leading national brand.

PAIN RELIEVER + FEVER REDUCER: Rite Aid Extra Strength Acetaminophen PM caplets reduce fevers temporarily while offering minor headache/migraine relief, menstrual pain relief, relief from muscular or body aches, and or joint pain relief.

Three boxes of 40 count Midol Complete Menstrual Pain Relief Caplets with Acetaminophen, Caffeine and Pyrilamine Maleate for Menstrual Symptom Relief

Contains acetaminophen for effective period pain relief while also providing backache, muscle ache and headache relief

Includes caffeine and pyrilamine maleate to relieve fatigue, bloating and water weight gain

PAIN & FEVER REDUCER: Rite Aid Acetaminophen tablets reduce fevers temporarily while offering minor headache relief, relief from muscular and body aches, often associated with arthritis and/or joint pain.

NO ASPRIN: Each tablet contains 650 mg of ache relieving, fever reducing acetaminophen without any aspirin. This aspirin-free arthritis relief, back relief, joint relief, and muscle relief medicine is formulated without aspirin.

EASY TO SWALLOW CAPLETS: Acetaminophen caplets’ shape make them easier to swallow. Rite Aid Acetaminophen’s easy-to-swallow caplet makes these menstrual relief, joint/muscle relief, and migraine relief pills ideal for use at home or on-the-go.

144-ct of Advil Dual Action Back Pain Caplets, 250mg Ibuprofen and 500mg Acetaminophen, Provide 8 Hours of Back Pain Relief

Pain relief pills fight back pain 2 ways; acetaminophen blocks pain signals and ibuprofen targets pain caused by inflammation

Each caplet contains acetaminophen and ibuprofen for back pain relief; back pain medication also provides headache, toothache, menstrual cramp, muscle pain and lower back pain relief

INCLUDES: One (1) 30-count bottle of Unisom PM Pain Nighttime Sleep-aid + Pain Reliever; one caplet per dose

MAKE THE NIGHT RESTFUL, NOT PAINFUL: Unisom PM Pain is one caplet with two solutions: nighttime sleep-aid combined with a leading pain reliever* *acetaminophen

NON-HABIT FORMING: Dual-action sleep-aid is safe if used as directed, non-habit forming and helps you sleep soundly

✅ ACTIVE INGREDIENT: The active ingredient in this product is Acetaminophen and Caffeine, it provides headache and pain relief. Compare Safrel All Day Allergy Relief to the active ingredient of Excedrin Extra Strength Headache Relief.

✅ COMPLETE AND FAST PAIN RELIEF – This extra-strength headache medicine also helps relieve other aches and pains, such as arthritis, muscles aches, toothaches, and menstrual cramps. Caffeine provides you energy and restore mental focus to keep you active during the day.

✅ HELPS WITH HEADACHE & OTHER ACHES/PAIN: Provides relief from Headaches, Toothaches, menstrual cramps, arthritis, joint pain and more in one easy to swallow caplet. Adults and children 12 years and older : take 2 caplets every 6 hours.

Multi-symptom relief: Maximum Strength Arthriten offers relief from minor arthritis pain, joint pain, muscle aches, and mobility discomfort. For pain relief that single ingredient formulas may not provide, experience the multi-symptom relief of Arthriten.

Dependable and long-lasting: Arthriten provides hour-after-hour of dependable pain relief from minor arthritis pain symptoms of joint pain, muscle aches & mobility pain. For dependable relief that lasts for up to six hours, choose Maximum Strength Arthriten.

Easy swallow caps: Maximum Strength Arthriten comes in coated speedcaps for an easy-to-swallow formula. Each 2-caplet dose contains 2 maximum strength pain relievers, plus an ingredient to help them work faster and better.

Temporarily relieves occasional headaches and minor aches and pains with 500 mg of acetaminophen per caplet

Temporarily provides relief for accompanying sleeplessness with 25 mg of diphenhydramine HCI per caplet

No artificial sweeteners or preservatives, artificial dyes, parabens, or common allergens

One box of 20 count Midol Long Lasting Relief Menstrual Pain Relief Caplets with Acetaminophen

Effective up to 8 hour pain relief of pain due to premenstrual and menstrual symptoms

With extended-release acetaminophen for back pain, muscle pain, headache relief and period pain relief