Best Tylenol Flu Medicine in 2026

Daisy
Last Updated: Jul 18, 2026

At a Glance: Our Top Picks for Tylenol Flu Medicine

Theraflu Multi-Symptom Severe Cold Medicine, Cold and Cough Medicine Powder Packets, Green Tea and Honey Lemon Flavors - 6 Packets
#TOP1
Theraflu Multi-Symptom Severe Cold Medicine, Cold And Cough
9.9
PM SCORE
Theraflu, Night Time Severe Cold and Cough Packets, 6 Count Packaging May Vary
#TOP2
Theraflu, Night Time Severe Cold And Cough Packets,
9.9
PM SCORE
Theraflu Combo Daytime and Nighttime Severe Cold Relief Honey Lemon Flavor Powder​ and Daytime Severe Cold Relief Berry Burst Flavor Powder, ​6 Daytime + 6 Nighttime, and 6 Berry Burst Powder Packets
#TOP3
Theraflu Combo Daytime And Nighttime Severe Cold Relief
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Tylenol Flu Medicine of 2026

Market Overview
Tylenol Flu Medicine Reviewed
  • Reviews Analyzed: 22950 Items
  • PM Avg. Rating: 8.1 / 10
18 Products Evaluated
  • Highest Price: $27.75
  • Lowest Price: $5.12
  • Avg. Price: $13.24

Theraflu Multi-Symptom Severe Cold Medicine, Cold And Cough Medicine Powder Packets, Green Tea And Honey Lemon Flavors - 6 Packets

THERAFLU
B0114LQN7C
1.78 X 3.13 X 4.94 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Divine Sales Direct 5.56

Features

Package contains 6 powder packets of Theraflu Multi-Symptom Severe Cold Medicine, Cold and Cough Medicine Powder Packets, Green Tea and Honey Lemon Flavors

Powerful relief from cold symptoms such as sore throat pain, headache, minor body aches and pains, nasal and sinus congestion, cough and fever

Theraflu powder dissolves quickly in hot water for cold, cough and sore throat relief that is as easy as making a cup of tea

Cough and cold medicine with delicious green tea infusions and honey lemon flavors

Each packet contains dextromethorphan HBr 20 mg, acetaminophen 500 mg and phenylephrine HCl 10 mg

Dissolve one Theraflu powder packet in 8 ounces of hot water for multi-symptom relief

Adults and children ages 12 and older take every four hours as needed for symptom relief

Theraflu, Night Time Severe Cold And Cough Packets, 6 Count Packaging May Vary

THERAFLU
79180602
1.78 X 3.13 X 4.94 Inches
0.18 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

6 packets of Theraflu Nighttime Severe Cold Relief Honey Lemon Flavor Powder

Powerful relief from severe cold, cough, and flu symptoms such as sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Hot liquid provides a soothing effect

Cold and cough medicine with delicious honey lemon, chamomile and white tea flavors

Can be taken every 4 hours, while symptoms persist. Do not take more than 5 packets in 24 hours unless directed by a doctor

Cold, flu, and cough relief powder for adults and children 12 years of age and over

Contains Acetaminophen 650 mg, Diphenhydramine HCl 25 mg, and Phenylephrine HCI 10 mg

HSA and FSA eligible product

Theraflu Combo Daytime And Nighttime Severe Cold Relief Honey Lemon Flavor Powder​ And Daytime Severe Cold Relief Berry Burst Flavor Powder, ​6 Daytime + 6 Nighttime, And 6 Berry Burst Powder Packets

THERAFLU
60000000133197
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

6 packets of Theraflu Daytime Honey Lemon Flavor Severe Cold Relief Powder and 6 packets of Nighttime Severe Cold Relief Honey Lemon Flavor Powder plus 6 packets of Theraflu Daytime Severe Cold Relief Berry Burst flavor Powder

Multi-symptom cold medicine that provides powerful relief from severe cold symptoms such as sore throat pain, headache, minor body aches and pains, nasal and sinus congestion, cough and fever

Theraflu cold relief packets dissolve quickly in hot water for cough medicine and flu relief that is as easy as making a cup of tea

Daytime cold and flu medicine features delicious flavors, great for stocking up on for cold and flu season

Theraflu daytime cold medicine provides symptom relief, while nighttime cold medicine helps you relieve symptoms so you can get a good night's sleep

Theraflu Combo Nighttime Severe Cold Relief Syrup, Berry Flavor, 8.3 Fl Oz And Theraflu Daytime Severe Cold Relief Powder, Honey Lemon Flavor, 6 Ct

THERAFLU
60000000133201
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Ramons Market 9.33

Features

Package contains one 8.3 fl oz bottle of Theraflu Nighttime Severe Symptom Cold Relief Syrup, Berry Flavor and six packets of Theraflu Daytime Severe Cold Relief Powder, Honey Lemon Flavor

Multi-symptom cold medicine that provides powerful relief from severe cold and flu symptoms such as sore throat pain, headache, minor body aches and pains, sinus congestion, severe cough and fever

Theraflu cold relief packets dissolve quickly in hot water for daytime cough medicine and flu relief that is as easy as making a cup of tea, great for stocking up on for cold and flu season

Theraflu cold and cough medicine provides a warming sensation for fast relief and is easy to take for on the go treatment

Cold and flu medicine packets have delicious green tea and honey lemon flavors, and Severe Cold Relief syrup has a pleasant berry flavor

Theraflu daytime cold medicine provides symptom relief, while nighttime cough medicine relieves symptoms to help you get a good night's sleep

Adults and children ages 12 and older take this flu remedy every four hours as needed for cold and flu symptom relief

Theraflu Expressmax Severe Cold And Flu Syrup With Included Dosing Cup, Berry Flavor - 8.3 Fl Oz Syrup

THERAFLU
I00104714
4.73 X 2.86 X 5.90 Inches
0.70 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One 8.3 fl oz bottle of Theraflu ExpressMax Severe Cold and Flu Syrup with Dosing Cup, Berry Flavor

Powerful cold and cough medicine that defeats all the worst cold and flu symptoms, including headache and body aches, cough, chest congestion, fever, sore throat pain and nasal congestion

This cough syrup for adults provides a unique warming sensation and delivers cough, cold and sore throat relief

Cold medicine for adults that features a berry flavor

Cold, cough and pain relief medicine that contains acetaminophen 650 mg, dextromethorphan HBr 20 mg, guaifenesin 400 mg and phenylephrine HCI 10 mg

Use the included dosing cup to take 30mL every four hours as needed for nasal congestion relief, headache relief, and cold and cough relief

Cough and cold medicine formulated for adults and children 12 years and older

HSA and FSA eligible product

Theraflu Expressmax Severe Cold And Cough Medicine, Daytime And Nighttime Cough And Cold Medicine For Cough Relief, Berry Flavor - 8.3 Fl Oz (Pack Of 2)

THERAFLU
300678125167
1.63 X 5.75 X 6.00 Inches
16.60 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Package contains one 8.3 fl oz bottle of Theraflu ExpressMax Severe Cold and Cough Daytime Cough and Cold Medicine, Berry Flavor and one 8.3 fl oz bottle of Theraflu ExpressMax Severe Cold and Cough Nighttime Cough and Cold Medicine, Berry Flavor

Delivers powerful pain relief, headache relief and nasal congestion relief, along with relief from sore throat, fever and cough

Daytime and nighttime cough syrup formulations provide a unique warming sensation and delivers fast cough, cold and sore throat relief

Both syrups come in a delicious berry flavor

Nighttime adult cough syrup and sore throat medicine also contains an antihistamine to relieve runny nose and sneezing

Both cold and cough syrups contain acetaminophen 650 mg and phenylephrine HCl 10 mg; daytime syrup also contains dextromethorphan HBr and nighttime contains Diphenhydramine HCI

Adults and children 12 years and older: take 30mL of either daytime or nighttime cold medicine every four hours as needed for cold and cough symptom relief

The nighttime syrup formula contains Acetaminophen 650 mg, Diphenhydramine HCl 25 mg, and Phenylephrine HCI 10 mg

Amazon Basic Care Severe Cold & Flu Relief Powder, Relieves Cough, Sore Throat Pain, Body Ache, Headache And Fever, Green Tea & Honey Lemon Flavors, 6 Count

AMAZON BASIC CARE
03282830
1.81 X 3.13 X 5.00 Inches
0.23 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

ACTIVE INGREDIENTS: This product contains acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant) and phenylephrine HCl (nasal decongestant) which compare to the active ingredients in Theraflu Multi-Symptom Severe Cold.

HOT LIQUID COLD AND FLU RELIEF: Each packet dissolves in hot water and provides daytime cold and flu relief from common symptoms such as nasal and sinus congestion, sore throat pain, cough, headache, body ache and fever.

NON-DROWSY: When used as directed, this hot liquid cold and flu relief is a non-drowsy solution for cold symptoms such as nasal and sinus congestion, sore throat pain, cough, headache, body ache and fever.

JUST ADD WATER: Add Severe Cold & Flu Relief powder to hot water for cold and flu hot liquid therapy that provides fast relief of nasal and sinus congestion, sore throat, headache, body aches, fever and cough.

An Amazon brand

Amazon Basic Care Nighttime Severe Cold, Flu And Cough Suppressant Medicine Powder, Pain Reliever/Fever Reducer, Nasal Decongestant, Antihistamine, Honey Lemon Infused With White Tea Flavors, 6 Count

AMAZON BASIC CARE
0615424
1.81 X 3.13 X 5.00 Inches
0.20 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING

Features

ACTIVE INGREDIENTS: The active ingredients in Severe Cold, Flu and Cough are acetaminophen 650 mg, pain reliever/fever reducer; diphenhydramine HCl 25 mg, antihistamine/cough suppressant; phenylephrine HCl 10 mg, nasal decongestant which compares to Theraflu Severe Cold and Cough active ingredients.

FAST RELIEF: Severe Cold, Flu and Cough offers hot liquid therapy for fast relief of nasal and sinus congestion, cough, runny nose, sneezing, body ache, sore throat pain, headache and fever.

CONVENIENT PACKETS: Dissolve powder into 8 oz. of hot water and sip while hot for nighttime cold and flu relief. Take every four hours while symptoms persist.

COMFORTING WARMTH WITH GREAT TASTE: This flu medicine relieves pain with soothing honey lemon infused with white tea flavors.

ALCOHOL-FREE COLD AND FLU POWDER: This product contains no alcohol or gluten.

Theraflu Powder For Daytime Severe Cold And Cough, Berry Infused With Menthol (6 Packets)

THERAFLU
625706
0.13 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Wisermerchant 9.67

Features

This powerful cold medicine helps fight the nasal congestion, cough, body aches, sore throat pain, sinus congestion, headache and fever.

Theraflu Max Strength Daytime Flu Symptom Relief, Honey And Elderberry Syrup, 8.3 Fl Oz And Nighttime Flu Symptom Relief, Honey Lemon - 6 Count

THERAFLU
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

One 8.3 fl oz bottle of Theraflu Max Strength (1) Daytime Flu Symptom Relief, Honey and Elderberry Flavored Syrup plus 6 powder packets of Theraflu Max Strength (1) Nighttime Flu Symptom Relief

Powerful relief from flu symptoms such as sore throat pain, headache, body aches and pains, cough and fever

Theraflu flu symptom relief syrup is easy to take

Each dose of daytime syrup contains acetaminophen 1,000 mg and dextromethorphan HBr 30 mg

Each nighttime packet contains acetaminophen 1,000 mg, dextromethorphan HBr 30 mg and chlorpheniramine maleate 4 mg

Adults and children ages 12 and older take this flu symptom relief liquid every six hours as needed for symptom relief. Do not take more than 3 doses in 24 hours unless directed by a doctor

Theraflu Max Strength Flu Symptom Relief - 20 Caplets Plus Max Strength Nighttime Flu Medicine For Flu Symptom Relief- 20 Caplets Combo Pack

THERAFLU
60000000129818
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

20 count of Theraflu Max Strength (1) Flu Symptom Relief Caplets plus 20 count of Theraflu Max Strength (1) Nighttime Flu Medicine for Flu Symptom Relief Caplets

Theraflu flu symptom relief for daytime provides powerful relief from flu symptoms such as sore throat pain, headache, body aches and pains, cough and fever

Nighttime provides powerful relief from flu symptoms such as sore throat pain, headache, body aches and pains, cough and also provides relief from runny nose

Pain relief, antihistamine and cough suppressant for adults in convenient and easy to take caplets

Each dose contains acetaminophen 1,000 mg, dextromethorphan HBr 30 mg and nighttime also has chlorpheniramine maleate 4 mg

Adults and children ages 12 and older take every six hours as needed for symptom relief

Do not take both products simultaneously

Theraflu Multi Symptom Severe Cold Packets, Green Tea And Honey Lemon - 6 Ea

THERAFLU
DG6
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Focus Health 9.90

Features

ACETAMINOPHEN PAIN RELIEVER FEVER REDUCER

COUGH SUPRESSANT, NASAL DECONGESTANT

COUGH, HEADACHE, BODY ACHES, FEVER

SORE THROAT PAIN

GREEN TEA & HONEY LEMON FLAVORS

Theraflu Expressmax Syrup For Nighttime Severe Cold And Cough, Berry Cough Syrup, 8.3 (Pack Of 2)

THERAFLU
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Gefen Trading Company 9.56

Features

Theraflu ExpressMax Nighttime Severe Cold and Cough Syrup medicine

Powerful relief from severe cold and cough symptoms such as sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Specially formulated cold and cough syrup provides a warming sensation and relief from cold and flu symptoms

Powerful daytime cold medicine in a berry flavored syrup

30 mL can be taken every 4 hours using the enclosed dosing cup, while symptoms persist. Do not take more than 5 doses (150 mL) in 24 hours unless directed by a doctor

Theraflu Day Time Cough C Size 6Ct Theraflu Day Time Cough Cold 6Ct

THERAFLU
B011845D30
5.15 X 3.20 X 1.90 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Theraflu Daytime Severe Cold and Cough Hot Liquid Powder medicine

Powerful relief from severe cold and flu symptoms such as fever, sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Hot liquid provides a soothing effect

Cold and cough medicine with berry, menthol, and green tea flavors

Can be taken every 4 hours, while symptoms persist. Do not take more than 5 packets in 24 hours unless directed by a doctor

Cold, flu, and cough relief powder for adults and children 12 years of age and over

Contains Acetaminophen 650 mg, Dextromethorphan HBr 20 mg, and Phenylephrine HCI 10 mg

HSA and FSA eligible product

Product Of Theraflu, Daytime Severe Cold & Cough, Count 1 - Medicine Cold/Sinus/Allergy/ Grab Varieties & Flavors

PRODUCT OF THERAFLU
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Big & Cheap Wholesale 9.77

Features

Product Of Theraflu, Daytime Severe Cold & Cough, Count 1 - Medicine Cold/Sinus/Allergy/ Grab All Varieties

Theraflu Max Strength Daytime Flu Medicine For Flu Symptom Relief With Acetaminophen And Dextromethorphan Hbr, Honey And Elderberry Flavored - 8.3 Fl Oz Syrup

THERAFLU
60000000129819
0.52 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
ISKOLIVE 12 INC 9.86

Features

One 8.3 fl oz bottle of Theraflu Max Strength (1) Daytime Flu Medicine for Flu Symptom Relief with Acetaminophen and Dextromethorphan HBr, Honey and Elderberry Flavored Syrup

Powerful relief from flu symptoms such as sore throat pain, headache, body aches and pains, cough and fever

Theraflu flu symptom relief syrup is easy to take

Pain relief and cough suppressant for adults in delicious honey and elderberry flavored syrup

Each dose contains acetaminophen 1,000 mg and dextromethorphan HBr 30 mg

Adults and children ages 12 and older take every six hours as needed for symptom relief

Theraflu Max Strength Daytime Flu Symptom Relief - 6 Ct Plus Max Strength Nighttime Flu Medicine For Flu Symptom Relief - 6 Ct Combo

THERAFLU
60000000132813
0.43 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
The Happy Box LV 4.55

Features

Contains one package of 6 powder packets of Theraflu Max Strength (1) Daytime Flu Medicine for Flu Symptom Relief and one package of 6 powder packets of Theraflu Max Strength (1) Nighttime Flu Medicine for Flu Symptom Relief

Max-strength (1) fever fighting formula for long lasting relief

Theraflu powders dissolve quickly in hot water for flu symptom relief

Each powder delivers pain relief and a cough suppressant for adults in delicious honey lemon flavor

Each packet of daytime medicine contains acetaminophen 1,000 mg and dextromethorphan HBr 30, and each packet of nighttime medicine contains acetaminophen 1,000 mg, dextromethorphan HBr 30 mg and chlorpheniramine maleate 4 mg

Dissolve one Theraflu powder packet in 8 ounces of hot water for multi-symptom relief

Adults and children ages 12 and older take every six hours as needed for symptom relief, do not take both products at the same time; Do not take more than 3 packets in 24 hours unless directed by a doctor

Theraflu Expressmax Daytime For Relief From Severe Cold And Cough, Berry Flavor Syrup, 8.3 Ounce Bottle (Pack Of 2)

THERAFLU
300678127086
1.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

The below information is per pack only

Theraflu ExpressMax Daytime Severe Cold and Cough Syrup medicine

Powerful relief from severe cold and cough symptoms such as sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Specially formulated cold and cough syrup provides a warming sensation and relief from cold and flu symptoms

Powerful daytime cold medicine in a berry flavored syrup

30 mL can be taken every 4 hours using the enclosed dosing cup, while symptoms persist. Do not take more than 5 doses (150 mL) in 24 hours unless directed by a doctor

Top 10 flu medicine Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Theraflu 15
Amazon Basic Care 2
Product Of Theraflu 1

Top 10 flu medicine Brands Pie Chart


We've carried out a comprehensive analysis of 22,950 reviews on flu medicine, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select flu medicine priced around $13.24, with top brands including vicks, mucinex, valumeds, boiron, tylenol, amazon basic care, alka-seltzer plus, tukol and frida baby and sinus plumber

Our team of expert editors reviewed these high-quality items and handpicked the top 18 flu medicine for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, stam sales, valumeds, greensations products, genexa, babyluck and rite aid, inc. and divine sales direct .

We are dedicated to assisting our users in finding the right medicine Products based on their needs, saving them considerable time when choosing which flu medicine to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.