Best 80 To 89 Pounds Dog Flea Drops in 2026

Daisy
Last Updated: Jul 19, 2026

At a Glance: Our Top Picks for 80 To 89 Pounds Dog Flea Drops

FRONTLINE Plus for Dogs Flea and Tick Treatment (Medium Dog, 23-44 lbs.) 3 Doses (Blue Box)
#TOP1
Frontline Plus For Dogs Flea And Tick Treatment
9.9
PM SCORE
FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)
#TOP2
Frontline Plus For Dogs Flea And Tick Treatment
9.9
PM SCORE
K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply
#TOP3
K9 Advantix Ii Medium Dog Vet-Recommended Flea, Tick
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best 80 To 89 Pounds Dog Flea Drops of 2026

Frontline Plus For Dogs Flea And Tick Treatment (Medium Dog, 23-44 Lbs.) 3 Doses (Blue Box)

FRONTLINE
P004FLTSP-23-44
5.75 X 0.75 X 4.50 Inches
0.06 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Petco 9.92

Features

Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 23-44 lbs.

Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.

Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.

Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older

Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Frontline Plus For Dogs Flea And Tick Treatment (Large Dog, 45-88 Lbs.) 3 Doses (Purple Box)

FRONTLINE
P004FLTSP-45-88
5.75 X 0.75 X 4.50 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 45-88 lbs.

Break the flea life cycle with Frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.

Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.

Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older.

Lasting flea and tick protection: Frontline's long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

K9 Advantix Ii Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 Lbs. | 2-Mo Supply

K9 ADVANTIX
86314991
1.00 X 4.38 X 4.75 Inches
0.05 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Mustang sales 4.46

Features

K9 Advantix II Medium Dog 30-day treatment & prevention protects dogs 11-20 lbs. from fleas, ticks, mosquitoes, biting flies and lice

Kills fleas within 12 hours of application

Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die

Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours

No prescription needed

Frontline Plus For Dogs Flea And Tick Treatment (Small Dog, 5-22 Lbs.) 3 Doses (Orange Box)

FRONTLINE
P004FLTSP-0-22
5.75 X 0.75 X 4.50 Inches
0.01 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 5-22 lbs.

Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.

Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.

Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older

Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Tevrapet Activate Ii Flea And Tick Prevention For Dogs | 4 Months Supply | Extra Large Dogs 55+ Lbs | Fast Acting Treatment And Control | Topical Drops

TEVRAPET
3
1.50 X 4.80 X 7.60 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
TevraBrands 9.89

Features

COMPARE TO K9 ADVANTIX II II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes four (4) monthly doses

ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses

STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application

EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application

MADE IN AMERICA - QUALITY GUARANTEED: TevraPet Activate II is made to the exacting standards we demand for our own pets. We're proud to help you protect your dog with confidence

Capstar (Nitenpyram) Oral Flea Treatment For Dogs, Fast Acting Tablets Start Killing Fleas In 30 Minutes, Medium & Large Dogs (Over 25 Lbs), 6 Doses

CAPSTAR
CA4925Y07AMZ1
0.63 X 5.75 X 4.50 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

FAST-ACTING FLEA TREATMENT: One oral flea tablet starts killing fleas within 30 minutes.

TACKLE FLEA INFESTATIONS FAST: Give Capstar oral flea treatment and watch dead fleas fall off your pet.

TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas, simply give another dose as often as once a day.

WITHOUT A VET PRESCRIPTION: Flea treatment without needing a veterinarian prescription, administer this cat flea tablet orally to kill adult fleas fast.

KILL ADULT FLEAS: Capstar oral flea treatment tablets (57 mg) are safe for dogs and puppies from 25.1-125 lbs., four (4) weeks and older.

Tevrapet Activate Ii Flea And Tick Prevention For Dogs | Large Dogs 21-55 Lbs | Fast Acting Flea Drops | 8 Month Supply | Vet Quality Protection

TEVRAPET
60
1.50 X 4.30 X 6.70 Inches
0.15 pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 8 monthly doses

ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses

STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application

EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application

MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence

K9 Advantix Ii Xl Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 Lbs. | 4-Mo Supply

K9 ADVANTIX
710546040004
7.75 X 1.00 X 4.25 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice

Kills fleas within 12 hours of application

Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die

Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours

No prescription needed

K9 Advantix Ii Xl Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 Lbs. | 6-Mo Supply

K9 ADVANTIX
86315068
7.75 X 1.00 X 4.25 Inches
0.10 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Dynamic Duo Distribution 9.86

Features

K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice

Kills fleas within 12 hours of application

Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die

Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours

No prescription needed

K9 Advantix Ii Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 Lbs. | 6-Mo Supply

K9 ADVANTIX
86315092
7.75 X 1.00 X 4.25 Inches
0.10 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice

Kills fleas within 12 hours of application

Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die

Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours

No prescription needed

Top 10 dog flea drops 80 to 89 pounds Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
K9 Advantix 4
Frontline 3
Tevrapet 2
Capstar 1

Top 10 dog flea drops 80 to 89 pounds Brands Pie Chart


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