Best Liquids Sinus Medicine in 2026

Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses

Breathe better all day or all night long with Vicks Sinex Severe; For instant; 12-hour; nasal congestion and sinus pressure relief

This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell; Not intended for daily use

Restores moisture to dry and irritated nasal membranes

Formulated to be compatible with delicate nasal tissue

Gentle enough for babies and year-round use

100% PURE INGREDIENTS: Purified water, salt and ARM & HAMMER Baking Soda.

ISOTONIC FORMULA: Unique nasal spray formula helps to naturally moisten dry nasal passages and clear congestion associated with year-round allergies and the common cold.

RELIEVES DRYNESS: Gentle mist helps to moisturize and relieve dryness in the nose

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies

Pain reliever and nasal decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure

Each sinus relief caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever as well as 5 mg of phenylephrine HCl, a nasal decongestant to help clear nasal passages

ACTIVE INGREDIENTS: This product contains acetaminophen (pain reliever and fever reducer), dextromethorphan HBr (cough suppressant) and doxylamine succinate (antihistamine) which compares to the active ingredients in Vicks NyQuil Cold & Flu.

POWERFUL NIGHTTIME RELIEF: This cold and flu medicine provides multi-symptom relief of common cold and flu symptoms while you sleep.

PAIN RELIEVER AND FEVER REDUCER: Relieves sore throat, minor aches and pains and reduces fever associated with the common cold and flu.

24-count box of Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant Tablets provide powerful relief of sinus pain, sinus pressure, nasal congestion and headaches

Each caplet contains 5 milligrams of the decongestant phenylephrine HCl and 325 milligrams of acetaminophen, a pain reliever and fever reducer

This sinus congestion & pain medicine also temporarily relieves nasal congestion associated with hay fever, upper respiratory allergies and the common cold

ACTIVE INGREDIENT: The active ingredient in GoodSense Maximum Strength Nasal Decongestant PE is phenylephrine HCl 10 mg, a nasal decongestant, which compares to the active ingredient in Sudafed PE Congestion

NASAL DECONGESTANT: This product provides maximum strength, non-drowsy relief for nasal and sinus congestion, and sinus pressure due to the common cold, hay fever or other upper respiratory allergies

MAXIMUM STRENGTH: GoodSense Maximum Strength Nasal Decongestant PE provides maximum strength relief for sinus pressure, nasal and sinus congestion

VAPOPADS REFILL – These Vicks VapoPads are non-medicated refill pads for Vicks Humidifiers, Vaporizers, Waterless Vaporizers, and Plug-Ins. This 6 count pack of vapor pads is designed to provide relief from cold, cough and flu with soothing menthol vapors

LONG-LASTING RELIEF – Each pad provides eight hours of comfort with Vicks plug-in and waterless vaporizers, inhalers and humidifiers, so you can breathe easier and sleep better

NO MESS REFILL – These menthol vapor pads are easy to use and install, with no messy spills. You’ll never have to worry about vaporizer liquid spills again

NATURAL SALINE SOLUTION & NASAL RINSE: Our nasal saline spray will gently clean and moisturize the sinus tissues. Unlike other normal saline nasal sprays our spray can also decongest the sinuses by targeting the primary causes of nasal congestion. Our nose spray will help reduce tissue swelling from pollen, pollution, contaminants, and other irritants.

SAFE NASAL RINSE & SPRAY: Our all-natural nasal cleaner is safe for kids, non-addictive, Non-GMO Project Verified and is effective without the use of steroids, drugs, or chemicals. It is the ideal daily sinus medicine that will reduce swelling and open your airways. Using our saline nose spray before bed may reduce snoring.

IMPROVED FORMULA WITH XYLITOL: Our patented saline nasal spray solution may reduce tissue inflammation and naturally open airways. Xylitol's powerful oral and upper respiratory health benefits come from its unique five-carbon structure. Xylitol may help reduce swelling and allergy symptoms by reducing contaminant adhesion on your nasal tissue.

Nose spray

Unblocks your nose fast

Lasts up to 10 hours

YOUR BODYGUARD IN A BOTTLE: Propolis Throat Spray is the powerful, clean immune support you’ve been searching for. Bee Propolis is nature's ultimate protector and serves as the hive's immune system. It has been used for centuries for immune support, soothing scratchy throats, and promoting recovery.

IMMUNE SUPPORT: Naturally rich in antioxidants and 300+ beneficial compounds, this is a natural solution that is painstakingly tested for quality & potency. No refined sugars, artificial ingredients, or additives. Our products are always third party lab tested to ensure they never contain pesticide residue or nasty chemicals.

ONLY 3 INGREDIENTS: High-grade bee propolis extract, non-GMO vegetable glycerin, and purified water. Contains NO: artificial preservatives, colors, refined sugar, gluten, wheat, yeast, corn, soy, dairy, egg. People allergic to bees or bee products may experience allergic reactions. Not recommended for pregnant or lactating women

4-fluid ounces of Children's Tylenol Oral Suspension Liquid Medicine with grape flavor to temporarily relieve kids' cold & flu symptoms, including cough, headache and fever

This multi-symptom relief medicine for kids also helps relieve minor aches and pains, sore throat, stuffy or runny nose, sneezing and congestion

Each 5mL contains 160 mg of acetaminophen pain reliever and fever reducer, 5 mg of dextromethorphan HBr cough suppressant, 2.5 mg of phenylephrine HCl decongestant and 1 mg of the antihistamine chlorpheniramine maleate

24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold

This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.

Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs

Package contains 6 powder packets of Theraflu Multi-Symptom Severe Cold Medicine, Cold and Cough Medicine Powder Packets, Green Tea and Honey Lemon Flavors

Powerful relief from cold symptoms such as sore throat pain, headache, minor body aches and pains, nasal and sinus congestion, cough and fever

Theraflu powder dissolves quickly in hot water for cold, cough and sore throat relief that is as easy as making a cup of tea

One package of 50 coated tablets of Advil Allergy and Congestion Relief Tablets, Pain Reliever, Fever Reducer and Allergy Relief with Ibuprofen, Phenylephrine HCl and Chlorpheniramine Maleate 4 mg

200mg ibuprofen pain medication temporarily relieves fever, minor body aches and headache

Phenylephrine HCl 10 mg tablets with chlorpheniramine maleate 4mg work together to deliver sinus pressure relief, nasal congestion relief, runny nose relief and nasal swelling relief

4-fluid ounces of Children's Sudafed PE Nasal Decongestant provides temporary relief for children's nasal congestion and sinus pressure due to the common cold and hay fever

Non-drowsy nasal decongestant formula that is alcohol-free and sugar-free and includes the active ingredient of phenylephrine HCl as a nasal decongestant

Find both sinus pressure and nasal congestion relief with this cold medicine for kids ages 4-11 with a non-drowsy formula

COLD & FLU RELIEF - Get fast, temporary relief from cold & flu symptoms, including nasal and sinus congestion, runny nose, sore throat, coughing, sneezing, chills and fever

DISSOLVING TABLETS - Take at the first sign of symptoms — the quick-dissolving tablets melt quickly in your mouth with no water needed! Works in combination with our syrups, gummies, and lozenges

NON-DROWSY HOMEOPATHIC MEDICINE - Sambucol Black Elderberry tablets are non-drowsy cold and flu relief tablets that are perfect for the whole family. Less than 1g of sugar per tablet

Your NOSE is the body’s AIR FILTER, the first line of defense against airborne particulates. Now you can keep your nose clean with easy-to-use Naväge nasal rinse!

Naväge uses POWERED SUCTION to FLUSH OUT ragweed, pollen, encrusted mucus, and airborne particulates. Naväge is the world’s ONLY nose cleaner with powered suction. You’ll love that clean-nose feeling!

For fast, all-natural relief from allergies and sinus congestion – WITHOUT DRUGS! Naväge operates only with genuine Naväge SaltPod capsules.

POWERFUL, MAXIMUM STRENGTH 9-SYMPTOM RELIEF: NyQuil SEVERE relieves coughing, sneezing, stuffy nose, minor body pain, sinus congestion, sinus pressure, sore throat, headache, and fever

POWERFUL NIGHTTIME COLD & FLU RELIEF: NyQuil SEVERE temporarily relieves common cold & flu symptoms so you can get the rest you need

FAST RELIEF SO YOU CAN SLEEP: Don't let your cold keep you up, Just one dose of NyQuil SEVERE starts working fast to provide effective cold & flu relief

6 packets of Theraflu Nighttime Severe Cold Relief Honey Lemon Flavor Powder

Powerful relief from severe cold, cough, and flu symptoms such as sore throat pain, headache, minor body aches and pains, and nasal and sinus congestion

Hot liquid provides a soothing effect

MAXIMUM STRENGTH MUCINEX FAST-MAX COLD & FLU: Multi-Symptom Relief medicine; 1 dose treats 9 symptoms - get back to what’s important thanks to the fast, powerful medicine

DAY TIME MULTI-SYMPTOM RELIEF: Maximum Strength Day Time Cold and Flu helps reduce fever, relieve cough, chest, nasal & sinus congestion that can cause mucus buildup, sinus pressure, minor aches and pains, headache and sore throat

NIGHT TIME MULTI-SYMPTOM RELIEF: Maximum Strength Night Time Cold and Flu helps reduce fever, relieve cough, nasal congestion that leads to stuffy nose, minor aches and pains, headache, sneezing, runny nose and sore and itchy throat

PERSONAL STEAM INHALER – Vicks Personal Sinus Steam Inhaler provides a warm mist of steam for temporary symptomatic relief from cough, congestion and allergies in a 5-15 minute treatment. Compatible with soothing menthol Vicks VapoPads for added comfort.

QUICK AND EASY TO USE – Get fast relief in a quick 5-15 treatment. With this Vicks steam inhaler, no filters are required and it’s designed to work with tap water.

COUGH AND CONGESTION RELIEF – This personal steam inhaler features an ergonomic designed face mask, for targeted delivery of pure, germ-free mist. Soothing steam penetrates nasal, sinus and throat passages for fast relief.

Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.

Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.

ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.

One two-pack box of 15 mL Afrin No Drip Severe Congestion Maximum Strength 12 Hour Nasal Congestion Relief Spray

Maximum strength nasal spray with menthol for instant nasal and sinus congestion relief

No drip nasal spray allows easier breathing through the nose without dripping down your nose or throat. Health Concern: Nasal Congestion Allergy

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Fast-Max DM MAX helps relieve cough, thins and loosens mucus and relieves chest congestion

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.

#1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*

PAIN RELIEVER: Contains Acetaminophen which relieves minor aches and pains

Contains two (2) 0.57 fl. oz. spray bottles of Nasacort 24HR Allergy Nasal Spray for Adults (120 Sprays)

Nasacort is eliminating 96k pounds of plastic with its new recyclable carton; packaging might vary

Nasacort Nasal Allergy Spray provides a full 24 hours of relief from the worst nasal allergy symptoms, such as congestion

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.

#1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*

PAIN RELIEVER: Contains Acetaminophen which relieves minor aches, pains and headache

25% smaller pill: Alka-Seltzer Plus Maximum Strength cold & Flu Powermax gels have a concentrated formula to provide powerful fast relief

Maximum strength day time and night time relief from your worst cold & Flu symptoms

Day time multi-symptom relief of nasal congestion, cough, headache, body ache, sore throat, Sinus pressure and fever. Night time multi-symptom relief of runny nose, nasal congestion, cough, headache, body ache, sore throat and fever.

MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Fast-Max Severe Congestion & Cough helps relieve cough, thins and loosens mucus and relieves chest and nasal congestion

#1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand

COUGH SUPPRESSANT: Contains Dextromethorphan HBr that helps relieve cough