Best Alka-Seltzer Plus in 2026

ALKA-SELTZER PLUS Severe Cold Sparkling Original POWERFAST Fizz EFFERVESCENT Cold Tablets provide fast relief from cold symptoms

Our severe cold, cough formula provides fizzy fast relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, headache, fever, sore throat and body aches & pains.

Provides severe cold relief from congestion, coughing, and sore throat

Our fantastic formula made even better: improved flavor, less sodium, & aspartame free

Our severe Cold night formula provides unbeatably liquid fast relief of headache, sore throat, cough, nasal congestion, sinus pressure & Congestion, runny nose, sneezing, Aches & pains and fever.

Quickly dissolves in water and instantly ready to start working so you can get back to your busy life.

Our fantastic formula made even better: improved flavor, less sodium, & aspartame free

Our severe Cold & Flu medicine formula provides unbeatably fast relief of headache, sore throat, cough, nasal & sinus congestion, runny nose, sneezing, aches & pains and fever.

#1 Cold & Flu effervescent Brand

Provides temporary relief from nasal congestion, sneezing, runny nose, sore throat, fever, headache & body ache, and sinus pressure

Comes in Effervescent form

Sparkling Original flavor

Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.

Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.

ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.

25% smaller than original liquid gel: Alka seltzer plus cold maximum strength cough, mucus & Congestion Powermax gels have a concentrated formula to provide powerful fast relief

Provides powerful maximum multi-symptom relief from nasal congestion, cough, headache, chest congestion, body ache, sore throat, Sinus pressure & Congestion and fever

Fast cold relief so you can get back to your busy life

25% smaller pill: Alka-Seltzer Plus Maximum Strength cold & Flu Powermax gels have a concentrated formula to provide powerful fast relief

Maximum strength day time and night time relief from your worst cold & Flu symptoms

Day time multi-symptom relief of nasal congestion, cough, headache, body ache, sore throat, Sinus pressure and fever. Night time multi-symptom relief of runny nose, nasal congestion, cough, headache, body ache, sore throat and fever.

New 25% smaller pill: Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain relieving Powermax gels have a concentrated formula to provide powerful fast relief

Take BACK your day with fast, effective cold and sinus medicine in one

Powerful relief of your worst sinus & cold symptoms that won't make you drowsy so you can get back to your busy life

New 25% smaller pill: Alka-Seltzer Plus Maximum Strength sinus & cold Powermax gels have a concentrated formula to provide powerful fast relief

Take BACK your day with fast, effective cold and sinus medicine in one

Powerful relief, day or night, from your worst sinus & cold symptoms

Our fantastic formula made even better: Improved flavor, less sodium and aspartame free

Our severe Cold and Flu formula provides unbeatably liquid fast relief of headache, sore throat, cough, nasal and sinus congestion, runny nose, sneezing, Aches, pains and fever.

Quickly dissolves in water and instantly ready to start working so you can get back to your busy life.

ALKA-SELTZER PLUS Severe Non-Drowsy Cold & Cough PowerFast Fizz Effervescent Tablets is a cold remedy for adults, with less sodium, improved flavor, and aspartame free.

Our severe Cold & Cough formula provides unbeatably liquid fast cold relief of headache, sore throat, cough, nasal & sinus congestion, runny nose, sneezing, aches, pains, fever and other severe cold symptoms.

Also acting as a cough suppressor and dry cough medicine, the non-drowsy formula allows individuals to stay alert and productive while battling cold symptoms.

NEW 25 percent smaller pill: Alka Seltzer Plus Maximum Strength Cold & Flu PowerMax Gels have a concentrated formula in a smaller liquid gel so it's easier to swallow

Provides up to 4 hours of relief: one dose provides 4 hour day time relief of cough, nasal congestion, headache & body ache, sore throat, and sinus pressure

Alka Seltzer Plus Maximum Strength Cold & Flu PowerMax Gels contain a pain reliever, fever reducer, cough suppressant, and nasal decongestant

Our fantastic formula made even better: improved flavor, less sodium, and aspartame free

Our severe Cold and Cough medicine formula provides unbeatably liquid fast relief of headache, sore throat, cough, nasal and sinus congestion, runny nose, sneezing, aches and pains and fever

Quickly dissolves in water and instantly ready to start working so you can get back to your busy life

ALKA-SELTZER PLUS Severe, Cold, PowerFast Fizz, Zest Effervescent Tablets are designed for adults who have multiple common cold symptoms, including headaches, sore throat, sinus congestion, runny nose, sneezing, fever, body aches, and pains.

Our severe cold, orange zest, pain reliever formula provides unbeatably liquid fast relief of headache, sore throat, nasal & sinus congestion, runny nose, sneezing, and fever

Alka Seltzer Plus quickly dissolves in water and instantly ready to start working so you can get back to your busy life.

6 day formula packets

6 night formula packets

Honey lemon flavor

Pain reliever formula that provides relief at night so that you can enjoy a good night sleep

Effective treatment for nasal and sinus congestion

Cough suppressant properties that contain Acetaminophen

Alka-Seltzer plus severe cold powder is a cold medicine

Day time formula

Honey lemon flavor

1. Provides temporary daytime relief from nasal congestion, cough, headache & body ache, sore throat, sinus pressure, and fever

2. Provides temporary nighttime relief from runny nose, nasal congestion, cough, headache & body ache, sore throat, and fever

3. Daytime and nighttime medication in one convenient package

Our fantastic formula made even better: improved flavor, less sodium, & aspartame free

Our severe non-drowsy formula provides unbeatably liquid fast relief of sore throat, cough, nasal & sinus congestion, headache, Aches & pains and fever.

Quickly dissolves in water and instantly ready to start working so you can get back to your busy life.

Fast relief of fever + body ache, cough, headache, runny nose and sore throat

Contains: acetaminophen (pain reliever / fever reducer), Chlorpheniramine maleate (antihistamine) and dextromethorphan Hydrobromide (cough suppressant)

Temporarily reduces fever

Relief

Alka-Seltzer plus day/night cold and flu liquid gels 20ct is a combo pack with both multi-symptom cold and flu formula for day and night

12 multi-symptom cold and flu day liquid gels

8 multi-symptom cold and flu night liquid gels20 liquid gels

ALKA-SELTZER PLUS Severe Cold Day Night Medicine is a powerful cold and flu medicine designed specifically for adults and children 12 years and older.

Our Severe Day and Night cold and flu medicine provides fizzy fast daytime relief of nasal & sinus congestion, cough, headache, fever, sore throat and body aches & pains. Provides nighttime cold relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, cough, headache, fever, sore throat and body aches & pains.

This cold and flu medicine for adults and children 12 years and older quickly dissolves in water and instantly ready to start working so you can get back to your busy life

PROTECT YOUR HEART: Bayer Aspirin helps prevent another heart attack or clot-related (ischemic) stroke when taken as directed by your doctor

HEART HEALTH: Bayer Aspirin reduces the chance of a second heart attack by 31%

LOW DOSE ASPIRIN: Made especially for adults whose doctors recommend a low dose aspirin regimen

HOMEOPATHIC FLU RELIEF: Oscillococcinum works with your body to help temporarily relieve fatigue, headache, body aches, chills & fever. Safe for ages 2 & up, take at the first sign of flu-like symptoms.

HOLISTIC SUPPORT: Looking for homeopathic flu relief for the whole family? Oscillococcinum's sweet-tasting pellets dissolve quickly & easily under the tongue; no water, chewing, or swallowing required.

SHORTEN YOUR SYMPTOMS: Oscillo has been shown in clinical studies to help reduce both the duration & the severity of flu-like symptoms when taken at the onset. Non-drowsy, easy-to-take relief!

MAXIMUM STRENGTH MUCINEX CHEST CONGESTION MEDICINE: Clinically proven to last up to 12 hours and provide relief for your severe chest congestion and make cough more productive congestion

POWERFUL SYMPTOM RELIEF: Maximum Strength Mucinex 12 hour relieves chest congestion and thins and loosens mucus

BI-LAYER TABLET: A unique bi-layer tablet, one layer for immediate release and one layer for extended release so the medicine starts to release right away and last for up to 12 hours

HOMEOPATHIC FLU RELIEF: Oscillococcinum works with your body to help temporarily relieve fatigue, headache, body aches, chills & fever. Safe for ages 2 & up, take at the first sign of flu-like symptoms.

HOLISTIC SUPPORT: Looking for homeopathic flu relief for the whole family? Oscillococcinum's sweet-tasting pellets dissolve quickly & easily under the tongue; no water, chewing, or swallowing required.

SHORTEN YOUR SYMPTOMS: Oscillo has been shown in clinical studies to help reduce both the duration & the severity of flu-like symptoms when taken at the onset. Non-drowsy, easy-to-take relief!

100-count bottle of Motrin IB 200mg ibuprofen tablets helps provide effective relief from minor aches and pains, to help you take control of your pain.

Motrin IB tablets help temporarily reduce fever and offer pain relief due to the common cold, flu, minor pain of arthritis, headache, backache, toothache and menstrual cramps

Each Motrin IB tablet contains 200 milligrams of ibuprofen to help stop pain at its source and provide powerful relief when it counts

ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg's active ingredient is acetaminophen 500 mg. Compare to the active ingredient of Extra Strength Tylenol Caplets.

PAIN RELIEVER AND FEVER REDUCER: Temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps Also temporarily reduces fever

EASY TO SWALLOW: Count on these easy-to-swallow caplets for fast-acting headache and fever relief. Amazon Basic Care Extra Strength Acetaminophen Caplets 500 mg may be used as a pain reliever and fever reducer for adults and children 12 years and over.

225-count of Tylenol Extra Strength Caplets with 500mg of acetaminophen to provide temporary relief of minor aches and pains and help reduce fever

Each extra strength caplet contains 500 mg of acetaminophen for effective, lasting pain relief, and has an excellent safety profile when used as directed

Use as a fever reducer and to help provide relief of common pain symptoms including headache, backache, toothache, menstrual cramps and pain caused by the common cold