Best Tylenol Cold Flu Medicine in 2026

Daisy
Last Updated: Jul 18, 2026

At a Glance: Our Top Picks for Tylenol Cold Flu Medicine

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
#TOP1
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets,
9.9
PM SCORE
Tylenol Children's Cold + Flu Oral Suspension, Grape, 4 Fl. Oz
#TOP2
Tylenol Children's Cold + Flu Oral Suspension, Grape,
9.9
PM SCORE
Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.
#TOP3
Tylenol Cold + Flu Severe Medicine Caplets For
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Tylenol Cold Flu Medicine of 2026

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325Mg, Nasal Decongestant For Sinus Pressure, Headache & Nasal Congestion Relief, 24 Ct

TYLENOL
JJ-2320
4.50 X 0.75 X 3.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Deep Seas Wares 8.64

Features

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies

Pain reliever and nasal decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure

Each sinus relief caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever as well as 5 mg of phenylephrine HCl, a nasal decongestant to help clear nasal passages

The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages

From the #1 doctor-recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older

Tylenol Children's Cold + Flu Oral Suspension, Grape, 4 Fl. Oz

TYLENOL
300450391056
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounces of Children's Tylenol Oral Suspension Liquid Medicine with grape flavor to temporarily relieve kids' cold & flu symptoms, including cough, headache and fever

This multi-symptom relief medicine for kids also helps relieve minor aches and pains, sore throat, stuffy or runny nose, sneezing and congestion

Each 5mL contains 160 mg of acetaminophen pain reliever and fever reducer, 5 mg of dextromethorphan HBr cough suppressant, 2.5 mg of phenylephrine HCl decongestant and 1 mg of the antihistamine chlorpheniramine maleate

Indicated for children ages 6 to 11 years, this kids cold and flu medicine comes in a kid-friendly grape flavor with a formula that is free of aspirin, alcohol and ibuprofen

Tylenol is the #1 pediatrician recommended brand for pain & fever relief and has been relied on by parents for over 60 years.

Tylenol Cold + Flu Severe Medicine Caplets For Fever, Pain, Cough & Congestion, 24 Ct.

TYLENOL
JJ-2309
0.79 X 4.52 X 2.91 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy And Cough Medicine For Adults And Children 12 Years And Older - Relieves Symptoms From Allergies, Colds Or Hay Fever, 24 Count

ALKA-SELTZER PLUS
3.50 X 1.50 X 5.00 Inches
0.11 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.

Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.

ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.

This sinus, allergy, and cough medicine contains an antihistamine which helps to reduce allergy symptoms like sneezing, runny nose, and itchy/watery eyes.

This Sinus, Allergy & Cough relief medicine also contains cough suppressant and nasal decongestant to help relieve cough, nasal congestion, sinus congestion and pressure.

Tylenol Sinus Congestion & Pain, Severe Caplets Daytime Non-Drowsy 24 Ea (Pack Of 3)

TYLENOL
302752500
4.00 X 3.00 X 3.00 Inches
0.19 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
KOSLOK 9.96

Features

Qty is 3 pk, Tylenol Sinus Congestion and Pain Severe - 24 Caplets

Temporarily relieves these symptoms associated with hay fever or other respiratory allergies, and the common cold: sinus congestion and pressure; headache; nasal congestion; minor aches and pains.

24 Caplets per-pk

Rite Aid Non-Drowsy Daytime Sinus Congestion & Pain Relief, Rapid Release Gelcaps - 24 Count | Nasal Decongestant | Cold Medicine For Adults | Allergy Medication | Allergy Relief | Sinus Relief

RITE AID
011822434133
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Rite Aid, Inc. 9.98

Features

MULTI-SYMPTOM RELIEF: Rite Aid Sinus Congestion & Pain Relief relieves headache, nasal congestion, sinus congestion, and sinus pressure. Compare Rite Aid’s Daytime rapid release gelcaps to the active ingredients in Tylenol Sinus + Headache Day.

DAYTIME NON-DROWSY FORMULA: With Rite Aid allergy and cold medicine for adults, you’ll feel relief from symptoms associated with hay fever or other respiratory allergies, and the common cold— formulated without ingredients that may cause drowsiness.

FEVER, PAIN RELIEVER + NASAL DECONGESTANT: The Acetaminophen 325 mg & Phenylephrine HCI 5 mg in each gelcap temporarily relieves minor aches and pains, headache, sore throat and fever. While our nasal decongestant reduces sinus congestion and pressure.

RAPID RELEASE GELCAPS: Rite Aid’s Rite Aid Sinus Congestion & Pain Relief cold and allergy medicine for adults is designed to quickly release and relieve your symptoms offering you fast sinus relief, nasal congestion relief, and allergy relief.

TRUSTED BRAND SINCE 1962: We hope you continue to choose us first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.

Rite Aid Daytime Severe Sinus Congestion & Pain Relief - Acetaminophen, 325 Mg - 24 Caplets | Multi-Symptom Non-Drowsy | Sinus Relief | Cold And Flu Medicine | Severe Cold & Sinus Medicine For Adults

RITE AID
012000227165
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Rite Aid, Inc. 9.98

Features

FEVER & PAIN RELIEVER: 325mg of Acetaminophen in each caplet temporally relieves common cold symptoms like minor aches and pains, headache, sore throat, and fever. While the expectorant and nasal decongestant clear mucus and nasal congestion.

MULTI-SYMPTOM RELIEF: Rite Aid Severe Sinus Congestion & Pain Relief relieves headache, nasal congestion, sinus congestion and sinus pressure, chest congestion and mucus. Compare the active ingredients to the national brand and get the same benefits.

DAYTIME NON-DROWSY FORMULA: With Rite Aid cold medicine for adults, you’ll feel relief from symptoms associated with the common cold— formulated without ingredients that may cause drowsiness— So you can take on the day without feeling drowsy.

FOR YOUR SEVERE SYMPTOMS: With Rite Aid Severe Cold & Flu sinus medicine for adults, you’ll get a pain reliever/fever reducer, cough suppressant to calm your cough, expectorant to power through mucus, and nasal decongestants for adults for congestion.

TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.

Children's Tylenol, Grape Splash Flavor - 4 Oz. - 2 Pk.

TYLENOL
67608
0.25 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Kazer 9.95

Features

Pain Reliever/Fever Reducer

For a parent, it's understandable to be concerned when your child has a fever. Usually, a fever is just a symptom of an infection or other condition. In most cases, a fever will go away on its own in 2 or 3 days.

Two - 4 ounce bottles

Tylenol Head + Cold Severe Congestion 24Ct - Pack Of 3

TYLENOL
PPAX1363410
5.12 X 3.70 X 2.28 inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
346 Unlimited 9.60

Features

Acetaminophen 325mg - Pain reliever/fever reducer

Guaifenesin 200mg - Expectorant

Phenylephrine HCl 5mg - Nasal decongestant

Controls Headache, Fever, Sore Throat - Tylenol Cold And Flu Severe Caplets, 24 Count (Pack Of 2)

TYLENOL
824-847-PK2A
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

Pack of 2, 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Alka-Seltzer Plus Severe Cold & Flu Day/Night Medicine For Adults And Children 12 Years And Older - Powerfast Fizz Effervescent Tablets For Common Cold Relief And Other Cold Symptoms, 48Ct

ALKA-SELTZER PLUS
3.86 X 3.23 X 4.33 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING

Features

ALKA-SELTZER PLUS Severe Cold Day Night Medicine is a powerful cold and flu medicine designed specifically for adults and children 12 years and older.

Our Severe Day and Night cold and flu medicine provides fizzy fast daytime relief of nasal & sinus congestion, cough, headache, fever, sore throat and body aches & pains. Provides nighttime cold relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, cough, headache, fever, sore throat and body aches & pains.

This cold and flu medicine for adults and children 12 years and older quickly dissolves in water and instantly ready to start working so you can get back to your busy life

Each flu & cold relief box has 24 Sachets each containing 1 individually wrapped dose (2 effervescent cold tablets), which makes it easy to take with you on the go

Each cold and flu medicine tablet comes in Effervescent form. Use as directed.

Packaging may vary

Tylenol Day And Night Cold And Flu Capsule, 24 Count Per Pack - 48 Per Case.

TYLENOL
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

DAYTIME RELIEF CAPLETS: Formulated to reduce fever, loosen phlegm, and relieve headache, body aches, cough, sore throat, stuffy nose, and chest congestion

NIGHTTIME RELIEF CAPLETS: Help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure

EACH COLD AND FLU CAPLET: Contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

DAYTIME CAPSLETS: Contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make a cough more productive. The night capsules also contain 2 mg of chlorpheniramine maleate, an antihistamine

#1 DOCTOR-RECOMMENDED BRAND: Combo pack of 24 capsules of Tylenol Cold + Flu Severe Day/Night to relieve cold and flu symptoms. Combo Pack includes 16 Day Capsules and 8 Night Capsules for any time of day relief

Top 10 cold flu medicine tylenol Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Tylenol 41
Alka-Seltzer Plus 2
Rite Aid 2

Top 10 cold flu medicine tylenol Brands Pie Chart


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