Best Systane Eye Drops For Hydration in 2026
Daisy
Last Updated: Feb 9, 2026
Daisy
Last Updated: Feb 9, 2026
* PickSmartly editors independently research, review, and endorse the top products through comprehensive data analysis. We may earn a commission for qualifying purchases made through our product links.
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Amazon.com | 9.68 | ✅ | ✅ | ✅ |
0.5-fluid ounce bottle of Visine Red Eye Hydrating Comfort Redness Relief Eye Drops to offer eye redness relief in 30 seconds and lubricate irritated eyes
Formula contains 1% polyethylene glycol 400 and 0.05% tetrahydrozoline HCl which helps lubricate, refresh and relieve red irritated eyes
Fast-acting redness relief & moisturizing formula relieves symptoms due to minor eye irritations like exposure to smoke, lack of sleep and extended screen time and comes from Visine, a brand backed by 60 years of expertise
The sterile eye drops help hydrate to soothe eye irritation & provide redness relief
The small bottle is conveniently-sized and can be easily carried in your pocket, purse or bag for on-the-go relief anywhere
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| JJBookIt | 9.73 | ✅ | ✅ | ✅ |
Dual-action formula lubricates and hydrates
Relieves mild symptoms of eye dryness
Works fast by delivering soothing moisture
The doctor recommended brand with over 30 years of experience; Ipsos healthcare, 2019 REFRESH ECP Recommendation Study
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Amazon.com | 9.68 | ✅ | ✅ | ✅ |
Triple-action relief drop
Lubricants and hydrates dry, burning, irritated eyes
Helps prevent tears from evaporating
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Stam Sales | 9.93 | ✅ | ✅ | ✅ |
Acts fast to relieve dryness, burning, irritation, and discomfort in the eyes that may be due to digital device use
Delivers soothing hydration by supporting all three tear film layers
Helps prevent tears from evaporating due to lipid layer deficiencies
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Amazon.com | 9.68 | ✅ | ✅ | ✅ |
LONG LASTING, FAST RELIEF DRY EYE THERAPY: Use Soothe Lubricant Eye Drops to help moisturize & refresh dry eyes for long-lasting relief & comfort Formulated to relieve dryness of the eye & help prevent irritation
DRY EYE DROPS: Tear replacement drops are important to help relieve dry eye symptoms
BAUSCH + LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to make sure your eyes feel healthy, moisturized, & protected
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| RealbestQuality products LLC | 2.60 | ❌ | ❌ | ❌ |
DESIGNED: To apply like a drop, yet relieve like a gel for soothing comfort
DELIVERS: Moisture and extended relief from moderate symptoms of eye dryness day or night
FEATURES: HydroCell technology which enables hydration and maintains the volume of cells on the ocular surface
CLINICALLY SHOWN: To significantly reduce eye dryness symptoms in 7 days and 30 days of use
CONVENIENT: Comes in a multi-dose bottle and does not require shaking before use
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Amazon.com | 9.68 | ✅ | ✅ | ✅ |
Nighttime relief for intense eye dryness
Preservative-free
Soothes eyes while you sleep
Protects eyes from nighttime dryness due to exposure
Ideal for use at bedtime
Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| ❌ | ❌ | ❌ |
Contains Refresh Optive Mega-3 Lubricant Eye Drops, Preservative-Free (0.01 Fl Oz Single-Use Containers, 30 Count) and Refresh P.M. Lubricant Eye Ointment, Nighttime Relief, Preservative-Free (0.12 Oz Sterile)
Preservative-free moisture-rich formula; Designed to relieve moderate symptoms of eye dryness.
Nighttime relief for intense eye dryness
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Amazon.com | 9.68 | ✅ | ✅ | ✅ |
Extended relief plus protection for dry, irritated eyes
Our most comprehensive gel formula
Anytime relief, day or night
Feels like a drop but works like a gel for lasting comfort
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
Doctor recommended with over 30 years of experience; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
| SELLER | SELLER SCORE | AMAZON FULFILLED | PRIME | FREE SHIPPING |
|---|---|---|---|---|
| Amazon.com | 9.68 | ✅ | ✅ | ✅ |
Preservative free formula relieves discomfort due to dry, irritated eyes
Prevents further irritation
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
Recommended for sensitive eyes
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
On-the-go single use vials
Also available in a preservative-free formula that comes in a multidose bottle.
The #1 selling brand in preservative-free artificial tears.* *REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.
Here is the list of top-rated brands that were evaluated by PM.
| Brand | Count |
|---|---|
| Refresh | 8 |
| Soothe | 1 |
| Visine | 1 |
We've carried out a comprehensive analysis of 49,058 reviews on eye drops for hydration, using our selection criteria to identify the best options in the categories. Our findings reveal that most customers typically select eye drops for hydration priced around $14.61, with top brands including theratears, lumify, biotrue, systane, optase, renu, refresh, visine and alcon and ocusoft
Our team of expert editors reviewed these high-quality items and handpicked the top 10 eye drops for hydration for your consideration. We've also done extensive research on numerous sellers, identifying the best ones in the categories category. These include amazon.com, scope eyecare, healthi solutions, liquid i.v., dripdrop hydration, jjbookit, stam sales, zazzee naturals and evergreencreations and aytu consumer health .
We are dedicated to assisting our users in finding the right drops Products based on their needs, saving them considerable time when choosing which eye drops for hydration to buy. We take pride in the number of satisfied users we've helped through our thorough and insightful reviews.
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