Best Bottle Sinus Medicine in 2025

Daisy
Last Updated: Nov 5, 2025

At a Glance: Our Top Picks for Bottle Sinus Medicine

Benadryl CH Allergy Liquid 8 OZ Cherry
#TOP1
Benadryl Ch Allergy Liquid 8 Oz Cherry
10.0
PM SCORE
Nature's Way Umcka ColdCare Shortens Duration & Reduces Severity, Cherry Flavored, 20 Chewables
#TOP2
Nature's Way Umcka Coldcare Shortens Duration & Reduces
9.8
PM SCORE
Amazon Basic Care Children's Allergy Relief Oral Solution, Diphenhydramine HCl, Cherry Flavor, 4 Fl Oz
#TOP3
Amazon Basic Care Children's Allergy Relief Oral Solution,
9.8
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Bottle Sinus Medicine of 2025

Market Overview
Bottle Sinus Medicine Reviewed
  • Reviews Analyzed: 24993 Items
  • PM Avg. Rating: 8.0 / 10
15 Products Evaluated
  • Highest Price: $39.89
  • Lowest Price: $4.06
  • Avg. Price: $17.30
#TOP1

Benadryl Ch Allergy Liquid 8 Oz Cherry

BENADRYL
53416
3.19 X 3.19 X 6.30 Inches
0.50 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

8-fl. oz of Children's Benadryl Allergy Liquid in cherry flavor is specially formulated to provide temporary relief of allergy symptoms caused by hay fever and other upper respiratory allergies

This allergy medicine for kids contains 12.5 mg of diphenhydramine HCl per teaspoon (5 mL) dose, an antihistamine that works to help alleviate children's allergy symptoms so they can start feeling more like themselves

From the brand moms turn to first when they first treat their children's upper respiratory allergies, this children's allergy medicine helps your child feel better when they need it most by easing symptoms with its alcohol-free formula

Antihistamine for kids is specially formulated to relieve allergy symptoms caused by hay fever and other upper respiratory allergies including runny nose, sneezing, itching of nose or throat, and itchy, watery eyes

Children's allergy liquid medicine is available in a tasty, kid-friendly cherry flavor and comes with a convenient dosing cup to help give your child's allergies a time out

Nature's Way Umcka Coldcare Shortens Duration & Reduces Severity, Cherry Flavored, 20 Chewables

NATURE'S WAY
15144
1.38 X 3.00 X 4.75 Inches
0.11 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Nature's Way Umcka ColdCare helps you feel better faster. Made with proprietary Pelargonium sidoides 1X dervied from South African geranium root to relieve cold symptoms.

Non-drowsy formula is clinically proven to shorten the duration and reduce the severity of colds, cough, congestion, sore throat, and nasal and bronchial irritations. It speeds up your recovery to get you back to life faster.

Adults and children 12 years of age and older chew one tablet three times daily. These delicious cherry flavored chewables can be taken whenever you need relief.

Made with wholesome ingredients, including proprietary Pelargonium sidoides 1X derived from South African Geranium root.

Nature’s Way is a trusted health partner that believes healthy starts inside, with supplements that support your immune system health.*

Amazon Basic Care Children's Allergy Relief Oral Solution, Diphenhydramine Hcl, Cherry Flavor, 4 Fl Oz

AMAZON BASIC CARE
2.00 X 2.03 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

ACTIVE INGREDIENT: Amazon Basic Care Children's Allergy Relief contains Diphenhydramine HCl 12.5 mg/5 mL, an antihistamine, which compares to the active ingredient in Children's Benadryl Allergy Liquid

CHERRY FLAVOR: Temporarily relieves symptoms due to hay fever or other upper respiratory allergies - in a cherry flavor kids will love

MULTI-SYMPTOM ALLERGY RELIEF: Provides temporary multi-symptom relief of sneezing, runny nose, itching of the nose or throat and itchy, watery eyes

4-6 HOURS OF ALLERGY RELIEF: Relieves allergies for up to 4-6 hours per dose when taken as directed; dosage cup included

GLUTEN FREE: This complete allergy medicine is gluten free and alcohol free; for kids ages 6-11

Nature's Way Umcka Allergy And Sinus Homeopathic Chewable Tablets- Cherry Flavor- 20 Count

NATURE'S WAY
0033674121948
1.38 X 3.00 X 2.00 Inches
0.05 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Alpha SH Supports the relief of allergy and sinus symptoms including sneezing, runny nose, itchy watery eyes, nasal congestion, and sinus pressure

COMPLETE: Multi-action allergy, sinus, and cold formula

Made with Umcka (Pelargonium Sidoides 1x) which is used traditionally in South African medicine

GREAT TASTING: Made in a great tasting cherry chewable tablet, and is non-drowsy

TRUSTED: From the same trusted brand that brings you Umcka ColdCare products. These indications are based solely on traditional homeopathic use. They have not been evaluated by the Food & Drug Administration.

Zicam Cold Remedy Zinc Rapidmelts, Cherry Flavor, 25 Count (Pack Of 2)

ZICAM
630168
6.50 X 2.00 X 2.75 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
VerSure 9.98

Features

Zicam Cold Remedy RapidMelts Zinc Tablets: These non-drowsy cold remedy tablets contain zinc, which helps shorten the length of colds when taken at the first sign; Getting better tastes better with Zicam Cold Remedy

Zicam RapidMelts Cold Remedy: Our quick-dissolve tablets are different from most other cold medicine that just treats symptoms. They're clinically proven to shorten colds when taken at the first sniffle, sneeze and cough

From Cold to No Cold Faster: Zicam Cold Remedy products are clinically proven to shorten colds when taken at the first sign, so you feel better, faster; Help calm your cold with Zicam Cold Remedy products like our nasal spray, swabs and RapidMelt tablets

Zicam Homeopathic Remedies: Known for Zicam Cold Remedy products, we also offer products for homeopathic allergy relief and nasal congestion and sinus relief

Zicam for Shorter Colds: Zicam homeopathic cold remedy is meant to be used in the beginning of a cold; Try Zicam the next time you feel the first sniffle, sneeze or cough of an oncoming cold; Satisfaction guaranteed

Lung, Bronchial & Sinus Health By Natural Factors, Natural Supplement For Respiratory Health And Easy Breathing, 90 Tablets

NATURAL FACTORS
3505
2.69 X 2.69 X 4.56 Inches
0.29 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
NetRush 9.98

Features

RESPIRATORY SUPPORT: A natural formula crafted to help break down mucus buildup and promote lung capacity and oxygen flow

NON-DROWSY: Features a non-drowsy formulation so you can breathe easy throughout the day without any lingering aftereffects

NATURAL INGREDIENTS: Contains wild cherry, marshmallow, mullein, horehound and ivy extracts, bromelain and N-acetyl-L-cysteine

ONE TABLET: Taken 3-4 times daily for adults and children 12 years and older; Children 6-12 take 3 times daily; Non-GMO, free of gluten and soy

THIRD-PARTY CERTIFIED: Independently tested for GMOs and over 700 contaminants using advanced technology such as mass spectrometry to ensure purity and potency

Zicam Cold Remedy Zinc Rapidmelts, Cherry Flavor, 18 Count (Pack Of 1)

ZICAM
201094A
1.75 X 2.75 X 4.63 Inches
0.09 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
DESTENY STORE LLC 6.12

Features

Zicam Cold Remedy RapidMelts Zinc Tablets: These non-drowsy cold remedy tablets contain zinc, which helps shorten the length of colds when taken at the first sign; Getting better tastes better with Zicam Cold Remedy

Zicam RapidMelts Cold Remedy: Our quick-dissolve tablets are different from most other cold medicine that just treats symptoms; They're clinically proven to shorten colds when taken at the first sniffle, sneeze and cough

From Cold to No Cold Faster: Zicam Cold Remedy products are clinically proven to shorten colds when taken at the first sign, so you feel better, faster; Help calm your cold with Zicam Cold Remedy products like our nasal spray, swabs and RapidMelt tablets

Zicam Homeopathic Remedies: Known for Zicam Cold Remedy products, we also offer products for homeopathic allergy relief and nasal congestion and sinus relief

Zicam for Shorter Colds: Zicam homeopathic cold remedy is meant to be used in the beginning of a cold; Try Zicam the next time you feel the first sniffle, sneeze or cough of an oncoming cold; Satisfaction guaranteed

Mucinex Children's Liquid - Freefrom Multi-Symptom Cold, Flu & Sore Throat 4Oz, 1 Pack

MUCINEX
0.40 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

MULTI-SYMPTOM COLD, FLU & SORE THROAT RELIEF: Mucinex Children’s FreeFrom Multi-Symptom Cold, Flu & Sore Throat helps relieve cold and flu symptoms: cough, sore throat, stuffy nose, chest & nasal congestion, headache and reduces fever

FREE FROM UNWANTED ADDITIVES: Free from unwanted additives such as artificial flavors, colors, dyes; No alcohol and sugar

#1 PEDIATRICIAN RECOMMENDED: Mucinex Children’s is the #1 Pediatrician Recommended Brand among Non-Homeopathic Children’s Cough / Cold OTC products

PAIN RELIEVER & FEVER REDUCER: Contains Acetaminophen which relieves pain, reduces fever and help relieve your sore throat symptoms

COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough

EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure​

FLAVOR: Available in Elderberry & Cherry Natural Flavor; Use as directed; For ages 6+ years​

#TOP9

Children's Benadryl Allergy, Cherry Flavored Liquid 8 Fl Oz (Pack Of 2)

BENADRYL
PFI017055-X2
6.00 X 5.00 X 4.00 Inches
0.83 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
BIGZI 6.13

Features

Two 8 ounce bottles

Cherry flavored

No added colors

Pack of two, 8-ounce boxes (total of 16 ounces)

Alcohol-free

Provides relief from allergies for children

Works well against severe cold and cough, pain relief, nasal congestion, cough, runny nose, sneezing, sore throat

Cherry flavor

Pack of two, 8-ounce boxes (total of 16 ounces)

Alcohol-free

Provides relief from allergies for children

Works well against severe cold and cough, pain relief, nasal congestion, cough, runny nose, sneezing, sore throat

Cherry flavor

Mucinex Freefrom Cold, Flu & Congestion, Multi-Symptom Relief, Cherry, 6 Fl Oz

MUCINEX
1.44 X 2.51 X 5.77 Inches
0.48 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
MAGIC CITY INC. 9.83

Features

MULTI-SYMPTOM COLD, FLU & CONGESTION RELIEF: Mucinex FreeFrom Cold, Flu & Congestion helps these common cold and flu symptoms: relieves nasal & chest congestion, sore throat, headache, minor aches and pains, and reduces fever.

FREE FROM UNWANTED ADDITIVES: No Artificial flavors, Colors, Dyes; Free from Alcohol and Sugar

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

PAIN RELIEVER & FEVER REDUCER: Contains Acetaminophen which relieves minor aches and pains thereby relieving your sore throat pain and reduces fever

EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

FLAVOR: Available in Elderberry & Cherry Natural Flavor

Benadryl Allergy Liquid Cherry For Children 4 Oz (Pack Of 2)

BENADRYL
763500
6.00 X 6.00 X 10.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
OneStep OneSolution 5.27

Features

4 fl. oz of Childrenâ€s Benadryl Allergy Liquid in cherry flavor is specially formulated to provide temporary relief of allergy symptoms caused by hay fever and other upper respiratory allergies

This allergy medicine for kids contains 12.5 mg of diphenhydramine HCl per teaspoon (5 mL) dose, an antihistamine that works to help alleviate childrenâ€s allergy symptoms so they can start feeling more like themselves

From the brand moms turn to first when they first treat their childrenâ€s upper respiratory allergies, this childrenâ€s allergy medicine helps your child feel better when they need it most by easing symptoms with its alcohol-free formula.

Antihistamine for kids is specially formulated to relieve allergy symptoms caused by hay fever and other upper respiratory allergies including runny nose, sneezing, itching of nose or throat, and itchy, watery eyes

Childrenâ€s allergy liquid medicine is available in a tasty, kid-friendly cherry flavor and comes with a convenient dosing cup to help give your childâ€s allergies a time out

Mucinex Children's Liquid - Freefrom Multi-Symptom Cold & Flu Nighttime 4Oz

MUCINEX
1683675
1.97 X 1.97 X 5.63 Inches
0.31 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

MULTI-SYMPTOM COLD & FLU RELIEF: Mucinex Children’s FreeFrom Multi-Symptom Cold & Flu Nighttime helps relieve common cold and flu symptoms: cough, sore throat, stuffy & runny nose, reduces fever, sneezing, nasal congestion, headache and minor aches and pains

FREE FROM UNWANTED ADDITIVES: Free from unwanted additives such as artificial flavors, colors, dyes; No alcohol and sugar

#1 PEDIATRICIAN RECOMMENDED: Mucinex Children’s is the #1 Pediatrician Recommended Brand among Non-Homeopathic Children’s Cough / Cold OTC products

PAIN RELIEVER & FEVER REDUCER: Contains Acetaminophen which relieves pain, reduces fever and help relieve your sore throat symptoms

COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

ANTIHISTAMINE: Contains Triprolidine HCl that alleviates sneezing, runny nose, itching of the nose and watery eyes

FLAVOR: Available in Elderberry & Cherry Natural Flavor; Use as directed; For ages 6+ years

Kindermed Kids' Nighttime Cold & Cough Medicine, Children's Nighttime Multi-Symptom Cold And Cough Relief, Organic Cherry Flavor, 4 Fl Oz

KINDERMED
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Kinderfarms 9.94

Features

REAL MEDICINE, KINDER INGREDIENTS – KinderMed Kids’ Nighttime Cold & Cough is made with the same effective, active ingredients (diphenhydramine HCl and phenylephrine HCl) as the leading brand without dyes, parabens, artificial sweeteners or flavors, so you can trust it to provide safe and effective relief for your child.

RELIEVES NIGHTTIME COLD & COUGH SYMPTOMS – Proven nighttime medicine that temporarily relieves nasal and sinus congestion, sneezing, runny nose, itchy nose or throat, or intensity of coughs in children 6+.

DOCTOR-FORMULATED AND KID-APPROVED – KinderMed Kids’ Nighttime Cold & Cough is doctor-formulated with only 6 ingredients including organic cherry flavor, and it’s Non-GMO Project Verified, vegan, gluten-free, kosher, and free from the top 9 major food allergens.

BE THE CHANGE – Every purchase gives back! KinderFarms partners with 1% for the Planet to support the wellbeing of families around the world.

FOUNDED BY PARENTS, BACKED BY SCIENCE – KinderFarms, the kinder “farmaceutical” company, was founded by parents, Jessica Biel and Jeremy Adams, when they couldn’t find health products that were both effective and fit with their values. KinderFarms uses proven science to create clean products that are kinder to children, animals, and the planet.

Kindermed Kids’ Allergy Medicine With Diphenhydramine Hcl | Dye-Free Allergy Relief | Organic Cherry Flavor, 4 Fl Oz

KINDERMED
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Kinderfarms 9.89

Features

REAL MEDICINE, KINDER INGREDIENTS – KinderMed Kids’ Allergy is made with the same effective, active ingredient (diphenhydramine HCl) as the leading brand without dyes, parabens, artificial sweeteners or flavors, so you can trust it to provide safe and effective relief for your child.

RELIEVES INDOOR & OUTDOOR ALLERGY SYMPTOMS – Proven antihistamine for kids that temporarily relieves symptoms due to hay fever or upper respiratory allergies including runny nose, sneezing, itchy nose, itchy throat, and itchy, watery eyes in children ages 6 to 11.

DOCTOR-FORMULATED AND KID-APPROVED – KinderMed Kids’ Allergy is doctor- formulated with only 5 ingredients including organic cherry flavor, and it’s Non-GMO Project Verified, vegan, gluten-free, kosher, and free from the top 9 major food allergens.

BE THE CHANGE – Every purchase gives back! KinderFarms partners with 1% for the Planet to support the wellbeing of families around the world.

FOUNDED BY PARENTS, BACKED BY SCIENCE – KinderFarms, the kinder “farmaceutical” company, was founded by parents, Jessica Biel and Jeremy Adams, when they couldn’t find health products that were both effective and fit with their values. KinderFarms uses proven science to create clean products that are kinder to children, animals, and the planet.

Medinatura Reboost Zinc +10 - Max Cold & Flu 60Ct Lemon, Reboost Zinc +13 Sore Throat And Cold & Flu 0.68 Oz Spray, Cherry And Reboost Decongestion Nasal Spray 0.68Oz Bundle

MEDINATURA
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
MediNatura 9.84

Features

ZINC +10 = MAXIMUM RELIEF - Compare to the active ingredients in Oscillococcinum and Zicam, PLUS 10 natural actives known to be beneficial when taken at the first sign of illness and to relieve symptoms when you are already sick.

ZINC +13 = FAST SORE THROAT RELIEF - Compare to the active ingredients in Oscillococcinum and Zicam, PLUS 13 natural actives to temporarily relieve minor sore throat pain and up to 6 cold and flu symptoms like headache, chills, fatigue, body aches, cough and runny nose.

ECHINACEA +6 = FAST, NATURAL CONGESTION RELIEF - Compare to the active ingredient in Oscillococcinum PLUS organic Echinacea and 6 natural actives to temporarily relieve nasal congestion, sinus headache and pressure, and up to 6 accompanying cold and flu symptoms.

HOMEOPATHIC APPROACH - Homeopathy treats symptoms with a micro dose of an active ingredient to stimulate the body’s own defenses. Our approach combines multiple potent actives, in multiple concentrations for greater relief of more symptoms.

READY WHEN YOU ARE - ReBoost can be used as needed for quick relief during any season and is non-addictive and safe for long-term use.

Top 10 sinus medicine Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Benadryl 3
Mucinex 3
Kindermed 2
Nature's Way 2
Zicam 2
Amazon Basic Care 1
Medinatura 1
Natural Factors 1

Top 10 sinus medicine Brands Pie Chart


We've carried out a comprehensive analysis of 24,993 reviews on sinus medicine, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select sinus medicine priced around $17.30, with top brands including mucinex, vicks, neilmed, pressureze, benadryl, tylenol, boiron, sudafed and zyrtec and rsszl

Our team of expert editors reviewed these high-quality items and handpicked the top 15 sinus medicine for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include vagabond exchange, amazon.com, whole premium store, usasellerllc, cedar health science, inc., bnt distributor, rsszl, healthy pantry and iskolive 12 inc and rhinosystems .

We are dedicated to assisting our users in finding the right medicine Products based on their needs, saving them considerable time when choosing which sinus medicine to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.