Best Eye Drops For Itch Control in 2025

Daisy
Last Updated: Nov 5, 2025

At a Glance: Our Top Picks for Eye Drops For Itch Control

Refresh Tears Lubricant Eye Drops (0.5 Fl Oz - 2 Count) & Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count - 60 Day Supply)
#TOP1
Refresh Tears Lubricant Eye Drops (0.5 Fl Oz
9.9
PM SCORE
Zaditor Antihistamine Eye Drops Twin Pack 0.34 Fl oz
#TOP2
Zaditor Antihistamine Eye Drops Twin Pack 0.34 Fl
9.9
PM SCORE
GenTeal Tears Lubricant Eye Drops, Moderate Liquid Drops, Twin Pack ,0.5 Fl Oz (Pack of 2) Package May Vary
#TOP3
Genteal Tears Lubricant Eye Drops, Moderate Liquid Drops,
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Eye Drops For Itch Control of 2025

Market Overview
Eye Drops For Itch Control Reviewed
  • Reviews Analyzed: 97112 Items
  • PM Avg. Rating: 9.7 / 10
19 Products Evaluated
  • Highest Price: $42.87
  • Lowest Price: $4.49
  • Avg. Price: $19.06

Refresh Tears Lubricant Eye Drops (0.5 Fl Oz - 2 Count) & Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count - 60 Day Supply)

REFRESH
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Contains Refresh Tears Lubricant Eye Drops, 0.5 Fl Oz (2 Count) and Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count) 60 Day Supply

Original strength formula; Relieves mild symptoms of eye dryness

FAST-ACTING EYE ITCH RELIEF: Relieves itchy eyes from allergies in as little as 3 minutes

Zaditor Antihistamine Eye Drops Twin Pack 0.34 Fl Oz

ZADITOR
65401106
2.00 X 2.00 X 2.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
JF BestDeal LLC 9.92

Features

Works as an antihistamine to relieve itchy eyes in minutes

Stabilizes to prevent itchy eyes for up to 12 hours

Hinders allergic reactions by limiting the release of chemicals that cause inflammation

Genteal Tears Lubricant Eye Drops, Moderate Liquid Drops, Twin Pack ,0.5 Fl Oz (Pack Of 2) Package May Vary

GENTEAL
0065042637
1.25 X 2.56 X 4.25 Inches
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Moderate Dry Eye Symptom Relief

Fast Soothing Relief

Quick relief from moderate irritation and discomfort

Relieves discomfort: Provides relief from moderate irritation and discomfort caused by dry eye symptoms

Similasan Allergy Eye Relief Eye Drops 0.33 Ounce Bottle, For Temporary Relief From Red Eyes, Itchy Eyes, Burning Eyes, And Watery Eyes

SIMILASAN
60094841300247
1.38 X 1.63 X 4.25 Inches
0.08 pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Similasan Allergy Eye Relief eye drops provide temporary relief from allergy symptoms. Homeopathic ingredients stimulate the body's natural defenses instead of masking the symptoms.

Made with natural active ingredients like eyebright and sabadilla, not harsh chemicals. Unlike mainstream allergy eye drops Similasan does not contain vasoconstrictors, which can cause a rebound effect. Use as often as you need

No harsh vasoconstrictors or antihistamines. No known side effects. Gluten and dairy free

Trusted by pharmacists and families in Switzerland for over 35 years, Similasan is a leading Swiss brand of remedies that uses natural active ingredients instead of harsh chemicals to keep families healthy.

Similasan is a Swiss brand dedicated to helping families feel good about feeling better. Our gentle eye drops provide natural temporary relief from allergy eye symptoms.

Refresh Relieva Lubricant Eye Drops, 0.33 Fl Oz Sterile, Packaging May Vary

REFRESH
1.13 X 1.75 X 3.50 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Innovative formula relieves discomfort due to dry, irritated eyes

Prevents further irritation

Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface

Also available in a preservative-free formula and a formula for contact lens wearers. Store at 59-86F 15-30C

Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Visine Allergy Relief Multi-Action Antihistamine Eye Drops, Red, Itchy Eyes, 0.5 Fl. Oz

VISINE
JO524937800
1.06 X 1.77 X 3.75 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

0.5-fluid ounce bottle of original prescription strength Visine Allergy Eye Relief Multi-Action Eye Drops with redness reliever & antihistamine for temporary relief of multiple eye allergy symptoms

These clinically-proven allergy eye drops contain 0.3% pheniramine maleate, an effective antihistamine to help relieve irritated red, itchy, eyes due to common allergens such as pollen, ragweed, grass, and animal hair and dander

The eye drops are also formulated with .025% of the redness reliever naphazoline hydrochloride to provide temporary relief from red eyes

Available in a convenient and compact size, these allergy relief eye drops fit easily in a purse, pocket, backpack or desk for effective symptom relief both at home and on-the-go

Visine is backed by 60 years of science and expertise. Experience effective multi-symptom eye allergy relief with Visine Allergy Eye Relief Multi-Action Eye Drops.

Muro 128 Eye Drops, Temporary Relief For Corneal Edema, 5% Solution, 0.5 Fl Oz

MURO 128
BAU027715
1.63 X 1.06 X 3.50 Inches
0.06 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
SaraGu BH 6.57

Features

15 ml of muro 128

Doctor recommended

Directions : Instill 1 or 2 drops in the affected eye(s) every 3 or 4 hours, or as directed

Store upright at 15°–25°C (59°–77°F)

Refresh Optive Advanced Eye Drops, 0.33 Fl Oz (Pack Of 2)(Twin Pack)

REFRESH
94771
1.26 X 2.20 X 3.81 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Triple-action relief drop

Lubricants and hydrates dry, burning, irritated eyes

Helps prevent tears from evaporating

Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface

Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

#TOP9

Refresh Celluvisc Lubricant Eye Gel Single-Use Containers 30 Ea (Pack Of 3)

REFRESH
178053
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Healthy Eyes 9.87

Features

Safe to use as often as needed.

Remove contact lenses prior to use.

Rohto Dryaid Eye Relief Lubricant Eye Drops, Twin Pack, Dry Eye Relief, 0.34 Fl Oz

ROHTO
9843
2.59 X 1.28 X 4.31 Inches
0.08 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Two 0.34 fl oz bottles of Rohto Dry-Aid Eye Relief Lubricant Eye Drops

Provides fast-acting, non-blurring dry eye relief and superior comfort; Dry eye treatment with Liquidshield (TM) technology to mimic real tears and restore moisture

Relieves dryness due to electronics use, hormonal issues, environmental factors, and other irritation; Compact, portable bottle for convenient use

Apply one to two drops for up to 12 hours of relief

From the #1 global OTC eye care brand

Systane Lubricant Eye Gel Drops, 10-Ml (Packaging May Vary)

SYSTANE
ALCON528448
1.25 X 1.76 X 3.86 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

#1 Dr Recommended Brand of Artificial Tears*

Thicker eye drop formulation that creates a protective shield over your eyes.

Convenience of a drop with a protection of a gel.

For the temporary relief of burning and irritation due to dryness of the eye

NOTE: PRODUCT PACKAGING MAY VARY

Clear Eyes Cooling Comfort Relief Eye Drops, 0.5 Fl Oz

CLEAR EYES
10678112101259A
6.00 X 4.00 X 4.00 Inches
0.01 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Clear Eyes Cooling Comfort Eye Drops provide cooling relief for red eyes

Relief from redness, dryness, burning, itching and irritated eyes

From the #1-selling eye drops brand

Provides up to 12 hours of soothing comfort

Contains 1 bottle of Clear Eyes Cooling Comfort Eye Drops, 0.5 fl oz

FSA- and HSA-eligible product in the U.S.

Refresh P.m. Lubricant Eye Ointment, Nighttime Relief, Preservative-Free, 0.12 Oz Sterile, Packaging May Vary

REFRESH
95761
2.80 X 0.90 X 3.30 inches
0.01 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Nighttime relief for intense eye dryness

Preservative-free

Soothes eyes while you sleep

Protects eyes from nighttime dryness due to exposure

Ideal for use at bedtime

Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Allergy Eye Drops By Bausch & Lomb, For Itch & Redness Relief, 15 Ml

BAUSCH & LOMB
622090
1.50 X 1.20 X 3.30 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Super Cyber Savings 9.68

Features

When allergies have your eyes feeling like they're on fire, soothe them with the Bausch and Lomb Redness and Itchy Eye Drops

Made with an antihistamine to help fight allergy symptoms

Bausch and Lomb Eye Drops act as a redness reliever to give you complete allergy eye relief

Zaditor Eye Drops, 5Ml

ZADITOR
NOVARTIS057034
1.95 X 1.15 X 3.85 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
LTN IMPORTS 8.11

Features

Up to 12 hours eye itch relief

works in minutes

original prescription strength

antihistamine eye drops

ketotifen fumarate ophthalmic solution

Healthcareaisle Eye Allergy Itch Relief - Olopatadine Hydrochloride Ophthalmic Solution Usp, 0.2% - 2.5Ml (Twin Pack), Eye Allergy Drops

HEALTHCAREAISLE
1
1.25 X 2.00 X 3.75 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Allergy eye drops: Now available without a prescription, Olopatadine eye drops provide effective eye allergy itch relief

Our allergy eye drops is an antihistamine that temporarily relieves itchy eyes due to pollen, ragweed, grass, animal hair and dander

Comparable to the national brand: Has the same active ingredient as Pataday Once Daily Relief*

Effective eye allergy itch relief within minutes that lasts all day

Once daily relief: Put one eye drop in the affected eye(s) once daily, no more than once per day for eye allergy itch relief; see package label for warnings, directions and other important information; use only as directed

Can-C Eye Drops 5 Milliliter Liquid (2 In 1Pack)

CAN-C
CAN-C-1
2.10 X 1.10 X 2.70 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
E SHOPPE 9.95

Features

Country of origin is United States

Package Dimensions: 2.794 L x 6.35 H x 5.334 W (centimeters)

Ingredients: Use one or two drops twice a days, or as directed by a medical health professional. Before using, read the enclosed insert carefully.,As a soothing eye drop, for temporary relief of minor irritations to the eye and exposure to sun and wind, etc.,Remove the lower ring. Turn the cap anti-clockwise to break the seal.,Remove the cap, dispense drops with gentle pressure. Replace the cap after every use.,Always avoid contamination by replacing cap after use. Do not touch the end of the vial to any sur

Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count) 60 Day Supply, Amazon Exclusive

LASTACAFT
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

FAST-ACTING: Relieves itchy eyes from allergies in as little as 3 minutes

LONG-LASTING: A once daily drop that lasts up to 24 hours (based on 16-24 hour studies)

GREAT VALUE: Each bottle of LASTACAFT contains a 60-day supply and is FSA / HSA eligible

Rx-STRENGTH: Patented, prescription-strength formula available without the prescription

RELIEF FROM ALLERGENS: Works in minutes against seasonal and year-round allergens: pollen, grass, ragweed, animal hair, and pet dander

USAGE: Approved for use in adults and children ages 2 and older

EASY TO USE: LASTACAFT is a once daily treatment that comes in a convenient multi-dose bottle

No matter the season, IT’S LASTACAFT SEASON

Ocuphase Soothing Lubricant Eye Drops With 1% Nac (N-Acetylcarnosine), Two Pack Of 5Ml Vials

TANGO
OCUPHASE
0.05 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Tango Advanced Nutrition, Inc. 6.65

Features

Fast Relief for your Eyes: Our soothing lubricating eye drops quickly help to combat dry eyes and other forms of eye irritation, such as blurry vision, night glare or computer eye strain.

Effective Formula: OcuPhase contains 1% NAC, a antioxidant and antiglycating agent that has been shown to support healthy vision while increasing transmissivity of light through the lens.

Support your Vision: N-Acetylcarnosine-containing eye drops have demonstrated efficacy in benefiting a variety of ophthalmic conditions while delaying vision senescence in humans.

Safe to Use: Our soothing natural tears eye drop formula is save to use by people with Cataracts, Glaucoma, Age-Related Macular Degeneration (ARMD/AMD), and Floaters.

Each box of OcuPhase contains two resealable, sterile vials, containing a total of approximately 200 all-natural moisturizing eye drops.

Top 10 eye drops for itch control Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Refresh 5
Zaditor 2
Bausch & Lomb 1
Can-C 1
Clear Eyes 1
Genteal 1
Healthcareaisle 1
Lastacaft 1
Muro 128 1
Rohto 1

Top 10 eye drops for itch control Brands Pie Chart


We've carried out a comprehensive analysis of 97,112 reviews on eye drops for itch control, using our selection criteria to identify the best options in the categories. Our findings reveal that most customers typically select eye drops for itch control priced around $19.06, with top brands including agepha, lumify, lastacaft, refresh, pataday, biotrue, visine, clear eyes and similasan and healthcareaisle

Our team of expert editors reviewed these high-quality items and handpicked the top 19 eye drops for itch control for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the categories category. These include agepha, amazon.com, evergreencreations, barginhousedeals, health marvel, scope eyecare, super cyber savings, ltn imports and bleam and healthy eyes .

We are dedicated to assisting our users in finding the right drops Products based on their needs, saving them considerable time when choosing which eye drops for itch control to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.