Best Cartridge Eye Drops in 2025

Daisy
Last Updated: Nov 5, 2025

At a Glance: Our Top Picks for Cartridge Eye Drops

Refresh Tears Lubricant Eye Drops (0.5 Fl Oz - 2 Count) & Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count - 60 Day Supply)
#TOP1
Refresh Tears Lubricant Eye Drops (0.5 Fl Oz
9.9
PM SCORE
Refresh Tears Lubricant eye drops 4x15 ml, 1x5 ml
#TOP2
Refresh Tears Lubricant Eye Drops 4X15 Ml, 1X5
9.9
PM SCORE
GenTeal Tears Lubricant Eye Drops, Moderate Liquid Drops, Twin Pack ,0.5 Fl Oz (Pack of 2) Package May Vary
#TOP3
Genteal Tears Lubricant Eye Drops, Moderate Liquid Drops,
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Cartridge Eye Drops of 2025

Market Overview
Cartridge Eye Drops Reviewed
  • Reviews Analyzed: 92608 Items
  • PM Avg. Rating: 9.3 / 10
20 Products Evaluated
  • Highest Price: $39.95
  • Lowest Price: $4.49
  • Avg. Price: $18.62

Refresh Tears Lubricant Eye Drops (0.5 Fl Oz - 2 Count) & Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count - 60 Day Supply)

REFRESH
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Contains Refresh Tears Lubricant Eye Drops, 0.5 Fl Oz (2 Count) and Lastacaft Once Daily Eye Allergy Itch Relief Drops, (1 Count) 60 Day Supply

Original strength formula; Relieves mild symptoms of eye dryness

FAST-ACTING EYE ITCH RELIEF: Relieves itchy eyes from allergies in as little as 3 minutes

Refresh Tears Lubricant Eye Drops 4X15 Ml, 1X5 Ml

REFRESH
REFRSH-MULT
3.15 X 3.15 X 1.18 Inches
0.22 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Trends Goods 9.89

Features

Protects and Lubricates the eyes

Reduces the risk of eye infection

Washes away foreign particles

Keeps The surface of the eyes smooth and clear

Genteal Tears Lubricant Eye Drops, Moderate Liquid Drops, Twin Pack ,0.5 Fl Oz (Pack Of 2) Package May Vary

GENTEAL
0065042637
1.25 X 2.56 X 4.25 Inches
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Moderate Dry Eye Symptom Relief

Fast Soothing Relief

Quick relief from moderate irritation and discomfort

Relieves discomfort: Provides relief from moderate irritation and discomfort caused by dry eye symptoms

Refresh Relieva Lubricant Eye Drops, 0.33 Fl Oz Sterile, Packaging May Vary

REFRESH
1.13 X 1.75 X 3.50 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Innovative formula relieves discomfort due to dry, irritated eyes

Prevents further irritation

Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface

Also available in a preservative-free formula and a formula for contact lens wearers. Store at 59-86F 15-30C

Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Visine Allergy Relief Multi-Action Antihistamine Eye Drops, Red, Itchy Eyes, 0.5 Fl. Oz

VISINE
JO524937800
1.06 X 1.77 X 3.75 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

0.5-fluid ounce bottle of original prescription strength Visine Allergy Eye Relief Multi-Action Eye Drops with redness reliever & antihistamine for temporary relief of multiple eye allergy symptoms

These clinically-proven allergy eye drops contain 0.3% pheniramine maleate, an effective antihistamine to help relieve irritated red, itchy, eyes due to common allergens such as pollen, ragweed, grass, and animal hair and dander

The eye drops are also formulated with .025% of the redness reliever naphazoline hydrochloride to provide temporary relief from red eyes

Available in a convenient and compact size, these allergy relief eye drops fit easily in a purse, pocket, backpack or desk for effective symptom relief both at home and on-the-go

Visine is backed by 60 years of science and expertise. Experience effective multi-symptom eye allergy relief with Visine Allergy Eye Relief Multi-Action Eye Drops.

Muro 128 Eye Drops, Temporary Relief For Corneal Edema, 5% Solution, 0.5 Fl Oz

MURO 128
BAU027715
1.63 X 1.06 X 3.50 Inches
0.06 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
SaraGu BH 6.57

Features

15 ml of muro 128

Doctor recommended

Directions : Instill 1 or 2 drops in the affected eye(s) every 3 or 4 hours, or as directed

Store upright at 15°–25°C (59°–77°F)

Refresh Optive Advanced Eye Drops, 0.33 Fl Oz (Pack Of 2)(Twin Pack)

REFRESH
94771
1.26 X 2.20 X 3.81 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Triple-action relief drop

Lubricants and hydrates dry, burning, irritated eyes

Helps prevent tears from evaporating

Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface

Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

Rohto Dryaid Eye Relief Lubricant Eye Drops, Twin Pack, Dry Eye Relief, 0.34 Fl Oz

ROHTO
9843
2.59 X 1.28 X 4.31 Inches
0.08 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Two 0.34 fl oz bottles of Rohto Dry-Aid Eye Relief Lubricant Eye Drops

Provides fast-acting, non-blurring dry eye relief and superior comfort; Dry eye treatment with Liquidshield (TM) technology to mimic real tears and restore moisture

Relieves dryness due to electronics use, hormonal issues, environmental factors, and other irritation; Compact, portable bottle for convenient use

Apply one to two drops for up to 12 hours of relief

From the #1 global OTC eye care brand

Systane Lubricant Eye Gel Drops, 10-Ml (Packaging May Vary)

SYSTANE
ALCON528448
1.25 X 1.76 X 3.86 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

#1 Dr Recommended Brand of Artificial Tears*

Thicker eye drop formulation that creates a protective shield over your eyes.

Convenience of a drop with a protection of a gel.

For the temporary relief of burning and irritation due to dryness of the eye

NOTE: PRODUCT PACKAGING MAY VARY

Clear Eyes Cooling Comfort Relief Eye Drops, 0.5 Fl Oz

CLEAR EYES
10678112101259A
6.00 X 4.00 X 4.00 Inches
0.01 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Clear Eyes Cooling Comfort Eye Drops provide cooling relief for red eyes

Relief from redness, dryness, burning, itching and irritated eyes

From the #1-selling eye drops brand

Provides up to 12 hours of soothing comfort

Contains 1 bottle of Clear Eyes Cooling Comfort Eye Drops, 0.5 fl oz

FSA- and HSA-eligible product in the U.S.

Refresh Optive Mega-3 Preservative-Free Eye Drops (0.01 Fl Oz, 30 Count) P.m. Eye Ointment, Nighttime Relief, Preservative-Free (0.12 Oz)

REFRESH
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING

Features

Contains Refresh Optive Mega-3 Lubricant Eye Drops, Preservative-Free (0.01 Fl Oz Single-Use Containers, 30 Count) and Refresh P.M. Lubricant Eye Ointment, Nighttime Relief, Preservative-Free (0.12 Oz Sterile)

Preservative-free moisture-rich formula; Designed to relieve moderate symptoms of eye dryness.

Nighttime relief for intense eye dryness

Allergy Eye Drops By Bausch & Lomb, For Itch & Redness Relief, 15 Ml

BAUSCH & LOMB
622090
1.50 X 1.20 X 3.30 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Super Cyber Savings 9.68

Features

When allergies have your eyes feeling like they're on fire, soothe them with the Bausch and Lomb Redness and Itchy Eye Drops

Made with an antihistamine to help fight allergy symptoms

Bausch and Lomb Eye Drops act as a redness reliever to give you complete allergy eye relief

Eye Ointment By Bausch & Lomb, Lubricant Relief For Dry Eyes, 3.5 G

SOOTHE
AB31336
0.01 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Vitabox 9.88

Features

Soothing nighttime dry eye relief

Contains no preservatives

Gentle enough to use as often as needed

Remove contact lenses before using

Zaditor Eye Drops, 5Ml

ZADITOR
NOVARTIS057034
1.95 X 1.15 X 3.85 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
LTN IMPORTS 8.11

Features

Up to 12 hours eye itch relief

works in minutes

original prescription strength

antihistamine eye drops

ketotifen fumarate ophthalmic solution

Can-C Eye Drops 5 Milliliter Liquid (2 In 1Pack)

CAN-C
CAN-C-1
2.10 X 1.10 X 2.70 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
E SHOPPE 9.95

Features

Country of origin is United States

Package Dimensions: 2.794 L x 6.35 H x 5.334 W (centimeters)

Ingredients: Use one or two drops twice a days, or as directed by a medical health professional. Before using, read the enclosed insert carefully.,As a soothing eye drop, for temporary relief of minor irritations to the eye and exposure to sun and wind, etc.,Remove the lower ring. Turn the cap anti-clockwise to break the seal.,Remove the cap, dispense drops with gentle pressure. Replace the cap after every use.,Always avoid contamination by replacing cap after use. Do not touch the end of the vial to any sur

Ocuphase Soothing Lubricant Eye Drops With 1% Nac (N-Acetylcarnosine), Two Pack Of 5Ml Vials

TANGO
OCUPHASE
0.05 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Tango Advanced Nutrition, Inc. 6.65

Features

Fast Relief for your Eyes: Our soothing lubricating eye drops quickly help to combat dry eyes and other forms of eye irritation, such as blurry vision, night glare or computer eye strain.

Effective Formula: OcuPhase contains 1% NAC, a antioxidant and antiglycating agent that has been shown to support healthy vision while increasing transmissivity of light through the lens.

Support your Vision: N-Acetylcarnosine-containing eye drops have demonstrated efficacy in benefiting a variety of ophthalmic conditions while delaying vision senescence in humans.

Safe to Use: Our soothing natural tears eye drop formula is save to use by people with Cataracts, Glaucoma, Age-Related Macular Degeneration (ARMD/AMD), and Floaters.

Each box of OcuPhase contains two resealable, sterile vials, containing a total of approximately 200 all-natural moisturizing eye drops.

Octiq Lubricant Eye Drops For Dry Eyes, Dry Eye Symptom Reliever (Twin Pack 2X 15 Ml Bottles)

OCTIQ
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Aytu Consumer Health 9.95

Features

OPTIC REFRESHMENT: Octiq drops moisturize and replenish the corneal surface, allowing the eyelids to glide smoothly over the eyes. It facilitates comfort for red eyes, itchy eyes, and sore eyes.

HIGH QUALITY: Octiq contains 0.3% hypromellose and cetrimide that act as tear substitutes for dry eyes. Hypromellose helps the eye remain lubricated and produces high quality artificial tears.

HYDRATION: Designed to hydrate and soothe dry eyes. These eye drops for red eyes are gentle, convenient and non-irritating.

LUBRICATING EYE DROPS: Oqtic help to provide soothing comfort and long-lasting eye lubricant, keeping your eyes feeling refreshed throughout the day. This exciting advanced formula helps maintain the natural moisture balance in your eyes, providing effective, long lasting dry eye relief for mild to moderate dry eye.

LUBRICATING EYE DROPS: Oqtic help to provide soothing comfort and long-lasting eye lubricant, keeping your eyes feeling refreshed throughout the day. This exciting advanced formula helps maintain the natural moisture balance in your eyes, providing effective, long lasting dry eye relief for mild to moderate dry eye.

#TOP18
Best For Dry

Optimel Manuka+ Honey Dry Eye Drops, Hydrate And Alleviate Symptoms Of Chronic Dry Eye, Restore Eye Comfort, Pharmaceutical Grade Manuka Honey, Natural By Design, 0.34Oz (Pack Of 1)

OPTIMEL
OPMEL001
1.18 X 1.42 X 1.18 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Vitabox 9.88

Features

Restore Eye Comfort: Made with glycerine and pharmaceutical grade honey (Manuka+), Optimel Manuka+ Dry Eye Drops work to help restore eye comfort and stabilize the overall surface health of the eye

Hydrate & Alleviate Symptoms: Our active hydrating agents help to quickly reduce debris build up on the eyelid margin that can cause prolonged discomfort and inflammation

Fast Relief For Your Eyes: The fast acting Optimel Dry Eye drops are designed to temporarily alleviate mild to moderate symptoms such as sore, irritated eyes and eyelids, prolonged eye discomfort, and redness, burning and irritation. Initial stinging and redness on application may occur

Natural Honey Traceable To The Origin: Our natural Manuka+ honey originates in Australia and New Zealand, which make up the richest floral diversity in the world. Each batch is traceable to the individual bee-keepers and forest location of the Leptospermum spp plants that produce the unique nectar that bees use to produce honey

Optimel Promise: Optimel products are designed to improve eye comfort, however we recognize the outcome may not be the same for each patient. If you are unsatisfied with our products, we promise to replace or refund your purchase

Similasan Allergy Relief Eye Drops #2, 0.33 Fz

SIMILASAN
I00001927
4.31 X 1.62 X 1.28 Inches
0.02 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
I Buy Direct 9.74

Features

Relieve itching, burning & watery eyes

100% natural active ingredients

Sting-free formula

Optase Hylo Relief Dry Eye Drops - Fast-Acting Preservative Free Eye Drops For Dry Eyes - With Patented Hylo Delivery System - Artificial Tears For Mild To Moderate Dry Eye Relief - .33 Oz, 300 Doses

OPTASE
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Scope Eyecare 9.96

Features

PRESERVATIVE AND PHOSPHATE FREE FORMULA - Made with moisturizing hyaluronic acid and glycerin, OPTASE HYLO Relief uses a phosphate and preservative free artificial tears formula for dry eye relief

NO WASTED EYE DROPS - The innovative, one-click, multi-use bottle of OPTASE HYLO Relief dry eyes eye drops provides 300 calibrated doses, while maintaining sterility for 6 months after opening

MILD TO MODERATE DRY EYE RELIEF - OPTASE HYLO Relief drops provides comfortable relief from mild to moderate dry eye symptoms. Plus, it is contact lens safe for convenient use throughout the day

INNOVATIVE BOTTLE DESIGN – OPTASE HYLO Relief’s unique bottle technology releases one drop of lubricating eye drops with just a press, with no waste – simply grip, position, and click

PAIR WITH OPTASE HYLO NIGHT – For optimal results, use OPTASE HYLO Relief moisturizing eye drops with OPTASE HYLO Relief Nighttime Eye Gel as part of the complete line of expert dry eye relief

Top 10 eye drops cartridge Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Refresh 5
Bausch & Lomb 1
Can-C 1
Clear Eyes 1
Genteal 1
Muro 128 1
Octiq 1
Optase 1
Optimel 1
Rohto 1

Top 10 eye drops cartridge Brands Pie Chart


We've carried out a comprehensive analysis of 92,608 reviews on eye drops cartridge, using our selection criteria to identify the best options in the categories. Our findings reveal that most customers typically select eye drops cartridge priced around $18.62, with top brands including agepha, oclumed, ocusoft, rohto, refresh, optase, tums, biotrue and clear eyes and systane

Our team of expert editors reviewed these high-quality items and handpicked the top 20 eye drops cartridge for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the categories category. These include agepha, oclumed nutritional eye drops, amazon.com, scope eyecare, kackol shopping, barginhousedeals, vitabox, evergreencreations and heliostatix and aytu consumer health .

We are dedicated to assisting our users in finding the right drops Products based on their needs, saving them considerable time when choosing which eye drops cartridge to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.