Best Vicks Cough Sore Throat Medicine in 2026

Daisy
Last Updated: Jul 20, 2026

At a Glance: Our Top Picks for Vicks Cough Sore Throat Medicine

Mucinex Chest Congestion Maximum Strength 12 Hour Extended Release Tablets Relieves Chest Congestion Caused by Excess Mucus(#1 Doctor Recommended OTC expectorant), 1200mg, 42 Count (Pack of 1)
#TOP1
Mucinex Chest Congestion Maximum Strength 12 Hour Extended
10.0
PM SCORE
Maximum Strength Mucinex FastMax DM Max & Mucinex Nightshift Cold & Flu Liquid (2 x 6 fl. oz.) Thins & Loosens Mucus, Relieves Cough & Chest Congestion, Pain, Fever, Sneezing, Sore Throat, Runny Nose
#TOP2
Maximum Strength Mucinex Fastmax Dm Max & Mucinex
9.9
PM SCORE
Mucinex Fast-Max Day Time Cold & Flu and Night Time Cold & Flu Liquid Medicine, 12 fl oz, Maximum Strength All in One Multi Symptom Relief for Congestion, Sore Throat, Headache,Cough and Reduces Fever
#TOP3
Mucinex Fast-Max Day Time Cold & Flu And
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Vicks Cough Sore Throat Medicine of 2026

Market Overview
Vicks Cough Sore Throat Medicine Reviewed
  • Reviews Analyzed: 70502 Items
  • PM Avg. Rating: 8.9 / 10
44 Products Evaluated
  • Highest Price: $49.99
  • Lowest Price: $4.98
  • Avg. Price: $18.03

Mucinex Chest Congestion Maximum Strength 12 Hour Extended Release Tablets Relieves Chest Congestion Caused By Excess Mucus(#1 Doctor Recommended Otc Expectorant), 1200Mg, 42 Count (Pack Of 1)

MUCINEX
LA-XEU2-4Y52
1.38 X 5.00 X 3.50 Inches
0.12 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

MAXIMUM STRENGTH MUCINEX CHEST CONGESTION MEDICINE: Clinically proven to last up to 12 hours and provide relief for your severe chest congestion and make cough more productive congestion

POWERFUL SYMPTOM RELIEF: Maximum Strength Mucinex 12 hour relieves chest congestion and thins and loosens mucus

BI-LAYER TABLET: A unique bi-layer tablet, one layer for immediate release and one layer for extended release so the medicine starts to release right away and last for up to 12 hours

TRUSTED COLD and COUGH BRAND: Mucinex is the Cold and Cough brand doctors trust and Pharmacist Recommended Brand

CONTINUOUS RELIEF: Maximum strength Mucinex lasts up to 12 hours so you can say goodbye to retaking medicine every 4 hours

ACTIVE INGREDIENT: Contains Guaifenesin which is an expectorant that relieves chest congestion and thins and loosens mucus making cough more productive

USAGE: Use as directed; Adults and Children 12 years of age and over

Maximum Strength Mucinex Fastmax Dm Max & Mucinex Nightshift Cold & Flu Liquid (2 X 6 Fl. Oz.) Thins & Loosens Mucus, Relieves Cough & Chest Congestion, Pain, Fever, Sneezing, Sore Throat, Runny Nose

MUCINEX
1.44 X 5.01 X 5.77 Inches
1.00 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

POWERFUL MULTI-SYMPTOM RELIEF: This combo pack of Maximum Strength Mucinex Fast-Max DM Max and Nightshift Cold and Flu provides powerful multi-symptom relief for your worst symptoms

CHEST CONGESTION and COUGH SYMPTOM RELIEF: Maximum Strength Mucinex Fast-Max DM MAX relieves Chest Congestion, Controls Cough and Thins and Loosens Mucus

COLD and FLU SYMPTOM NIGHT RELIEF: Mucinex Nightshift Cold and Flu reduces Fever, relieves Headache, Minor Aches and Pains, Sore Throat, Coughing, Sneezing, Runny Nose for a better morning

TRUSTED COLD and COUGH BRAND: Mucinex is the Cold and Cough brand doctors trust and Pharmacist Recommended Brand

MUCINEX FAST-MAX DM MAX ACTIVE INGREDIENTS: Contains Dextromethorphan HBr - Cough suppressant; Guaifenesin – Expectorant

MUCINEX NIGHTSHIFT COLD and FLU ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Triprolidine HCl – Antihistamine

USAGE: Use as directed; For ages 12 plus years

FSA and HSA ELIGIBLE: Save up to 30 percent. Cover your out-of-pocket expenses with pre-tax dollars.

#TOP3

Mucinex Fast-Max Day Time Cold & Flu And Night Time Cold & Flu Liquid Medicine, 12 Fl Oz, Maximum Strength All In One Multi Symptom Relief For Congestion, Sore Throat, Headache,Cough And Reduces Fever

MUCINEX
ASA-100
1.44 X 5.01 X 5.77 Inches
0.75 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
GREATPRICES4U 9.67

Features

MUCINEX FAST-MAX: Maximum strength multi-symptom relief medicine; 1 dose treats 9 symptoms - get back to what’s important thanks to the fast, powerful relief of Mucinex

DAY TIME SYMPTOMS TREATED: Maximum strength day time cold and flu non-drowsy liquid relieves cough, chest, nasal & sinus congestion that can cause mucus buildup, sinus pressure, fever, body pain & headache and sore throat

NIGHT TIME SYMPTOMS TREATED: Maximum strength night time cold and flu liquid relieves cough, nasal congestion that leads to stuffy nose, fever, body pain & headache, sneezing, runny nose and sore & itchy throat

DAY TIME ACTIVE INGREDIENTS per 20 mL: Acetaminophen - 650 mg pain reliever and fever reducer; Phenylephrine HCI - 10 mg nasal decongestant; Dextromethorphan HBr - 20 mg cough suppressant; Guaifenesin - 400 mg expectorant/thins and loosens mucus

NIGHT TIME ACTIVE INGREDIENTS per 20 mL: Acetaminophen - 650 mg pain reliever and fever reducer; Phenylephrine HCI - 10 mg nasal decongestant; Diphenhydramine HCI - 25 mg cough suppressant/antihistamine

FAST ACTING LIQUID: 2 bottles 6 fl oz each; adults and children 12 years of age and older, 20 ml in provided dosing cup every 4 hours

TRUST MUCINEX: Mucinex is the #1 Cold & Cough Brand Doctors Trust for Themselves & Their Families

FSA & HSA ELIGIBLE: Save up to 30%. Cover your out-of-pocket expenses with pre-tax dollars.

Chest Congestion, Mucinex 12 Hour Extended Release Tablets, 40Ct, 600 Mg Guaifenesin Relieves Chest Congestion Caused By Excess Mucus, #1 Doctor Recommended Otc Expectorant

MUCINEX
363824008400
1.38 X 3.50 X 3.78 Inches
0.09 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Hollywoodseller 9.88

Features

MUCINEX CHEST CONGESTION MEDICINE: Clinically proven to last up to 12 hours and provide relief for your chest congestion and make cough more productive

POWERFUL SYMPTOM RELIEF: Mucinex 12 hour relieves chest congestion and thins and loosens mucus

BI-LAYER TABLET: A unique bi-layer tablet, one layer for immediate release and one layer for extended release so the medicine starts to release right away and last for up to 12 hours

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

CONTINUOUS RELIEF: Mucinex lasts up to 12 hours so you can say goodbye to retaking medicine every 4 hours

ACTIVE INGREDIENT: Contains Guaifenesin which is an expectorant that relieves chest congestion and thins & loosens mucus making cough more productive

USAGE: Use as directed; Adults and Children 12 years of age and over

Mucinex Maximum Strength Sinus-Max Pressure, Pain & Cough & Nightshift Sinus Caplets, Fast Release, Powerful Multi-Symptom Relief, 40 Count

MUCINEX
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

MAXIMUM STRENGTH MUCINEX SINUS-MAX (DAY) PRESSURE, PAIN and COUGH and NIGHTSHIFT (NIGHT) SINUS: Fast Release, Powerful Multi-Symptom Relief medicine. Get back to what’s important thanks to the fast, powerful medicine

DAY TIME MULTI-SYMPTOM RELIEF: Maximum Strength Mucinex Sinus-Max Day Pressure, Pain and Cough Caplets help to relieve pain, sinus pressure and congestion, headaches, controls cough and thins and loosens mucus

NIGHT TIME MULTI-SYMPTOM RELIEF: Maximum Strength Mucinex Nightshift (Night) Sinus Caplets help to relieve pain, cough, reduce fever, sore throat, runny nose, sneezing and nasal congestion. Nighttime relief for a better morning.

TRUSTED COLD and COUGH BRAND: Mucinex is the Cold and Cough brand doctors trust

AY TIME ACTIVE INGREDIENTS PER CAPLET: Contains Acetaminophen - Pain reliever; Dextromethorphan HBr - Cough Suppressant; Guaifenesin - Expectorant; Phenylephrine HCI - Nasal Decongestant

NIGHT TIME ACTIVE INGREDIENTS PER CAPLET: Contains Acetaminophen - Pain reliever; Dextromethorphan HBr - Cough Suppressant; Phenylephrine HCI - Nasal Decongestant; Triprolidine HCI - Antihistamine

FSA and HSA ELIGIBLE: Cover out-of-pocket expenses with pre-tax dollars.

Cold & Cough, Mucinex Children's Multi-Symptom Day/Night Liquid, Very Berry, 4 Fl Oz (Pack Of 2)

MUCINEX
ASA-104
2.00 X 4.13 X 5.70 Inches
0.79 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

MULTI-SYMPTOM DAY TIME COLD RELIEF : Helps control cough, relieves stuffy nose, chest congestion and thins and loosens mucus

MULTI-SYMPTOM NIGHT TIME COLD RELIEF: Helps to reduce fever, control cough, relieves stuffy nose, runny nose, sneezing and sore throat

#1 PEDIATRICIAN RECOMMENDED: Mucinex Children’s is the #1 Pediatrician Recommended Brand among Non-Homeopathic Children’s Cough / Cold OTC products

ACTIVE INGREDIENTS DAY TIME MULTI-SYMPTOM COLD: Contains Dextromethorphan HBr for cough suppression, Guaifenesin as an expectorant and Phenylephrine HCl for nasal decongestion

ACTIVE INGREDIENTS NIGHT TIME MULTI-SYMPTOM COLD : Contains Acetaminophen as a pain reliever/fever reducer, Diphenhydramine HCI as an Antihistamine/Cough Suppressant and Phenylephrine HCl for nasal decongestion

FLAVOR: Available in Very Berry Flavor; Use as directed; Day Time ages 4 and up, Night time ages 6 and up

INSTRUCTIONS: Do not give the MUCINEX CHILDREN'S DAY TIME MULTI-SYMPTOM COLD and MUCINEX CHILDREN'S NIGHT TIME MULTI-SYMPTOM COLD liquids at the same time. Always wait at least 4 hours before giving another dose of MUCINEX CHILDREN'S LIQUID. Do not give more than a total of 5 doses in any 24-hour period.

Congestion And Cough Liquid, Mucinex Fast-Max Severe Congestion And Cough Liquid, 6 Fl. Oz.(Package May Vary)

MUCINEX
6382401465
1.44 X 2.51 X 5.77 Inches
0.51 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Fast-Max Severe Congestion & Cough helps relieve cough, thins and loosens mucus and relieves chest and nasal congestion

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough

EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

USAGE: Use as directed; For ages 12+ years

Mucinex Nightshift Sinus 6 Fl. Oz. Relieves Fever, Sore Throat, Runny Nose, Sneezing, Nasal Congestion, And Controls Cough

MUCINEX
1.44 X 2.51 X 5.77 Inches
0.48 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust*

Mucinex® Nightshift® Cold & Flu Liquid 9 Fl. Oz. Relieves Fever, Sneezing, Sore Throat, Runny Nose, And Controls Cough

MUCINEX
1.46 X 2.95 X 6.30 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

Safrel Pharma Mucus Relief Guaifenesin 400 Mg - 200 Count (Mini Caplets) Fast Acting Expectorant, Thins And Loosens Mucus, Relieves Chest Congestion, Cough, Cold And Flu | Compare To Mucinex Tablets

SAFREL
008-02
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Safrel 9.90

Features

✅ ACTIVE INGREDIENT: The active ingredient in this product is Guaifenesin, an expectorant that helps reduce chest congestion caused by colds, infections or irritants. Clinically proven to provide powerful relief for your toughest chest congestion. Compare Safrel Mucus Relief to the active ingredient of Mucinex.

✅ FAST ACTING: Safrel Mucus Relief Guaifenesin is a fast-acting expectorant helps loosen and thin mucus. Take 1 tablet every 4 hours with water.

✅ EASY TO SWALLOW: Our 400 mg tablets are small in size making it easier to swallow to promote clearer breathing by providing continuous relief through out the day and night. Enjoy cough mucus relief with tablets that can be used by those with allergies, colds, infections, and flu bugs.

✅ VALUE PACK SAVINGS: Did you know, with Safrel Mucus Relief of 200 count value pack can save you significant amount of money with the same active ingredient as Mucinex and Robitussin DM.

✅ MADE IN USA: A Non-Drowsy Immediate Release Formula carefully manufactured in USA to gurantee 100% satisfaction.

Mucinex Nightshift Cold & Flu Liquid That Relieves Fever/Sneezing/Sore Throat/Runny Nose And Cough, 6 Fl Oz (Pack Of 1)

MUCINEX
6382401470
1.44 X 2.51 X 5.77 inches
0.48 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
BRANDO-787 6.24

Features

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust*

Mucinex Freefrom Cold & Flu Daytime, Multi-Symptom Relief, Cherry, 6 Fl Oz

MUCINEX
1.44 X 2.51 X 5.77 Inches
0.48 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Premium Possibilities 9.88

Features

MULTI-SYMPTOM COLD & FLU RELIEF: FreeFrom Cold and Flu Daytime liquid helps reduce fever and relieve Cough, Sore Throat, Stuffy Nose, Chest & Nasal Congestion, Headache and Minor Aches and Pains

FREE FROM UNWANTED ADDITIVES: No Artificial flavors, Colors, Dyes; Free from Alcohol and Sugar

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

PAIN RELIEVER & FEVER REDUCER: Contains Acetaminophen which relieves minor aches and pains thereby relieving your sore throat pain and reduces fever

COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough

EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

FLAVOR: Available in Elderberry & Cherry Natural flavor

Cold, Cough, And Sore Throat, Mucinex Children's Cold, Cough, & Sore Throat Liquid, Mixed Berry, 4Oz (Packaging May Vary) Controls Cough, Relieves Nasal & Chest Congestion, Thins & Soothes Sore Throat

MUCINEX
RE27864
1.97 X 1.97 X 5.63 Inches
0.25 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Lunch money 9.93

Features

MULTI-SYMPTOM RELIEF: Mucinex Children’s Cold & Flu helps control cough and relieves sore throat, stuffy nose, chest & nasal congestion, headache and minor aches and pains

#1 PEDIATRICIAN RECOMMENDED: Mucinex Children’s is the #1 Pediatrician Recommended Brand among Non-Homeopathic Children’s Cough / Cold OTC products

PAIN RELIEVER & FEVER REDUCER: Contains Acetaminophen which relieves pain, reduces fever and helps relieve your child’s sore throat

COUGH SUPPRESSANT: Contains Dextromethorphan HBr which helps control cough

EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

FLAVOR: Available in Very Berry Flavor

USAGE: Use as directed; For ages 6+ years

Cold And Fever, Mucinex Children's Multi-Symptom, Night Time Cold Liquid, Mixed Berry, 4Oz, Reduces Fever, Controls Cough, Relieves Stuffy Nose, "Packaging May Vary"

MUCINEX
ASA-148
1.97 X 1.97 X 5.63 Inches
0.40 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Durr's Outlet 9.76

Features

MULTI-SYMPTOM RELIEF: Mucinex Children’s Night Time Multi-Symptom Cold helps reduce fever, relieves stuffy nose, sore throat, sinus pressure, nasal congestion, cough, and runny nose & sneezing

#1 PEDIATRICIAN RECOMMENDED: Mucinex Children’s is the #1 Pediatrician Recommended Brand among Non-Homeopathic Children’s Cough / Cold OTC products

PAIN RELIEVER & FEVER REDUCER: Contains Acetaminophen which relieves pain, reduces fever and helps relieve your child’s sore throat

ANTIHISTAMINE & COUGH SUPPRESSANT: Contains Diphenhydramine HCI which provides relief for stuffy nose, sneezing and cough

NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure

FLAVOR: Available in Very Berry Flavor

USAGE: Use as directed; For ages 6+ years

Mucinex Instasoothe Sore Throat + Pain Relief Spray, Powerful With Soothing Cherry Flavor, 3.8 Fl Oz

MUCINEX
1709000
2.00 X 2.00 X 2.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Mucinex InstaSoothe Sore Throat plus Pain Relief. Powerful sore throat relief with soothing cherry flavor.

Easy-to-use throat spray numbs pain fast so you can get back to your day.

Temporarily relieves occasional minor irritation and pain associated with: Sore Throat, Sore Mouth, Canker Sores

Adults and children 12 years of age and over. Children 6 to under 12 years of age: Supervise use. Children under 6 years of age: Do not use.

Apply to affected area (one spray); gargle, swish around in the mouth, or allow to remain in place at least 1 minute then spit out. Use up to 4 times daily or as directed by a doctor.

FSA and HSA Eligible: Save up to 30%. Cover out-of-pocket expenses with pre-tax dollars.

Quality Choice Mucus Relief Cold, Flu & Sore Throat 20 Caplets Each (1)

QUALITY CHOICE
QC97052
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
PLQC 9.84

Features

Quality Choice Max Strength Mucus Relief Cold, Flu & Sore Throat, Compares to the Active Ingredients in Mucinex Fast-Max Cold, Flu & Sore Throat. Comes in a 20 count package.

Max Strength Cold Flu & Sore Throat is a Pain Reliever, Fever Reducer, Cough Suppressant, Expectorant and Nasal Decongestant designed to provide relief and restore comfort.

Maximum Strength Cold and Flu Medicine containing 325 mg of Acetaminophen for pain and fever relief, 10 mg of Dextromethorphan HBr a cough suppressant, Guaifenesin 200 mg an expectorant, and Phenylephrine HCI 5 mg a Nasal Decongestant.

Maximum Strength Cold and Flu Medicine use to Provide Temporary Relief of Nasal Congestion, Cough, Sore Throat, Headache, Minor Aches and Pains.

Medication Temporarily Reduces Fever and helps to loosen phlegm and mucus and thins bronchial secretions to rid the bronchial passageways of mucus and phlegm making your coughs more productive

Top 10 cough sore throat medicine Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Mucinex 42
Quality Choice 1
Safrel 1

Top 10 cough sore throat medicine Brands Pie Chart


We've carried out a comprehensive analysis of 70,502 reviews on cough sore throat medicine, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select cough sore throat medicine priced around $18.03, with top brands including mucinex, boiron, chloraseptic, vicks, theraflu, alka-seltzer plus, robitussin, hyland's and sucrets and ricola

Our team of expert editors reviewed these high-quality items and handpicked the top 16 cough sore throat medicine for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, nc commercial, greatprices4u, bnt distributor, incredible designs llc, name brand overstock, healthy products a plus llc, the customer land and beekeeper's naturals and focus health .

We are dedicated to assisting our users in finding the right medicine Products based on their needs, saving them considerable time when choosing which cough sore throat medicine to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.