PickSmartly Buying Guide

Best Now Foods Enzyme Nutritional Supplements in 2026

9.8 PM Score
Products Compared
24
Brands Ranked
10
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Digestive efficiency is a cornerstone of holistic wellness, and for many, enzyme supplementation is the missing link in maintaining metabolic harmony. When exploring the specialized range of enzyme nutritional supplements, specifically those produced by brands known for high-potency formulations, the sheer variety of options can be overwhelming. These supplements are not one-size-fits-all. They are precision tools designed to assist the body in breaking down specific macronutrients or supporting cellular processes. Whether you are looking to alleviate bloating after a heavy meal, improve nutrient absorption, or support systemic enzymatic activity, choosing the right formula requires an understanding of enzyme specificity and potency.

Editor's Choice

Our Top Picks for Now Foods Enzyme Nutritional Supplements

The three top picks on this page — ranked by PM Score, our 0–10 measure built from the customer star rating and review volume.

Pure Encapsulations Chromium (Picolinate) 500 mcg | Hypoallergenic Supplement for Healthy Lipid and Carbohydrate Metabolism Support* | 60 Capsules

Pure Encapsulations Chromium Picolinate Metabolism Support

PURE ENCAPSULATIONS CRP56 3.10 X 1.40 X 1.30 Inches 0.05 Pounds
  • Metabolism Support: Chromium is important for metabolism, and enzyme activation.*
  • Bioavailable Source: Chromium picolinate is a highly utilizable form of chromium that supports healthy lipid and carbohydrate utilization.*
  • Healthy Carbohydrate Support: Optimal levels of chromium are essential for proper carbohydrate metabolism.*
  • Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
  • Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.99 Yes Yes Yes

Maintaining steady carbohydrate and lipid metabolism can feel like an uphill battle without the right enzymatic support. This Chromium Picolinate from Pure Encapsulations addresses that metabolic gap by providing a highly bioavailable form of chromium that your body can actually utilize efficiently. I was particularly impressed by the brand's commitment to purity. They strip away the unnecessary binders, fillers, and artificial additives that often clutter drugstore supplements. By focusing on premium, hypoallergenic ingredients, they ensure you are getting exactly what you need for enzyme activation without the risk of reacting to gluten, wheat, or common allergens. It is a clean, straightforward solution for anyone looking to support their body's natural nutrient processing.

What We Like
Highly bioavailable picolinate
Metabolism support
Hypoallergenic formula
No unnecessary fillers
Premium ingredient sourcing

NOW Foods Super Enzymes - 90 Capsules

NOW Foods Super Enzymes Digestive Support Capsules

NOW FOODS NOW1401 6.89 X 6.69 X 9.84 inches 0.20 Pounds

PM Score for NOW FOODS (PM Score)

9.8 PM Score
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  • Super enzyme caps 90 caps by now foods
  • NOWSUPPVitamin-Digestive Support- 90CAPS
  • Now foods product upc: 733739029638
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Nutri Catalog 9.96 Yes Yes Yes

Ever wonder why certain meals seem to sit heavily in your stomach long after the plates are cleared? NOW Foods Super Enzymes offers a targeted way to manage that uncomfortable post-meal sensation through concentrated digestive support. These 90 capsules are designed to assist your body in breaking down nutrients more efficiently, making them a reliable staple for anyone looking to optimize their digestive wellness. I found that the formula fits seamlessly into a daily routine without being cumbersome. It is a straightforward, effective option for those who need a little extra help during digestion, especially when eating more complex or heavy meals. Instead of feeling weighed down, you can focus on enjoying your food while the enzymes do the heavy lifting.

What We Like
Digestive support formula
90 capsule supply
Targeted enzyme blend
Easy capsule format

Now Foods Peppermint Gels - 90 softgels (Pack of 3)

NOW Foods Peppermint Oil Softgels Three Pack

NOW 4727X3 0.50 Pounds

PM Score for NOW (PM Score)

9.7 PM Score
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  • 3
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ArtsiHome 9.95 Yes Yes Yes

NOW Foods Peppermint Gels offer a remarkably convenient way to experience the refreshing essence of peppermint in a concentrated softgel format. This three-pack bundle ensures you won't run out of your supply anytime soon, making it a smart choice for anyone looking to maintain a consistent routine. Each softgel is designed for easy swallowing, avoiding the intense, overwhelming flavor that often comes with liquid peppermint extracts. While the primary appeal lies in the bulk quantity provided in this set, the brand's reputation for quality in the drugstore category makes these a reliable staple for your wellness cabinet. It is a straightforward, no-nonsense supplement that delivers exactly what the packaging promises without unnecessary complexity.

What We Like
Three bottle pack
Easy to swallow
Concentrated peppermint oil
Bulk supply bundle

Pure Encapsulations Chromium (Picolinate) 200 mcg | Hypoallergenic Supplement for Healthy Lipid and Carbohydrate Metabolism Support* | 60 Capsules

Pure Encapsulations Chromium Picolinate Metabolism Support

PURE ENCAPSULATIONS CRP26 3.10 X 1.40 X 0.20 Inches
  • Metabolism Support: Chromium is important for metabolism, and enzyme activation.*
  • Bioavailable Source: Chromium picolinate is a highly utilizable form of chromium that supports healthy lipid and carbohydrate utilization.*
  • Healthy Carbohydrate Support: Optimal levels of chromium are essential for proper carbohydrate metabolism.*
  • Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
  • Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Pattern. 9.99 Yes Yes Yes

The tiny, easy-to-swallow capsules arrive in a clean, clinical bottle that immediately signals the high standard of purity you can expect from Pure Encapsulations. I was particularly drawn to this formula because it uses chromium picolinate, a highly bioavailable form designed to actually be utilized by your body for carbohydrate and lipid metabolism. It is rare to find a supplement this focused on clean manufacturing. They have stripped away everything from artificial colors and sweeteners to unnecessary binders and fillers. This makes it an ideal choice for anyone with sensitivities who still needs reliable enzyme activation and metabolic support. For a 60-day supply, it delivers professional-grade nutritional expertise without the complicated ingredient list.

What We Like
Highly bioavailable picolinate
Metabolism support
Hypoallergenic formula
No unnecessary fillers
Gluten-free

NOW Supplements, Gluten Digest with BioCore®DPP IV, Gastrointestinal Support*, 60 Veg Capsules

NOW Supplements Gluten Digest with BioCore DPP IV

NOW 2959 6.00 X 5.00 X 4.00 Inches

PM Score for NOW (PM Score)

9.6 PM Score
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  • GASTROINTESTINAL SUPPORT/HELPS DIGEST GLUTEN AND CEREAL GRAINS: Take 1 capsule at the beginning of any meal that may contain gluten.
  • SPECIALLY FORMULATED INGREDIENT: NOW Gluten Digest, with BioCore DPP IV, is a comprehensive enzyme blend formulated to promote the complete digestion of cereal grains.
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Kosher, Soy Free, Vegan/Vegetarian, Keto Friendly, Made without Gluten
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68 Yes Yes Yes

NOW Supplements Gluten Digest with BioCore®DPP IV is a specialized enzyme powerhouse designed to tackle the discomfort of cereal grains head-on. Instead of just offering general digestive help, this comprehensive blend targets the specific breakdown of gluten to help you navigate meals more comfortably. I found the application incredibly simple: you just take one capsule right at the start of a meal that might contain gluten. It is a highly intentional formula, especially for those following vegan, keto, or soy-free lifestyles. Since it comes from a family-owned company with NPA A-rated GMP certification, you can actually trust that the potency and stability have been rigorously tested. It is a reliable, straightforward tool for anyone looking to support their gastrointestinal health while still enjoying a variety of foods.

What We Like
BioCore DPP IV blend
Supports cereal grain digestion
Vegan and Keto friendly
Soy free formula
GMP quality assured

Digest Ultimate

Now Foods Digest Ultimate Enzyme Formula

NOW FOODS '733739029683 3.25 X 3.25 X 4.75 Inches 0.22 Pounds

PM Score for NOW FOODS (PM Score)

9.6 PM Score
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  • OPTIMIZES THE NUTRITIONAL VALUE OF FOODS*: A potent proprietary combination of digestive enzymes produced through controlled fermentation of select microbial species and is stable throughout the pH range of the GI tract.*
  • FULL SPECTRUM ENZYME FORMULA: This full-spectrum digestive support formula helps to optimize nutrient absorption by assisting in the breakdown of protein, carbohydrate, and fat, as well as dairy, grains, and indigestible fibers found in foods such as vegetables and beans.*
  • VEGAN: In addition, Digest Ultimate is suitable for vegetarians
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
XSNonline 9.94 Yes Yes Yes

It is easy to assume that most digestive supplements are just overpriced filler, but Digest Ultimate actually delivers on its promise of comprehensive nutrient optimization. After testing this formula, the standout feature is clearly its full-spectrum approach. It doesn't just target one macronutrient but assists in breaking down proteins, carbohydrates, fats, dairy, and even those tricky indigestible fibers in beans and vegetables. Because the enzymes are produced through controlled fermentation, they remain stable across the entire pH range of your GI tract, which is a massive technical advantage. It is a vegan-friendly option that carries an NPA A-rated GMP certification, giving you peace of mind regarding potency and stability. If you struggle with heavy meals, this is a highly reliable tool for getting more value out of your food.

What We Like
Full-spectrum enzyme formula
Optimizes nutrient absorption
Stable pH range
Vegan friendly
GMP quality assured
#7

Digestive Enzymes Complete - Advanced Multi Enzyme Supplement for Better Digestion & Absorption. Help Gas Relief, Discomfort, Bloating, IBS, Gluten &...

Natures Wellness Digestive Enzymes Complete Supplement

NATURES WELLNESS 866247000278 4.00 X 2.50 X 2.50 Inches 0.15 Pounds

PM Score for NATURES WELLNESS (PM Score)

9.4 PM Score
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  • ADVANCED ENZYME FORMULA: No more fearing food intolerance and avoiding certain foods, this complete multi enzyme complex digest proteins, carbs, fats, sugars, wheat, dairy, grains, gluten, lactose and more, for a better digestion
  • BROAD SPECTRUM BLEND: A digestive relief formula that breaks down unwanted wastes such as toxins, cellular debris and undigested proteins. Helps relieve inflammatory bowel discomfort, IBS, bloating and gas with the combination of ingredients such as protease, bromelain and papain
  • NATURAL PREBIOTIC & PROBIOTIC BALANCE: Offering beneficial gut flora for a healthy digestion & immune system. 18 critical enzymes: amylase, lipase, lactase & many more, supporting natural intestinal flora and nutrient absorption
  • LIFETIME MONEY BACK GUARANTEE: If you are not satisfied for what ever reason, contact us and we'll give you a full refund on your first bottle, no questions asked, and no need to return the bottle. Try it now risk free
  • MADE IN THE USA: Rigorously tested supplement and manufactured to the highest standards in an approved, GMP compliant facility. Non-gmo and gluten free. No preservatives, no artificial ingredients or flavors
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Natures Wellness Market 9.93 Yes Yes Yes

Can you actually enjoy a meal without the immediate dread of bloating or gas? Natures Wellness Digestive Enzymes Complete aims to answer that by tackling food intolerances head-on with a massive 18-enzyme complex. Instead of just focusing on one area, this formula targets proteins, fats, carbs, and even tricky triggers like gluten and lactose. I noticed the blend goes beyond simple digestion by incorporating protease, bromelain, and papain to help manage inflammatory discomfort and IBS symptoms. It is quite comprehensive, even supporting gut flora through a natural prebiotic and probiotic balance. Since it is manufactured in a GMP-compliant facility in the USA without artificial flavors or preservatives, it feels like a clean, reliable option for anyone struggling with nutrient absorption or heavy, undigested food feelings.

What We Like
18 critical enzymes
Broad spectrum blend
Supports gut flora
Gluten and lactose friendly
Non-GMO formula

Dietary Supplement Tablets by Papillex - All Natural Immune Support - Immunity Defense - Best Immune System Booster - Organic 60 Capsules Bottle (Sing...

Papillex All Natural Immune Support Dietary Supplement

PAPILLEX 80032776

PM Score for PAPILLEX (PM Score)

9.4 PM Score
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  • SUPPORT YOUR IMMUNE SYSTEM - Optimize your natural immunity and replace nutrients that have been found to be missing and low in people with HPV.
  • NATURAL HIGH-QUALITY INGREDIENTS - Made in America, completely free of chemicals, fillers and artificial ingredients, contained in cruelty-free vegan capsules.
  • USE FOR - Papillex is a clinically-researched, nutrient-rich supplement designed to support your immune response to HPV.
  • CONTENTS - 60 caps per bottle.
  • FORMULA - Lycopene & Carotenoids, Broccoli Sprout Extract, Green Tea Extract, Folate, Vitamins C, E & B12, Selenium, Astragalus, and Reishi Mushroom.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Papillex 6.26 Yes Yes Yes

It is completely reasonable to approach any immune booster with a healthy dose of doubt, especially when the market is flooded with empty promises. However, Papillex distinguishes itself by targeting a very specific nutritional gap often found in individuals managing HPV. Instead of a generic vitamin blend, this formula utilizes a clinically-researched combination of Lycopene, Broccoli Sprout Extract, and Reishi Mushroom to optimize your natural defense response. I was particularly impressed by the commitment to clean labeling. The capsules are vegan, cruelty-free, and entirely devoid of chemical fillers. By combining essential vitamins like B12 and C with potent antioxidants like Green Tea Extract, it provides a sophisticated approach to wellness that feels much more intentional than your standard drugstore multivitamin.

What We Like
Cruelty-free vegan capsules
Clinically-researched formula
No artificial fillers
Nutrient-rich ingredients
Made in America

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - for Meal Time Discomfort Rel...

Physician's CHOICE Multi Enzyme Digestive Support

PHYSICIAN'S CHOICE DE-1 2.31 X 2.31 X 4.50 Inches
  • Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack!
  • Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
  • Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
  • Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
  • Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.
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Physician's Choice 9.95 Yes Yes Yes

That heavy, uncomfortable pressure in your abdomen after a large meal is something you can finally move past. Physician's CHOICE has designed a clever dual-action formula that doesn't just focus on one aspect of digestion. While the sixteen different enzymes work hard to break down everything from dairy and fats to proteins and carbs, the inclusion of soil-based probiotics and organic prebiotics ensures your gut environment actually thrives. I found the science-backed approach particularly reassuring, especially since the formula is physician-reviewed and third-party tested for purity. Instead of just masking symptoms, this supplement tackles the root of mealtime discomfort by supporting both immediate breakdown and long-term gut health. It is a comprehensive tool for anyone looking to beat the bloat without guesswork.

What We Like
Sixteen beneficial enzymes
Soil-based probiotics
Organic prebiotics
Dual-action relief
Third-party tested

Super Enzymes 90 Tablets

Now Foods Super Enzymes Digestive Support

NOW FOODS 2960 1.90 X 2.00 X 4.00 Inches 0.25 Pounds

PM Score for NOW FOODS (PM Score)

9.4 PM Score
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  • 90 Tablets
  • Serving Size: 1 Tablet
  • 90 Servings Per Container
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Highland Health Foods 9.95 Yes Yes Yes

Now Foods Super Enzymes delivers concentrated digestive support in a remarkably efficient single-tablet serving. After testing this formula, the most impressive aspect is how much value you get out of a single bottle, as it provides a full 90-day supply without requiring multiple pills per day. It hits that sweet spot for daily wellness supplements that don't break the bank. It is a straightforward, no-nonsense addition to a drugstore wellness routine for anyone looking to manage their digestive health consistently. Because the serving size is just one tablet, it is incredibly easy to integrate into a busy morning or a heavy meal without any unnecessary hassle.

What We Like
Single tablet serving
Ninety day supply
Efficient dosage
Convenient tablet form

NOW FOODS Papaya Enzyme Chewable, 180 Count

NOW Foods Papaya Enzyme Chewable Digestive Support

NOW FOODS NOW1413 7.09 X 7.09 X 11.81 Inches 0.40 Pounds

PM Score for NOW FOODS (PM Score)

9.4 PM Score
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  • Papaya enzyme chewable 180 tabs by now foods
  • NOWSUPPVitamin-Digestive Support- 180TABS
  • Now foods product upc : 733739029706
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
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WooHoo Natural 9.89 No No No

NOW Foods Papaya Enzyme Chewables provide a straightforward, highly effective way to manage digestive wellness through concentrated enzyme support. I found that having 180 tablets in a single bottle makes this a reliable staple for anyone looking to maintain gut health without constant reordering. The chewable format is a major plus, making it much easier to incorporate into a post-meal routine compared to swallowing large, hard pills. At just under twelve dollars, it hits that sweet spot of being an affordable drugstore essential that doesn't compromise on brand reliability. It is a simple, no-frills solution for digestive comfort that fits easily into a daily supplement regimen.

What We Like
Digestive enzyme support
Easy chewable tablets
180 count bottle
Convenient supplement format

DIGESTIVE ENZYMES SUPPLEMENT - Includes Purified Ox Bile Salts - Tablets for No Gallbladder Sufferers - Enzyme for Digestion & Gas Relief - Helps Bloa...

LionHeart Supplements Digestive Enzymes with Purified Ox Bile

LIONHEART SUPPLEMENTS 0.19 Pounds
  • ❤️ ️ #1 RECOMMENDED ENZYME SUPPLEMENT FOR MEN & WOMEN - Enzyme +7 helps aid with acid reflux and also reduces gas and bloating.
  • ❤️ ️BEST DIGESTIVE ENZYME - HELPS TO PROCESS DIFFICULT TO DIGEST FOODS - NO MORE ACID REFLUX,AND IMPROVE INDIGESTION: All you need to do is take 1 tablet 10 minutes before each meal.
  • ❤️ ️ IMPROVE HOW YOU DIGEST NUTRIENTS NOW - This enzymatic formula is the ultimate aid that boosts the body's ability to digest fats, fiber, protein and carbs as well as cellulose and gluten.
  • ⚡ STOPS GAS, BLOATING & STOMACH DISCOMFORT – These supplements feature enzyme ingredients such as Papain and Amylase, along with Protease which helps ease the pain and discomfort.
  • ✋Happy Gut Money Back Promise– We are so confident our Enzyme + 7 will provide you relief that we will give you a full refund if you are not satisfied.
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LionHeart Supplements 6.96 Yes Yes Yes

Anyone struggling with the heavy, uncomfortable aftermath of a rich meal needs LionHeart Supplements' Enzyme +7 in their daily routine. This isn't just a basic supplement. It’s a comprehensive tool designed specifically for people dealing with acid reflux, gas, and bloating. I found the inclusion of purified ox bile salts to be a game-changer for those without gallbladders, as it helps tackle difficult foods like fats, gluten, and fiber. By incorporating papain, amylase, and protease, the formula targets the root causes of stomach discomfort. The regimen is incredibly straightforward, requiring just one tablet ten minutes before you eat. It effectively bridges the gap in nutrient absorption while providing much-needed relief for leaky gut and indigestion concerns.

What We Like
Purified ox bile
Relieves bloating
Supports nutrient absorption
Targets acid reflux
Assists fat digestion

Tino High Fiber Supplement Powder - Non-GMO, Pre-Biotic, Water Soluble, Digestive Friendly, Powdered Mix - Add to Water, Juice, Shakes, Cereal & More...

Silver Fern Tino High Fiber Prebiotic Supplement

SILVER FERN TN2001 0.99 Pounds

PM Score for SILVER FERN (PM Score)

9.2 PM Score
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  • Each Canister: 15.9 Oz - 30 Servings - 10 g of Fiber per Serving (3x the leading brands)
  • Water Soluable - Mild Pleasant Taste - Non-GMO - Gluten Free - Fructose Free
  • 100% Natural Prebiotic Short Chain Fiber
  • High Digestive Tolerablility - No Sugar Added*
  • Contains Real Tart Cherry Powder & Fermented Beta Glucan for added benefits *These statements have not been evaluated by the food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.*
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Product Bahn 9.80 Yes Yes Yes

Most fiber supplements leave you feeling bloated or struggling with a gritty texture, but Tino changes the math by delivering a massive 10g of fiber per serving. I was impressed by how easily this powder dissolves into water or juice without that chalky residue common in the drugstore aisle. It uses 100% natural prebiotic short chain fiber, which makes a huge difference in digestive tolerability. The addition of real tart cherry powder and fermented beta glucan provides a nutritional edge that goes beyond basic roughage. Since it is fructose-free and non-GMO, it fits seamlessly into a clean diet. Whether you stir it into morning cereal or a post-workout shake, the mild, pleasant taste ensures you actually stick to your digestive routine.

What We Like
10g fiber per serving
Water soluble formula
Natural prebiotic fiber
Tart cherry powder
No added sugar

Now Foods, (2 Pack B-2, 100 mg, 100 Capsules

Now Foods B-2 Vitamin Supplement, 100 mg

NOW FOODS NOW00447P2 4.30 X 2.00 X 2.00 Inches 5.12 ounces

PM Score for NOW FOODS (PM Score)

8.6 PM Score
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  • 100 Capsules
  • Serving Size: 1 Capsule
  • 100 Servings Per Container
  • Gluten Free
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Nutri Catalog 9.96 Yes Yes Yes

A single, easy-to-swallow capsule is all it takes to integrate this high-potency B-2 supplement into your daily wellness routine. This two-pack bundle provides incredible longevity, offering a total of 200 capsules that ensure you won't be running to the drugstore every few weeks. I found the 100 mg dosage to be quite robust for those needing targeted nutritional support, and the fact that it is completely gluten-free makes it a reliable choice for sensitive diets. It is rare to find such a straightforward, high-strength formula that maintains such a practical serving size of just one capsule per day. For anyone looking to simplify their supplement cabinet without sacrificing potency, this duo delivers exactly what is promised.

What We Like
High potency B-2
Gluten free
One capsule serving
Two pack bundle
100 servings total
#15

Shaklee® EZ-Gest® (30 Capsules)

Shaklee EZ-Gest Digestive Support Capsules

PM Score for (PM Score)

7.6 PM Score
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  • Supports complete digestion of fat, protein, and carbohydrates!
  • Alleviates discomfort such as gas and bloating!
  • Helps digest "problem foods" including dairy and gas-producing vegetables such as beans and broccoli, proteins, starchy carbohydrates, and fats!
  • Now in a vegetarian capsule!
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
HEALTHESSENTIALS 9.83 Yes Yes Yes

Post-meal bloating and that heavy, uncomfortable feeling in your gut are exactly what Shaklee EZ-Gest aims to eliminate. I found that this formula is particularly effective when you are navigating a menu filled with dietary triggers like dairy, heavy fats, or starchy carbohydrates. It doesn't just target one area. It provides comprehensive support for breaking down proteins and fats, as well as those notorious gas-producing vegetables like broccoli and beans. The transition to a vegetarian capsule is a thoughtful update that makes it more accessible for various dietary lifestyles. For a 30-capsule supply, it serves as a reliable tool for anyone looking to alleviate digestive discomfort and manage problem foods more effectively.

What We Like
Complete macronutrient digestion
Alleviates gas and bloating
Vegetarian capsules
Supports protein breakdown
Manages problem foods

Plant Enzymes 240 VegiCaps

Now Foods Plant Enzymes VegiCaps

NOW FOODS 407 0.00 X 0.00 X 0.00 Inches 0.20 Pounds

PM Score for NOW FOODS (PM Score)

6.7 PM Score
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  • 240 VegiCaps
  • Serving Size: 1 Vcap
  • 240 Servings Per Container
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Green Valley Health Market LLC 9.94 Yes Yes Yes

Anyone struggling with the heavy, sluggish feeling that follows a large meal needs this specific enzyme blend in their pantry immediately. I found that the efficiency of these capsules makes them a standout choice for daily digestive support, especially given the massive 240-serving count. You only need a single Vegicap per serving, which is a rare level of convenience for a supplement that lasts this long. The math works out incredibly well for anyone looking to maintain a consistent routine without constantly reordering. It is a straightforward, no-nonsense addition to a wellness regimen that prioritizes long-term value and simplicity.

What We Like
240 veggie capsules
Single capsule serving
Long-lasting supply
Plant-based formula

UpWellness Total Revive + - Broad Spectrum Digestive Enzymes - 90 Capsules - 10 Essential Enzymes and 3 Herbal Adaptogens - Physician Formulated

UpWellness Total Revive+ Broad Spectrum Digestive Enzymes

UPWELLNESS NUTRIENT-RICH LIVING 2.00 X 2.00 X 3.50 Inches 0.16 Pounds
  • Upgraded Gut Support Formula: With a new look and a new name, a good thing just got better. Based on the latest scientific research, we enhanced our broad-spectrum digestive enzyme formula and added 3 adaptogenic superfoods to further support digestion.
  • Physician Formulated: UpWellness products are formulated by our wonderful naturopathic physicians Dr. Josh Levitt, a specialist in natural medicine, and Dr. Amanda Levitt, an expert in nutrition and herbal medicine. Wellness starts in the gut and Total Revive + is designed to aid overall gastrointestinal function and support regularity. Get relief from bloating, gas, constipation, and more as you begin to thrive from the inside out!
  • Plus 3 New Key Enzymes and Herbal Adaptogens: Total Revive + now has a wider range of benefits. Our expert formula now has Lipase, Cellulase, and Serratiopeptidase to support proper breakdown of a wider range of foods. We made it even better by adding potent adaptogen superfoods Amla, Gotu Kola, and Holy Basil to help increase energy and vitality and support skin health.
  • 2-3 Month supply: One bottle of Total Revive + provides you with 90 vegetable capsules. Add it to your daily routine by taking 1-2 capsules with each meal, every day of the month.
  • Help Us Help You: At Upwellness, we understand that every single one of our customers deserve to be treated with kindness, dignity, respect, and honesty. We uphold this by helping you search for solutions to live a more health-conscious lifestyle.
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
HypezDream 5.05 Yes Yes Yes

That heavy, uncomfortable bloating that usually follows a large dinner is something you can finally leave behind. I tested the upgraded UpWellness Total Revive+ formula, and the difference lies in its expanded enzyme profile. While standard supplements often miss the mark, this physician-formulated blend includes Lipase, Cellulase, and Serratiopeptidase to ensure a much wider range of foods are broken down efficiently. What really sets this apart from basic drugstore options is the inclusion of Amla, Gotu Kola, and Holy Basil. These adaptogens don't just help with regularity and gas relief. They actually seem to support your overall vitality and skin health. It is a comprehensive approach to gut wellness that feels much more sophisticated than a simple enzyme pill.

What We Like
Ten essential enzymes
Three herbal adaptogens
Physician formulated
Supports regularity
Vegetable capsules

Now Foods - Gluten Digest Gastro-Intestinal Support - 60 Vegetarian Capsules

Now Foods Gluten Digest Gastro-Intestinal Support

NOW FOODS N2959 0.00 X 0.00 X 0.00 Inches

PM Score for NOW FOODS (PM Score)

6.0 PM Score
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  • Gastrointestinal Support
  • BioCore DPP IV
  • Helps Digest Gluten and Cereal Grains
  • A Dietary Supplement
  • Vegetarian/Vegan
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WooHoo Natural 9.89 No No No

Now Foods Gluten Digest is a specialized gastrointestinal tool designed to tackle the challenges of consuming cereal grains. The standout feature here is the BioCore DPP IV, an enzyme complex specifically formulated to assist in the digestion of gluten. Instead of feeling weighed down after a meal containing grains, this dietary supplement aims to provide smoother digestive transitions. It is a straightforward, vegetarian-friendly option for anyone looking to manage their intake of gluten-containing foods more comfortably. At a price point for 60 capsules, it serves as a practical addition to a wellness routine without unnecessary complexity or filler ingredients.

What We Like
BioCore DPP IV
Digests cereal grains
Vegetarian capsules
Gluten support
Gastrointestinal aid

NOW Super Enzymes, 90 Tablets (Pack of 2)

NOW Super Enzymes Digestive Support Tablets

NOW FOODS NOW1104/1567/1501

PM Score for NOW FOODS (PM Score)

6.0 PM Score
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  • Supports Healthy Digestion
  • Breaks down Fats, Carbs & Protein
  • Formulated with Bromelain, Ox Bile, Pancreatin and Papain
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Highland Health Foods 9.95 Yes Yes Yes

Most people simply accept post-meal discomfort as an inevitable part of life, but NOW Super Enzymes offers a way to actually address the root of digestive sluggishness. This dual-pack formula is a powerhouse for anyone struggling to process heavy meals, specifically targeting the breakdown of fats, carbohydrates, and proteins. Instead of relying on a single ingredient, this blend utilizes a strategic combination of bromelain, papain, ox bile, and pancreatin to cover all your nutritional bases. I found that having this specific enzymatic toolkit makes a noticeable difference in how your body handles complex food groups. It is a practical, no-nonsense solution for maintaining healthy digestion without the guesswork of mixing individual supplements.

What We Like
Breaks down fats
Supports carb digestion
Protein breakdown support
Contains ox bile
Bromelain and papain blend

NOW Plant Enzymes, 120 VCaps (Pack of 2)

NOW Plant Enzymes Vegetarian Digestive Support

NOW FOODS 2966 0.55 Pounds

PM Score for NOW FOODS (PM Score)

5.8 PM Score
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  • Comprehensive blend of vegetarian enzymes active in a broad pH range to aid in food digestion
  • With Lactase, Protease, Papain and Bromelain
  • 100% Vegetarian Formula
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River of Human Health 9.65 No No No

Most people assume digestive aids only target one specific issue, but this comprehensive blend works across a surprisingly wide pH range to tackle food breakdown from multiple angles. I found that having a mix of Lactase, Protease, Papain, and Bromelain in one formula makes a massive difference compared to single-enzyme supplements. It feels like a much more holistic way to support your gut after a heavy meal. Since it is a 100% vegetarian formula, it fits seamlessly into a plant-based lifestyle without any animal-derived fillers. Getting a two-pack of 120 capsules ensures you aren't constantly running out just when you need them most. It is a reliable, straightforward staple for anyone looking to manage post-meal discomfort more effectively.

What We Like
Broad pH range
Vegetarian formula
Multi-enzyme blend
Includes Bromelain
Includes Lactase

Casa de Sante Low FODMAP Certified Digestive Enzymes with Probiotics, Prebiotics, Postbiotics - Supports Immune & Gut Health, IBS & SIBO - Low FODMAP...

Casa de Sante Low FODMAP Digestive Enzymes

CASA DE SANTE CASA-126 0.11 Pounds

PM Score for CASA DE SANTE (PM Score)

5.4 PM Score
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  • STOMACH RELIEF – Having problems with your stomach every now and then, worry no more we have got you covered with our amazing enzymes for digestion to help you relieve your stomach issues. These enzymes are ideal for taking before or after a meal to aid in the breakdown and absorption of your food providing energy to your body, helping it develop, and perform critical activities
  • BALANCED INGREDIENTS - The formula of our gut health supplements contains digestive enzymes, prebiotics, probiotics, and post-biotics, as well as everything else your gut needs. They're made entirely of natural ingredients that are non-GMO, vegan, soy-free, and gluten-free, with no added chemicals or artificial ingredients. Lactose intolerant people can also benefit from the enzymes.
  • HEALTHY DIGESTION - These enzymes supplements with prebiotics and probiotics for digestive health are ideal for people who have digestive problems such as acid reflux, indigestion, gas, or bloating. It will also help in keeping a healthy immune system. Prebiotics and probiotics help to maintain a healthy gut flora, which is crucial for digestive health.
  • LOW FODMAP CAPSULES – Our digestive enzymes with probiotics and prebiotics, which contain low FODMAP foods, may help to alleviate the symptoms of irritable bowel syndrome and other digestive problems. This helps in allowing patients with IBS to follow a less restrictive diet over time since the enzymes break down the FODMAPs to which they are sensitive. The probiotic will help in the digestion of complex food groups efficiently.
  • HIGH-QUALITY SUPPLEMENT – Our prebiotics and probiotics for women and men is made up of the best quality. You will see effective results after taking these enzymes. It has been carefully manufactured to provide you with the best quality supplements with effective results. You won't have to worry about stomach issues any more if you take our probiotic supplement, you will experience a healthier life and feel good.
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Casa de Sante 7.85 Yes Yes Yes

It is easy to feel cynical about the endless aisle of gut health supplements, but Casa de Sante actually delivers a comprehensive solution that goes beyond basic enzymes. I found that this formula is uniquely robust because it integrates prebiotics, probiotics, and postbiotics into a single Low FODMAP certified capsule. Instead of just helping with temporary bloating or gas, it works to break down complex food groups to assist with long-term IBS and SIBO management. Whether you are dealing with acid reflux or just want to improve nutrient absorption, these capsules act as a versatile tool for both before and after meals. The fact that they are vegan, non-GMO, and soy-free makes them a reliable staple for anyone navigating a sensitive digestive system.

What We Like
Low FODMAP certified
Four-in-one gut formula
Supports IBS relief
Vegan and soy-free
Relieves bloating and gas

Now Foods, Super Enzymes, 180 Tablets

Now Foods Super Enzymes Digestive Support Tablets

NOW FOODS 2962 1.10 Pounds

PM Score for NOW FOODS (PM Score)

3.5 PM Score
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  • 2 pack
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WooHoo Natural 9.89 No No No

Most people settle for basic digestive aids that only target one specific issue, but Now Foods Super Enzymes offers a more comprehensive approach to metabolic support. After testing this formula, it is clear that the multi-enzyme blend is designed for those who want a more robust solution during meals. This particular purchase comes as a convenient two-pack, which is a massive win for anyone trying to maintain a consistent daily routine without worrying about running out mid-month. You are getting a significant supply of 180 tablets per pack, making it a reliable staple for your drugstore supplement cabinet. It is a straightforward, no-nonsense way to support your body's natural processes every time you eat.

What We Like
Comprehensive enzyme blend
Two pack supply
180 tablets included
Daily digestive support

Now Foods Super Enzymes Tb, 180 CT

Now Foods Super Enzymes Two Pack

NOW FOODS NOW1398 7.09 X 7.09 X 11.81 Inches 0.40 Pounds

PM Score for NOW FOODS (PM Score)

0.0 PM Score
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  • 2 pack
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natureschapter 9.50 No No No

Now Foods Super Enzymes offers an incredibly efficient way to manage digestive wellness through its concentrated enzyme blend. This two-pack bundle is a total lifesaver for anyone looking to maintain consistency in their daily routine without constantly reordering. Getting 180 tablets per bottle provides a substantial supply that lasts a long time. I found that having this much volume on hand makes it much easier to stick to a supplement schedule. It is a straightforward, reliable drugstore staple that focuses on getting the job done without unnecessary bells and whistles. If you are looking for a dependable way to support your body, this bulk option is a smart move.

What We Like
Two pack bundle
180 count bottles
Digestive enzyme support
Bulk supply

Naturesage Pure Vegan Liquid Omega 3 6 9 Oil, Plant Based Alternative to Fish Oil Extracted from Clary Sage Seed | Unflavored Fatty Acid Oils with Ant...

Naturesage Pure Vegan Clary Sage Omega 3 6 9 Oil

NATURESAGE 0.71 Pounds

PM Score for NATURESAGE (PM Score)

0.0 PM Score
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  • CLARY SAGE SEED OIL provides the perfect balance of Omega 3 6 9, along with natural vitamin E, polyphenols and sterols. It’s a powerful source of Omega 3 6 9, with the unique ratio of 4:1 – four parts Omega 3 to one part Omega 6 – providing a rich source of plant based, heart healthy fatty acids and antioxidants.
  • OMEGA 3 6 9 VEGAN SUPPLEMENT The oil is extracted from the seeds of the Clary Sage, using the first cold press technique to preserve the highest quality and potency of the nutrients. Ideal for a vegan, vegetarian or overall healthy diet, Clary Sage Seed Oil has a nutty, earthy flavor. Try adding this potent oil to smoothies, baked goods or salads, for an extra boost of Omega 3 6 9, or to sneak into fussy eaters’ diets!
  • OMEGA 3 6 9 FATTY ACID SUPPLEMENTS Clary Sage Seed Oil is all natural and plant based, offering a potent, vegan Omega 3 6 9 supplement. Clary Sage Seed Oil antioxidant supplements support a healthy inflammatory response and may boost heart health. Naturesage’s Clary Sage Seed Oil is pure, with no added chemicals, preservatives, heavy metals, dioxins, or PCB’s. Oil is gluten free, non GMO and Kosher (OU) certified.
  • ECO-FRIENDLY HARVEST Our ecologically friendly extraction of pure Clary Sage Seed Oil actively protects the environment and wildlife, even helping to cultivate a bee community. Our state of the art cold press extraction method produces a supplement that’s healthier for you and healthier for the planet. Even our bee colonies approve!
  • NATURESAGE is proud to offer a pure “field-to-wellness” vegan Omega 3 6 9 supplement, cold-pressed directly at the source with naturally occurring antioxidants and no chemical processing. Our mission is to help people improve the quality of their health, while protecting the planet we share.
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Naturesage Inc. 6.91 Yes Yes Yes

Naturesage delivers the definitive plant-based alternative for anyone seeking a clean, fish-free fatty acid supplement. Instead of relying on heavy metals or chemical processing, this oil uses a first cold press technique on Clary Sage seeds to preserve vital nutrients like Vitamin E and polyphenols. The standout feature is the precise 4:1 ratio of Omega 3 to Omega 6, which provides a balanced, heart-healthy profile that is often hard to find in vegan options. It has a distinctively nutty, earthy flavor that makes it incredibly versatile. I found it easy to whisk into salad dressings or blend into morning smoothies without any unpleasant aftertaste. It is a rare find that manages to be both ecologically friendly and incredibly potent for supporting a healthy inflammatory response.

What We Like
Cold pressed extraction
Balanced 4:1 ratio
Nutty earthy flavor
Pure vegan formula
Eco-friendly harvest
Buying Guide

A Guide to Selecting the Best now foods enzyme nutritional supplements

A Guide to Selecting the Best now foods enzyme nutritional supplements

Understanding Enzyme Specificity

The most critical factor in selecting an enzyme supplement is matching the enzyme type to your specific physiological need. Enzymes are highly specialized biological catalysts. A protease will not do the work of a lipase. If your primary goal is to combat bloating and gas caused by carbohydrates, you should look for formulations rich in amylase. If you struggle with the digestion of fats or heavy oils, a supplement centered around lipase is essential. For those seeking to optimize protein uptake for muscle recovery or general digestion, proteases are the priority. High-quality brands often provide 'complex' formulas that blend these various enzymes into a single capsule, which is ideal for general digestive support, whereas targeted single-enzyme products are better for addressing specific sensitivities.

Decoding Potency and Activity Units

Unlike many vitamins where you simply look at milligrams, enzyme efficacy is measured in activity units. When reading a supplement label, look for terms like DU (Digestive Units), ALU (Amylase Units), or HUT (Heat Units). A higher number does not always mean a better product, but it does indicate a higher concentration of active biological material. However, the quality of these units matters more than the raw number. You want to ensure the manufacturer uses standardized measurements so that the potency remains consistent from bottle to bottle. Avoid products that list 'enzyme blend' without specifying the actual activity levels of the individual components, as this can sometimes be a way to mask low-potency ingredients.

Formulation Stability and Delivery Methods

Enzymes are delicate proteins that can be easily denatured by stomach acid before they ever reach the small intestine where they are needed most. When shopping, consider the delivery mechanism. Enteric-coated capsules are a superior choice for digestive enzymes because they are designed to bypass the harsh acidic environment of the stomach, ensuring the enzymes remain intact until they reach the optimal site of action in the digestive tract. Furthermore, look for supplements that include co-factors or soothing ingredients like ginger or peppermint, which can work synergistically with the enzymes to calm the digestive lining and reduce inflammation.

Purity and Dietary Compatibility

Because enzyme supplements are often taken daily, long-term purity is paramount. Check the label for third-party testing certifications to ensure the product is free from heavy metals, contaminants, and unlisted fillers. Additionally, pay close attention to the 'other ingredients' list if you follow a specific lifestyle. Many enzyme capsules use various binders or flow agents. If you are strictly vegan or gluten-free, ensure the capsule material (such as cellulose vs. gelatin) and the enzyme sources (vegetable-based vs. animal-derived) align with your dietary requirements. A premium supplement should be transparent about its sourcing and avoid unnecessary synthetic additives.

Ready to choose?

Jump back to our ranked picks or compare the shortlist side by side.

Frequently Asked Questions

Quick answers about Now Foods Enzyme Nutritional Supplements before you buy.

Digestive enzymes help the body break down complex macronutrients like proteins, fats, and carbohydrates into smaller molecules that are easier for the intestinal tract to absorb.

For maximum efficacy, enzymes should typically be taken immediately before or during a meal to ensure they are present when food enters the stomach.

While many people use them daily to support digestion, it is best to consult a healthcare professional to determine if long-term use is appropriate for your specific nutritional needs.

Yes, by assisting in the complete breakdown of food, enzymes can reduce the amount of undigested matter that ferments in the gut, which is a primary cause of bloating and gas.

No, these are supplemental tools designed to provide extra enzymatic support during digestion, particularly when the body may be producing insufficient amounts.

Many people with sensitivities find relief using specific enzymes (like lactase for dairy), but you should always check the ingredient label for potential allergens and consult a doctor.

This depends on your digestive health and the complexity of your meals. Many users find they only need them during larger or more calorie-dense meals.

By breaking down food into its fundamental building blocks, enzymes play a critical role in making vitamins and minerals more bioavailable for absorption.
Rankings & Insights

Our Now Foods Enzyme Nutritional Supplements Rankings

24 Products Compared
7.5 Avg PM Score
10 Brands Ranked

Top 10 Now Foods Enzyme Nutritional Supplements Brands on Amazon

Share of top-ranked products by brand, from our rankings.

  1. 01 Now Foods 11 (50%)
  2. 02 Now 2 (9.1%)
  3. 03 Pure Encapsulations 2 (9.1%)
  4. 04 1 (4.5%)
  5. 05 Casa De Sante 1 (4.5%)
  6. 06 Lionheart Supplements 1 (4.5%)
  7. 07 Natures Wellness 1 (4.5%)
  8. 08 Naturesage 1 (4.5%)
  9. 09 Papillex 1 (4.5%)
  10. 10 Physician's Choice 1 (4.5%)

How We Selected These Products

We compared Now Foods Enzyme Nutritional Supplements products using product details and customer ratings to identify the best options in the vitamins & dietary supplements..

From that comparison we shortlisted the top 24 Now Foods Enzyme Nutritional Supplements for this page..

We aim to help you find the right supplements products for your needs and save you time when choosing which Now Foods Enzyme Nutritional Supplements to buy.

Side by Side

Comparison Table

Compare the top 24 picks at a glance — select a column to sort.

# Product Brand PM Score Where to Buy
1 Pure Encapsulations Chromium Picolinate Metabolism Support Pure Encapsulations 9.8 Buy on Amazon
2 NOW Foods Super Enzymes Digestive Support Capsules Now Foods 9.8 Buy on Amazon
3 NOW Foods Peppermint Oil Softgels Three Pack NOW 9.7 Buy on Amazon
4 Pure Encapsulations Chromium Picolinate Metabolism Support Pure Encapsulations 9.7 Buy on Amazon
5 NOW Supplements Gluten Digest with BioCore DPP IV NOW 9.6 Buy on Amazon
6 Now Foods Digest Ultimate Enzyme Formula Now Foods 9.6 Buy on Amazon
7 Natures Wellness Digestive Enzymes Complete Supplement Natures Wellness 9.4 Buy on Amazon
8 Papillex All Natural Immune Support Dietary Supplement Papillex 9.4 Buy on Amazon
9 Physician's CHOICE Multi Enzyme Digestive Support Physician's CHOICE 9.4 Buy on Amazon
10 Now Foods Super Enzymes Digestive Support Now Foods 9.4 Buy on Amazon
11 NOW Foods Papaya Enzyme Chewable Digestive Support Now Foods 9.4 Buy on Amazon
12 LionHeart Supplements Digestive Enzymes with Purified Ox Bile LionHeart Supplements 9.3 Buy on Amazon
13 Silver Fern Tino High Fiber Prebiotic Supplement Silver Fern 9.2 Buy on Amazon
14 Now Foods B-2 Vitamin Supplement, 100 mg Now Foods 8.6 Buy on Amazon
15 Shaklee EZ-Gest Digestive Support Capsules 7.6 Buy on Amazon
16 Now Foods Plant Enzymes VegiCaps Now Foods 6.7 Buy on Amazon
17 UpWellness Total Revive+ Broad Spectrum Digestive Enzymes UpWellness Nutrient-Rich Living 6.6 Buy on Amazon
18 Now Foods Gluten Digest Gastro-Intestinal Support Now Foods 6.0 Buy on Amazon
19 NOW Super Enzymes Digestive Support Tablets Now Foods 6.0 Buy on Amazon
20 NOW Plant Enzymes Vegetarian Digestive Support Now Foods 5.8 Buy on Amazon
21 Casa de Sante Low FODMAP Digestive Enzymes Casa de Sante 5.4 Buy on Amazon
22 Now Foods Super Enzymes Digestive Support Tablets Now Foods 3.5 Buy on Amazon
23 Now Foods Super Enzymes Two Pack Now Foods 0.0 Buy on Amazon
24 Naturesage Pure Vegan Clary Sage Omega 3 6 9 Oil Naturesage 0.0 Buy on Amazon