Best Acetaminophen Cold Medicine in 2026

ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks DayQuil Cold & Flu and Vicks NyQuil Cold & Flu

NON-DROWSY DAYTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, nasal congestion, cough, and minor aches and pains

NIGHTTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, sneezing, runny nose, cough, and minor aches and pains

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies

Pain reliever and nasal decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure

Each sinus relief caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever as well as 5 mg of phenylephrine HCl, a nasal decongestant to help clear nasal passages

24-count box of Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant Tablets provide powerful relief of sinus pain, sinus pressure, nasal congestion and headaches

Each caplet contains 5 milligrams of the decongestant phenylephrine HCl and 325 milligrams of acetaminophen, a pain reliever and fever reducer

This sinus congestion & pain medicine also temporarily relieves nasal congestion associated with hay fever, upper respiratory allergies and the common cold

4-fluid ounces of Children's Tylenol Oral Suspension Liquid Medicine with grape flavor to temporarily relieve kids' cold & flu symptoms, including cough, headache and fever

This multi-symptom relief medicine for kids also helps relieve minor aches and pains, sore throat, stuffy or runny nose, sneezing and congestion

Each 5mL contains 160 mg of acetaminophen pain reliever and fever reducer, 5 mg of dextromethorphan HBr cough suppressant, 2.5 mg of phenylephrine HCl decongestant and 1 mg of the antihistamine chlorpheniramine maleate

ALKA-SELTZER PLUS Severe Cold Sparkling Original POWERFAST Fizz EFFERVESCENT Cold Tablets provide fast relief from cold symptoms

Our severe cold, cough formula provides fizzy fast relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, headache, fever, sore throat and body aches & pains.

Provides severe cold relief from congestion, coughing, and sore throat

24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

The #1 brand that gives powerful cold symptom relief without raising your blood pressure

Provides fast, powerful cold relief for people with high blood pressure

Relieves cough, runny nose, and sneezing

Package contains 6 powder packets of Theraflu Multi-Symptom Severe Cold Medicine, Cold and Cough Medicine Powder Packets, Green Tea and Honey Lemon Flavors

Powerful relief from cold symptoms such as sore throat pain, headache, minor body aches and pains, nasal and sinus congestion, cough and fever

Theraflu powder dissolves quickly in hot water for cold, cough and sore throat relief that is as easy as making a cup of tea

POWERFUL MULTI-SYMPTOM RELIEF: This combo pack of Maximum Strength Mucinex Fast-Max DM Max and Nightshift Cold and Flu provides powerful multi-symptom relief for your worst symptoms

CHEST CONGESTION and COUGH SYMPTOM RELIEF: Maximum Strength Mucinex Fast-Max DM MAX relieves Chest Congestion, Controls Cough and Thins and Loosens Mucus

COLD and FLU SYMPTOM NIGHT RELIEF: Mucinex Nightshift Cold and Flu reduces Fever, relieves Headache, Minor Aches and Pains, Sore Throat, Coughing, Sneezing, Runny Nose for a better morning

MUCINEX FAST-MAX: Maximum strength multi-symptom relief medicine; 1 dose treats 9 symptoms - get back to what’s important thanks to the fast, powerful relief of Mucinex

DAY TIME SYMPTOMS TREATED: Maximum strength day time cold and flu non-drowsy liquid relieves cough, chest, nasal & sinus congestion that can cause mucus buildup, sinus pressure, fever, body pain & headache and sore throat

NIGHT TIME SYMPTOMS TREATED: Maximum strength night time cold and flu liquid relieves cough, nasal congestion that leads to stuffy nose, fever, body pain & headache, sneezing, runny nose and sore & itchy throat

6 packets of Theraflu Nighttime Severe Cold Relief Honey Lemon Flavor Powder

Powerful relief from severe cold, cough, and flu symptoms such as sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Hot liquid provides a soothing effect

NON-DROWSY, DAYTIME RELIEF. DayQuil Cold & Flu LiquiCaps help you get your power back so you can enjoy the day

POWERFUL 6-SYMPTOM RELIEF. Temporarily relieves common cold & flu symptoms, including nasal congestion, cough due to minor throat and bronchial irritation, sore throat, headache, minor aches & pains, and fever

#1 PHARMACIST RECOMMENDED over-the-counter cold & cough medicine from Vicks, the world’s #1 selling cough & cold brand

Helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion

Thins & loosens mucus with active ingredient guaifenesin expectorant

Relieves headache pain with active ingredient acetaminophen pain relievers and fever reducers

NIGHTTIME RELIEF FOR A BETTER MORNING: Get Powerful Nighttime Cold & Flu Multi-Symptom Relief with Maximum Strength Mucinex NightShift Cold & Flu fast release caplets. Relieves Headache, Body Pain, Cough, Sneezing, Runny Nose, and Reduces Fever so you can get to sleep.

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust*

ACTIVE INGREDIENTS PER CAPLET: Contains Acetaminophen (325 mg) - Pain reliever and Fever reducer; Dextromethorphan HBr (10 mg) - Cough Suppressant; Triprolidine HCI (1.25 mg) - Antihistamine.

Fifty packets of 1 coated tablet of Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate

Powerful Ibuprofen 200mg, chlorpheniramine maleate 4mg and phenylephrine HCL 10 mg tablets for multi-symptom relief

Uniquely formulated to fight common cold and flu symptoms, providing nasal congestion, nasal swelling, sneezing, sinus pressure, headache, fever, body aches and runny nose relief

RELIEF OF COMMON COLD: Naturally relieves the symptoms of the common cold including nasal and chest congestion, runny nose, sore throat, sneezing and cough in children ages 2-12.

EASY TO TAKE: Natural syrup to relieve nasal congestion, runny nose, sore throat, sneezing and cough.

4 FL OZ= UP TO 23 DOSES of Hyland's 4 Kids Cold 'n Cough syrup.

MAXIMUM STRENGTH MUCINEX SINUS-MAX (DAY) PRESSURE, PAIN and COUGH and NIGHTSHIFT (NIGHT) SINUS: Fast Release, Powerful Multi-Symptom Relief medicine. Get back to what’s important thanks to the fast, powerful medicine

DAY TIME MULTI-SYMPTOM RELIEF: Maximum Strength Mucinex Sinus-Max Day Pressure, Pain and Cough Caplets help to relieve pain, sinus pressure and congestion, headaches, controls cough and thins and loosens mucus

NIGHT TIME MULTI-SYMPTOM RELIEF: Maximum Strength Mucinex Nightshift (Night) Sinus Caplets help to relieve pain, cough, reduce fever, sore throat, runny nose, sneezing and nasal congestion. Nighttime relief for a better morning.

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.

#1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*

PAIN RELIEVER: Contains Acetaminophen which relieves minor aches, pains and headache

MULTI-SYMPTOM DAY TIME COLD RELIEF : Helps control cough, relieves stuffy nose, chest congestion and thins and loosens mucus

MULTI-SYMPTOM NIGHT TIME COLD RELIEF: Helps to reduce fever, control cough, relieves stuffy nose, runny nose, sneezing and sore throat

#1 PEDIATRICIAN RECOMMENDED: Mucinex Children’s is the #1 Pediatrician Recommended Brand among Non-Homeopathic Children’s Cough / Cold OTC products

One 8.3 fl oz bottle of Theraflu ExpressMax Severe Cold and Flu Syrup with Dosing Cup, Berry Flavor

Powerful cold and cough medicine that defeats all the worst cold and flu symptoms, including headache and body aches, cough, chest congestion, fever, sore throat pain and nasal congestion

This cough syrup for adults provides a unique warming sensation and delivers cough, cold and sore throat relief

25% smaller pill: Alka-Seltzer Plus Maximum Strength cold & Flu Powermax gels have a concentrated formula to provide powerful fast relief

Maximum strength day time and night time relief from your worst cold & Flu symptoms

Day time multi-symptom relief of nasal congestion, cough, headache, body ache, sore throat, Sinus pressure and fever. Night time multi-symptom relief of runny nose, nasal congestion, cough, headache, body ache, sore throat and fever.

Coldcalm Tablets address symptoms at every stage of a cold. It temporarily relieves symptoms such as sneezing, runny nose, nasal congestion and minor sore throat.

Coldcalm Tablets do not cause drowsiness and it has no known interactions with other medications.

Recommended for everyone ages 3 and up, and is available in a box of 60 quick-dissolving tablets.

MAX STRENGTH: Maximum Strength, Multi-Symptom Cold + Flu Relief

28 CAPLETS: 16 Non-Drowsy Relief Day Caplets, 12 Restful Relief Night Caplets

SYMPTOM RELIEF: Both Day & Night caplets provide symptom relief for Nasal Congestion, Sinus Pressure, Sore Throat, Head & Minor Body Aches, Fever, while Night caplets provide additional symptom relief for Runny Nose & Sneezing

Relieve Cold & Flu Symptoms: For use as a cough suppressant, pain reliever, and nasal decongestant. Our daytime cold and flu medicine combats the toughest colds, fast!

Power Through the Day: This cough medicine is a non-drowsy cold and sinus formula that allows you to stay focused and alert while on the go at home, work, or school.

Relieve Joint & Muscle Aches: Extra strength acetaminophen in our formula helps reduce fevers, aches and pains, for adults experiencing even the most severe cold and cough symptoms.

BC Powder Sinus Pain & Congestion temporarily relieves sinus pain and congestion and is a fever reducer for colds and allergy symptoms including runny nose, sneezing, and minor aches

The speed of powder formula works fast to relieve sinus headaches and congestion that can accompany allergies, a cold, or the flu

Sinus pain relief powder that dissolves faster than pills and contains Acetaminophen, 650 mg, Chlorpheniramine Maleate (Antihistamine), 4 mg, Phenylephrine Hydrochloride (Nasal Decongestant), 10 mg

RELIEF OF MUCUS & CONGESTION: Natural relief of symptoms of colds, including accumulation of mucus in chest, throat and nose: cough with expectoration of thick, discolored mucus; runny nose, sneezing and nasal congestion. Safe for ages 2-12

EASY TO TAKE: Natural syrup to ease mucus & congestion, runny nose and cough

4 FL OZ= UP TO 23 DOSES of Hyland's 4 Kids Cold 'n Mucus

EFFECTIVE: Compare GoodSense Nighttime Cold and Flu Relief Liquid to the active ingredients of NyQuil Cold & Flu. The active ingredients of this cold and flu relief liquid are Acetaminophen 650 mg, Dextromethorphan HBr 30 mg, and Doxylamine succinate 12.5 mg. They all combine to create an effective cold and flu medicine

COLD AND FLU MEDICINE: GoodSense Nighttime Cold and Flu Relief provides multi-symptom relief by helping with common symptoms such as aches, fever, cough, sneezing and runny nose

NIGHTTIME COLD AND FLU RELIEF: GoodSense Nighttime Cold and Flu Relief provides through the night cold care. This cold remedy relieves cold and flu symptoms so you can rest. Does not contain Pseudoephedrine; contains 10% Alcohol.

One 4 fl oz bottle of Robitussin Maximum Strength Severe Nighttime Multi-Symptom Cough, Cold and Flu Medicine, Nighttime CF Max, Raspberry Flavor

Robitussin multi symptom nighttime cold medicine provides multi symptom relief and acts as a nasal decongestant

Quick and easy-to-use liquid cough suppressant formula contains no dextromethorphan and has acetaminophen, a fever reducer and pain reliever. Health Concern: Cold Flu Cough

Temporarily relieves cold symptoms: Cough due to minor throat and bronchial irritation; sneezing; runny nose

Without alcohol, aspirin, or acetaminophen—so your child can rest, and you can relax

For children 6 years and older

MULTI-SYMPTOM RELIEF: Rite Aid Sinus Congestion & Pain Relief relieves headache, nasal congestion, sinus congestion, and sinus pressure. Compare Rite Aid’s Daytime rapid release gelcaps to the active ingredients in Tylenol Sinus + Headache Day.

DAYTIME NON-DROWSY FORMULA: With Rite Aid allergy and cold medicine for adults, you’ll feel relief from symptoms associated with hay fever or other respiratory allergies, and the common cold— formulated without ingredients that may cause drowsiness.

FEVER, PAIN RELIEVER + NASAL DECONGESTANT: The Acetaminophen 325 mg & Phenylephrine HCI 5 mg in each gelcap temporarily relieves minor aches and pains, headache, sore throat and fever. While our nasal decongestant reduces sinus congestion and pressure.