Best Vicks Cough Sore Throat Medicine in 2026

Daisy
Last Updated: Jul 20, 2026

At a Glance: Our Top Picks for Vicks Cough Sore Throat Medicine

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
#TOP1
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets,
9.9
PM SCORE
Tylenol Children's Cold + Flu Oral Suspension, Grape, 4 Fl. Oz
#TOP2
Tylenol Children's Cold + Flu Oral Suspension, Grape,
9.9
PM SCORE
Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.
#TOP3
Tylenol Cold + Flu Severe Medicine Caplets For
9.9
PM SCORE

* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.

Summary of the Best Vicks Cough Sore Throat Medicine of 2026

Market Overview
Vicks Cough Sore Throat Medicine Reviewed
  • Reviews Analyzed: 38544 Items
  • PM Avg. Rating: 7.9 / 10
20 Products Evaluated
  • Highest Price: $430.78
  • Lowest Price: $6.57
  • Avg. Price: $37.15

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325Mg, Nasal Decongestant For Sinus Pressure, Headache & Nasal Congestion Relief, 24 Ct

TYLENOL
JJ-2320
4.50 X 0.75 X 3.00 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Deep Seas Wares 8.64

Features

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies

Pain reliever and nasal decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure

Each sinus relief caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever as well as 5 mg of phenylephrine HCl, a nasal decongestant to help clear nasal passages

The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages

From the #1 doctor-recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older

Tylenol Children's Cold + Flu Oral Suspension, Grape, 4 Fl. Oz

TYLENOL
300450391056
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounces of Children's Tylenol Oral Suspension Liquid Medicine with grape flavor to temporarily relieve kids' cold & flu symptoms, including cough, headache and fever

This multi-symptom relief medicine for kids also helps relieve minor aches and pains, sore throat, stuffy or runny nose, sneezing and congestion

Each 5mL contains 160 mg of acetaminophen pain reliever and fever reducer, 5 mg of dextromethorphan HBr cough suppressant, 2.5 mg of phenylephrine HCl decongestant and 1 mg of the antihistamine chlorpheniramine maleate

Indicated for children ages 6 to 11 years, this kids cold and flu medicine comes in a kid-friendly grape flavor with a formula that is free of aspirin, alcohol and ibuprofen

Tylenol is the #1 pediatrician recommended brand for pain & fever relief and has been relied on by parents for over 60 years.

Tylenol Cold + Flu Severe Medicine Caplets For Fever, Pain, Cough & Congestion, 24 Ct.

TYLENOL
JJ-2309
0.79 X 4.52 X 2.91 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Children's Cold + Cough + Runny Nose Oral Suspension, Grape, 4 Fl. Oz

TYLENOL
456373
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounce bottle of Children's Tylenol Cold + Cough + Runny Nose Oral Suspension Medicine to temporarily relieve cold and flu symptoms, including, sore throat, cough, runny nose and sneezing

The kids' liquid pain relief medicine also relieves minor aches & pains, headache & temporarily reduces fever fast with an ibuprofen-, aspirin-, and alcohol-free formula

Each 5-milliliter dose of the children's medicine contains 160 milligrams of acetaminophen pain reliever and fever reducer; 1 milligram of the antihistamine chlorpheniramine maleate; and 5 milligrams of the cough suppressant dextromethorphan HBr

The liquid cold medicine for children comes in a kid-friendly grape flavor that is gentle on the tummy and ideal for kids ages 6 to 11 years

Tylenol is the #1 pediatrician recommended brand for pain and fever relief, and has been used by parents decade after decade

Tylenol Cold + Flu Severe Day & Night Caplets For Fever, Pain, Cough & Congestion Relief, 24 Count

TYLENOL
30045055024
4.52 X 0.78 X 2.95 Inches
13.00 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

24-count combo pack of Tylenol Cold + Flu Severe Day/Night Caplets for multi-symptom cold and flu symptom relief. From the #1 doctor recommended pain relief brand, the combo pack includes 16 Daytime and 8 Nighttime caplets for relief any time of the day

The Daytime relief caplets are formulated to reduce fever, loosen phlegm and relieve headache, body aches, cough, sore throat, nasal congestion and chest congestion

The Nighttime relief caplets help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion and pressure

Each cold & flu caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg of phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

The Daytime caplets also contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make coughs more productive. The Nighttime caplets also contain 2 mg of chlorpheniramine maleate, an antihistamine.

Tylenol Cold + Flu Multi-Action Day Caplets, Pack Of 2

TYLENOL
00300450270344
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

Twin 2 Pack of 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Children's Tylenolcold + Flu Oral Suspension, Bubblegum, 4 Fl. Oz

TYLENOL
300450169044
1.97 X 1.97 X 5.13 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

4-fluid ounce bottle of children’s cold, cough, and sore throat medicine

Temporarily relieves cold and flu symptoms, including minor aches and pains, headache, sore throat, and cough

Temporarily reduces fever

Each 5-milliliter dose contains 160 milligrams of acetaminophen and 5 milligrams of dextromethorphan HBr

Ibuprofen-, alcohol-, and aspirin-free formula

Tylenol Cold Max Daytime Non-Drowsy Cold And Flu Relief, Acetaminophen, 24 Ct

TYLENOL
JJ-2321
0.76 X 4.45 X 2.95 inches
0.03 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
BTRGoods 9.85

Features

24-count of Tylenol Cold Max non-drowsy cold and flu medicine with acetaminophen for multi-symptom relief

Medicine provides temporary relief for cold and flu symptoms including aches and pains, sore throat, nasal congestion, sinus congestion and pressure, cough and fever

Each cold & flu caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains

Each non-drowsy caplet also contains 10 mg of dextromethorphan to suppress cough, and 5 mg phenylephrine to relieve nasal congestion

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for daytime multi-symptom

Tylenol Cold + Flu + Cough Night Liquid Medicine With Acetaminophen, Wild Berry, Grabe, 8 Fl Oz

TYLENOL
JO305620800
2.00 X 3.00 X 5.25 Inches
0.66 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
OTCRx4u 9.93

Features

8-fluid ounce bottle of Tylenol Cold + Flu + Cough Night Liquid medicine in Wild Berry Burst flavor for multi-symptom relief due to cold & flu

This liquid cold & flu relief medicine comes in a nighttime formula and provides temporary relief of symptoms including fever, sore throat, nasal congestion and cough to help you sleep

Each 15-milliliter contains 325 milligrams of acetaminophen, a pain reliever and fever reducer and 10 milligrams dextromethorphan HBr to help suppress your cough

Each 15-milliliter also contains 5 milligrams of phenylephrine HCl, a nasal decongestant and 6.25 milligrams of doxylamine succinate, an antihistamine

The triple-action nighttime cold and flu medicine for adults provides temporary relief of multiple symptoms and features a Wild Berry Burst flavor

Tylenol Cold + Flu Severe Medicine Caplets For Fever & Cough Relief, Red, 2 Count, Pack Of 50

TYLENOL
3.29 X 4.42 X 5.76 Inches
0.31 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Amazon.com 9.68

Features

2-count of Tylenol Cold + Flu Severe Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Cold + Flu Severe Medicine W/Acetaminophen, Dextromethorphanhbr, Guaifenesin, Phenylephrinehci, Liquid Daytime Cold/Fever & Chest Congestion Relief, Warming Honey Lemon, 8 Fl. Oz

TYLENOL
JJ-289
2.06 X 3.02 X 5.33 Inches
8.00 ounces
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
westlake 9.87

Features

Tylenol Cold + Flu Severe liquid flu medicine provides temporary pain relief and mucus and chest congestion relief with a warming honey lemon flavor

Cold medicine and flu relief for fever and sore throat, as well as relief from head and body aches and cough. It also aids in loosening phlegm, or mucus, and thinning bronchial secretions so coughs can be more productive.

With this severe daytime flu relief for adults, get relief from nasal congestion, as well as mucus and chest congestion in a powerful non-drowsy formula

It combines acetaminophen for pain relief and fever reduction with three other ingredients, phenylephrine HCl for a nasal decongestant, guaifenesin as an expectorant and dextromethorphan HBr as a cough suppressant

This non-drowsy cold medicine and flu relief comes in a daytime formula, which provides temporary relief of symptoms including fever, sore throat, and chest congestion during your waking hours

Tylenol Children's Cold + Cough + Sore Throat Oral Suspension, Bubblegum, 4 Fl. Oz

TYLENOL
1.93 X 1.93 X 4.97 Inches
0.42 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Southern Mountain LLC 6.54

Features

Cures fever and sore throat

Treats runny and stuffy nose, coughs and sneezing

Also cures aches and pains and fever

Tylenol Cold + Flu Severe Medicine Caplets For Cold & Flu Symptom Relief, Fever Reducer, Pain Reliever, Cough Suppressant, Nasal Decongestant & Expectorant, 24 Ct. ( Pack Of 6)

TYLENOL
421650
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
MASKU LLC 9.70

Features

24-capsule (Pack of 6) of Tylenol Cold + Flu Severe Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Cold + Flu Severe Medicine Caplets For Cold, Flu, Fever, Cough & Congestion Relief, 24 Ct

TYLENOL
2.28 X 4.34 X 2.85 Inches
0.04 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Cloud-Kart Inc. 9.82

Features

24-count of Tylenol Cold + Flu Severe Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Cold + Flu Severe Day & Night Caplets 24 Ea (3 Pack)

TYLENOL
PPAX1477780
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Trio Shippers LLC 9.78

Features

DAYTIME RELIEF CAPLETS: Formulated to reduce fever, loosen phlegm, and relieve headache, body aches, cough, sore throat, stuffy nose, and chest congestion

NIGHTTIME RELIEF CAPLETS: Help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure

EACH COLD AND FLU CAPLET: Contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

DAYTIME CAPSLETS: Contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make a cough more productive. The night capsules also contain 2 mg of chlorpheniramine maleate, an antihistamine

#1 DOCTOR-RECOMMENDED BRAND: Combo pack of 24 capsules of Tylenol Cold + Flu Severe Day/Night to relieve cold and flu symptoms. Combo Pack includes 16 Day Capsules and 8 Night Capsules for any time of day relief

Tylenol Cold Multi-Symptom Relief Caplets, 24 Count

TYLENOL
300450271259
3.05 X 4.50 X 0.80 Inches
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Element One 7.41

Features

Nondrowsy daytime formula

Pain reliever, fever reducer, nasal decongestant

Relieves headache, fever, sore throat, nasal congestion and cough

Sinus

Cold and Flu

#TOP17

Tylenol Cold & Flu Tylenol Cold + Flu + Cough Night Liquid Medicine With Acetaminophen, Wild Berry, 8 Fl. Ounce, 8.0 Fl Ounce (Pack Of 3)

TYLENOL
6.00 X 3.00 X 5.25 Inches
2.07 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

8-fluid ounce bottle of Tylenol Cold Flu Cough Night Liquid medicine in Wild Berry Burst flavor for multi-symptom relief due to cold flu

This liquid cold flu relief medicine comes in a nighttime formula and provides temporary relief of symptoms including fever, sore throat, nasal congestion and cough to help you sleep

Each 15-milliliter contains 325 milligrams of acetaminophen, a pain reliever and fever reducer and 10 milligrams dextromethorphan HBr to help suppress your cough

Each 15-milliliter also contains 5 milligrams of phenylephrine HCl, a nasal decongestant and 6.25 milligrams of doxylamine succinate, an antihistamine

The triple-action nighttime cold and flu medicine for adults provides temporary relief of multiple symptoms and features a Wild Berry Burst flavor.

Tylenol Cold And Flu Severe, 24-Count Caplets (Pack Of 2)

TYLENOL
0.88 X 3.38 X 3.50 Inches
0.07 Pounds
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Vitabox 9.88

Features

Headache, fever, sore throat

Nasal congestion

Clears cough

Chest congestion, clears out mucus

Controls Headache, Fever, Sore Throat - Tylenol Cold And Flu Severe Caplets, 24 Count (Pack Of 2)

TYLENOL
824-847-PK2A
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

Pack of 2, 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive

From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief

Tylenol Day And Night Cold And Flu Capsule, 24 Count Per Pack - 48 Per Case.

TYLENOL
SELLER SELLER SCORE AMAZON FULFILLED PRIME FREE SHIPPING
Royal Meds 9.95

Features

DAYTIME RELIEF CAPLETS: Formulated to reduce fever, loosen phlegm, and relieve headache, body aches, cough, sore throat, stuffy nose, and chest congestion

NIGHTTIME RELIEF CAPLETS: Help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion, and pressure

EACH COLD AND FLU CAPLET: Contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant

DAYTIME CAPSLETS: Contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make a cough more productive. The night capsules also contain 2 mg of chlorpheniramine maleate, an antihistamine

#1 DOCTOR-RECOMMENDED BRAND: Combo pack of 24 capsules of Tylenol Cold + Flu Severe Day/Night to relieve cold and flu symptoms. Combo Pack includes 16 Day Capsules and 8 Night Capsules for any time of day relief

Top 10 cough sore throat medicine Brands on Amazon

Here is the list of top-rated brands that were evaluated by PM.

Brand Count
Tylenol 20

Top 10 cough sore throat medicine Brands Pie Chart


We've carried out a comprehensive analysis of 38,544 reviews on cough sore throat medicine, using our selection criteria to identify the best options in the health & household products. Our findings reveal that most customers typically select cough sore throat medicine priced around $37.15, with top brands including mucinex, boiron, chloraseptic, vicks, theraflu, alka-seltzer plus, robitussin, hyland's and sucrets and ricola

Our team of expert editors reviewed these high-quality items and handpicked the top 20 cough sore throat medicine for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the health & household products category. These include amazon.com, nc commercial, greatprices4u, bnt distributor, incredible designs llc, name brand overstock, healthy products a plus llc, the customer land and beekeeper's naturals and focus health .

We are dedicated to assisting our users in finding the right medicine Products based on their needs, saving them considerable time when choosing which cough sore throat medicine to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.