Best Hydroxyapatite Toothpaste in 2025

WHAT YOU'LL GET: Two 5.5-ounce tubes of Tom's of Maine Fluoride-Free Antiplaque & Whitening Toothpaste in Peppermint Flavor

FLUORIDE-FREE TOOTHPASTE: Helps fights tartar buildup with antiplaque formula

WHITENS TEETH: Natural toothpaste helps remove surface stains for a brighter, whiter smile

Coco Ginger: a subtle coconut flavor paired with spicy ginger with notes of chamomile flower.

Features Nano Hydroxyapatite (n-HA): We are trading out fluoride for n-HA, the mineral that makes up enamel used to remineralize teeth. It's the perfect choice for natural oral care.

Remineralizes and Whitens Teeth: Refreshing natural toothpaste that improves your overall tooth enamel health and helps to brighten those pearly whites.

Whitening Without The Sensitivity: What does taking care of your mouth mean to us? Well, when it comes to whitening, it means to lift stains without taking the enamel too. Your teeth can and should be whitened without the use of harsh bleaches that damage your tooth structure, leading to sensitivity.

Clinically Proven: Let’s be honest, all the better-for-you ingredients mean nothing if they don’t prove results. So, we set out to scientifically show your brightest smile could be achieved with Lumineux and we have! With over 50 double-blind, university studies backing us up, Lumineux can proudly say we clean, freshen and whiten as well as the other guys, without the harm.

Microbiome Safe: This one is unique. In fact, I would wager that Lumineux is the only oral care company on the market that can claim that we are certified non-toxic and microbiome safe. That means our products actually work with your body to achieve oral health by protecting your good bacteria and detoxifying the bad.

One 3.4 oz tube of Extra Fresh Sensodyne Pronamel Intensive Enamel Repair Toothpaste for Sensitive Teeth, to Reharden and Strengthen Enamel

Toothpaste for enamel repair that inhibits demineralization, repairs microdamage and rebuilds enamel strength

Providing lasting relief, this sensitive enamel toothpaste protects your against pain triggers

[WIN THE BATTLE AGAINST TOOTH DECAY]: Do you ever wonder why some of us continue to get cavities despite meticulous oral hygiene, whereas others who rarely brush and floss do not? The risk of cavities varies from person to person and is based on eating and drinking habits, hygiene (brushing and flossing), saliva flow, as well as other factors. *NEW LOOK and larger 2.4 oz size for our CariFree CTx4 Gel 1100; same great product!*

[PROTECT YOUR ENAMEL]: The CariFree Gel 1100 contains .24% sodium fluoride (1100 ppm), which stops cavities as well as prevents tooth decay and white spots. Evidence shows that fluoride strengthens your teeth. The CariFree Gel 1100 also contains nano-hydroxyapatite, a natural component of saliva, and the mineral your teeth are made of. In combination, these work together to help protect your smile.

[FORMULATED WITH XYLITOL]: Our Gel 1100 contains 25% xylitol! Xylitol is a naturally occurring, sweet-tasting ingredient found in many types of plants. Research shows that regular use of xylitol-rich products may reduce your risk of dental cavities.

DR. SQUATCH NATURAL TOOTHPASTE on sensitive teeth as well as normal teeth, for men formulated specifically for your morning and night routines without the harsh chemicals found in conventional toothpaste

START YOUR DAY LIKE A CHAMPION citrus mint toothpaste blasts away morning breath with a burst of peppermint. Green tea extract and vitamin B12 give you the refreshing kick you need

WHITENING POWER THAT NEVER SLEEPS intensive stain removal whitening toothpaste that never sleeps. End your day with a Soothing Spearmint for a boost of extra whitening from natural clay stain removal toothpaste

Fluoride-Free Toothpaste: Davids replaces fluoride and other common toothpaste chemicals with high-performing ingredients to effectively reduce plaque, naturally whiten, and freshen breath.

Gentle Whitening: Micro polishing agents remove surface stains to safely whiten without causing the sensitivity normally found with peroxide or other bleaching agents. RDA of 101 to effectively remove plaque and surface stains while being enamel safe for daily brushing. Safe range per ADA (American Dental Association).

Improve Oral Health: Formulated to restore a healthy PH balance and support your mouth’s natural oral microbiome. Davids is designed to aggressively stop plaque from forming and reduce existing plaque buildup while leaving your mouth feeling minty fresh and exceptionally clean.

Features Nano Hydroxyapatite (n-HA) - the same ingredient that naturally makes up 97% of your teeth material. We eliminated the fluoride and replaced with this biocompatible ingredient to remineralize your enamel, reduce teeth sensitivity and naturally whiten.

Safe & Gentle Whitening – micro polishing agents gently remove surface stains to safely whiten without causing the sensitivity normally found with peroxide or other bleaching agents. RDA (abrasive rating) of 101 to effectively remove plaque and surface stains while being enamel safe for daily brushing. Safe range per ADA (American Dental Association).

Bioactive Sensitive Relief - most sensitive toothpastes uses Potassium Nitrate (nerve numbing drug) to temporarily numb the tooth nerves. We use Hydroxyapatite (n-HA) to reduce sensitivity by remineralizing the enamel and passageways (tubules) to the nerves.

PERFECT FOR THE WHOLE FAMILY: Treat your family to a gentler oral care experience with our Fluoride Free Toothpaste Pack. The Active Remineralization Toothpaste creates a healthy smile for yourself and the kids’ toothpaste gets their teeth squeaky clean.

SAFE FOR KIDS 3 MONTHS AND OLDER: Our kids’ toothpaste has a mild natural blueberry taste and only uses ingredients derived from nature. It has a low relative dentin abrasivity value of under 30 that cleans gently and prevents harm to gums and enamel.

UNIQUE FORMULA: The adult toothpaste has hydroxyapatite that bonds with and repairs demineralized enamel damaged by acids that plaque produces. Xylitol raises saliva’s pH level and works with natural minerals to be deposited into demineralized enamel.

[WIN THE BATTLE AGAINST TOOTH DECAY]: Do you ever wonder why some of us continue to get cavities despite meticulous oral hygiene, whereas others who rarely brush and floss do not? The risk of cavities varies from person to person and is based on eating and drinking habits, hygiene (brushing and flossing), saliva flow, as well as other factors. *NEW LOOK, same great product. Larger 2.4oz. tube (20% MORE)!*

[PROTECT YOUR SMILE]: CariFree Fluoride Free Gel (formally called CTx3 Gel) contains nano-hydroxyapatite, a natural component of saliva, and the mineral your teeth are made of. The nano-hydroxyapatite in this gel is bio-available and mimics the size and shape hydroxyapatite that is naturally found in saliva.

[FORMULATED WITH XYLITOL]: The Fluoride Free Gel contains 25% xylitol! Xylitol is a naturally occurring, sweet-tasting ingredient found in many types of plants. Research shows that regular use of xylitol-rich products may reduce your risk of dental cavities.

FLUORIDE, PARABEN, AND SLS FREE – Kinder Karex gently cleanses teeth without fluoride, parabens, and Sodium Lauryl Sulfate.

BIOHAP PRIMARY INGREDIENT — BioHAP or biomimetic hydroxyapatite is a toothlike ingredient with many known benefits

SAFE IF SWALLOWED — Small children are often not yet able to properly spit out toothpaste and are known to swallow toothpaste. Kinder Karex is safe if accidentally swallowed.

One 3.0 oz. tube of Colgate Total Plaque Pro Release Whitening Toothpaste

Unique anticavity, antigingivitis, anti sensitivity toothpaste formula helps interfere with the harmful effects of plaque bacteria associated with gingivitis for healthy gums

This Colgate Total toothpaste uses unique breakthrough formula with smart foam technology to penetrate hard to reach places to fight plaque bacteria along the gum line

The Black Alternative To Extra White Teeth - Our activated charcoal toothpaste is perfect for those looking for a natural way to whiten their teeth. With a mixture of coconut charcoal that acts like a natural teeth whitening agent, you can achieve brighter teeth without any harsh chemicals.

Confidence Booster - Not only does our black toothpaste help whiten teeth, but it also removes plaque and stubborn staining while repairing cavities. Keep your smile looking its best all day long. Never have to worry about bad breath again.

Nothing Extra Added - Twin Lotus charcoal toothpaste, does not contain any harmful chemicals or additives. No alcohol, Sugar Free, Vegan, Cruelty-Free, SLS Free. This black charcoal toothpaste is safe for both adults and kids, and is gentle enough for those with sensitive teeth.

Multiple action toothpaste with bioactive calcium is intended for enamel restoration and tooth sensitivity reduction. The high content of these ingredients makes it possible to strengthen and remineralise dental enamel and reduce hypersensitivity.

Natural papaya enzyme prevents plaque development. The Sp.White System gently whitens and polishes enamel to a brilliant shine. Biocalcium is a multiple-action toothpaste with bioactive calcium obtained from eggshell and hydroxyapatite, an essential component in the composition of dental enamel.

The essential natural elements of dental enamel are calcium (33-39 procent) and phosphates (16-18 procent). The saturation of enamel with these ingredients determines its integrity and resistance to acids that cause tooth decay.

Repairs and protects enamel from night erosion.

MicroRepair consists of particles constituted by Hydroxyapatite whose composition is very similar to that of tooth enamel. This similarity gives microRepair the biomimetic properties to integrate microparticles with enamel and dentin, with consequent mineralising and restorative action.

Biorepair does NOT contain: Fluoride, Titanium dioxide,Sodium Lauryl Sulphate,Parabens

Nano hydroxyapatite is an effective fluoride alternative. The nano size particles remineralize teeth, creating a stronger, smoother, whiter enamel.

Creates a healthy pH to increase remineralization.

Xylitol and erythritol minimize the source of plaque and acid.

[WIN THE BATTLE]: Do you ever wonder why some of us continue to get cavities despite meticulous oral hygiene, whereas others who rarely brush and floss do not? The risk of cavities varies from person to person and is based on dietary habits, hygiene (brushing and flossing), saliva flow, as well as other factors. This CariFree kit contains a 1-month supply of our CariFree Gel 1100 and CaiFree Maintenance Rinse.

[CARIFREE GEL 1100 TOOTHPASTE]: CariFree Gel 1100 toothpaste (previously know as CTx4 Gel 1100) replacement contains 0.24% sodium fluoride (1100 ppm). Evidence shows that fluoride strengthens your teeth and helps with prevention. CariFree Gel 1100 also contains nano-hydroxyapatite, a natural component of saliva, xylitol and an elevated pH. In combination, these protective ingredients work together to help protect your smile.

[MAINTENACNE RINSE]: CariFree mouthwash (previously know as CTx3 Rinse) contains 0.05% sodium fluoride, which helps prevent tooth decay and white spots. Maintenance Rinse also contains 25% xylitol and has an elevated pH. Research shows that regular use of xylitol-rich products reduces your risk of dental cavities.

BioHAP or Biomimetic Hydroxyapatite: Teeth consist of approximately 97% hydroxyapatite, which is one of the hardest substances in the human body. This substance makes the dental enamel hard and resistant, protecting the teeth from acids and bacteria. Hydroxyapatite is essential for strong, healthy teeth. However, this mineral wears away over time and cannot be restored by the human body.

High Performance: With 20% BioHAP or Biomimetic Hydroxyapatite – better known as artificial enamel – Bioniq PLUs also formulated with Lactoferrin and Hyaluronic acid to help clean the teeth to prevent plaque buildup and promote healthy moist gums

FLUORIDE AND SLS FREE: Bioniq PLUS gently cleanses teeth without Fluoride and Sodium Lauryl Sulfate.

Vanman's Tooth Powder: We have people DREAMING again… & vivid dreams on top of that! With a rich amount of minerals & a lack of fluoride, our natural teeth whitening powder has taken the internet by storm. This teeth whitener powder is made with bentonite clay and activated coconut charcoal for teeth.

Wakeup With A Smile: Our tooth cleaner will have you waking up without a gross mouth feeling often created by foaming agents ruining your saliva production. This coconut charcoal teeth whitening powder can be used by itself or as a booster to your favorite flavored toothpaste.

Healthier & Whiter Teeth: Vanman’s whitening teeth care powder is loaded with eggshell powder (a natural source for hydroxyapatite that has shown a reversal in tooth decay) & bentonite clay (aged volcanic ash) to purify, detoxify, and alkalize the mouth. Our tooth polish powder provides your mouth with a feeling of freshness and cleanliness that will last all day.

America's only nano Hydroxyapatite natural toothpaste developed and produced by a licensed dentist to help prevent tooth decay.

Features 100% Real Nano Hydroxyapatite. Safe to swallow and clinically proven ingredient to remineralize tooth enamel, fight sensitivity and safely whiten teeth.

Includes Dr Jen’s proprietary blend of essential oils (Peppermint, Spearmint, Black Cherry, and Papaya) designed to kill bad breath bacteria while promoting a healthy mouth microbiome.

DOESN'T contain: Fluoride, Abrasive Silica, Titanium Dioxide, Sodium Lauryl Sulfate and Parabens.

Helps Repair and strengthen the surface of the enamel

Made in Italy.

FRESH MINT WHITENING TOOTHPASTE - Our innovative formula of whitening toothpaste combines the power of baking soda and mint with added hydroxyapatite to help make your teeth whiter with every brush

SAFE FOR SENSITIVE TEETH - Highly effective, gentle whitening solutions and oral care that helps in reducing tooth sensitivity, remineralizing and strengthening enamel, and with cavity protection

USE DAILY FOR A BRIGHTER SMILE - Use at least a 1-inch strip of this tooth whitening toothpaste on your toothbrush to brighten teeth and help remove years of stains

Five tongue-tingling flavours of toothpastes to choose from

Hi by Hismile Flavoured Toothpastes Range

Flavour with a burst of freshness

For your oral health - Periosciences Natural Toothpaste gently removes stains + thoroughly takes care of your teeth without fluoride or harsh chemicals. Antioxidants phloretin and ferulic acid work with green tea catechins for maximum antioxidant effect for teeth and gums.

Natural ingredients - The mint-flavored AO Pro Toothpaste is made using our signature antioxidants and essential oils such as peppermint oil as well as unique ingredients such as hydroxyapatite and chamomile. The natural toothpaste contains green tea catechins which targets odor and can help with toothaches and mouth sores.

Dentist recommended - Scientifically proven ingredients were chosen for properties that focus on the mouth's natural defense system. Toothpaste with antioxidants is gentle on oral tissue but tough on impurities and common problems.

NATURALLY DERIVED MINERAL TOOTHPASTE - The ELIMS Reflection Toothpaste is a naturally derived mineral toothpaste powered by 10% nano-hydroxyapatite. Nano-hydroxyapatite is a natural fluoride alternative which supports and protects your teeth whilst also helping to reduce sensitivity.

FLUORIDE FREE & NON TOXIC - The ELIMS toothpaste is free from fluoride. Instead, we've used a natural fluoride alternative - Nano-hydroxyapatite; a clinically proven alternative that has been used and loved in Japan for over 40 years. It's just as effective as fluoride when used in the right concentration but without any of the nasty chemicals. Our toothpaste is also free from parabens, toxins, SLS and artificial dyes and colors.

GENTLE TEETH WHITENING - Removes stains and whitens teeth to reveal a brighter smile using the power of natural ingredients! We use baking soda and coconut oil in our formula which is nice and gentle even on sensitive teeth.

GENTLE ON TEETH: Our SNOW whitening toothpaste is formulated using ingredients such as hydrated silica, glycerin, sorbitol, calcium carbonate, hydroxyapatite, sodium lauroyl sarcosinate, kaolin, bromelain, flavor, and xylitol. Without fluoride or sulfates, the whitening action of this toothpaste can gently whiten teeth.

WHITENS TEETH AT NIGHT: Our Snow Midnight Mist whitening toothpaste works its magic while you sleep. Use it before bedtime and experience the transformative power of its many ingredients. Pair with our AM toothpaste, Morning Frost, for the best results.

AN IDEAL ALTERNATIVE: A great alternative to harsh teeth whitening products or charcoal toothpaste, our teeth whitening toothpaste is made with a special ingredient, hydroxyapatite, that remineralizes enamel gently and effectively.

FLUORIDE-FREE PROTECTION: Our effective and safe baby, toddler and kid toothpaste is shown to reduce plaque and remineralize, protect and strengthen enamel.

DELICIOUS FLAVOR: A berry-licious strawberry toothpaste flavor little ones will love, without any mint that children are often sensitive to. A great first training toothpaste for babies and toddlers.

GENTLE: Made for the most sensitive mouths, our kids toothpaste has a low RDA (Relative Dentin Abrasivity) score, which means brushing will be more comfortable.

WHY IS OUR HYDROXYAPATITE TOOTHPASTE DIFFERENT: Clinical research has shown that a minimum of 10% concentration of hydroxyapatite is essential for effective sensitivity relief and enamel strengthening. Unlike many other toothpastes that put a token amount of hydroxyapatite, we pack ours with a full 11% (including 6% being nano-hydroxyapatite) for assured results. This is more expensive for us, but we are committed to seeing that our products work.

HOLISTIC DENTIST RESEARCHED AND FORMULATED: Built upon years of experience as a holistic dentist, our toothpaste is completely FREE OF FLUORIDE, SLS, sulfates and is non-GMO. It is loaded with potent ingredients, such as xylitol (for its proven anti-cavity properties) and organic aloe vera (for natural healing and calming) plus many other healthy kickers like zinc, tea tree oil, herbal and fruit extract–all to help support the healthiest mouth possible!

EFFECTIVE SENSITIVITY RELIEF: With 21 active ingredients, our remineralizing toothpaste was created by a holistic dentist as an ideal toothpaste for his patients. It took years of research, and a complex manufacturing process to achieve this goal. Packed with healing ingredients to provide powerful sensitivity relief, cavity control and enamel strengthening –plus a gentle, non-harmful whitening action. All to help you to heal your mouth and achieve great oral health.

Wild mint flavored, When used twice daily, one 4 oz. tube lasts about 3 months.

Fluoride-free, paraben-free, vegan and cruelty-free

No harsh foaming agents; SLS and sulfate-free

TRAVEL-FRIENDLY: Bite Toothpaste Bits are a plastic-free and travel-friendly way to brush your teeth. Perfectly portioned for easy travel and mess-free brushing.

PLASTIC-FREE: Contains two (2) recyclable glass bottles of 62 Toothpaste Bits (124 bits total). A 2-month supply for twice-daily brushing.

REMINERALIZES: These Bits are made with Nano-Hydroxyapatite, a non-toxic alternative to fluoride that helps remineralize enamel and reduce sensitivity.