Best Headache Flu Medicine in 2025

ACTIVE INGREDIENTS: This cold and flu medicine contains acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant) and phenylephrine HCl (nasal decongestant) which compare to the active ingredients in Vicks DayQuil Cold and Flu

MULTI-SYMPTOM RELIEF: Temporarily relieves headache, fever, sore throat, minor aches and pains, nasal congestion and cough due to the common cold and flu

NON-DROWSY: Each dose is designed for daytime use, so you can get through the day

HOMEOPATHIC FLU RELIEF: Oscillococcinum works with your body to help temporarily relieve fatigue, headache, body aches, chills & fever. Safe for ages 2 & up, take at the first sign of flu-like symptoms.

HOLISTIC SUPPORT: Looking for homeopathic flu relief for the whole family? Oscillococcinum's sweet-tasting pellets dissolve quickly & easily under the tongue; no water, chewing, or swallowing required.

SHORTEN YOUR SYMPTOMS: Oscillo has been shown in clinical studies to help reduce both the duration & the severity of flu-like symptoms when taken at the onset. Non-drowsy, easy-to-take relief!

FAST, POWERFUL MULTI-SYMPTOM RELIEF for your headache, fever, sore throat, minor aches and pains, sneezing, runny nose, and cough

EFFECTIVE NIGHTTIME COLD & FLU SYMPTOM RELIEF. NyQuil Cold & Flu Liquicaps temporarily relieves common cold & flu symptoms so you can get the rest you need

FAST RELIEF SO YOU CAN SLEEP. Don't let your cold keep you up. Just one dose of NyQuil starts working fast to provide effective cold & flu relief

Provides temporary relief from nasal congestion, sneezing, runny nose, sore throat, fever, headache & body ache, and sinus pressure

Comes in Effervescent form

Sparkling Original flavor

4-fluid ounce bottle of Children's Tylenol Cold + Cough + Runny Nose Oral Suspension Medicine to temporarily relieve cold and flu symptoms, including, sore throat, cough, runny nose and sneezing

The kids' liquid pain relief medicine also relieves minor aches & pains, headache & temporarily reduces fever fast with an ibuprofen-, aspirin-, and alcohol-free formula

Each 5-milliliter dose of the children's medicine contains 160 milligrams of acetaminophen pain reliever and fever reducer; 1 milligram of the antihistamine chlorpheniramine maleate; and 5 milligrams of the cough suppressant dextromethorphan HBr

FAST, POWERFUL MULTI-SYMPTOM RELIEF: Use non-drowsy DayQuil for daytime relief and at night try NyQuil for fast relief so you can rest

EFFECTIVE COLD & FLU SYMPTOM RELIEF: DayQuil and NyQuil Cold & Flu medicine temporarily relieve common cold & flu symptoms

FEEL BETTER FAST: Just one dose starts working fast to provide effective cold & flu relief

RELIEF OF COLD: Natural relief of runny nose, congestion and sneezing due to common head colds in babies 6 months+

EASY TO USE: Quick-dissolving tablets that melt in your baby's mouth instantly to relieve runny nose and eyes, cough, congestion, headache and sneezing due to common head colds in babies 6 months+

125 TABLETS=UP TO 62 DOSES of Hyland's Naturals Baby Tiny Cold Tablets

6 packets of Theraflu Daytime Honey Lemon Flavor Severe Cold Relief Powder and 6 packets of Nighttime Severe Cold Relief Honey Lemon Flavor Powder plus 6 packets of Theraflu Daytime Severe Cold Relief Berry Burst flavor Powder

Multi-symptom cold medicine that provides powerful relief from severe cold symptoms such as sore throat pain, headache, minor body aches and pains, nasal and sinus congestion, cough and fever

Theraflu cold relief packets dissolve quickly in hot water for cough medicine and flu relief that is as easy as making a cup of tea

ALKA-SELTZER PLUS Severe Cold Sparkling Original POWERFAST Fizz EFFERVESCENT Cold Tablets provide fast relief from cold symptoms

Our severe cold, cough formula provides fizzy fast relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, headache, fever, sore throat and body aches & pains.

Provides severe cold relief from congestion, coughing, and sore throat

6 packets of Theraflu Nighttime Severe Cold Relief Honey Lemon Flavor Powder

Powerful relief from severe cold, cough, and flu symptoms such as sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Hot liquid provides a soothing effect

MAXIMUM STRENGTH MUCINEX FAST-MAX COLD & FLU: Multi-Symptom Relief medicine; 1 dose treats 9 symptoms - get back to what’s important thanks to the fast, powerful medicine

DAY TIME MULTI-SYMPTOM RELIEF: Maximum Strength Day Time Cold and Flu helps reduce fever, relieve cough, chest, nasal & sinus congestion that can cause mucus buildup, sinus pressure, minor aches and pains, headache and sore throat

NIGHT TIME MULTI-SYMPTOM RELIEF: Maximum Strength Night Time Cold and Flu helps reduce fever, relieve cough, nasal congestion that leads to stuffy nose, minor aches and pains, headache, sneezing, runny nose and sore and itchy throat

Helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion

Thins & loosens mucus with active ingredient guaifenesin expectorant

Relieves headache pain with active ingredient acetaminophen pain relievers and fever reducers

The #1 brand that gives powerful cold symptom relief without raising your blood pressure. *Based on unit sales.

Provides fast, powerful cold symptom relief for people with high blood pressure

Relieves fever, runny nose, sneezing, body aches & pains, headache, and sore throat

NIGHTTIME RELIEF FOR A BETTER MORNING: Get Powerful Nighttime Cold & Flu Multi-Symptom Relief with Maximum Strength Mucinex NightShift Cold & Flu fast release caplets. Relieves Headache, Body Pain, Cough, Sneezing, Runny Nose, and Reduces Fever so you can get to sleep.

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust*

ACTIVE INGREDIENTS PER CAPLET: Contains Acetaminophen (325 mg) - Pain reliever and Fever reducer; Dextromethorphan HBr (10 mg) - Cough Suppressant; Triprolidine HCI (1.25 mg) - Antihistamine.

Relieve Cold & Flu Symptoms: For use as a cough suppressant, pain reliever, and nasal decongestant. Our daytime cold and flu medicine combats the toughest colds, fast!

Power Through the Day: This cough medicine is a non-drowsy cold and sinus formula that allows you to stay focused and alert while on the go at home, work, or school.

Relieve Joint & Muscle Aches: Extra strength acetaminophen in our formula helps reduce fevers, aches and pains, for adults experiencing even the most severe cold and cough symptoms.

MAX STRENGTH: Maximum Strength, Multi-Symptom Cold + Flu Relief

SYMPTOM RELIEF: Contac Cold + Flu Day caplets provide symptom relief for Nasal Congestion, Sinus Pressure, Sore Throat, Head & Minor Body Aches, and Fever.

NON-DROWSY: Contac Cold + Flu Day provides multi-symptom relief in a non-drowsy caplet.

20-count of Sudafed PE Non-Drowsy Head Congestion + Pain Relief Caplets for effective nasal congestion relief and nasal swelling relief, now coupled with the powerful pain relief of ibuprofen

From the #1 pharmacist recommended brand among oral OTC decongestants, it provides non-drowsy relief from head congestion and pain symptoms caused by head colds

Each coated caplet contains 200 milligrams of ibuprofen, the #1 doctor-recommended pain reliever, to help reduce fever while also helping to alleviate headache and minor body aches and pains

RELIEF OF COLD: Natural relief of runny nose, congestion and sneezing due to common head colds and with Nighttime: cough and occasional sleeplessness in babies 6 months+

EASY TO USE: Quick-dissolving tablets that melt in your baby's mouth instantly to relieve runny nose and eyes, nighttime cough, congestion, headache, sneezing and occasional sleeplessness due to common head colds in babies 6 months+

125 TABLETS OF EACH = UP TO 125 DOSES of Hyland's Baby Nighttime Tiny Cold Tablets

24-count of Tylenol Cold Max non-drowsy cold and flu medicine with acetaminophen for multi-symptom relief

Medicine provides temporary relief for cold and flu symptoms including aches and pains, sore throat, nasal congestion, sinus congestion and pressure, cough and fever

Each cold & flu caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains

ALKA-SELTZER PLUS Severe Non-Drowsy Cold & Cough PowerFast Fizz Effervescent Tablets is a cold remedy for adults, with less sodium, improved flavor, and aspartame free.

Our severe Cold & Cough formula provides unbeatably liquid fast cold relief of headache, sore throat, cough, nasal & sinus congestion, runny nose, sneezing, aches, pains, fever and other severe cold symptoms.

Also acting as a cough suppressor and dry cough medicine, the non-drowsy formula allows individuals to stay alert and productive while battling cold symptoms.

NEW 25 percent smaller pill: Alka Seltzer Plus Maximum Strength Cold & Flu PowerMax Gels have a concentrated formula in a smaller liquid gel so it's easier to swallow

Provides up to 4 hours of relief: one dose provides 4 hour day time relief of cough, nasal congestion, headache & body ache, sore throat, and sinus pressure

Alka Seltzer Plus Maximum Strength Cold & Flu PowerMax Gels contain a pain reliever, fever reducer, cough suppressant, and nasal decongestant

One bottle of 20 coated tablets of Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate

Powerful Ibuprofen 200mg, chlorpheniramine maleate 4mg and phenylephrine HCL 10 mg tablets for multi-symptom relief

Uniquely formulated to fight common cold and flu symptoms, providing nasal congestion, nasal swelling, sneezing, sinus pressure, headache, fever, body aches and runny nose relief

24-count of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies

Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure

Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever; 5 mg of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 mg of the expectorant guaifenesin to help make coughs more productive

Combat the symptoms of sinus congestion with maximum strength formula

Relieves Headache & Fever

Thins & Loosens Mucus

Temporarily relieves common cold and flu symptoms including cough due to minor throat and bronchial irritation, sore throat, headache, minor aches and pains, fever, runny nose and sneezing.

Qty is 3 pk, Tylenol Sinus Congestion and Pain Severe - 24 Caplets

Temporarily relieves these symptoms associated with hay fever or other respiratory allergies, and the common cold: sinus congestion and pressure; headache; nasal congestion; minor aches and pains.

24 Caplets per-pk

NIGHTTIME RELIEF OF COLD; Natural relief of runny nose and eyes, nighttime cough, congestion, headache, sneezing and occasional sleeplessness due to common head colds in babies 6 months+

EASY TO USE; Quick-dissolving tablets that melt in your baby's mouth instantly to relieve runny nose and eyes, nighttime cough, congestion, headache, sneezing and occasional sleeplessness due to common head colds in babies 6 months+

125 TABLETS = UP TO 62 DOSES of Hyland's Naturals Baby Nighttime Tiny Cold Tablets

MULTI-SYMPTOM RELIEF: Sinus wash temporarily relieves symptoms associated with sinusitis, cold, flu, or allergies. Rite Aid rinse kit relieves sneezing, runny nose, nasal stuffiness, postnasal drip, and removes inhaled irritants such as dust & pollen.

SOFT COMFORT TIP: Soft, flexible tip provides maximum comfort while using this nasal irrigation kit. Neti Pots use the gentle flow of gravity to wash nasal passages and has been clinically proven to provide effective relief for nasal congestion.

ALL-NATURAL SALINE: Included packets are all-natural saline for use with your Neti Pot or squeeze bottle. Natural saline promotes nasal and sinus drainage, helps reduce swelling of nasal membranes, and allergy relief, all while moisturizing dry nasal passages.

RELIEF OF COLD SYMPTOMS: Naturally relieves the symptoms of the common cold including sneezing, cough, watery eyes, runny nose and sore throat in children ages 2-12.

FORMULATED WITH ZINC: Formulated with zinc 2x (HPUS) for the symptoms of runny nose and sore throat.

ZINC GLUCONATE: Clinically proven to shorten the duration of a cold and reduce severity.

Safe & sugar free: Diabetic Tussin Nighttime is a sugar-free nighttime cold and flu medicine that is safe for people with diabetes.

Cold and flu symptom relief: This product can be taken for minor aches & pains, runny nose & sneezing, headache relief, and sore throat relief

Formulated to be effective for all: This product is formulated with diabetic individuals in mind but can also be effectively used by anyone needing effective cold and flu symptom relief while being conscious of sugar intake.