Best Tylenol Cough Cold Medicine in 2025

Daisy
Last Updated: Nov 5, 2025

At a Glance: Our Top Picks for Tylenol Cough Cold Medicine

Tylenol Children's Cold + Cough + Runny Nose Oral Suspension, Grape, 4 Fl. Oz
#TOP1
Tylenol Children's Cold + Cough + Runny Nose
9.9
PM SCORE
Tylenol Children's Cold + Flu Oral Suspension, Grape, 4 Fl. Oz
#TOP2
Tylenol Children's Cold + Flu Oral Suspension, Grape,
9.9
PM SCORE
Tylenol Children's Dissolve Powder Packets with 160 mg Acetaminophen, Wild Berry, 30 ct
#TOP3
Tylenol Children's Dissolve Powder Packets With 160 Mg
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Tylenol Cough Cold Medicine of 2025

Market Overview
Tylenol Cough Cold Medicine Reviewed
  • Reviews Analyzed: 20610 Items
  • PM Avg. Rating: 7.7 / 10
25 Products Evaluated
  • Highest Price: $430.78
  • Lowest Price: $6.57
  • Avg. Price: $33.88

Tylenol Children's Cold + Cough + Runny Nose Oral Suspension, Grape, 4 Fl. Oz

TYLENOL
456373
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounce bottle of Children's Tylenol Cold + Cough + Runny Nose Oral Suspension Medicine to temporarily relieve cold and flu symptoms, including, sore throat, cough, runny nose and sneezing

The kids' liquid pain relief medicine also relieves minor aches & pains, headache & temporarily reduces fever fast with an ibuprofen-, aspirin-, and alcohol-free formula

Each 5-milliliter dose of the children's medicine contains 160 milligrams of acetaminophen pain reliever and fever reducer; 1 milligram of the antihistamine chlorpheniramine maleate; and 5 milligrams of the cough suppressant dextromethorphan HBr

The liquid cold medicine for children comes in a kid-friendly grape flavor that is gentle on the tummy and ideal for kids ages 6 to 11 years

Tylenol is the #1 pediatrician recommended brand for pain and fever relief, and has been used by parents decade after decade

Tylenol Children's Cold + Flu Oral Suspension, Grape, 4 Fl. Oz

TYLENOL
300450391056
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounces of Children's Tylenol Oral Suspension Liquid Medicine with grape flavor to temporarily relieve kids' cold & flu symptoms, including cough, headache and fever

This multi-symptom relief medicine for kids also helps relieve minor aches and pains, sore throat, stuffy or runny nose, sneezing and congestion

Each 5mL contains 160 mg of acetaminophen pain reliever and fever reducer, 5 mg of dextromethorphan HBr cough suppressant, 2.5 mg of phenylephrine HCl decongestant and 1 mg of the antihistamine chlorpheniramine maleate

Indicated for children ages 6 to 11 years, this kids cold and flu medicine comes in a kid-friendly grape flavor with a formula that is free of aspirin, alcohol and ibuprofen

Tylenol is the #1 pediatrician recommended brand for pain & fever relief and has been relied on by parents for over 60 years.

Tylenol Children's Dissolve Powder Packets With 160 Mg Acetaminophen, Wild Berry, 30 Ct

TYLENOL
00300450416308
1.34 X 4.02 X 3.58 inches
0.01 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

30-count of Children's Tylenol Dissolve Packs made with acetaminophen features a kid-friendly Wild Berry flavor and helps temporarily relieve multiple cold & flu symptoms

This children's dissolving powder medicine temporarily reduces fever and provides relief from minor aches and pains due to the common cold, flu, headache, sore throat and toothache

Each kids' powder packet contains 160 milligrams of acetaminophen, an effective pain reliever and fever reducer, and is both ibuprofen-free and aspirin-free

Safe and effective for children ages 6 to 11 years when used as directed, this portable kids' cold & flu symptom medicine powder dissolves in seconds on the tongue with no water needed

From the #1 pediatrician recommended brand for pain & fever relief, these Children's Tylenol Dissolve Packs are dye-free and available in a kid-friendly fruity Wild Berry flavor

Tylenol Cold Max Daytime Non-Drowsy Cold And Flu Relief, Acetaminophen, 24 Ct

TYLENOL
JJ-2321
0.76 X 4.45 X 2.95 inches
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
BTRGoods 9.85

Features

24-count of Tylenol Cold Max non-drowsy cold and flu medicine with acetaminophen for multi-symptom relief

Medicine provides temporary relief for cold and flu symptoms including aches and pains, sore throat, nasal congestion, sinus congestion and pressure, cough and fever

Each cold & flu caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains

Each non-drowsy caplet also contains 10 mg of dextromethorphan to suppress cough, and 5 mg phenylephrine to relieve nasal congestion

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for daytime multi-symptom

Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy And Cough Medicine For Adults And Children 12 Years And Older - Relieves Symptoms From Allergies, Colds Or Hay Fever, 24 Count

ALKA-SELTZER PLUS
3.50 X 1.50 X 5.00 Inches
0.11 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.

Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.

ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.

This sinus, allergy, and cough medicine contains an antihistamine which helps to reduce allergy symptoms like sneezing, runny nose, and itchy/watery eyes.

This Sinus, Allergy & Cough relief medicine also contains cough suppressant and nasal decongestant to help relieve cough, nasal congestion, sinus congestion and pressure.

Tylenol Children's Tylenolcold + Flu Oral Suspension, Bubblegum, 4 Fl. Oz

TYLENOL
300450169044
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounce bottle of children’s cold, cough, and sore throat medicine

Temporarily relieves cold and flu symptoms, including minor aches and pains, headache, sore throat, and cough

Temporarily reduces fever

Each 5-milliliter dose contains 160 milligrams of acetaminophen and 5 milligrams of dextromethorphan HBr

Ibuprofen-, alcohol-, and aspirin-free formula

Tylenol Sinus Severe Daytime Caplets With Acetaminophen 325Mg, Guaifenesin 200Mg & Phenylephrine Hcl 5Mg, Non-Drowsy Pain Reliever, Expectorant & Nasal Decongestant, 24 Ct

TYLENOL
289711
6.00 X 4.00 X 4.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
VerSure 9.98

Features

Pain Reliever, Decongestant And Expectorant To Temporarily Relieve Symptoms Of Chest Congestion, Nasal Congestion, Sinus Headache And Pressure.

The Non-Drowsy Formula Of This Sinus Medicine Provides Effective Daytime Symptom Relief By Promoting Sinus Drainage.

Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy cold, flu & allergy symptom relief

Pain reliever, decongestant, fever reducer & expectorant to help relieve sinus headache & pressure

Cold & flu symptom relief medicine helps decongest sinus openings & passages & loosens phlegm

Tylenol Cold + Flu Severe Medicine W/Acetaminophen, Dextromethorphanhbr, Guaifenesin, Phenylephrinehci, Liquid Daytime Cold/Fever & Chest Congestion Relief, Warming Honey Lemon, 8 Fl. Oz

TYLENOL
JJ-289
2.06 X 3.02 X 5.33 Inches
8.00 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
westlake 9.87

Features

Tylenol Cold + Flu Severe liquid flu medicine provides temporary pain relief and mucus and chest congestion relief with a warming honey lemon flavor

Cold medicine and flu relief for fever and sore throat, as well as relief from head and body aches and cough. It also aids in loosening phlegm, or mucus, and thinning bronchial secretions so coughs can be more productive.

With this severe daytime flu relief for adults, get relief from nasal congestion, as well as mucus and chest congestion in a powerful non-drowsy formula

It combines acetaminophen for pain relief and fever reduction with three other ingredients, phenylephrine HCl for a nasal decongestant, guaifenesin as an expectorant and dextromethorphan HBr as a cough suppressant

This non-drowsy cold medicine and flu relief comes in a daytime formula, which provides temporary relief of symptoms including fever, sore throat, and chest congestion during your waking hours

Children's Tylenol, Grape Splash Flavor - 4 Oz. - 2 Pk.

TYLENOL
67608
0.25 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Kazer 9.95

Features

Pain Reliever/Fever Reducer

For a parent, it's understandable to be concerned when your child has a fever. Usually, a fever is just a symptom of an infection or other condition. In most cases, a fever will go away on its own in 2 or 3 days.

Two - 4 ounce bottles

Tylenol Children's Oral Suspension, Bubblegum, 4 Fl. Oz

TYLENOL
00300450407047
2.00 X 1.95 X 5.01 Inches
0.43 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
HTF Goods 9.77

Features

4-fluid ounce bottle of Children's Tylenol Oral Suspension Medicine with bubble gum flavor to temporarily relieve cold and flu symptoms, including sore throat, headache and fever

This kids' cold & flu symptom medicine also helps relieve minor aches & pains, headache & temporarily reduces fever with an ibuprofen-, aspirin- and alcohol-free formula

Each 5 milliliter dose of this oral suspension medicine contains 160 milligrams of the pain reliever and fever reducer acetaminophen for effective cold and flu symptom relief

Our kids' cold & flu symptom medicine come in a kid-friendly bubble gum flavor that is gentle on the tummy and can be used by children ages 2 to 11 years.

Tylenol is the #1 pediatrician recommended brand for pain and fever relief, and has been used by parents decade after decade

Tylenol Cold Flu Severe 50 Packs Of 2 Caplets In Each Pack, Dispenser Pouch Box

TYLENOL
30036797
45.00 X 60.00 X 35.00 Inches
53.00 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
westlake 9.87

Features

50 packs of 2 caplets

Tylenol Children's Tylenoloral Suspension, Grape 4 Fl. Oz.

TYLENOL
300450296092
1.98 X 1.94 X 5.04 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
The A-Z Smartmart 4.85

Features

4-fluid ounce bottle of Children's Tylenol Oral Suspension Medicine with grape flavor to temporarily relieve cold and flu symptoms, including sore throat, headache and fever

This kids' cold & flu symptom medicine also helps relieve minor aches & pains, headache & temporarily reduces fever with an ibuprofen-, aspirin- and alcohol-free formula

Each 5 milliliter dose of this oral suspension medicine contains 160 milligrams of the pain reliever and fever reducer acetaminophen for effective cold and flu symptom relief

Our kids' cold & flu symptom medicine come in a kid-friendly grape flavor that is gentle on the tummy and can be used by children ages 2 to 11 years.

Tylenol is the #1 pediatrician recommended brand for pain and fever relief, and has been used by parents decade after decade

Tylenol Children's Cold + Cough + Sore Throat Oral Suspension, Bubblegum, 4 Fl. Oz

TYLENOL
1.93 X 1.93 X 4.97 Inches
0.42 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Southern Mountain LLC 6.54

Features

Cures fever and sore throat

Treats runny and stuffy nose, coughs and sneezing

Also cures aches and pains and fever

Tylenol Cold And Flu Severe Day And Night - 3 Pack (Total 72 Caplets)

TYLENOL
BJ 76487 *1.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
*Daily Deals* 9.75

Features

Provides temporary relief of cold and flu symptoms

Convenient combo pack of 72 day and night caplets

Tylenol Cold + Head Congestion Severe Medicine Caplets For Fever, Pain & Congestion Relief, 24 Ct.

TYLENOL
I00000398
4.57 X 2.87 X 0.75 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Clears out mucus

Headache

Fever

Tylenol Cold + Flu Severe Medicine Caplets For Cold & Flu Symptom Relief, Fever Reducer, Pain Reliever, Cough Suppressant, Nasal Decongestant & Expectorant, 24 Ct. ( Pack Of 6)

TYLENOL
421650
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
MASKU LLC 9.70

Features

24-capsule (Pack of 6) of Tylenol Cold + Flu Severe Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Cold + Head Congestion Severe, 24 Caplets (Pack Of 2)

TYLENOL
302612500
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
LosNacha 5.63

Features

Used for the temporary relief of the following cold symptoms:

minor aches and pains

headache, sore throat

nasal congestion, sinus congestion and pressure

Tylenol Head + Cold Severe Congestion 24Ct - Pack Of 3

TYLENOL
PPAX1363410
5.12 X 3.70 X 2.28 inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
346 Unlimited 9.60

Features

Acetaminophen 325mg - Pain reliever/fever reducer

Guaifenesin 200mg - Expectorant

Phenylephrine HCl 5mg - Nasal decongestant

Tylenol Cold + Flu Severe Medicine Caplets For Cold, Flu, Fever, Cough & Congestion Relief, 24 Ct

TYLENOL
2.28 X 4.34 X 2.85 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Cloud-Kart Inc. 9.82

Features

24-count of Tylenol Cold + Flu Severe Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Cold + Flu Severe Day & Night Caplets 24 Ea (3 Pack)

TYLENOL
PPAX1477780
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Trio Shippers LLC 9.78

Features

DAYTIME RELIEF CAPLETS: Formulated to reduce fever, loosen phlegm, and relieve headache, body aches, cough, sore throat, stuffy nose, and chest congestion

NIGHTTIME RELIEF CAPLETS: Help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure

EACH COLD AND FLU CAPLET: Contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

DAYTIME CAPSLETS: Contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make a cough more productive. The night capsules also contain 2 mg of chlorpheniramine maleate, an antihistamine

#1 DOCTOR-RECOMMENDED BRAND: Combo pack of 24 capsules of Tylenol Cold + Flu Severe Day/Night to relieve cold and flu symptoms. Combo Pack includes 16 Day Capsules and 8 Night Capsules for any time of day relief

Tylenol Cold Multi-Symptom Relief Caplets, 24 Count

TYLENOL
300450271259
3.05 X 4.50 X 0.80 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Element One 7.41

Features

Nondrowsy daytime formula

Pain reliever, fever reducer, nasal decongestant

Relieves headache, fever, sore throat, nasal congestion and cough

Sinus

Cold and Flu

Tylenol Cold And Flu Severe, 24-Count Caplets (Pack Of 2)

TYLENOL
0.88 X 3.38 X 3.50 Inches
0.07 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Vitabox 9.88

Features

Headache, fever, sore throat

Nasal congestion

Clears cough

Chest congestion, clears out mucus

Controls Headache, Fever, Sore Throat - Tylenol Cold And Flu Severe Caplets, 24 Count (Pack Of 2)

TYLENOL
824-847-PK2A
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

Pack of 2, 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Alka-Seltzer Plus Severe Cold & Flu Day/Night Medicine For Adults And Children 12 Years And Older - Powerfast Fizz Effervescent Tablets For Common Cold Relief And Other Cold Symptoms, 48Ct

ALKA-SELTZER PLUS
3.86 X 3.23 X 4.33 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING

Features

ALKA-SELTZER PLUS Severe Cold Day Night Medicine is a powerful cold and flu medicine designed specifically for adults and children 12 years and older.

Our Severe Day and Night cold and flu medicine provides fizzy fast daytime relief of nasal & sinus congestion, cough, headache, fever, sore throat and body aches & pains. Provides nighttime cold relief of: nasal congestion, sinus pressure & congestion, sneezing, runny nose, cough, headache, fever, sore throat and body aches & pains.

This cold and flu medicine for adults and children 12 years and older quickly dissolves in water and instantly ready to start working so you can get back to your busy life

Each flu & cold relief box has 24 Sachets each containing 1 individually wrapped dose (2 effervescent cold tablets), which makes it easy to take with you on the go

Each cold and flu medicine tablet comes in Effervescent form. Use as directed.

Packaging may vary

Tylenol Day And Night Cold And Flu Capsule, 24 Count Per Pack - 48 Per Case.

TYLENOL
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

DAYTIME RELIEF CAPLETS: Formulated to reduce fever, loosen phlegm, and relieve headache, body aches, cough, sore throat, stuffy nose, and chest congestion

NIGHTTIME RELIEF CAPLETS: Help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure

EACH COLD AND FLU CAPLET: Contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

DAYTIME CAPSLETS: Contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make a cough more productive. The night capsules also contain 2 mg of chlorpheniramine maleate, an antihistamine

#1 DOCTOR-RECOMMENDED BRAND: Combo pack of 24 capsules of Tylenol Cold + Flu Severe Day/Night to relieve cold and flu symptoms. Combo Pack includes 16 Day Capsules and 8 Night Capsules for any time of day relief

Top 10 cough cold medicine tylenol Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Tylenol 23
Alka-Seltzer Plus 2

Top 10 cough cold medicine tylenol Brands Pie Chart


We've carried out a comprehensive analysis of 20,610 reviews on cough cold medicine tylenol, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select cough cold medicine tylenol priced around $33.88, with top brands including and tylenol

Our team of expert editors reviewed these high-quality items and handpicked the top 25 cough cold medicine tylenol for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, btrgoods, otcrx4u, westlake, masku llc, royal meds, the a-z smartmart, danichoice and topline products llc and cloud-kart inc. .

We are dedicated to assisting our users in finding the right medicine Products based on their needs, saving them considerable time when choosing which cough cold medicine tylenol to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.