Best 30 To 49 Pounds Dog Flea Drops in 2026

Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 23-44 lbs.

Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.

Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.

K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice

Kills fleas within 12 hours of application

Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die

EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.

TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.

BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.

COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes four (4) monthly doses

ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses

STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application

FAST-ACTING FLEA TREATMENT: CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes

TACKLE FLEA INFESTATIONS FAST: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet

TREAT REINFESTATIONS FAST: If your pet gets reinfested with fleas, simply give another dose as often as once a day

NATURAL FLEA & TICK CONTROL: Flea Away is an all natural vitamin complex, made to FDA human standards and specifically formulated for dogs and cats, creating a safe barrier from fleas, ticks and mosquitos.

NO PESTICIDES: Flea Away repels fleas, ticks, & mosquitoes naturally, with no toxic chemicals or residue. Safe for both nursing mother and her litter.

ADDITIONAL BENEFITS: our Vitamin complex promotes healthier skin, reduces shedding, shinier coat, better joints and is Liver flavored. Your pet will love them!

Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age

Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment

Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days

KILLS FLEAS & TICKS AND REPELS MOSQUITOES: Kills fleas, flea eggs, flea larvae, deer ticks and brown dog ticks on contact and repels mosquitoes before they bite

PREVENT RE-INFESTATION: Long-lasting monthly topical flea treatment that prevents re-infestations for 1 month with dual Insect Growth Regulators (IGRs) that protect your pet and their environment

FAST ACTING FULL BODY PROTECTION: Safe yet powerful formula spreads across the skin using your dog's natural oil to quickly travel across the coat for full body protection from head to tail

KILLS FLEAS AT ALL LIFE STAGES: Breaks the flea life cycle by killing all stages of fleas: Eggs, Larvae, and Adults. This provides a well-rounded flea treatment for dogs.

SAME EFFECTIVENESS AS THE LEADING BRAND: The SAME amount of the SAME active ingredients delivering the SAME dog flea and tick control for a lot LESS!

WATERPROOF: ZoGuard Plus for Dogs is waterproof and will remain effective even after bathing, water immersion, or exposure to sunlight. It is a great dog flea and tick treatment option for even the most active dogs.

DOG FLEA AND TICK CONTROL: SENTRY Fiproguard topical flea and tick prevention for dogs kills fleas, ticks and chewing lice for up to 30 days.

VET QUALITY FORMULA: SENTRY Fiproguard is a vet-quality formula flea treatment that contains fipronil.

SMALL DOGS: Flea and tick control for use on dogs and puppies over 8 weeks of age, weighing 5-22 pounds; can be used on breeding, pregnant, and lactating dogs.

6 MONTHLY DOSES OF FLEA TREATMENT FOR DOGS: Each pack of TevraPet FirstAct Plus contains six (6) topical applicators of waterproof flea medicine for dogs that instantly begins to kill and control fleas and flea eggs, larvae, ticks, and chewing lice - and provides continuous protection for up to 30 days after each application

VET QUALITY FORMULA, EASY TO USE: FirstAct Plus uses Fipronil and (S)-methoprene - the same safe and effective active ingredients as Frontline Plus for Dogs. This powerful formula starts to kill fleas and ticks within 24 hours. Simply apply the applicator to the skin on the back of your dog’s neck and the formula will migrate through the skin providing whole-body protection

THE SAME ACTIVE INGREDIENTS AS FRONTLINE - FOR FAR LESS: It's worth repeating: Just like Frontline Plus, FirstAct Plus's powerful active ingredients REPEL and KILL fleas and ticks on contact and stop reinfestations. At TevraPet we firmly believe you shouldn't have to pay the "Brand tax" to protect your dog, and we are committed to providing affordable, veterinarian quality solutions without sacrificing an ounce of safety, effectiveness, or reliability

Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand

One 6 dose pack of Amazon Basics Flea, Tick & Mosquito Topical for Large Dogs (21-55 pounds)

Amazon Basics Flea, Tick & Mosquito starts eliminating fleas and ticks within 24 hours of treatment

FLEA WIPES FOR DOGS & CATS: Say goodbye to flea and tick infestations with our premium quality flea wipes, formulated for both dogs and cats; our wipes effectively kill fleas, flea larvae & eggs, and ticks, and also repel and kill mosquitoes

CERTIFIED NATURAL: Made with certified natural ingredients like peppermint oil and eugenol, our flea wipes for cats and dogs provide a natural and gentle solution to pest control that is free of harsh chemicals, making it safe for your pets

EASE OF USE: Our flea and tick wipes for dogs and cats provide for easy application, especially in sensitive areas like ears, paws, and face; the wipes are soft, yet sturdy, allowing for thorough cleansing and a refreshing scent

A Natural Flea + Tick Defense - These delicious hickory bacon flavored soft chews promote the body's natural response to ward off fleas, ticks and mites. These soft chews have been vet-reviewed and formulated by experts using natural ingredients like coconut oil, flaxseed, garlic and brewer's yeast (all within the safe limits for dogs) to provide safe defense for your dog!

Builds Daily + Long-Term Resistance When Given Every Day - 100% safe levels of natural ingredients like coconut oil, garlic, B vitamins and omegas help build up internal resistance to seasonal pests in your dog's body. These ingredients also have the added benefit of supporting your dog's skin, joint and immune health with omega-3's that help promote a healthy inflammatory response.

Easier + Less Mess Than Oils, Sprays and Collars - These soft chews have a delicious hickory bacon flavor that your dog will love.1-3 treats a day (depending on your dog's weight) will not only help provide additional protection against pests but will also help support joint, skin and immune health with the added omegas and vitamins. Please consult with your vet first before stopping any medication.

4X PROTECTION FOR ACTIVE DOGS: Topical formula destroys fleas, flea eggs, ticks, lice, and even mosquitos on contact

POWERFUL, LONG-LASTING PREVENTION: Prevent mosquito or tick bites and lice or flea infestations with a single application per month

THE OUTDOORSMAN’S CHOICE: Waterproof treatment drops offer protection through the harshest conditions of wind, sun, or even heavy rain

STARTS TO KILL FLEAS AND TICKS IN 5 MINUTES: Start your dog's flea and tick protection in just 5 minutes with NEXTSTAR flea and tick treatment for dogs, the fastest flea and tick topical on the market.

VET STRENGTH FORMULA: This flea and tick preventive formula is available without a prescription.

30-DAY PROTECTION: Easy-to-use topical application that kills fleas and ticks for 30 days. This flea and tick for dogs preventive offers long-lasting protection.

✅ FLEA & TICK PREVENTION: revolution flea & tick chewables treats provides daily protection and control for your dog, against fleas, ticks, eggs, larvae, mosquito.

✅ NATURAL & DELICIOUS & SAFE: the bio soft chews made with only natural and safe ingredients and it’s really tasty bacon flavor for dogs.

✅ BEST REPLACEMENT FOR COLLAR, DROPS, SPRAYS, SHAMPOO: Just give some chews your dog daily to protect from flee and ticks. RECOMMENDED SERVING PER DAY: up to 10 LB - single dose, 10-22lbs - 2 meds chews, 31-60 LB - 3 capsules, large 61-90 LB - 4 pill, 90 - 110 lbs - 5 tabs.

100% NATURAL - Advanllent flea and tick treatment supplement for dogs use Garlic Powder, Brewer's Yeast, VitaminB1 / B3 / B6 / B12, Apple Cider Vinegar as the main ingredient to protect your dog from fleas and ticks in a natural way. Meanwhile, add various fruits & vegetables mixture to provide additional nutrition needed.

3 IN 1 FUNCTIONAL - One soft chew has multi effects. Dog flea treatment, repel fleas, ticks and mosquitos, prevent flea infection, improve dog coat, and strengthen immune system. Advanllent dog flea & tick chews is your best choice.

GUIDANCE - This chemical free soft chews takes 30 days to start working. Choose the count of the chewables daily based on your dog's weight.

LONG-LASTING PROTECTION: Sergeant’s Guardian Topical is a flea and tick prevention for dogs that kills fleas and ticks plus repels moquitoes for up to 4 weeks.

AFFORDABLE FLEA & TICK TREATMENT: Sergeant’s Guardian Flea and Tick is an affordable way to protect your dog from fleas, ticks and mosquitoes.

QUICK-DRYING FORMULA: Sergeant's Guardian is quick drying flea and tick medication that is specially formulated for dogs over 12 weeks.