Best Tylenol Cold Flu Medicine in 2025

Daisy
Last Updated: Nov 5, 2025

At a Glance: Our Top Picks for Tylenol Cold Flu Medicine

Tylenol Children's Cold + Cough + Runny Nose Oral Suspension, Grape, 4 Fl. Oz
#TOP1
Tylenol Children's Cold + Cough + Runny Nose
9.9
PM SCORE
Tylenol Cold Max Daytime Non-Drowsy Cold and Flu Relief, Acetaminophen, 24 ct
#TOP2
Tylenol Cold Max Daytime Non-Drowsy Cold And Flu
9.8
PM SCORE
Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy and Cough Medicine for Adults and Children 12 Years and Older - Relieves Symptoms from Allergies, Colds or Hay Fever, 24 Count
#TOP3
Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy
9.8
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Tylenol Cold Flu Medicine of 2025

Tylenol Children's Cold + Cough + Runny Nose Oral Suspension, Grape, 4 Fl. Oz

TYLENOL
456373
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounce bottle of Children's Tylenol Cold + Cough + Runny Nose Oral Suspension Medicine to temporarily relieve cold and flu symptoms, including, sore throat, cough, runny nose and sneezing

The kids' liquid pain relief medicine also relieves minor aches & pains, headache & temporarily reduces fever fast with an ibuprofen-, aspirin-, and alcohol-free formula

Each 5-milliliter dose of the children's medicine contains 160 milligrams of acetaminophen pain reliever and fever reducer; 1 milligram of the antihistamine chlorpheniramine maleate; and 5 milligrams of the cough suppressant dextromethorphan HBr

The liquid cold medicine for children comes in a kid-friendly grape flavor that is gentle on the tummy and ideal for kids ages 6 to 11 years

Tylenol is the #1 pediatrician recommended brand for pain and fever relief, and has been used by parents decade after decade

Tylenol Cold Max Daytime Non-Drowsy Cold And Flu Relief, Acetaminophen, 24 Ct

TYLENOL
JJ-2321
0.76 X 4.45 X 2.95 inches
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
BTRGoods 9.85

Features

24-count of Tylenol Cold Max non-drowsy cold and flu medicine with acetaminophen for multi-symptom relief

Medicine provides temporary relief for cold and flu symptoms including aches and pains, sore throat, nasal congestion, sinus congestion and pressure, cough and fever

Each cold & flu caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains

Each non-drowsy caplet also contains 10 mg of dextromethorphan to suppress cough, and 5 mg phenylephrine to relieve nasal congestion

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for daytime multi-symptom

Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy And Cough Medicine For Adults And Children 12 Years And Older - Relieves Symptoms From Allergies, Colds Or Hay Fever, 24 Count

ALKA-SELTZER PLUS
3.50 X 1.50 X 5.00 Inches
0.11 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.

Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.

ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.

This sinus, allergy, and cough medicine contains an antihistamine which helps to reduce allergy symptoms like sneezing, runny nose, and itchy/watery eyes.

This Sinus, Allergy & Cough relief medicine also contains cough suppressant and nasal decongestant to help relieve cough, nasal congestion, sinus congestion and pressure.

Tylenol Sinus Severe Daytime Caplets With Acetaminophen, Guaifenesin & Phenylephrine Hcl, 24 Ct

TYLENOL
I00000399
5.00 X 3.00 X 1.00 Inches
0.56 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
I Buy Direct 9.75

Features

24-count of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies

Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure

Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever; 5 mg of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 mg of the expectorant guaifenesin to help make coughs more productive

The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive

From the #1 doctor-recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older

Tylenol Sinus Congestion & Pain, Severe Caplets Daytime Non-Drowsy 24 Ea (Pack Of 3)

TYLENOL
302752500
4.00 X 3.00 X 3.00 Inches
0.19 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
KOSLOK 9.96

Features

Qty is 3 pk, Tylenol Sinus Congestion and Pain Severe - 24 Caplets

Temporarily relieves these symptoms associated with hay fever or other respiratory allergies, and the common cold: sinus congestion and pressure; headache; nasal congestion; minor aches and pains.

24 Caplets per-pk

Children's Tylenol, Grape Splash Flavor - 4 Oz. - 2 Pk.

TYLENOL
67608
0.25 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Kazer 9.95

Features

Pain Reliever/Fever Reducer

For a parent, it's understandable to be concerned when your child has a fever. Usually, a fever is just a symptom of an infection or other condition. In most cases, a fever will go away on its own in 2 or 3 days.

Two - 4 ounce bottles

Tylenol Head + Cold Severe Congestion 24Ct - Pack Of 3

TYLENOL
PPAX1363410
5.12 X 3.70 X 2.28 inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
346 Unlimited 9.60

Features

Acetaminophen 325mg - Pain reliever/fever reducer

Guaifenesin 200mg - Expectorant

Phenylephrine HCl 5mg - Nasal decongestant

Controls Headache, Fever, Sore Throat - Tylenol Cold And Flu Severe Caplets, 24 Count (Pack Of 2)

TYLENOL
824-847-PK2A
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

Pack of 2, 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Alka-Seltzer Plus Severe Cold & Flu Day/Night Medicine For Adults And Children 12 Years And Older - Powerfast Fizz Effervescent Tablets For Common Cold Relief And Other Cold Symptoms, 48Ct

ALKA-SELTZER PLUS
3.86 X 3.23 X 4.33 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING

Features

ALKA-SELTZER PLUS Severe Cold Day Night Medicine is a powerful cold and flu medicine designed specifically for adults and children 12 years and older.

Our Severe Day and Night cold and flu medicine provides fizzy fast daytime relief of nasal & sinus congestion, cough, headache, fever, sore throat and body aches & pains. Provides nighttime cold relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, cough, headache, fever, sore throat and body aches & pains.

This cold and flu medicine for adults and children 12 years and older quickly dissolves in water and instantly ready to start working so you can get back to your busy life

Each flu & cold relief box has 24 Sachets each containing 1 individually wrapped dose (2 effervescent cold tablets), which makes it easy to take with you on the go

Each cold and flu medicine tablet comes in Effervescent form. Use as directed.

Packaging may vary

Tylenol Day And Night Cold And Flu Capsule, 24 Count Per Pack - 48 Per Case.

TYLENOL
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

DAYTIME RELIEF CAPLETS: Formulated to reduce fever, loosen phlegm, and relieve headache, body aches, cough, sore throat, stuffy nose, and chest congestion

NIGHTTIME RELIEF CAPLETS: Help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure

EACH COLD AND FLU CAPLET: Contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

DAYTIME CAPSLETS: Contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make a cough more productive. The night capsules also contain 2 mg of chlorpheniramine maleate, an antihistamine

#1 DOCTOR-RECOMMENDED BRAND: Combo pack of 24 capsules of Tylenol Cold + Flu Severe Day/Night to relieve cold and flu symptoms. Combo Pack includes 16 Day Capsules and 8 Night Capsules for any time of day relief

Top 10 cold flu medicine tylenol Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Tylenol 34
Alka-Seltzer Plus 2

Top 10 cold flu medicine tylenol Brands Pie Chart


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